Genetic instability favoring transversions associated with ErbB2-induced mammary tumorigenesis

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Genetic instability favoring transversions associated with ErbB2-induced mammary tumorigenesis is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode2002PNAS...99.3770L
P356DOI10.1073/PNAS.052710299
P932PMC publication ID122599
P698PubMed publication ID11867754
P5875ResearchGate publication ID11493971

P2093author name stringGlenn Merlino
Sankar Adhya
Wenjing Liu
William J Muller
John L Jakubczak
Shiquan Liu
Gregory L Erexson
Susan Garges
Richard Chan
Kenneth R Tindall
P2860cites workThe human RAD18 gene product interacts with HHR6A and HHR6BQ22254654
Cloning of a human homolog of the yeast OGG1 gene that is involved in the repair of oxidative DNA damageQ24311128
Cloning and characterization of hOGG1, a human homolog of the OGG1 gene of Saccharomyces cerevisiaeQ24317398
Single nucleotide instability without microsatellite instability in rat mammary carcinomasQ43566279
Fission yeast (Schizosaccharomyces pombe) cells defective in the MutY-homologous glycosylase activity have a mutator phenotype and are sensitive to hydrogen peroxideQ43781898
Genetic modulation of neu proto-oncogene-induced mammary tumorigenesisQ45232689
Analysis of spontaneous and induced mutations in transgenic mice using a lambda ZAP/lacl shuttle vectorQ46416940
Mutation in the DNA mismatch repair gene homologue hMLH1 is associated with hereditary non-polyposis colon cancerQ48084125
Age-associated increase of spontaneous mutant frequency and molecular nature of mutation in newborn and old lacZ-transgenic mouse.Q49083961
Spontaneous and ENU-induced mutation spectra at the cII locus in Big Blue Rat2 embryonic fibroblasts.Q50521983
The neu oncogene: an erb-B-related gene encoding a 185,000-Mr tumour antigenQ52827123
Tumors arising in DNA mismatch repair-deficient mice show a wide variation in mutation frequency as assessed by a transgenic reporter gene.Q53409212
Microsatellite instability is uncommon in breast cancerQ77356597
Mutation frequency and specificity with age in liver, bladder and brain of lacI transgenic miceQ24548104
The human ubiquitin carrier protein E2(Mr = 17,000) is homologous to the yeast DNA repair gene RAD6Q24556553
Tyrosine kinase signalling in breast cancer: ErbB family receptor tyrosine kinasesQ24802950
Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogeneQ27860693
Untangling the ErbB signalling networkQ27860884
Mutation of a mutL homolog in hereditary colon cancerQ28114939
Genetic instabilities in human cancersQ28131826
A novel SMC protein complex in Schizosaccharomyces pombe contains the Rad18 DNA repair proteinQ28140483
The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancerQ28256988
Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancerQ28257360
The clonal evolution of tumor cell populationsQ28271546
Expression of the neu protooncogene in the mammary epithelium of transgenic mice induces metastatic diseaseQ28570541
Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancerQ29547699
Destabilization of tracts of simple repetitive DNA in yeast by mutations affecting DNA mismatch repairQ29618879
Disorders of DNA replication and repairQ33368431
The mutY gene: a mutator locus in Escherichia coli that generates G.C----T.A transversionsQ33567384
HER-2/neu (c-erb-B2) gene and protein in breast cancer.Q33681765
Mammalian DNA mismatch repairQ33847720
First-line Herceptin monotherapy in metastatic breast cancerQ34100488
Molecular mechanisms underlying ErbB2/HER2 action in breast cancerQ34130548
Rationale for trastuzumab (Herceptin) in adjuvant breast cancer trialsQ34218132
The contribution of endogenous sources of DNA damage to the multiple mutations in cancerQ34263814
Stability of CII is a key element in the cold stress response of bacteriophage lambda infection.Q34441534
Rapid accumulation of genome rearrangements in liver but not in brain of old miceQ34449310
Single-step induction of mammary adenocarcinoma in transgenic mice bearing the activated c-neu oncogeneQ34560337
Tumors of DNA mismatch repair-deficient hosts exhibit dramatic increases in genomic instabilityQ36216663
Novel activating mutations in the neu proto-oncogene involved in induction of mammary tumorsQ36668724
Evidence that MutY and MutM combine to prevent mutations by an oxidatively damaged form of guanine in DNAQ37132610
Distinct spectra of somatic mutations accumulated with age in mouse heart and small intestineQ37226538
Analysis of genetic instability during mammary tumor progression using a novel selection-based assay for in vivo mutations in a bacteriophage lambda transgene targetQ37384583
Errors in DNA replication as a basis of malignant changesQ39870986
Transgenic systems for in vivo mutation analysisQ40487811
A series of mammalian expression vectors and characterisation of their expression of a reporter gene in stably and transiently transfected cellsQ40514473
The biology of erbB-2/neu/HER-2 and its role in cancerQ40567924
The presence of single nucleotide instability in human breast cancer cell linesQ40770780
Transgenic models for detection of mutations in tumors and normal tissues of rodentsQ40966983
The role of ErbB-2 tyrosine kinase receptor in cellular intrinsic chemoresistance: mechanisms and implicationsQ41717161
Elimination of the yeast RAD6 ubiquitin conjugase enhances base-pair transitions and G.C----T.A transversions as well as transposition of the Ty element: implications for the control of spontaneous mutationQ42962884
The yeast rad18 mutator specifically increases G.C----T.A transversions without reducing correction of G-A or C-T mismatches to G.C pairsQ43182530
P433issue6
P407language of work or nameEnglishQ1860
P304page(s)3770-3775
P577publication date2002-02-26
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleGenetic instability favoring transversions associated with ErbB2-induced mammary tumorigenesis
P478volume99

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cites work (P2860)
Q37121864A comparative analysis of algorithms for somatic SNV detection in cancer.
Q34018062A new mutator phenotype in breast cancer?
Q37885264Cytogenetic analysis of a malignant triton tumour by comparative genomic hybridization (CGH) and review of the literature
Q90278534DMBA promotes ErbB2‑mediated carcinogenesis via ErbB2 and estrogen receptor pathway activation and genomic instability
Q36032513Discriminating somatic and germline mutations in tumor DNA samples without matching normals
Q24602999Genome-wide detection of single-nucleotide and copy-number variations of a single human cell
Q36338289Intraductally administered pegylated liposomal doxorubicin reduces mammary stem cell function in the mammary gland but in the long term, induces malignant tumors
Q33849634Modeling variation in tumors in vivo
Q41325566Molecular mechanisms associated with leukemic transformation of MPL-mutant myeloproliferative neoplasms
Q21245746Phospholipase C delta-4 overexpression upregulates ErbB1/2 expression, Erk signaling pathway, and proliferation in MCF-7 cells
Q34173343Schizosaccharomyces pombe Int6 and Ras homologs regulate cell division and mitotic fidelity via the proteasome
Q40473008Surface charge and hydrophobicity determine ErbB2 binding to the Hsp90 chaperone complex.
Q28751110The mutational spectrum of non-CpG DNA varies with CpG content

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