The spike protein of SARS-CoV--a target for vaccine and therapeutic development

scientific article

The spike protein of SARS-CoV--a target for vaccine and therapeutic development is …
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review articleQ7318358
scholarly articleQ13442814

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P6179Dimensions Publication ID1042213744
P356DOI10.1038/NRMICRO2090
P932PMC publication ID2750777
P698PubMed publication ID19198616
P5875ResearchGate publication ID23986117

P50authorShuwen LiuQ87852411
Shibo JiangQ88118974
Lanying DuQ89375433
Yusen ZhouQ98175621
P2093author name stringBo-Jian Zheng
Yuxian He
P2860cites workCD209L (L-SIGN) is a receptor for severe acute respiratory syndrome coronavirusQ24307914
Severe acute respiratory syndrome coronavirus-like virus in Chinese horseshoe batsQ24536078
pH-dependent entry of severe acute respiratory syndrome coronavirus is mediated by the spike glycoprotein and enhanced by dendritic cell transfer through DC-SIGNQ24563490
Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirusQ28188496
A 193-amino acid fragment of the SARS coronavirus S protein efficiently binds angiotensin-converting enzyme 2Q28191005
Coronavirus as a possible cause of severe acute respiratory syndromeQ28200848
Characterization of a novel coronavirus associated with severe acute respiratory syndromeQ28202401
HIV entry and its inhibitionQ28273919
Bats are natural reservoirs of SARS-like coronavirusesQ28274751
Structural characterization of the SARS-coronavirus spike S fusion protein core.Q48009341
Laboratory-acquired SARS raises worries on biosafetyQ48020374
DNA vaccine of SARS-Cov S gene induces antibody response in miceQ48029320
Newly discovered coronavirus as the primary cause of severe acute respiratory syndrome.Q51660929
SARS-Associated CoronavirusQ51673467
Antibodies against trimeric S glycoprotein protect hamsters against SARS-CoV challenge despite their capacity to mediate FcgammaRII-dependent entry into B cells in vitro.Q51803005
Cross-neutralization of human and palm civet severe acute respiratory syndrome coronaviruses by antibodies targeting the receptor-binding domain of spike protein.Q52570591
Identification and characterization of novel neutralizing epitopes in the receptor-binding domain of SARS-CoV spike protein: revealing the critical antigenic determinants in inactivated SARS-CoV vaccine.Q52571074
The intracellular sites of early replication and budding of SARS-coronavirusQ56877432
Severe acute respiratory syndrome--retrospect and lessons of 2004 outbreak in ChinaQ57101917
A model of the ACE2 structure and function as a SARS-CoV receptor.Q64924413
Receptor-binding domain of SARS-CoV spike protein induces long-term protective immunity in an animal modelQ79340070
Generation and characterization of human monoclonal neutralizing antibodies with distinct binding and sequence features against SARS coronavirus using XenoMouseQ79426388
Priming with SARS CoV S DNA and boosting with SARS CoV S epitopes specific for CD4+ and CD8+ T cells promote cellular immune responsesQ80818723
Identification of a critical neutralization determinant of severe acute respiratory syndrome (SARS)-associated coronavirus: importance for designing SARS vaccinesQ81481051
Solution structure of the severe acute respiratory syndrome-coronavirus heptad repeat 2 domain in the prefusion stateQ82685553
Identification of critical determinants on ACE2 for SARS-CoV entry and development of a potent entry inhibitorQ82697155
A single amino acid substitution (R441A) in the receptor-binding domain of SARS coronavirus spike protein disrupts the antigenic structure and binding activityQ83157114
SARS-CoV, but not HCoV-NL63, utilizes cathepsins to infect cells: viral entryQ40220808
Proteolysis of SARS-associated coronavirus spike glycoproteinQ40220881
Recombinant adeno-associated virus expressing the receptor-binding domain of severe acute respiratory syndrome coronavirus S protein elicits neutralizing antibodies: Implication for developing SARS vaccinesQ40263910
Kinetics and synergistic effects of siRNAs targeting structural and replicase genes of SARS-associated coronavirus.Q40330912
SARS coronavirus, but not human coronavirus NL63, utilizes cathepsin L to infect ACE2-expressing cellsQ40341738
Severe acute respiratory syndrome vaccine efficacy in ferrets: whole killed virus and adenovirus-vectored vaccinesQ40411117
Synthetic peptides outside the spike protein heptad repeat regions as potent inhibitors of SARS-associated coronavirusQ40416852
Identification of murine CD8 T cell epitopes in codon-optimized SARS-associated coronavirus spike proteinQ40436586
Receptor-binding domain of severe acute respiratory syndrome coronavirus spike protein contains multiple conformation-dependent epitopes that induce highly potent neutralizing antibodiesQ40437929
Identification of two neutralizing regions on the severe acute respiratory syndrome coronavirus spike glycoprotein produced from the mammalian expression system.Q40471278
Silencing of SARS-CoV spike gene by small interfering RNA in HEK 293T cellsQ40500164
Receptor-binding domain of SARS-CoV spike protein induces highly potent neutralizing antibodies: implication for developing subunit vaccineQ40506063
An animal model of SARS produced by infection of Macaca mulatta with SARS coronavirusQ40508602
A DNA vaccine induces SARS coronavirus neutralization and protective immunity in miceQ40520942
Prophylactic and therapeutic effects of small interfering RNA targeting SARS-coronavirusQ40534160
Suppression of SARS-CoV entry by peptides corresponding to heptad regions on spike glycoproteinQ40548165
S protein of severe acute respiratory syndrome-associated coronavirus mediates entry into hepatoma cell lines and is targeted by neutralizing antibodies in infected patientsQ40551623
Silencing SARS-CoV Spike protein expression in cultured cells by RNA interferenceQ40585048
Short interfering RNA confers intracellular antiviral immunity in human cellsQ40721804
Cathepsin L functionally cleaves the severe acute respiratory syndrome coronavirus class I fusion protein upstream of rather than adjacent to the fusion peptideQ42407073
Antigenic and immunogenic characterization of recombinant baculovirus-expressed severe acute respiratory syndrome coronavirus spike protein: implication for vaccine designQ42424192
HIV-1 inhibition by a peptideQ42559777
Epidemiology and cause of severe acute respiratory syndrome (SARS) in Guangdong, People's Republic of China, in February, 2003.Q42612038
Amino acids 1055 to 1192 in the S2 region of severe acute respiratory syndrome coronavirus S protein induce neutralizing antibodies: implications for the development of vaccines and antiviral agentsQ42716746
Receptor and viral determinants of SARS-coronavirus adaptation to human ACE2.Q42844863
Identification of two critical amino acid residues of the severe acute respiratory syndrome coronavirus spike protein for its variation in zoonotic tropism transition via a double substitution strategy.Q43218942
SARS virus returns to China as scientists race to find effective vaccineQ43240810
Infectious diseases. Mounting lab accidents raise SARS fearsQ44274438
Amiodarone alters late endosomes and inhibits SARS coronavirus infection at a post-endosomal levelQ44282477
A patient with asymptomatic severe acute respiratory syndrome (SARS) and antigenemia from the 2003-2004 community outbreak of SARS in Guangzhou, ChinaQ44668500
Inactivated SARS-CoV vaccine elicits high titers of spike protein-specific antibodies that block receptor binding and virus entryQ45141976
Inhibition of SARS-CoV replication by siRNA.Q45206542
Induction of Th1 type response by DNA vaccinations with N, M, and E genes against SARS-CoV in mice.Q45262795
siRNA targeting the leader sequence of SARS-CoV inhibits virus replication.Q45496781
Evaluation of modified vaccinia virus Ankara based recombinant SARS vaccine in ferretsQ45501850
Mucosal immunisation of African green monkeys (Cercopithecus aethiops) with an attenuated parainfluenza virus expressing the SARS coronavirus spike protein for the prevention of SARS.Q45622393
Organ distribution of severe acute respiratory syndrome (SARS) associated coronavirus (SARS-CoV) in SARS patients: implications for pathogenesis and virus transmission pathwaysQ45640664
Interaction between heptad repeat 1 and 2 regions in spike protein of SARS-associated coronavirus: implications for virus fusogenic mechanism and identification of fusion inhibitorsQ45659807
Human monoclonal antibody as prophylaxis for SARS coronavirus infection in ferretsQ47283945
The SARS-CoV S glycoprotein: expression and functional characterizationQ47346882
Characterization of neutralizing monoclonal antibodies recognizing a 15-residues epitope on the spike protein HR2 region of severe acute respiratory syndrome coronavirus (SARS-CoV).Q47736945
A molecular docking model of SARS-CoV S1 protein in complex with its receptor, human ACE2.Q47774466
Evaluation by indirect immunofluorescent assay and enzyme linked immunosorbent assay of the dynamic changes of serum antibody responses against severe acute respiratory syndrome coronavirus.Q47827023
Identification of novel small-molecule inhibitors of severe acute respiratory syndrome-associated coronavirus by chemical genetics.Q47924234
Crystal structure of severe acute respiratory syndrome coronavirus spike protein fusion coreQ47932220
Neutralizing antibodies in patients with severe acute respiratory syndrome-associated coronavirus infectionQ47939183
An efficient method to make human monoclonal antibodies from memory B cells: potent neutralization of SARS coronavirusQ47957009
Peptides corresponding to a predictive alpha-helical domain of human immunodeficiency virus type 1 gp41 are potent inhibitors of virus infectionQ28369033
Vaccine efficacy in senescent mice challenged with recombinant SARS-CoV bearing epidemic and zoonotic spike variantsQ28764574
Isolation and characterization of viruses related to the SARS coronavirus from animals in southern ChinaQ29618055
The Genome sequence of the SARS-associated coronavirusQ29619007
Inhibition of SARS-CoV replication cycle by small interference RNAs silencing specific SARS proteins, 7a/7b, 3a/3b and S.Q30230264
Severe acute respiratory syndrome (SARS): a year in review.Q30350011
Obstacles and advances in SARS vaccine development.Q30351493
Protease-mediated enhancement of severe acute respiratory syndrome coronavirus infectionQ30447031
B-cell responses in patients who have recovered from severe acute respiratory syndrome target a dominant site in the S2 domain of the surface spike glycoproteinQ31149856
The life cycle of SARS coronavirus in Vero E6 cellsQ33203307
The spike protein of severe acute respiratory syndrome (SARS) is cleaved in virus infected Vero-E6 cellsQ33207348
Molecular and biological characterization of human monoclonal antibodies binding to the spike and nucleocapsid proteins of severe acute respiratory syndrome coronavirusQ33210858
Screening and identification of linear B-cell epitopes and entry-blocking peptide of severe acute respiratory syndrome (SARS)-associated coronavirus using synthetic overlapping peptide library.Q33223061
Structure of severe acute respiratory syndrome coronavirus receptor-binding domain complexed with neutralizing antibodyQ33239031
Adaptive evolution of the spike gene of SARS coronavirus: changes in positively selected sites in different epidemic groupsQ33259340
Quaternary structure, substrate selectivity and inhibitor design for SARS 3C-like proteinaseQ33266597
Long-term persistence of robust antibody and cytotoxic T cell responses in recovered patients infected with SARS coronavirus.Q33267285
A mouse-adapted SARS-coronavirus causes disease and mortality in BALB/c miceQ33269158
Structural basis for membrane fusion by enveloped virusesQ33637921
Severe acute respiratory syndrome coronavirus spike protein expressed by attenuated vaccinia virus protectively immunizes miceQ33696283
Evasion of antibody neutralization in emerging severe acute respiratory syndrome coronavirusesQ33756740
Evaluation of human monoclonal antibody 80R for immunoprophylaxis of severe acute respiratory syndrome by an animal study, epitope mapping, and analysis of spike variantsQ33780455
Identification and characterization of the putative fusion peptide of the severe acute respiratory syndrome-associated coronavirus spike proteinQ33788831
Antibodies in the therapy of colon cancer.Q33800949
Recombinant modified vaccinia virus Ankara expressing the spike glycoprotein of severe acute respiratory syndrome coronavirus induces protective neutralizing antibodies primarily targeting the receptor binding region.Q33834543
Inhibitors of cathepsin L prevent severe acute respiratory syndrome coronavirus entryQ33920306
Pathology and pathogenesis of severe acute respiratory syndromeQ34003202
Coronavirus pathogenesis and the emerging pathogen severe acute respiratory syndrome coronavirusQ34193942
Severe acute respiratory syndrome coronavirus (SARS-CoV) infection inhibition using spike protein heptad repeat-derived peptides.Q34376025
An exposed domain in the severe acute respiratory syndrome coronavirus spike protein induces neutralizing antibodiesQ34437463
Structure of SARS coronavirus spike receptor-binding domain complexed with receptorQ34451350
Therapy with a severe acute respiratory syndrome-associated coronavirus-neutralizing human monoclonal antibody reduces disease severity and viral burden in golden Syrian hamstersQ34490759
Conformational states of the severe acute respiratory syndrome coronavirus spike protein ectodomainQ34717693
Pneumonitis and multi-organ system disease in common marmosets (Callithrix jacchus) infected with the severe acute respiratory syndrome-associated coronavirusQ35085075
SARS coronavirus: a new challenge for prevention and therapyQ35143451
Utility of the aged BALB/c mouse model to demonstrate prevention and control strategies for severe acute respiratory syndrome coronavirus (SARS-CoV)Q35740733
Natural mutations in the receptor binding domain of spike glycoprotein determine the reactivity of cross-neutralization between palm civet coronavirus and severe acute respiratory syndrome coronavirusQ35857387
Laboratory diagnosis of four recent sporadic cases of community-acquired SARS, Guangdong Province, ChinaQ35880772
Potent cross-reactive neutralization of SARS coronavirus isolates by human monoclonal antibodiesQ35901171
Synthetic reconstruction of zoonotic and early human severe acute respiratory syndrome coronavirus isolates that produce fatal disease in aged miceQ35914462
Angiotensin-converting enzyme 2: a functional receptor for SARS coronavirusQ35953179
From genome to antivirals: SARS as a test tube.Q36062699
Immunological responses against SARS-coronavirus infection in humans.Q36280532
Specific asparagine-linked glycosylation sites are critical for DC-SIGN- and L-SIGN-mediated severe acute respiratory syndrome coronavirus entryQ36315018
Heptad repeat-derived peptides block protease-mediated direct entry from the cell surface of severe acute respiratory syndrome coronavirus but not entry via the endosomal pathwayQ36424025
Amino acid substitutions in the S2 subunit of mouse hepatitis virus variant V51 encode determinants of host range expansionQ36424092
Contributions of the structural proteins of severe acute respiratory syndrome coronavirus to protective immunityQ36449078
Structural basis for potent cross-neutralizing human monoclonal antibody protection against lethal human and zoonotic severe acute respiratory syndrome coronavirus challengeQ36498144
SARS coronavirus and innate immunityQ36539000
Cleavage of spike protein of SARS coronavirus by protease factor Xa is associated with viral infectivityQ36572218
Potent neutralization of severe acute respiratory syndrome (SARS) coronavirus by a human mAb to S1 protein that blocks receptor associationQ36602721
Localization of neutralizing epitopes and the receptor-binding site within the amino-terminal 330 amino acids of the murine coronavirus spike proteinQ36634787
HIV entry inhibitors targeting gp41: from polypeptides to small-molecule compoundsQ36725249
A review of studies on animal reservoirs of the SARS coronavirusQ36798770
Pathways of cross-species transmission of synthetically reconstructed zoonotic severe acute respiratory syndrome coronavirusQ36845879
Pathogenetic mechanisms of severe acute respiratory syndrome.Q36934231
Prior infection and passive transfer of neutralizing antibody prevent replication of severe acute respiratory syndrome coronavirus in the respiratory tract of miceQ37010921
Priming with rAAV encoding RBD of SARS-CoV S protein and boosting with RBD-specific peptides for T cell epitopes elevated humoral and cellular immune responses against SARS-CoV infection.Q37011150
Intranasal vaccination of recombinant adeno-associated virus encoding receptor-binding domain of severe acute respiratory syndrome coronavirus (SARS-CoV) spike protein induces strong mucosal immune responses and provides long-term protection againstQ37015424
Characterization of severe acute respiratory syndrome-associated coronavirus (SARS-CoV) spike glycoprotein-mediated viral entryQ37356916
Amino acids 270 to 510 of the severe acute respiratory syndrome coronavirus spike protein are required for interaction with receptorQ37423228
Small molecules blocking the entry of severe acute respiratory syndrome coronavirus into host cellsQ37567824
Immunization with modified vaccinia virus Ankara-based recombinant vaccine against severe acute respiratory syndrome is associated with enhanced hepatitis in ferretsQ37596935
Immunogenicity of a receptor-binding domain of SARS coronavirus spike protein in mice: implications for a subunit vaccineQ38310521
Using siRNA in prophylactic and therapeutic regimens against SARS coronavirus in Rhesus macaqueQ39362979
Identification of a receptor-binding domain of the spike glycoprotein of human coronavirus HCoV-229E.Q39700192
Search for potential target site of nucleocapsid gene for the design of an epitope-based SARS DNA vaccineQ39987729
A single amino acid substitution in the S1 and S2 Spike protein domains determines the neutralization escape phenotype of SARS-CoV.Q40073664
Clathrin-dependent entry of severe acute respiratory syndrome coronavirus into target cells expressing ACE2 with the cytoplasmic tail deletedQ40128591
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectvaccineQ134808
SARSr-CoVQ278567
SARS-CoV-1Q85438966
P304page(s)226-236
P577publication date2009-02-09
2009-03-01
P1433published inNature Reviews MicrobiologyQ1071797
P1476titleThe spike protein of SARS-CoV--a target for vaccine and therapeutic development
P478volume7

Reverse relations

cites work (P2860)
Q1070320023-Hydroxyphthalic Anhydride-Modified Chicken Ovalbumin as a Potential Candidate Inhibits SARS-CoV-2 Infection by Disrupting the Interaction of Spike Protein With Host ACE2 Receptor
Q33904997A 219-mer CHO-expressing receptor-binding domain of SARS-CoV S protein induces potent immune responses and protective immunity
Q96110341A Mouse Model of SARS-CoV-2 Infection and Pathogenesis
Q98178351A Perspective on Emerging Therapeutic Interventions for COVID-19
Q97519840A Universal Design of Betacoronavirus Vaccines against COVID-19, MERS, and SARS
Q33743790A conformation-dependent neutralizing monoclonal antibody specifically targeting receptor-binding domain in Middle East respiratory syndrome coronavirus spike protein.
Q35972651A facile inhibitor screening of SARS coronavirus N protein using nanoparticle-based RNA oligonucleotide
Q34135057A hexapeptide of the receptor-binding domain of SARS corona virus spike protein blocks viral entry into host cells via the human receptor ACE2.
Q64374803A highly immunogenic, protective and safe adenovirus-based vaccine expressing MERS-CoV S1-CD40L fusion protein in transgenic human DPP4 mouse model
Q95851276A human neutralizing antibody targets the receptor binding site of SARS-CoV-2
Q30379384A humanized neutralizing antibody against MERS-CoV targeting the receptor-binding domain of the spike protein.
Q27490484A new mouse-adapted strain of SARS-CoV as a lethal model for evaluating antiviral agents in vitro and in vivo
Q89046119A new threat from an old enemy: Re‑emergence of coronavirus (Review)
Q94670272A noncompeting pair of human neutralizing antibodies block COVID-19 virus binding to its receptor ACE2
Q36615939A novel peptide with potent and broad-spectrum antiviral activities against multiple respiratory viruses.
Q98222221A novel receptor-binding domain (RBD)-based mRNA vaccine against SARS-CoV-2
Q46374737A predicted receptor-binding and critical neutralizing domain in S protein of the novel human coronavirus HCoV-EMC.
Q37152873A safe and convenient pseudovirus-based inhibition assay to detect neutralizing antibodies and screen for viral entry inhibitors against the novel human coronavirus MERS-CoV
Q41272962A small region of porcine hemagglutinating encephalomyelitis virus spike protein interacts with the neural cell adhesion molecule
Q38275790A structural view of coronavirus-receptor interactions
Q35063993A truncated receptor-binding domain of MERS-CoV spike protein potently inhibits MERS-CoV infection and induces strong neutralizing antibody responses: implication for developing therapeutics and vaccines
Q91934668ADAM17 inhibition may exert a protective effect on COVID-19
Q92138204Advances in COVID-19: the virus, the pathogenesis, and evidence-based control and therapeutic strategies
Q98623661An adenovirus-vectored COVID-19 vaccine confers protection from SARS-COV-2 challenge in rhesus macaques
Q34539529An eight-year epidemiologic study based on baculovirus-expressed type-specific spike proteins for the differentiation of type I and II feline coronavirus infections.
Q89470675An emerging coronavirus causing pneumonia outbreak in Wuhan, China: calling for developing therapeutic and prophylactic strategies
Q38043556Animal models in virus research: their utility and limitations
Q30352512Anti-SARS coronavirus agents: a patent review (2008 - present).
Q38631970Anti-severe acute respiratory syndrome coronavirus spike antibodies trigger infection of human immune cells via a pH- and cysteine protease-independent FcγR pathway
Q84315455Antibodies and vaccines against Middle East respiratory syndrome coronavirus
Q44998852Antibodies induced by receptor-binding domain in spike protein of SARS-CoV do not cross-neutralize the novel human coronavirus hCoV-EMC.
Q39526647Antibody-dependent infection of human macrophages by severe acute respiratory syndrome coronavirus.
Q37361159Antigenicity and immunogenicity of SARS-CoV S protein receptor-binding domain stably expressed in CHO cells
Q90674928Are patients with inflammatory bowel disease at increased risk for Covid-19 infection?
Q97886695Association between COVID-19 and cardiovascular disease
Q107473208Biochemical evidence of furin specificity and potential for phospho-regulation at Spike protein S1/S2 cleavage site in SARS-CoV2 but not in SARS-CoV1 or MERS-CoV
Q97636279COVID-19 and cardiovascular disease: from basic mechanisms to clinical perspectives
Q97518345COVID-19 and the Chemical Senses: Supporting Players Take Center Stage
Q91945830COVID-19 for the Cardiologist: A Current Review of the Virology, Clinical Epidemiology, Cardiac and Other Clinical Manifestations and Potential Therapeutic Strategies
Q90425437COVID-19, an emerging coronavirus infection: advances and prospects in designing and developing vaccines, immunotherapeutics, and therapeutics
Q99419015COVID-19: Current status, Challenges and Future Perspectives
Q91717735COVID-19: Risk Groups, Mechanistic Insights, and Challenges
Q90744942COVID-19: what has been learned and to be learned about the novel coronavirus disease
Q51716894Calling for rapid development of a safe and effective MERS vaccine.
Q93188504Can Nanotechnology and Materials Science Help the Fight against SARS-CoV-2?
Q94589965Cell entry mechanisms of SARS-CoV-2
Q33552505Characterization of SARS-CoV-specific memory T cells from recovered individuals 4 years after infection
Q102058982Characterization of neutralizing antibody with prophylactic and therapeutic efficacy against SARS-CoV-2 in rhesus monkeys
Q90589863Characterization of the receptor-binding domain (RBD) of 2019 novel coronavirus: implication for development of RBD protein as a viral attachment inhibitor and vaccine
Q97086302Clinical, molecular, and epidemiological characterization of the SARS-CoV-2 virus and the Coronavirus Disease 2019 (COVID-19), a comprehensive literature review
Q107134863Coiled-coil heterodimers with increased stability for cellular regulation and sensing SARS-CoV-2 spike protein-mediated cell fusion
Q41967852Comparative analysis of the activation of unfolded protein response by spike proteins of severe acute respiratory syndrome coronavirus and human coronavirus HKU1.
Q34201227Computer aided prediction and identification of potential epitopes in the receptor binding domain (RBD) of spike (S) glycoprotein of MERS-CoV.
Q52595409Contribution of porcine aminopeptidase N to porcine deltacoronavirus infection.
Q98735592Contriving Multi-Epitope Subunit of Vaccine for COVID-19: Immunoinformatics Approaches
Q94539926Convalescent plasma in Covid-19: Possible mechanisms of action
Q96225284Corona virus versus existence of human on the earth: A computational and biophysical approach
Q92076061Coronavirus Infections in Children Including COVID-19: An Overview of the Epidemiology, Clinical Features, Diagnosis, Treatment and Prevention Options in Children
Q92102904Coronavirus as silent killer: recent advancement to pathogenesis, therapeutic strategy and future perspectives
Q90322109Coronavirus disease 2019: What we know?
Q99402735Coronavirus infections in children: from SARS and MERS to COVID-19, a narrative review of epidemiological and clinical features
Q91766933Coronavirus membrane fusion mechanism offers as a potential target for antiviral development
Q95602418Coronaviruses pandemics: Can neutralizing antibodies help?
Q30393364Crucial steps in the structure determination of a coronavirus spike glycoprotein using cryo-electron microscopy
Q97587517Cryo-EM analysis of the post-fusion structure of the SARS-CoV spike glycoprotein
Q46274625Cryo-EM structure of porcine delta coronavirus spike protein in the pre-fusion state
Q30845557Cryo-EM structures of MERS-CoV and SARS-CoV spike glycoproteins reveal the dynamic receptor binding domains
Q27314711Cryo-electron microscopy structure of a coronavirus spike glycoprotein trimer
Q40397876Cryo-electron microscopy structures of the SARS-CoV spike glycoprotein reveal a prerequisite conformational state for receptor binding
Q27012578Current advancements and potential strategies in the development of MERS-CoV vaccines
Q94589199Current development of COVID-19 diagnostics, vaccines and therapeutics
Q37921384Current status of multiple antigen-presenting peptide vaccine systems: Application of organic and inorganic nanoparticles
Q40061001Current treatment options and the role of peptides as potential therapeutic components for Middle East Respiratory Syndrome (MERS): A review
Q30400066DNA vaccine encoding Middle East respiratory syndrome coronavirus S1 protein induces protective immune responses in mice
Q107343965Deletion of ER-retention motif on SARS-CoV-2 spike protein reduces cell hybrid during cell–cell fusion
Q107073656Deletion of the SARS-CoV-2 Spike Cytoplasmic Tail Increases Infectivity in Pseudovirus Neutralization Assays
Q94588639Design of a peptide-based subunit vaccine against novel coronavirus SARS-CoV-2
Q94469287Development of CRISPR as an Antiviral Strategy to Combat SARS-CoV-2 and Influenza
Q56156866Development of SARS vaccines and therapeutics is still needed
Q44106409Development of small-molecule viral inhibitors targeting various stages of the life cycle of emerging and re-emerging viruses
Q34432011Development, characterization, and application of monoclonal antibodies against severe acute respiratory syndrome coronavirus nucleocapsid protein
Q98891841Difference in levels of SARS-CoV-2 S1 and S2 subunits- and nucleocapsid protein-reactive SIgM/IgM, IgG and SIgA/IgA antibodies in human milk
Q34983662Differential sensitivity of bat cells to infection by enveloped RNA viruses: coronaviruses, paramyxoviruses, filoviruses, and influenza viruses
Q98906660Disease severity dictates SARS-CoV-2-specific neutralizing antibody responses in COVID-19
Q97642571Distinct conformational states of SARS-CoV-2 spike protein
Q90576464Drug targets for corona virus: A systematic review
Q103028535Dynamic changes in anti-SARS-CoV-2 antibodies during SARS-CoV-2 infection and recovery from COVID-19
Q107143917Dysregulation of Cell Signaling by SARS-CoV-2
Q90004418Early transmission patterns of coronavirus disease 2019 (COVID-19) in travellers from Wuhan to Thailand, January 2020
Q34594139Effects of human anti-spike protein receptor binding domain antibodies on severe acute respiratory syndrome coronavirus neutralization escape and fitness
Q89613924Emerging novel coronavirus (2019-nCoV)-current scenario, evolutionary perspective based on genome analysis and recent developments
Q98626411Emerging strategies on in silico drug development against COVID-19: challenges and opportunities
Q100430770Enhanced elicitation of potent neutralizing antibodies by the SARS-CoV-2 spike receptor binding domain Fc fusion protein in mice
Q90617531Establishment and validation of a pseudovirus neutralization assay for SARS-CoV-2
Q100749460Exploring the out of sight antigens of SARS-CoV-2 to design a candidate multi-epitope vaccine by utilizing immunoinformatics approaches
Q96308456Focus on a 2019-novel coronavirus (SARS-CoV-2)
Q61818478From SARS to MERS, Thrusting Coronaviruses into the Spotlight
Q95298068From SARS-CoV to SARS-CoV-2: safety and broad-spectrum are important for coronavirus vaccine development
Q42282766Full genome analysis of a novel type II feline coronavirus NTU156.
Q38252639Functional nanomaterials can optimize the efficacy of vaccines
Q35801839Functional transcriptional regulatory sequence (TRS) RNA binding and helix destabilizing determinants of murine hepatitis virus (MHV) nucleocapsid (N) protein.
Q97551111Gaining insights on immune responses to the novel coronavirus, COVID-19 and therapeutic challenges
Q51771976Generating stable chinese hamster ovary cell clones to produce a truncated SARS‐CoV spike protein for vaccine development
Q95617512Genomic determinants of pathogenicity in SARS-CoV-2 and other human coronaviruses
Q91706263Genotype and phenotype of COVID-19: Their roles in pathogenesis
Q27728036Glycan shield and epitope masking of a coronavirus spike protein observed by cryo-electron microscopy
Q107344131Glycosylation is a key in SARS-CoV-2 infection
Q99711258Harnessing Memory NK Cell to Protect Against COVID-19
Q96647308Highlight of Immune Pathogenic Response and Hematopathologic Effect in SARS-CoV, MERS-CoV, and SARS-Cov-2 Infection
Q38667715Host Factors in Coronavirus Replication
Q99201268How can nanotechnology help to combat COVID-19? Opportunities and urgent need
Q34491357Human monoclonal antibodies against highly conserved HR1 and HR2 domains of the SARS-CoV spike protein are more broadly neutralizing
Q38098075Human monoclonal antibodies as candidate therapeutics against emerging viruses and HIV-1.
Q95851279Human neutralizing antibodies elicited by SARS-CoV-2 infection
Q96647310Humoral Immune Responses in COVID-19 Patients: A Window on the State of the Art
Q94938624Identification of Human Single-Domain Antibodies against SARS-CoV-2
Q101222456Identification of Required Host Factors for SARS-CoV-2 Infection in Human Cells
Q94672026Identification of SARS-CoV RBD-targeting monoclonal antibodies with cross-reactive or neutralizing activity against SARS-CoV-2
Q30951751Identification of a novel conserved HLA-A*0201-restricted epitope from the spike protein of SARS-CoV.
Q30432706Identification of a receptor-binding domain in the S protein of the novel human coronavirus Middle East respiratory syndrome coronavirus as an essential target for vaccine development
Q36760764Immunogenicity and protection efficacy of monomeric and trimeric recombinant SARS coronavirus spike protein subunit vaccine candidates
Q41752133Immunogenicity of an adenoviral-based Middle East Respiratory Syndrome coronavirus vaccine in BALB/c mice
Q89542206Immunoinformatics-aided identification of T cell and B cell epitopes in the surface glycoprotein of 2019-nCoV
Q99608160In Silico Structure-Based Repositioning of Approved Drugs for Spike Glycoprotein S2 Domain Fusion Peptide of SARS-CoV-2: Rationale from Molecular Dynamics and Binding Free Energy Calculations
Q36154930Increased antibody affinity confers broad in vitro protection against escape mutants of severe acute respiratory syndrome coronavirus
Q39095556Influence of hydrophobic and electrostatic residues on SARS-coronavirus S2 protein stability: insights into mechanisms of general viral fusion and inhibitor design
Q34009523Inhibition of SARS pseudovirus cell entry by lactoferrin binding to heparan sulfate proteoglycans
Q30359335Intranasal vaccination with recombinant receptor-binding domain of MERS-CoV spike protein induces much stronger local mucosal immune responses than subcutaneous immunization: Implication for designing novel mucosal MERS vaccines.
Q37434385Introduction of neutralizing immunogenicity index to the rational design of MERS coronavirus subunit vaccines
Q95269110Investigating the genomic landscape of novel coronavirus (2019-nCoV) to identify non-synonymous mutations for use in diagnosis and drug design
Q55463226Investigation of Antibody-Dependent Enhancement (ADE) of SARS coronavirus infection and its role in pathogenesis of SARS.
Q30235867Jumping species-a mechanism for coronavirus persistence and survival
Q100387986KIM-1/TIM-1 is a Receptor for SARS-CoV-2 in Lung and Kidney
Q89542749Learning from the Past: Possible Urgent Prevention and Treatment Options for Severe Acute Respiratory Infections Caused by 2019-nCoV
Q100694566Learning from the past: development of safe and effective COVID-19 vaccines
Q92083752MERS Coronavirus: An Emerging Zoonotic Virus
Q60813078MERS – A cautionary tale
Q30248743MERS-CoV spike protein: Targets for vaccines and therapeutics
Q30240139MERS-CoV spike protein: a key target for antivirals
Q34176466Metabolomics - a useful tool for prediction of protein production and processing?
Q64069097Middle East Respiratory Syndrome Coronavirus (MERS-CoV): Infection, Immunological Response, and Vaccine Development
Q61814884Middle East Respiratory Syndrome Vaccine Candidates: Cautious Optimism
Q30432264Middle East respiratory syndrome coronavirus (MERS-CoV): challenges in identifying its source and controlling its spread
Q42249511Middle East respiratory syndrome coronavirus spike protein delivered by modified vaccinia virus Ankara efficiently induces virus-neutralizing antibodies
Q26796501Middle East respiratory syndrome coronavirus: transmission, virology and therapeutic targeting to aid in outbreak control
Q37143501Middle East respiratory syndrome vaccines
Q95272052Model based approach for estimating the dosage regimen of indomethacin a potential antiviral treatment of patients infected with SARS CoV-2
Q42152380Molecular basis of binding between novel human coronavirus MERS-CoV and its receptor CD26.
Q100737088Molecular docking study of potential phytochemicals and their effects on the complex of SARS-CoV2 spike protein and human ACE2
Q89820495Montelukast, an Anti-asthmatic Drug, Inhibits Zika Virus Infection by Disrupting Viral Integrity
Q98157481Nanomedicine as a promising approach for diagnosis, treatment and prophylaxis against COVID-19
Q91578226Neutralizing Antibodies against SARS-CoV-2 and Other Human Coronaviruses
Q37929687Neutralizing human monoclonal antibodies to severe acute respiratory syndrome coronavirus: target, mechanism of action, and therapeutic potential
Q91912173Newcastle disease virus-based MERS-CoV candidate vaccine elicits high-level and lasting neutralizing antibodies in Bactrian camels
Q94551879Novel Coronavirus Polymerase and Nucleotidyl-transferase Structures: Potential to Target New Outbreaks
Q90538321Novel Coronavirus: What Neuroradiologists as Citizens of the World Need to Know
Q111537797Online Hydrophilic Interaction Chromatography (HILIC) Enhanced Top-Down Mass Spectrometry Characterization of the SARS-CoV-2 Spike Receptor-Binding Domain
Q114868908Open Science Resources for the Mass Spectrometry-Based Analysis of SARS-CoV-2
Q30401512Optimization of the Production Process and Characterization of the Yeast-Expressed SARS-CoV Recombinant Receptor-Binding Domain (RBD219-N1), a SARS Vaccine Candidate
Q99624588Overview of the current promising approaches for the development of an effective severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine
Q37188934Passive Transfer of A Germline-like Neutralizing Human Monoclonal Antibody Protects Transgenic Mice Against Lethal Middle East Respiratory Syndrome Coronavirus Infection
Q41965287Pathogenesis of neurotropic murine coronavirus is multifactorial
Q50131822Peptide-Based Membrane Fusion Inhibitors Targeting HCoV-229E Spike Protein HR1 and HR2 Domains.
Q93190302Pharmacological Therapeutics Targeting RNA-Dependent RNA Polymerase, Proteinase and Spike Protein: From Mechanistic Studies to Clinical Trials for COVID-19
Q97592236Planning for COVID-19 vaccines safety surveillance
Q34332142Potent and persistent antibody responses against the receptor-binding domain of SARS-CoV spike protein in recovered patients
Q35159147Potent neutralization of MERS-CoV by human neutralizing monoclonal antibodies to the viral spike glycoprotein
Q100384122Potential Anti-SARS-CoV-2 Therapeutics That Target the Post-Entry Stages of the Viral Life Cycle: A Comprehensive Review
Q94549050Potential Applications of Plant Biotechnology against SARS-CoV-2
Q97067433Potential of SARS-CoV-2 to Cause CNS Infection: Biologic Fundamental and Clinical Experience
Q37767654Potential of carbohydrate-binding agents as therapeutics against enveloped viruses
Q99406885Potential use of polyphenols in the battle against COVID-19
Q47210194Prevention and treatment of respiratory viral infections: Presentations on antivirals, traditional therapies and host-directed interventions at the 5th ISIRV Antiviral Group conference
Q98730822Prospect of SARS-CoV-2 spike protein: Potential role in vaccine and therapeutic development
Q57172187Prospects for a MERS-CoV spike vaccine
Q40744757Purified coronavirus spike protein nanoparticles induce coronavirus neutralizing antibodies in mice
Q99728288Quantification of SARS-CoV-2 neutralizing antibody by a pseudotyped virus-based assay
Q103027776RBD-Fc-based COVID-19 vaccine candidate induces highly potent SARS-CoV-2 neutralizing antibody response
Q100763479Rabies virus-based COVID-19 vaccine CORAVAX™ induces high levels of neutralizing antibodies against SARS-CoV-2
Q35943657Ready, set, fuse! The coronavirus spike protein and acquisition of fusion competence
Q97518859Reappearance of effector T cells is associated with recovery from COVID-19
Q64118341Recent Aspects on the Pathogenesis Mechanism, Animal Models and Novel Therapeutic Interventions for Middle East Respiratory Syndrome Coronavirus Infections
Q39727842Recent developments in anti-severe acute respiratory syndrome coronavirus chemotherapy
Q35033862Receptor binding domain based HIV vaccines.
Q35115572Receptor recognition mechanisms of coronaviruses: a decade of structural studies
Q30353170Receptor-binding domain as a target for developing SARS vaccines.
Q30399700Receptor-binding domain of MERS-CoV with optimal immunogen dosage and immunization interval protects human transgenic mice from MERS-CoV infection
Q26851979Receptor-binding domain-based subunit vaccines against MERS-CoV
Q99608352Receptor-binding domain-specific human neutralizing monoclonal antibodies against SARS-CoV and SARS-CoV-2
Q36779713Receptor-binding domains of spike proteins of emerging or re-emerging viruses as targets for development of antiviral vaccines.
Q37366744Recombinant receptor-binding domain of SARS-CoV spike protein expressed in mammalian, insect and E. coli cells elicits potent neutralizing antibody and protective immunity
Q35815644Reconstitution of the receptor-binding motif of the SARS coronavirus
Q98771893Renin-Angiotensin System and Coronavirus Disease 2019: A Narrative Review
Q99711236Repurposing Drugs, Ongoing Vaccine, and New Therapeutic Development Initiatives Against COVID-19
Q90748419Research and Development on Therapeutic Agents and Vaccines for COVID-19 and Related Human Coronavirus Diseases
Q97430314Revisiting potential druggable targets against SARS-CoV-2 and repurposing therapeutics under preclinical study and clinical trials: A comprehensive review
Q36650501Roadmap to developing a recombinant coronavirus S protein receptor-binding domain vaccine for severe acute respiratory syndrome
Q96342886Role of the GTNGTKR motif in the N-terminal receptor-binding domain of the SARS-CoV-2 spike protein
Q100464708SARS-CoV-2 S1 and N-based serological assays reveal rapid seroconversion and induction of specific antibody response in COVID-19 patients
Q102131196SARS-CoV-2 nucleocapsid protein phase-separates with RNA and with human hnRNPs
Q96642691SARS-CoV-2 nucleocapsid protein undergoes liquid-liquid phase separation stimulated by RNA and partitions into phases of human ribonucleoproteins
Q109295321SARS–CoV–2 Spike Impairs DNA Damage Repair and Inhibits V(D)J Recombination In Vitro
Q34324907Searching for an ideal vaccine candidate among different MERS coronavirus receptor-binding fragments--the importance of immunofocusing in subunit vaccine design
Q93230276Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2): An overview of viral structure and host response
Q64374628Single intranasal immunization with chimpanzee adenovirus-based vaccine induces sustained and protective immunity against MERS-CoV infection
Q39677274Single-dose treatment with a humanized neutralizing antibody affords full protection of a human transgenic mouse model from lethal Middle East respiratory syndrome (MERS)-coronavirus infection
Q95603898Site-specific N-glycosylation Characterization of Recombinant SARS-CoV-2 Spike Proteins
Q27675849Solution Structure of Mouse Hepatitis Virus (MHV) nsp3a and Determinants of the Interaction with MHV Nucleocapsid (N) Protein
Q91807337Structural and Functional Basis of SARS-CoV-2 Entry by Using Human ACE2
Q90738246Structural basis of receptor recognition by SARS-CoV-2
Q27678981Structure of MERS-CoV spike receptor-binding domain complexed with human receptor DPP4
Q38825332Structure of the S1 subunit C-terminal domain from bat-derived coronavirus HKU5 spike protein
Q36373305Sublingual immunization with recombinant adenovirus encoding SARS-CoV spike protein induces systemic and mucosal immunity without redirection of the virus to the brain.
Q33897964Substitution at aspartic acid 1128 in the SARS coronavirus spike glycoprotein mediates escape from a S2 domain-targeting neutralizing monoclonal antibody
Q99575736Substitutions in Spike and Nucleocapsid proteins of SARS-CoV-2 circulating in South America
Q91711469Subunit Vaccines Against Emerging Pathogenic Human Coronaviruses
Q40566186Synthetic virus-like particles prepared via protein corona formation enable effective vaccination in an avian model of coronavirus infection
Q41242033Systemic and mucosal immunity in mice elicited by a single immunization with human adenovirus type 5 or 41 vector-based vaccines carrying the spike protein of Middle East respiratory syndrome coronavirus
Q30241347T-cell immunity of SARS-CoV: Implications for vaccine development against MERS-CoV.
Q102369251Targeted intracellular degradation of SARS-CoV-2 via computationally optimized peptide fusions
Q97676079Targeting SARS-CoV-2 RBD interface: a supervised computational data-driven approach to identify potential modulators
Q88485680The First Disease X is Caused by a Highly Transmissible Acute Respiratory Syndrome Coronavirus
Q98171290The Impact of Mutations in SARS-CoV-2 Spike on Viral Infectivity and Antigenicity
Q99561915The Inhibitory Effect of a Coronavirus Spike Protein Fragment with ACE2
Q34652511The amino acids 736-761 of the MERS-CoV spike protein induce neutralizing antibodies: implications for the development of vaccines and antiviral agents
Q41922286The bulky and the sweet: How neutralizing antibodies and glycan receptors compete for virus binding
Q103002692The central role of the nasal microenvironment in the transmission, modulation, and clinical progression of SARS-CoV-2 infection
Q33934034The emergence of the Middle East respiratory syndrome coronavirus
Q98200267The immune system as a target for therapy of SARS-CoV-2: A systematic review of the current immunotherapies for COVID-19
Q98217818The importance of cell-mediated immunity in COVID-19 - An opinion
Q33614533The minor envelope glycoproteins GP2a and GP4 of porcine reproductive and respiratory syndrome virus interact with the receptor CD163.
Q93230756The old but new: Can unfractioned heparin and low molecular weight heparins inhibit proteolytic activation and cellular internalization of SARS-CoV2 by inhibition of host cell proteases?
Q90482703The outbreak of SARS-CoV-2 pneumonia calls for viral vaccines
Q92130769The potential danger of suboptimal antibody responses in COVID-19
Q38171580The receptor binding domain of MERS-CoV: the dawn of vaccine and treatment development
Q100512389The sequence at Spike S1/S2 site enables cleavage by furin and phospho-regulation in SARS-CoV2 but not in SARS-CoV1 or MERS-CoV
Q98936342Therapeutics for COVID-19: from computation to practices-where we are, where we are heading to
Q37169882Toward Developing a Preventive MERS-CoV Vaccine-Report from a Workshop Organized by the Saudi Arabia Ministry of Health and the International Vaccine Institute, Riyadh, Saudi Arabia, November 14-15, 2015.
Q64360051Towards the first multi-epitope recombinant vaccine against Crimean-Congo hemorrhagic fever virus: A computer-aided vaccine design approach
Q34339544US-like strain of porcine epidemic diarrhea virus outbreaks in Taiwan, 2013-2014.
Q38819802Understanding bat SARS-like coronaviruses for the preparation of future coronavirus outbreaks - Implications for coronavirus vaccine development
Q99712067Unraveling the Epidemiology, Geographical Distribution, and Genomic Evolution of Potentially Lethal Coronaviruses (SARS, MERS, and SARS CoV-2)
Q97592234Vaccines based on virus-like nano-particles for use against Middle East Respiratory Syndrome (MERS) coronavirus
Q99604172Vaccines for COVID-19: perspectives from nucleic acid vaccines to BCG as delivery vector system
Q93199923Vaccines for SARS-CoV-2: Lessons from Other Coronavirus Strains
Q38778044Vaccines for the prevention against the threat of MERS-CoV.
Q95627691Yeast-Expressed SARS-CoV Recombinant Receptor-Binding Domain (RBD219-N1) Formulated with Alum Induces Protective Immunity and Reduces Immune Enhancement
Q100514972Yeast-expressed SARS-CoV recombinant receptor-binding domain (RBD219-N1) formulated with aluminum hydroxide induces protective immunity and reduces immune enhancement
Q30218075Yeast-expressed recombinant protein of the receptor-binding domain in SARS-CoV spike protein with deglycosylated forms as a SARS vaccine candidate

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