Autophagy acts through TRAF3 and RELB to regulate gene expression via antagonism of SMAD proteins.

scientific article published on 16 November 2017

Autophagy acts through TRAF3 and RELB to regulate gene expression via antagonism of SMAD proteins. is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode2017NatCo...8.1537N
P356DOI10.1038/S41467-017-00859-Z
P932PMC publication ID5691083
P698PubMed publication ID29146913

P50authorSimon WilkinsonQ54933553
Christian BehrendsQ58757503
Alice C NewmanQ89292553
P2093author name stringAlain J Kemp
Yvette Drabsch
P2860cites workAutolysosomal β-catenin degradation regulates Wnt-autophagy-p62 crosstalkQ24294545
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The autophagosome: origins unknown, biogenesis complexQ38160660
Ubiquitin-Dependent And Independent Signals In Selective AutophagyQ38599451
Autophagy regulates hepatocyte identity and epithelial-to-mesenchymal and mesenchymal-to-epithelial transitions promoting Snail degradationQ38836438
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p53 status determines the role of autophagy in pancreatic tumour developmentQ39048945
Smad4 is dispensable for normal pancreas development yet critical in progression and tumor biology of pancreas cancerQ39076225
TGF-β Tumor Suppression through a Lethal EMT.Q39276093
Autophagy negatively regulates Wnt signalling by promoting Dishevelled degradationQ39678666
The adaptor protein p62/SQSTM1 targets invading bacteria to the autophagy pathway.Q39790194
The tumor suppressor Smad4 is required for transforming growth factor beta-induced epithelial to mesenchymal transition and bone metastasis of breast cancer cellsQ40314308
Regulation of the NF-kappaB-inducing kinase by tumor necrosis factor receptor-associated factor 3-induced degradationQ40566781
Ras and TGF[beta] cooperatively regulate epithelial cell plasticity and metastasis: dissection of Ras signaling pathwaysQ40757186
Transcriptional induction of multiple cytokines by human respiratory syncytial virus requires activation of NF-kappa B and is inhibited by sodium salicylate and aspirinQ41105440
Regulation of actin organisation by TGF-beta in H-ras-transformed fibroblasts.Q42818111
Transcriptional repression by the HDAC4-RelB-p52 complex regulates multiple myeloma survival and growthQ46667078
Diverse cellular and molecular mechanisms contribute to epithelial plasticity and metastasis.Q53376881
A dual role for autophagy in a murine model of lung cancerQ57183947
Autophagic targeting of Src promotes cancer cell survival following reduced FAK signallingQ57246312
Involvement of DNA binding domain in the cellular stability and importin affinity of NF-κB component RelBQ83584214
Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profilesQ24536351
Organelle-Specific Initiation of AutophagyQ26795727
Crystal structure of p50/p65 heterodimer of transcription factor NF-kappaB bound to DNAQ27748829
Histone methylation: a dynamic mark in health, disease and inheritanceQ28263573
TGFbeta in CancerQ28288866
Acute mutation of retinoblastoma gene function is sufficient for cell cycle re-entryQ28509466
Autophagy plays a critical role in the degradation of active RHOA, the control of cell cytokinesis, and genomic stability.Q28585375
NF-kappa B subunit-specific regulation of the interleukin-8 promoterQ28646361
The role of Atg proteins in autophagosome formationQ29547418
The role of autophagy during the early neonatal starvation periodQ29547489
lumi: a pipeline for processing Illumina microarrayQ29614924
The TBK1 adaptor and autophagy receptor NDP52 restricts the proliferation of ubiquitin-coated bacteriaQ29615619
A tissue-specific atlas of mouse protein phosphorylation and expressionQ29616549
DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1Q29616726
Pancreatic cancers require autophagy for tumor growthQ29620331
Regulation of cell proliferation and migration by p62 through stabilization of Twist1.Q33835263
Autophagy is critical for pancreatic tumor growth and progression in tumors with p53 alterationsQ34017017
Autophagy is required for glucose homeostasis and lung tumor maintenanceQ34017543
The noncanonical NF-κB pathwayQ34031207
The NF-κB genomic landscape in lymphoblastoid B cellsQ34175522
Proteomic profiling of the TRAF3 interactome network reveals a new role for the ER-to-Golgi transport compartments in innate immunityQ34335496
Autophagy facilitates glycolysis during Ras-mediated oncogenic transformationQ34489861
TBK1 kinase addiction in lung cancer cells is mediated via autophagy of Tax1bp1/Ndp52 and non-canonical NF-κB signallingQ34500600
The NF-κB RelB protein is an oncogenic driver of mesenchymal gliomaQ34603589
Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis.Q34626763
Comprehensive Evaluation of Nuclear Factor-κΒ Expression Patterns in Non-Small Cell Lung Cancer.Q35683345
Transforming Growth Factor TGFβ Increases Levels of Microtubule-Associated Protein MAP1S and Autophagy Flux in Pancreatic Ductal AdenocarcinomasQ35841939
The PINK1-PARKIN Mitochondrial Ubiquitylation Pathway Drives a Program of OPTN/NDP52 Recruitment and TBK1 Activation to Promote MitophagyQ36118105
The Retinoblastoma Tumor Suppressor Protein (pRb)/E2 Promoter Binding Factor 1 (E2F1) Pathway as a Novel Mediator of TGFβ-induced AutophagyQ36518216
Daxx represses RelB target promoters via DNA methyltransferase recruitment and DNA hypermethylationQ36585524
Autophagy suppresses progression of K-ras-induced lung tumors to oncocytomas and maintains lipid homeostasisQ37019194
The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4.Q37088112
RelB: an outlier in leukocyte biologyQ37238291
The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagyQ37246125
Autophagy-dependent production of secreted factors facilitates oncogenic RAS-driven invasionQ37692748
Nrf2 reduces levels of phosphorylated tau protein by inducing autophagy adaptor protein NDP52.Q37708598
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectautophagyQ288322
P304page(s)1537
P577publication date2017-11-16
P1433published inNature CommunicationsQ573880
P1476titleAutophagy acts through TRAF3 and RELB to regulate gene expression via antagonism of SMAD proteins
P478volume8

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cites work (P2860)
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Q92861783Targeting of early endosomes by autophagy facilitates EGFR recycling and signalling
Q58088089The role of autophagy in morphogenesis and stem cell maintenance
Q91152001Transcriptome analysis reveals autophagy as regulator of TGFβ/Smad-induced fibrogenesis in trabecular meshwork cells