| scholarly article | Q13442814 |
| P819 | ADS bibcode | 2002PNAS...99.3842F |
| P356 | DOI | 10.1073/PNAS.052025899 |
| P8608 | Fatcat ID | release_bhqnxeuovzfjndfvmffen4ls3e |
| P932 | PMC publication ID | 122611 |
| P698 | PubMed publication ID | 11904436 |
| P5875 | ResearchGate publication ID | 11460475 |
| P50 | author | Enrique Rodriguez-Boulan | Q88831508 |
| Silvia C Finnemann | Q90083234 | ||
| P2093 | author name string | Lawrence W Leung | |
| P2860 | cites work | A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION | Q25939000 |
| Participation of the retinal pigment epithelium in the rod outer segment renewal process | Q28609982 | ||
| The renewal of photoreceptor cell outer segments | Q28609983 | ||
| Isolation and one-step preparation of A2E and iso-A2E, fluorophores from human retinal pigment epithelium | Q28610021 | ||
| Oxidative damage and age-related macular degeneration | Q33774187 | ||
| Genetic susceptibility to age related macular degeneration | Q33831396 | ||
| Pathophysiology of age-related macular degeneration | Q34173084 | ||
| Ezrin promotes morphogenesis of apical microvilli and basal infoldings in retinal pigment epithelium | Q36326132 | ||
| Macrophage and retinal pigment epithelium phagocytosis: apoptotic cells and photoreceptors compete for alphavbeta3 and alphavbeta5 integrins, and protein kinase C regulates alphavbeta5 binding and cytoskeletal linkage | Q36375325 | ||
| An endogenous MDCK lysosomal membrane glycoprotein is targeted basolaterally before delivery to lysosomes | Q36530591 | ||
| Phagocytosis of rod outer segments by retinal pigment epithelial cells requires alpha(v)beta5 integrin for binding but not for internalization | Q36713393 | ||
| Vertebrate rod outer segment membranes | Q39934196 | ||
| Histopathology and immunocytochemistry of the neurosensory retina in fundus flavimaculatus. | Q40674593 | ||
| Fluorescence-based assays of lipases, phospholipases, and other lipolytic enzymes | Q40688554 | ||
| A2E, a lipofuscin fluorophore, in human retinal pigmented epithelial cells in culture. | Q40919605 | ||
| A human retinal pigment epithelial cell line that retains epithelial characteristics after prolonged culture | Q41354392 | ||
| Immortalization of polarized rat retinal pigment epithelium. | Q41582969 | ||
| Relation of smoking to the incidence of age-related maculopathy. The Beaver Dam Eye Study | Q41697313 | ||
| Hyperlipofuscinosis and subretinal fibrosis in Stargardt's disease. | Q49107580 | ||
| Retinal age pigments generated by self-assembling lysosomotropic detergents | Q59071585 | ||
| Age-related Macular Degeneration | Q59487848 | ||
| Peripherin. A rim-specific membrane protein of rod outer segment discs | Q68983119 | ||
| Anti-rhodopsin monoclonal antibodies of defined specificity: characterization and application | Q70122085 | ||
| A histopathologic study of Best's macular dystrophy | Q70392692 | ||
| The fate of the phagosome: conversion to 'age pigment' and impact in human retinal pigment epithelium | Q70950495 | ||
| Degradation of rhodopsin by a lysosomal fraction of retinal pigment epithelium: biochemical aspects of the visual process. XLI | Q71329868 | ||
| Lipofuscin of human retinal pigment epithelium | Q71424962 | ||
| Phospholipids of bovine outer segments | Q71672725 | ||
| Further studies on the identification of the phagocytosis receptor of rat retinal pigment epithelial cells | Q71834479 | ||
| Lipofuscin accumulation in iris pigment epithelial cells exposed to photoreceptor outer segments | Q73149381 | ||
| Does A2E, a retinoid component of lipofuscin and inhibitor of lysosomal degradative functions, directly affect the activity of lysosomal hydrolases? | Q73403626 | ||
| Photodamage to human RPE cells by A2-E, a retinoid component of lipofuscin | Q73991053 | ||
| Inhibition of lysosomal degradative functions in RPE cells by a retinoid component of lipofuscin | Q74586647 | ||
| P4510 | describes a project that uses | ImageQuant | Q112270642 |
| P433 | issue | 6 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | photoreceptor protein | Q7187894 |
| P304 | page(s) | 3842-3847 | |
| P577 | publication date | 2002-03-01 | |
| P1433 | published in | Proceedings of the National Academy of Sciences of the United States of America | Q1146531 |
| P1476 | title | The lipofuscin component A2E selectively inhibits phagolysosomal degradation of photoreceptor phospholipid by the retinal pigment epithelium | |
| P478 | volume | 99 |
| Q30583837 | A detailed three-step protocol for live imaging of intracellular traffic in polarized primary porcine RPE monolayers |
| Q89000215 | A non-retinoid antagonist of retinol-binding protein 4 rescues phenotype in a model of Stargardt disease without inhibiting the visual cycle |
| Q42496949 | A novel melano-lysosome in the retinal epithelium of rhesus monkeys |
| Q40004815 | A2E, a pigment of the lipofuscin of retinal pigment epithelial cells, is an endogenous ligand for retinoic acid receptor |
| Q50091811 | A2E-associated cell death and inflammation in retinal pigmented epithelial cells from human induced pluripotent stem cells |
| Q33777110 | Accelerated accumulation of lipofuscin pigments in the RPE of a mouse model for ABCA4-mediated retinal dystrophies following Vitamin A supplementation |
| Q53651823 | Acute central serous chorioretinopathy: a correlation study between fundus autofluorescence and spectral-domain OCT. |
| Q35126780 | Age-Related Macular Degeneration: Etiology, Pathogenesis, and Therapeutic Strategies |
| Q33234223 | Age-related macular disease: how to assess the retina using scanning laser techniques? |
| Q35056603 | Aging, age-related macular degeneration, and the response-to-retention of apolipoprotein B-containing lipoproteins |
| Q37055077 | Alphavbeta5 integrin receptors at the apical surface of the RPE: one receptor, two functions. |
| Q33906776 | Altered retinoid homeostasis catalyzed by a nicotine metabolite: implications in macular degeneration and normal development |
| Q42618735 | Altered rhythm of photoreceptor outer segment phagocytosis in beta5 integrin knockout mice. |
| Q99548948 | An In-Vitro Cell Model of Intracellular Protein Aggregation Provides Insights into RPE Stress Associated with Retinopathy |
| Q24298036 | An animal model of age-related macular degeneration in senescent Ccl-2- or Ccr-2-deficient mice |
| Q33755432 | Autophagy Regulates Proteasome Inhibitor-Induced Pigmentation in Human Embryonic Stem Cell-Derived Retinal Pigment Epithelial Cells |
| Q34903032 | Autophagy activation clears ELAVL1/HuR-mediated accumulation of SQSTM1/p62 during proteasomal inhibition in human retinal pigment epithelial cells |
| Q27008407 | Autophagy and heterophagy dysregulation leads to retinal pigment epithelium dysfunction and development of age-related macular degeneration |
| Q39512471 | Autophagy regulating kinases as potential therapeutic targets for age-related macular degeneration. |
| Q41875114 | Beneficial effect of antioxidants in retinopathies: a new hypothesis |
| Q34107188 | Bestrophins and retinopathies |
| Q36992465 | Bicyclic [3.3.0]-Octahydrocyclopenta[c]pyrrolo Antagonists of Retinol Binding Protein 4: Potential Treatment of Atrophic Age-Related Macular Degeneration and Stargardt Disease |
| Q34157474 | Bioremediation meets biomedicine: therapeutic translation of microbial catabolism to the lysosome |
| Q46243402 | Bis(monoacylglycero)phosphate lipids in the retinal pigment epithelium implicate lysosomal/endosomal dysfunction in a model of Stargardt disease and human retinas |
| Q42257831 | Bis-Retinoid A2E Induces an Increase of Basic Fibroblast Growth Factor via Inhibition of Extracellular Signal-Regulated Kinases 1/2 Pathway in Retinal Pigment Epithelium Cells and Facilitates Phagocytosis |
| Q37691648 | Bisretinoid-mediated complement activation on retinal pigment epithelial cells is dependent on complement factor H haplotype |
| Q34624202 | C20-D3-vitamin A slows lipofuscin accumulation and electrophysiological retinal degeneration in a mouse model of Stargardt disease |
| Q89910525 | Central Role of Oxidative Stress in Age-Related Macular Degeneration: Evidence from a Review of the Molecular Mechanisms and Animal Models |
| Q56502498 | Challenging but essential targets for genuine anti-ageing drugs |
| Q21195877 | Chloroquine treatment of ARPE-19 cells leads to lysosome dilation and intracellular lipid accumulation: possible implications of lysosomal dysfunction in macular degeneration |
| Q34020823 | Comparison of A2E cytotoxicity and phototoxicity with all-trans-retinal in human retinal pigment epithelial cells |
| Q58702202 | Complement System and Age-Related Macular Degeneration: Implications of Gene-Environment Interaction for Preventive and Personalized Medicine |
| Q33569372 | Complement modulation in the retinal pigment epithelium rescues photoreceptor degeneration in a mouse model of Stargardt disease |
| Q42880056 | Compositional studies of human RPE lipofuscin |
| Q35893349 | Crosstalk between Hsp70 molecular chaperone, lysosomes and proteasomes in autophagy-mediated proteolysis in human retinal pigment epithelial cells |
| Q34157723 | Defective lipid transport and biosynthesis in recessive and dominant Stargardt macular degeneration |
| Q34555955 | Defective macroautophagic turnover of brain lipids in the TgCRND8 Alzheimer mouse model: prevention by correcting lysosomal proteolytic deficits |
| Q36626060 | Defects in retinal pigment epithelial cell proteolysis and the pathology associated with age-related macular degeneration. |
| Q34243202 | Design, synthesis, and evaluation of nonretinoid retinol binding protein 4 antagonists for the potential treatment of atrophic age-related macular degeneration and Stargardt disease |
| Q34624198 | Deuterium Enrichment of Vitamin A at the C20 Position Slows the Formation of Detrimental Vitamin A Dimers in Wild-type Rodents |
| Q36323523 | Di-retinoid-pyridinium-ethanolamine (A2E) Accumulation and the Maintenance of the Visual Cycle Are Independent of Atg7-mediated Autophagy in the Retinal Pigmented Epithelium |
| Q35705397 | Dietary antioxidants prevent age-related retinal pigment epithelium actin damage and blindness in mice lacking αvβ5 integrin |
| Q42172254 | Differentiation of RPE cells from integration-free iPS cells and their cell biological characterization. |
| Q36591612 | Diseases caused by defects in the visual cycle: retinoids as potential therapeutic agents |
| Q39334780 | Diverse regulation of retinal pigment epithelium phagocytosis of photoreceptor outer segments by calcium-independent phospholipase A₂, group VIA and secretory phospholipase A₂, group IB. |
| Q37395303 | Dry age-related macular degeneration: mechanisms, therapeutic targets, and imaging |
| Q41442862 | Formation and growth of lipofuscin in the retinal pigment epithelium cells |
| Q33801874 | Formation of lipofuscin-like material in the RPE Cell by different components of rod outer segments. |
| Q86534236 | Functional assessment of the fundus autofluorescence pattern in Best vitelliform macular dystrophy |
| Q35174717 | Fundus Autofluorescence and RPE Lipofuscin in Age-Related Macular Degeneration |
| Q36860952 | Geographic atrophy: a histopathological assessment |
| Q36844624 | Hypoxia-induced metabolic stress in retinal pigment epithelial cells is sufficient to induce photoreceptor degeneration |
| Q34557391 | Identification of zebrafish insertional mutants with defects in visual system development and function |
| Q52688580 | Impaired Cargo Clearance in the Retinal Pigment Epithelium (RPE) Underlies Irreversible Blinding Diseases. |
| Q36252017 | Improved dual AAV vectors with reduced expression of truncated proteins are safe and effective in the retina of a mouse model of Stargardt disease |
| Q33725857 | Inherited mitochondrial DNA variants can affect complement, inflammation and apoptosis pathways: insights into mitochondrial-nuclear interactions |
| Q34199909 | Inhibition of the visual cycle by A2E through direct interaction with RPE65 and implications in Stargardt disease. |
| Q37200892 | Involvement of all-trans-retinal in acute light-induced retinopathy of mice |
| Q33821589 | Isolation and characterization of a retinal pigment epithelial cell fluorophore: an all-trans-retinal dimer conjugate |
| Q35610910 | Lack of alphavbeta5 integrin receptor or its ligand MFG-E8: distinct effects on retinal function |
| Q35415339 | Large-scale purification of porcine or bovine photoreceptor outer segments for phagocytosis assays on retinal pigment epithelial cells |
| Q40363400 | Lecithin:retinol acyltransferase is responsible for amidation of retinylamine, a potent inhibitor of the retinoid cycle |
| Q36481342 | Light and inherited retinal degeneration |
| Q37645850 | Light exposure stimulates formation of A2E oxiranes in a mouse model of Stargardt's macular degeneration |
| Q57184443 | Light-induced generation and toxicity of docosahexaenoate-derived oxidation products in retinal pigmented epithelial cells |
| Q35138088 | Lipids, lipoproteins, and age-related macular degeneration |
| Q34659679 | Lipofuscin in human glaucomatous optic nerves. |
| Q39137710 | Lipofuscins prepared by modification of photoreceptor cells via glycation or lipid peroxidation show the similar phototoxicity |
| Q34561000 | Looking chloride channels straight in the eye: bestrophins, lipofuscinosis, and retinal degeneration |
| Q36399778 | Loss of synchronized retinal phagocytosis and age-related blindness in mice lacking alphavbeta5 integrin. |
| Q36421374 | Lysosomes: Regulators of autophagy in the retinal pigmented epithelium |
| Q36587125 | Mechanisms for countering oxidative stress and damage in retinal pigment epithelium |
| Q37172423 | Medical bioremediation of age-related diseases |
| Q37155498 | Melanoregulin (MREG) modulates lysosome function in pigment epithelial cells |
| Q28587431 | Metabolic basis of visual cycle inhibition by retinoid and nonretinoid compounds in the vertebrate retina |
| Q37331675 | Metabolic constraints on the recovery of sensitivity after visual pigment bleaching in retinal rods. |
| Q27310679 | Microtubule motors transport phagosomes in the RPE, and lack of KLC1 leads to AMD-like pathogenesis |
| Q33957336 | Mitochondrial oxidative stress in the retinal pigment epithelium leads to localized retinal degeneration |
| Q35041343 | Morphological and physiological retinal degeneration induced by intravenous delivery of vitamin A dimers in rabbits |
| Q37639380 | Multiple A2E treatments lead to melanization of rod outer segment-challenged ARPE-19 cells |
| Q37126849 | Neuronal pigmented autophagic vacuoles: lipofuscin, neuromelanin, and ceroid as macroautophagic responses during aging and disease |
| Q36804427 | New therapeutic targets in atrophic age-related macular degeneration |
| Q38138089 | Next-generation therapeutic solutions for age-related macular degeneration |
| Q37096772 | Noncanonical autophagy promotes the visual cycle |
| Q28555093 | Norbixin Protects Retinal Pigmented Epithelium Cells and Photoreceptors against A2E-Mediated Phototoxicity In Vitro and In Vivo |
| Q64921129 | Nutrient deprivation and lysosomal stress induce activation of TFEB in retinal pigment epithelial cells. |
| Q91993268 | Oral Delivery of the P2Y12 Receptor Antagonist Ticagrelor Prevents Loss of Photoreceptors in an ABCA4-/- Mouse Model of Retinal Degeneration |
| Q42256993 | PI 3-kinase independent role for AKT in F-actin regulation during outer segment phagocytosis by RPE cells |
| Q33731918 | Phagocytosis of retinal rod and cone photoreceptors |
| Q34074393 | Pharmacological inhibition of lipofuscin accumulation in the retina as a therapeutic strategy for dry AMD treatment |
| Q34474600 | Phase ii, randomized, placebo-controlled, 90-day study of emixustat hydrochloride in geographic atrophy associated with dry age-related macular degeneration |
| Q33577803 | Phospholipid meets all-trans-retinal: the making of RPE bisretinoids |
| Q34105937 | Photoreceptor organization and rhythmic phagocytosis in the nile rat Arvicanthis ansorgei: a novel diurnal rodent model for the study of cone pathophysiology |
| Q35704155 | Possible therapy for age-related macular degeneration using human telomerase |
| Q54646753 | Potential of melatonin to treat or prevent age-related macular degeneration through stimulation of telomerase activity |
| Q36349956 | Protective effect of autophagy on human retinal pigment epithelial cells against lipofuscin fluorophore A2E: implications for age-related macular degeneration |
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| Q52657629 | RPE phagocytic function declines in age-related macular degeneration and is rescued by human umbilical tissue derived cells. |
| Q26765278 | Relationship between Oxidative Stress, Circadian Rhythms, and AMD |
| Q38199016 | Rescue of compromised lysosomes enhances degradation of photoreceptor outer segments and reduces lipofuscin-like autofluorescence in retinal pigmented epithelial cells |
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| Q34299750 | Retinal and nonocular abnormalities in Cyp27a1(-/-)Cyp46a1(-/-) mice with dysfunctional metabolism of cholesterol. |
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