Down-regulation of c-FLIP contributes to the sensitization effect of 3,3'-diindolylmethane on TRAIL-induced apoptosis in cancer cells.

scientific article published on December 2005

Down-regulation of c-FLIP contributes to the sensitization effect of 3,3'-diindolylmethane on TRAIL-induced apoptosis in cancer cells. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1158/1535-7163.MCT-05-0249
P698PubMed publication ID16373712

P50authorSiyuan ZhangQ38319338
Han-Ming ShenQ40151916
Choon Nam OngQ64025681
P2093author name stringChoon Nam Ong
P433issue12
P304page(s)1972-1981
P577publication date2005-12-01
P1433published inMolecular Cancer TherapeuticsQ2363144
P1476titleDown-regulation of c-FLIP contributes to the sensitization effect of 3,3'-diindolylmethane on TRAIL-induced apoptosis in cancer cells
P478volume4

Reverse relations

cites work (P2860)
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Q33997903Attenuation of multi-targeted proliferation-linked signaling by 3,3'-diindolylmethane (DIM): from bench to clinic
Q39293506Calyculin A causes sensitization to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis by ROS-mediated down-regulation of cellular FLICE-inhibiting protein (c-FLIP) and by enhancing death receptor 4 mRNA stabilization
Q35915103Cellular FLICE-like inhibitory protein (C-FLIP): a novel target for cancer therapy
Q33780121Functional drug screening assay reveals potential glioma therapeutics
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Q35223910Killing of resistant cancer cells with low Bak by a combination of an antimesothelin immunotoxin and a TRAIL Receptor 2 agonist antibody
Q35419466Lanatoside C sensitizes glioblastoma cells to tumor necrosis factor-related apoptosis-inducing ligand and induces an alternative cell death pathway
Q39770080Mitotic arrest and JNK-induced proteasomal degradation of FLIP and Mcl-1 are key events in the sensitization of breast tumor cells to TRAIL by antimicrotubule agents
Q28397635Novel phosphorylation and ubiquitination sites regulate reactive oxygen species-dependent degradation of anti-apoptotic c-FLIP protein
Q34202880Short-hairpin RNA-induced suppression of adenine nucleotide translocase-2 in breast cancer cells restores their susceptibility to TRAIL-induced apoptosis by activating JNK and modulating TRAIL receptor expression
Q36982967Structure-dependent activation of endoplasmic reticulum stress-mediated apoptosis in pancreatic cancer by 1,1-bis(3'-indoly)-1-(p-substituted phenyl)methanes
Q38707912The bounty of nature for changing the cancer landscape
Q33808654β-Elemene piperazine derivatives induce apoptosis in human leukemia cells through downregulation of c-FLIP and generation of ROS.

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