Autophagy is required for glucose homeostasis and lung tumor maintenance

scientific article

Autophagy is required for glucose homeostasis and lung tumor maintenance is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1158/2159-8290.CD-14-0363
P932PMC publication ID4125614
P698PubMed publication ID24875857

P50authorTyler JacksQ7860044
Xin TengQ57556129
Nada Y KalaanyQ60683425
Eileen WhiteQ61820577
Joshua D RabinowitzQ90243141
P2093author name stringSandy Price
Chang S Chan
Sinan Khor
Gizem Karsli-Uzunbas
Saurabh V Laddha
Jessie Yanxiang Guo
P2860cites workHomeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient miceQ24303752
In vivo analysis of autophagy in response to nutrient starvation using transgenic mice expressing a fluorescent autophagosome markerQ24633015
Autophagy-mediated tumor promotionQ27011920
Systematic and integrative analysis of large gene lists using DAVID bioinformatics resourcesQ27860739
Suppression of basal autophagy in neural cells causes neurodegenerative disease in miceQ28131756
Loss of autophagy in the central nervous system causes neurodegeneration in miceQ28131804
Deletion of the developmentally essential gene ATR in adult mice leads to age-related phenotypes and stem cell lossQ28274165
Impairment of starvation-induced and constitutive autophagy in Atg7-deficient miceQ28588080
Autophagy: renovation of cells and tissuesQ29547206
The role of autophagy during the early neonatal starvation periodQ29547489
Autophagy defends cells against invading group A StreptococcusQ29615620
Pancreatic cancers require autophagy for tumor growthQ29620331
Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis.Q34626763
Liver autophagy contributes to the maintenance of blood glucose and amino acid levelsQ35146053
Uncoupling cancer mutations reveals critical timing of p53 loss in sarcomagenesisQ35177312
Liver-specific loss of Atg5 causes persistent activation of Nrf2 and protects against acetaminophen-induced liver injuryQ35969312
Deconvoluting the context-dependent role for autophagy in cancerQ36876716
Autophagy suppresses progression of K-ras-induced lung tumors to oncocytomas and maintains lipid homeostasisQ37019194
Autophagy opposes p53-mediated tumor barrier to facilitate tumorigenesis in a model of PALB2-associated hereditary breast cancer.Q37086261
Autophagy regulates adipose mass and differentiation in miceQ37403082
Adipose-specific deletion of autophagy-related gene 7 (atg7) in mice reveals a role in adipogenesisQ37446431
Autophagy-dependent production of secreted factors facilitates oncogenic RAS-driven invasionQ37692748
Mechanisms regulating skeletal muscle growth and atrophyQ38091731
Autophagy is required for mitochondrial function, lipid metabolism, growth, and fate of KRAS(G12D)-driven lung tumorsQ38130127
p53 status determines the role of autophagy in pancreatic tumour developmentQ39048945
Autophagy sustains mitochondrial glutamine metabolism and growth of BrafV600E-driven lung tumorsQ39107065
Analysis of a lung defect in autophagy-deficient mouse strainsQ39801601
Autophagy-deficient mice develop multiple liver tumorsQ42099409
Loss of autophagy diminishes pancreatic beta cell mass and function with resultant hyperglycemiaQ42442810
Autophagy is important in islet homeostasis and compensatory increase of beta cell mass in response to high-fat dietQ42442818
Lipophagy: connecting autophagy and lipid metabolismQ42556437
Assessing therapeutic responses in Kras mutant cancers using genetically engineered mouse modelsQ43056152
Autophagy is required to maintain muscle mass.Q51411361
A dual role for autophagy in a murine model of lung cancerQ57183947
P433issue8
P921main subjectglucoseQ37525
autophagyQ288322
P304page(s)914-927
P577publication date2014-05-29
P1433published inCancer DiscoveryQ15724440
P1476titleAutophagy is required for glucose homeostasis and lung tumor maintenance
P478volume4

Reverse relations

cites work (P2860)
Q57191934A Potent and Selective ULK1 Inhibitor Suppresses Autophagy and Sensitizes Cancer Cells to Nutrient Stress
Q99566234A bidirectional crosstalk between autophagy and TP53 determines the pace of aging
Q89589492A novel Atg5-shRNA mouse model enables temporal control of Autophagy in vivo
Q41753200ATG7 promotes the tumorigenesis of lung cancer but might be dispensable for prognosis predication: a clinicopathologic study
Q38795278Activating autophagy to potentiate immunogenic chemotherapy and radiation therapy
Q92642778Adaptive Responses as Mechanisms of Resistance to BRAF Inhibitors in Melanoma
Q39461509Altered glycogen metabolism causes hepatomegaly following an Atg7 deletion.
Q39414846An Emerging Role for Tubulin Isotypes in Modulating Cancer Biology and Chemotherapy Resistance
Q99406594Anti-tumor immunity influences cancer cell reliance upon ATG7
Q38910539Atg7 Overcomes Senescence and Promotes Growth of BrafV600E-Driven Melanoma
Q36603857Atg7 cooperates with Pten loss to drive prostate cancer tumor growth
Q26781433Atg7 in development and disease: panacea or Pandora's Box?
Q96304244Autophagosome biogenesis and human health
Q40805952Autophagy Inhibition Dysregulates TBK1 Signaling and Promotes Pancreatic Inflammation.
Q30358631Autophagy Promotes Focal Adhesion Disassembly and Cell Motility of Metastatic Tumor Cells through the Direct Interaction of Paxillin with LC3
Q89224112Autophagy Regulates the Liver Clock and Glucose Metabolism by Degrading CRY1
Q46675174Autophagy acts through TRAF3 and RELB to regulate gene expression via antagonism of SMAD proteins.
Q49388079Autophagy and Disease
Q60912923Autophagy and Its Role in Protein Secretion: Implications for Cancer Therapy
Q39280823Autophagy and Tumor Metabolism
Q41911940Autophagy and cancer - insights from mouse models
Q92407174Autophagy and disease: unanswered questions
Q35330324Autophagy and its effects: making sense of double-edged swords
Q38796071Autophagy and p53.
Q52574176Autophagy as a cytoprotective mechanism in esophageal squamous cell carcinoma.
Q60198552Autophagy as a promoter of longevity: insights from model organisms
Q99418507Autophagy as a therapeutic target in pancreatic cancer
Q38547568Autophagy at the crossroads of catabolism and anabolism
Q92552819Autophagy gene haploinsufficiency drives chromosome instability, increases migration, and promotes early ovarian tumors
Q88515082Autophagy in C. elegans development
Q26999216Autophagy in cancer
Q38946182Autophagy in cancer metastasis
Q91973791Autophagy in cancer: moving from understanding mechanism to improving therapy responses in patients
Q26996211Autophagy in cellular metabolism and cancer
Q55388737Autophagy in the Tumor or in the Host: Which Plays a Greater Supportive Role?
Q91743614Autophagy in the mammalian nervous system: a primer for neuroscientists
Q36609034Autophagy inhibition re-sensitizes pulse stimulation-selected paclitaxel-resistant triple negative breast cancer cells to chemotherapy-induced apoptosis
Q33713052Autophagy inhibitor facilitates gefitinib sensitivity in vitro and in vivo by activating mitochondrial apoptosis in triple negative breast cancer.
Q38666985Autophagy inhibitors
Q59066319Autophagy maintains tumour growth through circulating arginine
Q90470329Autophagy promotes mammalian survival by suppressing oxidative stress and p53
Q37212988Autophagy provides metabolic substrates to maintain energy charge and nucleotide pools in Ras-driven lung cancer cells
Q98463461Autophagy regulates fatty acid availability for oxidative phosphorylation through mitochondria-endoplasmic reticulum contact sites
Q64073539Autophagy regulates lipid metabolism through selective turnover of NCoR1
Q47742163Autophagy sustains pancreatic cancer growth through both cell autonomous and non-autonomous mechanisms
Q33923174Autophagy, Metabolism, and Cancer
Q53210815Autophagy, Metabolism, and Cancer.
Q90661029Autophagy, cancer stem cells and drug resistance
Q42376893Autophagy-monitoring and autophagy-deficient mice
Q90706502BCR-ABL Independent Mechanisms of Resistance in Chronic Myeloid Leukemia
Q36379709BECLIN 1-VPS34 COMPLEX ARCHITECTURE: UNDERSTANDING THE NUTS AND BOLTS OF THERAPEUTIC TARGETS.
Q91725117Blockade of RAF and autophagy is the one-two punch to take out Ras
Q92901911Blocking transmembrane219 protein signaling inhibits autophagy and restores normal cell death
Q54118859CK1α suppresses lung tumour growth by stabilizing PTEN and inducing autophagy.
Q48277050Ca2+-dependent demethylation of phosphatase PP2Ac promotes glucose deprivation-induced cell death independently of inhibiting glycolysis.
Q41951413Calcium homeostasis and ER stress in control of autophagy in cancer cells
Q33700636Cancer cachexia associates with a systemic autophagy-inducing activity mimicked by cancer cell-derived IL-6 trans-signaling
Q35408800Casein kinase 1α-dependent feedback loop controls autophagy in RAS-driven cancers
Q38256306Cellular and metabolic functions for autophagy in cancer cells
Q26768687Cilia in autophagy and cancer
Q92431789Colorectal cancer cells respond differentially to autophagy inhibition in vivo
Q99406581Combination treatments with hydroxychloroquine and azithromycin are compatible with the therapeutic induction of anticancer immune responses
Q96638744Combined deletion of Glut1 and Glut3 impairs lung adenocarcinoma growth
Q90025843Comprehensive autophagy evaluation in cardiac disease models
Q34556943Cyclin D1 Restrains Oncogene-Induced Autophagy by Regulating the AMPK-LKB1 Signaling Axis.
Q35596987Development of an HTS-Compatible Assay for the Discovery of Ulk1 Inhibitors
Q35068068Different effects of LDH-A inhibition by oxamate in non-small cell lung cancer cells
Q35086734Discovery of autophagy inhibitors with antiproliferative activity in lung and pancreatic cancer cells.
Q60956528Do neurogenic and cancer-induced muscle atrophy follow common or divergent paths?
Q42576431Eat this, not that! How selective autophagy helps cancer cells survive
Q36634693Elevated p62/SQSTM1 determines the fate of autophagy-deficient neural stem cells by increasing superoxide
Q27009194Emerging strategies to effectively target autophagy in cancer
Q53710644Functions of autophagy in the tumor microenvironment and cancer metastasis.
Q26744062Fundamentals of cancer metabolism
Q88688533Genetically Engineered Mouse Models of K-Ras-Driven Lung and Pancreatic Tumors: Validation of Therapeutic Targets
Q26765438Genetics and biology of pancreatic ductal adenocarcinoma
Q90382725Glucose Metabolism in Pancreatic Cancer
Q64104124Glycine decarboxylase induces autophagy and is downregulated by miRNA-30d-5p in hepatocellular carcinoma
Q52316687HSP90 inhibition targets autophagy and induces a CASP9-dependent resistance mechanism in NSCLC.
Q42292319Honokiol Induces Apoptosis, G1 Arrest, and Autophagy in KRAS Mutant Lung Cancer Cells
Q93010911Human Papillomavirus 11 Early Protein E6 Activates Autophagy by Repressing AKT/mTOR and Erk/mTOR
Q92021279IKKβ slows Huntington's disease progression in R6/1 mice
Q39446526IP3 Receptor-Mediated Calcium Signaling and Its Role in Autophagy in Cancer
Q36069096Identification of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase as a novel autophagy regulator by high content shRNA screening.
Q90217131Identification of Eph receptor signaling as a regulator of autophagy and a therapeutic target in colorectal carcinoma
Q37687104Identification of breast cancer cell subtypes sensitive to ATG4B inhibition.
Q38329422Integrating autophagy and metabolism in cancer
Q47301172Interplay of autophagy, receptor tyrosine kinase signalling and endocytic trafficking
Q92753000Involvement of Actin in Autophagy and Autophagy-Dependent Multidrug Resistance in Cancer
Q38860336KLF4-SQSTM1/p62-associated prosurvival autophagy contributes to carfilzomib resistance in multiple myeloma models
Q57025342LC3-Associated Phagocytosis in Myeloid Cells Promotes Tumor Immune Tolerance
Q38624923LC3A Silencing Hinders Aggresome Vimentin Cage Clearance in Primary Choroid Plexus Carcinoma
Q100696512LncRNA SNHG11 promotes gastric cancer progression by activating Wnt/β-catenin pathway and oncogenic autophagy
Q92778431Loss of autophagy in chondrocytes causes severe growth retardation
Q62746316MAP kinase and autophagy pathways cooperate to maintain RAS mutant cancer cell survival
Q36459468Macroautophagy is dispensable for growth of KRAS mutant tumors and chloroquine efficacy
Q89893362Macropinocytosis Renders a Subset of Pancreatic Tumor Cells Resistant to mTOR Inhibition
Q60952270Macropinocytosis and autophagy crosstalk in nutrient scavenging
Q38763163Measuring Autophagy in the Context of Cancer
Q57269850Mechanism and medical implications of mammalian autophagy
Q92875471Mechanisms and Pathophysiological Roles of the ATG8 Conjugation Machinery
Q36840116Mechanisms of Selective Autophagy in Normal Physiology and Cancer
Q49544329Metabolic Changes During Cancer Cachexia Pathogenesis.
Q38423050Metabolic Dependencies in RAS-Driven Cancers
Q34452291Metabolic control of autophagy
Q60952272Metabolic functions of macropinocytosis
Q28086940Metabolic pathways promoting cancer cell survival and growth
Q93042179Metabolic regulation of cell growth and proliferation
Q38930811Metabolic scavenging by cancer cells: when the going gets tough, the tough keep eating
Q41693854Microenvironmental autophagy promotes tumour growth
Q38760551Mitochondria and Cancer
Q49708541Mitochondrial Dysfunction: A Novel Potential Driver of Epithelial-to-Mesenchymal Transition in Cancer.
Q37536809Mitochondrial clearance by the STK38 kinase supports oncogenic Ras-induced cell transformation
Q38622790Modeling K-Ras-driven lung adenocarcinoma in mice: preclinical validation of therapeutic targets
Q42660088Mouse models address key concerns regarding autophagy inhibition in cancer therapy
Q26739932Multiple Roles of the Small GTPase Rab7
Q88582817NRF2 and the Hallmarks of Cancer
Q64083375Non‑covalent proteasome inhibitor PI‑1840 induces apoptosis and autophagy in osteosarcoma cells
Q98225530Nrf2 promotes esophageal squamous cell carcinoma (ESCC) resistance to radiotherapy through the CaMKIIα-associated activation of autophagy
Q35036374Nutrient-sensing mechanisms and pathways.
Q92259393On ATG4B as Drug Target for Treatment of Solid Tumours-The Knowns and the Unknowns
Q91936391Oncogenic KIT mutations induce STAT3-dependent autophagy to support cell proliferation in acute myeloid leukemia
Q38830428Oxidative pentose phosphate pathway inhibition is a key determinant of antimalarial induced cancer cell death
Q26780372Pancreatic Cancer Metabolism: Breaking It Down to Build It Back Up
Q54979740Phosphatidylinositol-5-Phosphate 4-Kinases Regulate Cellular Lipid Metabolism By Facilitating Autophagy.
Q36884215Proteoglycans regulate autophagy via outside-in signaling: an emerging new concept
Q97526399Proteomics reveals a therapeutic vulnerability via the combined blockade of APE1 and autophagy in lung cancer A549 cells
Q41973618Q&A: targeting autophagy in cancer-a new therapeutic?
Q38586434Recent insights into cell death and autophagy.
Q37343004Recent insights into the function of autophagy in cancer
Q92187422Regulation of Apoptosis by Autophagy to Enhance Cancer Therapy
Q42516352Regulation of Glycolytic Metabolism by Autophagy in Liver Cancer Involves Selective Autophagic Degradation of HK2 (hexokinase 2).
Q97587570Ribosome profiling reveals a functional role for autophagy in mRNA translational control
Q38768455Role of ATG10 expression quantitative trait loci in non-small cell lung cancer survival
Q92500806Role of tumor and host autophagy in cancer metabolism
Q58737053Roles for the IKK-Related Kinases TBK1 and IKKε in Cancer
Q60923323Selective Autophagy Regulates Cell Cycle in Cancer Therapy
Q37736687Sesamol Induces Human Hepatocellular Carcinoma Cells Apoptosis by Impairing Mitochondrial Function and Suppressing Autophagy
Q90090983Silencing of circRACGAP1 sensitizes gastric cancer cells to apatinib via modulating autophagy by targeting miR-3657 and ATG7
Q37628979Simultaneous activation and inhibition of autophagy sensitizes cancer cells to chemotherapy
Q91738617Strategies For Targeting Chronic Myeloid Leukaemia Stem Cells
Q41595099Suppression of autophagy impedes glioblastoma development and induces senescence
Q50137656System-wide Benefits of Intermeal Fasting by Autophagy.
Q35338389Targeting Autophagy in BRAF-Mutant Tumors
Q41912265Targeting autophagy in cancer
Q88406511Targeting autophagy in cancer
Q91480154Targeting autophagy using natural compounds for cancer prevention and therapy
Q92861783Targeting of early endosomes by autophagy facilitates EGFR recycling and signalling
Q91304849Targeting quiescent leukemic stem cells using second generation autophagy inhibitors
Q92711500Temporal inhibition of autophagy reveals segmental reversal of ageing with increased cancer risk
Q36654206The Genomic Landscape of Renal Oncocytoma Identifies a Metabolic Barrier to Tumorigenesis
Q52631846The RNA binding protein tristetraprolin down-regulates autophagy in lung adenocarcinoma cells.
Q92230700The Role of Autophagy in Cancer
Q58610550The Roles of Autophagy in Cancer
Q90745502The Tripartite Nexus: Autophagy, Cancer, and Tripartite Motif-Containing Protein Family Members
Q52687668The autophagic network and cancer.
Q38612793The greedy nature of mutant RAS: a boon for drug discovery targeting cancer metabolism?
Q36111784The marine n-3 PUFA DHA evokes cytoprotection against oxidative stress and protein misfolding by inducing autophagy and NFE2L2 in human retinal pigment epithelial cells
Q35242506The role for autophagy in cancer
Q41339988The role of autophagy in hepatocellular carcinoma: friend or foe.
Q28078117Therapeutic Targeting of Autophagy
Q91387223Therapeutic modulation of autophagy: which disease comes first?
Q49886970To be or not to be cell autonomous? Autophagy says both
Q92487257Transcriptional regulation of autophagy-lysosomal pathway in cancer
Q44930465Transcriptional regulation of core autophagy and lysosomal genes by the androgen receptor promotes prostate cancer progression.
Q49522804Ubiquitin-Specific Protease 14 Negatively Regulates Toll-Like Receptor 4-Mediated Signaling and Autophagy Induction by Inhibiting Ubiquitination of TAK1-Binding Protein 2 and Beclin 1.
Q38865384Upregulation of ATG3 contributes to autophagy induced by the detachment of intestinal epithelial cells from the extracellular matrix, but promotes autophagy-independent apoptosis of the attached cells
Q38929715Using enhanced-mitophagy to measure autophagic flux.
Q38710573Verapamil treatment induces cytoprotective autophagy by modulating cellular metabolism
Q92822477Watch What You (Self-) Eat: Autophagic Mechanisms that Modulate Metabolism
Q39041227Why autophagy is good for retinal ganglion cells?
Q91861939[Tristetraprolin inhibits autophagy in cultured lung cancer cells via the nuclear factor-κB pathway]
Q38769519βIII-Tubulin alters glucose metabolism and stress response signaling to promote cell survival and proliferation in glucose-starved non-small cell lung cancer cells

Search more.