Attenuation of multi-targeted proliferation-linked signaling by 3,3'-diindolylmethane (DIM): from bench to clinic

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Attenuation of multi-targeted proliferation-linked signaling by 3,3'-diindolylmethane (DIM): from bench to clinic is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1016/J.MRREV.2011.06.001
P8608Fatcat IDrelease_tobu767mebhqjdyqjwcdqpsjse
P932PMC publication ID4120774
P698PubMed publication ID21703360

P50authorFazlul H. SarkarQ56648717
P2093author name stringBin Bao
Zhiwei Wang
Dejuan Kong
Sanjeev Banerjee
Gilda G Hillman
P2860cites workSelective growth regulatory and pro-apoptotic effects of DIM is mediated by AKT and NF-kappaB pathways in prostate cancer cellsQ40485942
BRCA1 induces antioxidant gene expression and resistance to oxidative stressQ40497271
Parallel signal processing among mammalian MAPKsQ40501929
Physiological modeling of formulated and crystalline 3,3'-diindolylmethane pharmacokinetics following oral administration in miceQ40509009
Therapeutic activity of 3,3'-diindolylmethane on prostate cancer in an in vivo modelQ40526433
Endoplasmic reticulum stress as a correlate of cytotoxicity in human tumor cells exposed to diindolylmethane in vitroQ40532508
Diindolylmethane alters gene expression in human keratinocytes in vitroQ40691533
Dietary indoles and isothiocyanates that are generated from cruciferous vegetables can both stimulate apoptosis and confer protection against DNA damage in human colon cell linesQ40785886
2,3,7,8-Tetrachlorodibenzo-p-dioxin and diindolylmethanes differentially induce cytochrome P450 1A1, 1B1, and 19 in H295R human adrenocortical carcinoma cells.Q40813823
p21--negative regulator of the cell cycleQ41226557
Ah receptor binding properties of indole carbinols and induction of hepatic estradiol hydroxylationQ42288805
Aryl hydrocarbon receptor-mediated antiestrogenic and antitumorigenic activity of diindolylmethaneQ42539035
The p38 MAPK pathway is critical for 5,5'-dibromodiindolylmethane-induced apoptosis to prevent oral squamous carcinoma cellsQ43233403
3,3'-Diindolylmethane attenuates experimental arthritis and osteoclastogenesisQ43255618
Methyl-substituted diindolylmethanes as inhibitors of estrogen-induced growth of T47D cells and mammary tumors in ratsQ43661614
Bcl-2 family-mediated apoptotic effects of 3,3'-diindolylmethane (DIM) in human breast cancer cellsQ43738757
Quantitative determination of 3,3'-diindolylmethane in urine of individuals receiving indole-3-carbinolQ44048179
Indole-3-carbinol and 3,3′-diindolylmethane induce apoptosis in human prostate cancer cellsQ44434784
Acid reaction products of indole-3-carbinol and their effects on cytochrome P450 and phase II enzymes in rat and monkey hepatocytes.Q44676971
Pilot study: effect of 3,3'-diindolylmethane supplements on urinary hormone metabolites in postmenopausal women with a history of early-stage breast cancerQ45204926
3,3'-Diindolylmethane inhibits angiogenesis and the growth of transplantable human breast carcinoma in athymic miceQ45231913
Indole-3-carbinol and 3,3'-diindolylmethane induce expression of NAG-1 in a p53-independent mannerQ45238294
Phytochemical-induced changes in gene expression of carcinogen-metabolizing enzymes in cultured human primary hepatocytesQ45239724
Inhibition of growth factor-induced Ras signaling in vascular endothelial cells and angiogenesis by 3,3'-diindolylmethaneQ46122131
A novel ring-substituted diindolylmethane,1,1-bis[3'-(5-methoxyindolyl)]-1-(p-t-butylphenyl) methane, inhibits extracellular signal-regulated kinase activation and induces apoptosis in acute myelogenous leukemiaQ46417590
Mitochondria-dependent reactive oxygen species-mediated programmed cell death induced by 3,3'-diindolylmethane through inhibition of F0F1-ATP synthase in unicellular protozoan parasite Leishmania donovani.Q46429094
Inhibitory effects of a dietary phytochemical 3,3'-diindolylmethane on the phenobarbital-induced hepatic CYP mRNA expression and CYP-catalyzed reactions in female ratsQ46590712
Indole-3-carbinol, but not its major digestive product 3,3'-diindolylmethane, induces reversible hepatocyte hypertrophy and cytochromes P450.Q46618227
3,3'-diindolylmethane (DIM) and its derivatives induce apoptosis in pancreatic cancer cells through endoplasmic reticulum stress-dependent upregulation of DR5.Q46839472
Gene expression profiles of I3C- and DIM-treated PC3 human prostate cancer cells determined by cDNA microarray analysisQ47996735
Differences in the hepatic P450-dependent metabolism of estrogen and tamoxifen in response to treatment of rats with 3,3'-diindolylmethane and its parent compound indole-3-carbinol.Q50959305
Oral administration of 3,3'-diindolylmethane inhibits lung metastasis of 4T1 murine mammary carcinoma cells in BALB/c mice.Q51606752
Multiple, disparate roles for calcium signaling in apoptosis of human prostate and cervical cancer cells exposed to diindolylmethane.Q52569386
Cancer chemoprevention: principles and prospects.Q53478356
3,3'-diindolylmethane and paclitaxel act synergistically to promote apoptosis in HER2/Neu human breast cancer cells.Q53629560
Adenomatous polyposis coli determines sensitivity to histone deacetylase inhibitor-induced apoptosis in colon cancer cells.Q54455472
3,3'-diindolylmethane inhibits migration and invasion of human cancer cells through combined suppression of ERK and AKT pathways.Q54626968
Influence of indole carbinols and growth hormone on the metabolism of 4-androstenedione by rat liver microsomesQ57665768
Chemoprevention of cancerQ69880729
The anticarcinogen 3,3'-diindolylmethane is an inhibitor of cytochrome P-450Q70918066
The role of c-Jun N-terminal kinase (JNK) in apoptosis induced by ultraviolet C and gamma radiation. Duration of JNK activation may determine cell death and proliferationQ71833616
3,3'-Diindolylmethane induces CYP1A2 in cultured precision-cut human liver slicesQ77314605
Indole-3-carbinol and diindolylmethane induce apoptosis of human cervical cancer cells and in murine HPV16-transgenic preneoplastic cervical epitheliumQ77340136
Single-dose and multiple-dose administration of indole-3-carbinol to women: pharmacokinetics based on 3,3'-diindolylmethaneQ79428709
Antiangiogenic effects of indole-3-carbinol and 3,3'-diindolylmethane are associated with their differential regulation of ERK1/2 and Akt in tube-forming HUVECQ84848256
Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factorQ22009126
Global cancer statisticsQ22241238
Ligand-dependent interaction of the aryl hydrocarbon receptor with a novel immunophilin homolog in vivoQ24314469
The hsp90 chaperone complex regulates intracellular localization of the dioxin receptorQ24550978
MicroRNAs: target recognition and regulatory functionsQ24609584
Up-regulation of miR-200 and let-7 by natural agents leads to the reversal of epithelial-to-mesenchymal transition in gemcitabine-resistant pancreatic cancer cellsQ24651034
3,3'-Diindolylmethane induces a G(1) arrest in human prostate cancer cells irrespective of androgen receptor and p53 statusQ24652101
Celecoxib analogues disrupt Akt signaling, which is commonly activated in primary breast tumoursQ24813725
Epithelial-mesenchymal transitions in development and diseaseQ27860630
MicroRNA gene expression deregulation in human breast cancerQ27860690
Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase BQ27860731
Role of the aromatic hydrocarbon receptor and [Ah] gene battery in the oxidative stress response, cell cycle control, and apoptosisQ28140867
Identification of Nrf2-regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotide microarrayQ28202142
Activation of the aryl hydrocarbon receptor by structurally diverse exogenous and endogenous chemicalsQ28204565
Current development of mTOR inhibitors as anticancer agentsQ28255366
Association of the Ah receptor with the 90-kDa heat shock proteinQ28281332
Estrogen induced metastatic modulators MMP-2 and MMP-9 are targets of 3,3'-diindolylmethane in thyroid cancerQ28476759
Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitorsQ29547463
The aryl hydrocarbon receptor complexQ29618805
microRNAs as oncogenes and tumor suppressorsQ29619907
Evidence of insulin-stimulated phosphorylation and activation of the mammalian target of rapamycin mediated by a protein kinase B signaling pathwayQ30454351
Induction of growth arrest and apoptosis in human breast cancer cells by 3,3-diindolylmethane is associated with induction and nuclear localization of p27kipQ33292308
Phase I clinical trial of histone deacetylase inhibitor: suberoylanilide hydroxamic acid administered intravenously.Q33356908
Induction of G1 and G2/M cell cycle arrests by the dietary compound 3,3'-diindolylmethane in HT-29 human colon cancer cellsQ33456210
Chemopreventive agent 3,3'-diindolylmethane selectively induces proteasomal degradation of class I histone deacetylasesQ33597363
Induction of cytochrome P4501A1.Q33636653
Selective activation of estrogen receptor-beta target genes by 3,3'-diindolylmethaneQ33772337
Enhancement of docetaxel anticancer activity by a novel diindolylmethane compound in human non-small cell lung cancerQ33837550
Structural organization of the microsomal glutathione S-transferase gene (MGST1) on chromosome 12p13.1-13.2. Identification of the correct promoter region and demonstration of transcriptional regulation in response to oxidative stressQ33899126
3,3'-Diindolylmethane (DIM) inhibits the growth and invasion of drug-resistant human cancer cells expressing EGFR mutantsQ33937876
3,3'-diindolylmethane enhances the efficacy of butyrate in colon cancer prevention through down-regulation of survivinQ33980057
The Pezcoller lecture: cancer cell cycles revisitedQ33987290
Activation of checkpoint kinase 2 by 3,3'-diindolylmethane is required for causing G2/M cell cycle arrest in human ovarian cancer cellsQ34051616
A phase I dose-escalation study of oral BR-DIM (BioResponse 3,3'- Diindolylmethane) in castrate-resistant, non-metastatic prostate cancerQ34073969
PKB/Akt mediates cell-cycle progression by phosphorylation of p27(Kip1) at threonine 157 and modulation of its cellular localizationQ34150579
3,3'-Diindolylmethane is a novel mitochondrial H(+)-ATP synthase inhibitor that can induce p21(Cip1/Waf1) expression by induction of oxidative stress in human breast cancer cellsQ34519972
Modulation of aflatoxin B1-mediated genotoxicity in primary cultures of human hepatocytes by diindolylmethane, curcumin, and xanthohumolsQ34612062
Therapy for recurrent respiratory papillomatosis.Q34636170
Concurrent inhibition of NF-kappaB, cyclooxygenase-2, and epidermal growth factor receptor leads to greater anti-tumor activity in pancreatic cancerQ34979358
Histone deacetylase inhibitors: from target to clinical trialsQ35011880
Oral diindolylmethane (DIM): pilot evaluation of a nonsurgical treatment for cervical dysplasia.Q35014562
Activation of nuclear TR3 (NR4A1) by a diindolylmethane analog induces apoptosis and proapoptotic genes in pancreatic cancer cells and tumorsQ35020448
Results from a dose-response study using 3,3'-diindolylmethane in the K14-HPV16 transgenic mouse model: cervical histologyQ35023935
Whole body pharmacokinetic modelsQ35186644
Fas-mediated apoptosis in cholangiocarcinoma cells is enhanced by 3,3'-diindolylmethane through inhibition of AKT signaling and FLICE-like inhibitory proteinQ35607306
Mitogen-activated protein kinases in apoptosis regulationQ35743118
Phase I study of an oral histone deacetylase inhibitor, suberoylanilide hydroxamic acid, in patients with advanced cancerQ35758280
Interplay of genes regulated by estrogen and diindolylmethane in breast cancer cell linesQ35795746
Sensitization of squamous cell carcinoma to cisplatin induced killing by natural agentsQ35954519
Agonist and chemopreventative ligands induce differential transcriptional cofactor recruitment by aryl hydrocarbon receptorQ36139135
Cytochrome P450-mediated metabolism of estrogens and its regulation in human.Q36236196
Quantitative combination effects between sulforaphane and 3,3'-diindolylmethane on proliferation of human colon cancer cells in vitro.Q40164660
Activation of caspase-8 contributes to 3,3'-Diindolylmethane-induced apoptosis in colon cancer cellsQ40191546
Down-regulation of androgen receptor by 3,3'-diindolylmethane contributes to inhibition of cell proliferation and induction of apoptosis in both hormone-sensitive LNCaP and insensitive C4-2B prostate cancer cellsQ40218951
Gene expression profiling revealed survivin as a target of 3,3'-diindolylmethane-induced cell growth inhibition and apoptosis in breast cancer cellsQ40284922
3,3'-diindolylmethane is a novel topoisomerase IIalpha catalytic inhibitor that induces S-phase retardation and mitotic delay in human hepatoma HepG2 cellsQ40335255
3,3'-Diindolylmethane downregulates pro-survival pathway in hormone independent prostate cancerQ40335810
Down-regulation of c-FLIP contributes to the sensitization effect of 3,3'-diindolylmethane on TRAIL-induced apoptosis in cancer cells.Q40336857
3,3'-Diindolylmethane, a cruciferous vegetable derived synthetic anti-proliferative compound in thyroid diseaseQ40363109
Inhibition of nuclear translocation of nuclear factor-{kappa}B contributes to 3,3'-diindolylmethane-induced apoptosis in breast cancer cells.Q40467145
The roles of BRCA1 and BRCA2 and associated proteins in the maintenance of genomic stabilityQ36602569
3,3'-diindolylmethane reduces levels of HIF-1alpha and HIF-1 activity in hypoxic cultured human cancer cellsQ36663529
Molecular basis for chemoprevention by sulforaphane: a comprehensive review.Q36775326
3,3'-Diindolylmethane induces apoptosis in human cancer cells.Q36831745
5,5'-Dibromo-bis(3'-indolyl)methane induces Kruppel-like factor 4 and p21 in colon cancer cellsQ36932062
Anticarcinogenesis by dietary phytochemicals: cytoprotection by Nrf2 in normal cells and cytotoxicity by modulation of transcription factors NF-kappa B and AP-1 in abnormal cancer cellsQ36976619
Single-dose pharmacokinetics and tolerability of absorption-enhanced 3,3'-diindolylmethane in healthy subjectsQ37014907
Targeting of aryl hydrocarbon receptor-mediated activation of cyclooxygenase-2 expression by the indole-3-carbinol metabolite 3,3'-diindolylmethane in breast cancer cellsQ37105790
Mammalian target of rapamycin repression by 3,3'-diindolylmethane inhibits invasion and angiogenesis in platelet-derived growth factor-D-overexpressing PC3 cellsQ37132900
Down-regulation of uPA and uPAR by 3,3'-diindolylmethane contributes to the inhibition of cell growth and migration of breast cancer cellsQ37132905
Chemoprevention of pancreatic cancer: characterization of Par-4 and its modulation by 3,3' diindolylmethane (DIM)Q37154124
Apoptosis-inducing effect of erlotinib is potentiated by 3,3'-diindolylmethane in vitro and in vivo using an orthotopic model of pancreatic cancerQ37164282
Cell cycle-dependent effects of 3,3'-diindolylmethane on proliferation and apoptosis of prostate cancer cellsQ37204538
3,3'-Diindolylmethane enhances taxotere-induced growth inhibition of breast cancer cells through downregulation of FoxM1.Q37243057
Inactivation of uPA and its receptor uPAR by 3,3'-diindolylmethane (DIM) leads to the inhibition of prostate cancer cell growth and migrationQ37335608
RETRACTED: 3,3'-Diindolylmethane enhances chemosensitivity of multiple chemotherapeutic agents in pancreatic cancerQ37345627
The paradox of autophagy and its implication in cancer etiology and therapyQ37378496
Low concentrations of diindolylmethane, a metabolite of indole-3-carbinol, protect against oxidative stress in a BRCA1-dependent mannerQ37421782
Diindolylmethane inhibits cervical dysplasia, alters estrogen metabolism, and enhances immune response in the K14-HPV16 transgenic mouse modelQ37440864
MicroRNAs in cancer: small molecules with a huge impactQ37474280
MicroRNAs and future therapeutic applications in cancer.Q37604233
Targeting NR4A1 (TR3) in cancer cells and tumorsQ37825901
DIM stimulates IFNgamma gene expression in human breast cancer cells via the specific activation of JNK and p38 pathwaysQ38329951
3,3'-Diindolylmethane (DIM) induces a G(1) cell cycle arrest in human breast cancer cells that is accompanied by Sp1-mediated activation of p21(WAF1/CIP1) expressionQ38363872
Induction of apoptosis in human prostate cancer cell line, PC3, by 3,3'-diindolylmethane through the mitochondrial pathwayQ38801802
Effect of diindolylmethane on Ca(2+) movement and viability in HA59T human hepatoma cellsQ39575476
3,3'-Diindolylmethane inhibits prostate cancer development in the transgenic adenocarcinoma mouse prostate modelQ39608493
3,3′-Diindolylmethane negatively regulates Cdc25A and induces a G2/M arrest by modulation of microRNA 21 in human breast cancer cellsQ39665391
Discovery and mechanistic characterization of a novel selective nuclear androgen receptor exporter for the treatment of prostate cancerQ39752772
Novel 3,3'-diindolylmethane derivatives: synthesis and cytotoxicity, structural characterization in solid stateQ39835913
3,3'-diindolylmethane induction of p75NTR-dependent cell death via the p38 mitogen-activated protein kinase pathway in prostate cancer cellsQ39846893
3,3'-Diindolylmethane enhances taxotere-induced apoptosis in hormone-refractory prostate cancer cells through survivin down-regulationQ39852552
Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.Q40048047
1,1-bis(3'-indolyl)-1-(p-methoxyphenyl)methane activates Nur77-independent proapoptotic responses in colon cancer cellsQ40063189
Inactivation of NF-kappaB by 3,3'-diindolylmethane contributes to increased apoptosis induced by chemotherapeutic agent in breast cancer cellsQ40072453
Regulation of FOXO3a/beta-catenin/GSK-3beta signaling by 3,3'-diindolylmethane contributes to inhibition of cell proliferation and induction of apoptosis in prostate cancer cellsQ40128741
Inhibition of angiogenesis and invasion by 3,3'-diindolylmethane is mediated by the nuclear factor-kappaB downstream target genes MMP-9 and uPA that regulated bioavailability of vascular endothelial growth factor in prostate cancerQ40149269
P433issue1-2
P407language of work or nameEnglishQ1860
P304page(s)47-66
P577publication date2011-06-15
P1433published inMutation ResearchQ6943732
P1476titleAttenuation of multi-targeted proliferation-linked signaling by 3,3'-diindolylmethane (DIM): from bench to clinic
P478volume728

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cites work (P2860)
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