SOCS3 regulates graft-versus-host disease

scientific article

SOCS3 regulates graft-versus-host disease is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1182/BLOOD-2009-12-259598
P932PMC publication ID2910612
P698PubMed publication ID20435883
P5875ResearchGate publication ID43534874

P50authorGeoffrey R HillQ38327210
Andrew D. CloustonQ38548319
Andrew W. RobertsQ43445505
Kate A MarkeyQ46223789
Kelli P MacDonaldQ55686060
Yana A WilsonQ60644270
P2093author name stringWarren S Alexander
Joel Tocker
Rachel D Kuns
Alistair L J Don
Neil C Raffelt
Stuart D Olver
P2860cites workA family of cytokine-inducible inhibitors of signallingQ24313168
Selective regulatory function of Socs3 in the formation of IL-17-secreting T cellsQ24547568
The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradationQ24654107
Cytokine-inducible SH2 protein-3 (CIS3/SOCS3) inhibits Janus tyrosine kinase by binding through the N-terminal kinase inhibitory region as well as SH2 domainQ28140535
SOCS-3 inhibits IL-12-induced STAT4 activation by binding through its SH2 domain to the STAT4 docking site in the IL-12 receptor β2 subunitQ28209831
Identification of functional roles for both IL-17RB and IL-17RA in mediating IL-25-induced activitiesQ28584827
STATs in cancer inflammation and immunity: a leading role for STAT3Q29547203
The pronounced Th17 profile in systemic sclerosis (SSc) together with intracellular expression of TGFbeta and IFNgamma distinguishes SSc phenotypesQ33470222
NKT cell-dependent leukemia eradication following stem cell mobilization with potent G-CSF analogs.Q34078681
SOCS-3 negatively regulates innate and adaptive immune mechanisms in acute IL-1-dependent inflammatory arthritisQ34619592
CD4+ regulatory T cells control TH17 responses in a Stat3-dependent manner.Q35006074
Absence of regulatory T-cell control of TH1 and TH17 cells is responsible for the autoimmune-mediated pathology in chronic graft-versus-host diseaseQ36141721
High level IL-12 production by murine dendritic cells: upregulation via MHC class II and CD40 molecules and downregulation by IL-4 and IL-10.Q36367196
Advances in the understanding of acute graft-versus-host disease.Q36759581
Prevention of graft versus host disease by inactivation of host antigen-presenting cellsQ78016071
Intracellular protein therapy with SOCS3 inhibits inflammation and apoptosisQ80353010
Cytokine expanded myeloid precursors function as regulatory antigen-presenting cells and promote tolerance through IL-10-producing regulatory T cellsQ81377803
Graft-versus-host disease causes failure of donor hematopoiesis and lymphopoiesis in interferon-gamma receptor-deficient hostsQ81451703
Suppressor of cytokine Signaling-3 inhibits interleukin-1 signaling by targeting the TRAF-6/TAK1 complexQ82858440
SOCS proteins, cytokine signalling and immune regulationQ36831668
Absence of donor Th17 leads to augmented Th1 differentiation and exacerbated acute graft-versus-host diseaseQ36843812
STAT-3 and ERK 1/2 phosphorylation are critical for T-cell alloactivation and graft-versus-host disease.Q37003577
IL-17 contributes to CD4-mediated graft-versus-host diseaseQ37071147
Increased T-bet+ cytotoxic effectors and type I interferon-mediated processes in chronic graft-versus-host disease of the oral mucosaQ37157967
Reciprocal differentiation and tissue-specific pathogenesis of Th1, Th2, and Th17 cells in graft-versus-host diseaseQ37373067
Regulation of immune responses by interleukin-27.Q37374967
Memory T cells in GVHD and GVL.Q37471741
SOCS3 negatively regulates IL-6 signaling in vivoQ38354512
Soluble lymphotoxin is an important effector molecule in GVHD and GVL.Q39793545
TGF-beta promotes Th17 cell development through inhibition of SOCS3.Q39950912
Suppressor of cytokine signaling-3 is recruited to the activated granulocyte-colony stimulating factor receptor and modulates its signal transductionQ40716523
Suppressors of cytokine signaling proteins are differentially expressed in Th1 and Th2 cells: implications for Th cell lineage commitment and maintenanceQ40743352
Loss of SOCS3 in T helper cells resulted in reduced immune responses and hyperproduction of interleukin 10 and transforming growth factor-beta 1Q42766950
Conventional dendritic cells are the critical donor APC presenting alloantigen after experimental bone marrow transplantationQ46140762
IL-6 induces an anti-inflammatory response in the absence of SOCS3 in macrophagesQ46376203
Adaptive immunity maintains occult cancer in an equilibrium stateQ46891052
Donor treatment with pegylated G-CSF augments the generation of IL-10-producing regulatory T cells and promotes transplantation tolerance.Q47262629
CD40-CD154 interaction and IFN-gamma are required for IL-12 but not prostaglandin E2 secretion by microglia during antigen presentation to Th1 cells.Q48286228
Differential production of IL-23 and IL-12 by myeloid-derived dendritic cells in response to TLR agonists.Q50776421
SOCS3 is a critical physiological negative regulator of G-CSF signaling and emergency granulopoiesis.Q51027830
Helminth-modified pulmonary immune response protects mice from allergen-induced airway hyperresponsiveness.Q51827445
Suppressor of cytokine signaling 3 regulates CD8 T-cell proliferation by inhibition of interleukins 6 and 27.Q53543101
Deficient SOCS3 expression in CD4+CD25+FoxP3+ regulatory T cells and SOCS3-mediated suppression of Treg functionQ56901192
Stem cell mobilization with G-CSF induces type 17 differentiation and promotes sclerodermaQ57252626
IFN differentially controls the development of idiopathic pneumonia syndrome and GVHD of the gastrointestinal tractQ57252630
TGF- in allogeneic stem cell transplantation: friend or foe?Q57252637
Donor pretreatment with progenipoietin-1 is superior to granulocyte colony-stimulating factor in preventing graft-versus-host disease after allogeneic stem cell transplantationQ57252638
Mechanism of crosstalk inhibition of IL-6 signaling in response to LPS and TNFαQ62818261
An experimental model of idiopathic pneumonia syndrome after bone marrow transplantation: I. The roles of minor H antigens and endotoxinQ71881409
P433issue2
P407language of work or nameEnglishQ1860
P304page(s)287-296
P577publication date2010-04-30
P1433published inBloodQ885070
P1476titleSOCS3 regulates graft-versus-host disease
P478volume116

Reverse relations

cites work (P2860)
Q56888756A whole-blood RNA transcript-based gene signature is associated with the development of CTLA-4 blockade-related diarrhea in patients with advanced melanoma treated with the checkpoint inhibitor tremelimumab
Q45050218Addition of interleukin-6 inhibition with tocilizumab to standard graft-versus-host disease prophylaxis after allogeneic stem-cell transplantation: a phase 1/2 trial.
Q38661579Cellular and molecular mechanisms in graft-versus-host disease
Q37603497Combined nifuroxazide and SAT05f therapy reduces graft-versus-host disease after experimental allogeneic bone marrow transplantation
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Q36761824Expression of SOCS1 and SOCS3 genes in human graft-versus-host disease after allogeneic hematopoietic stem cell transplantation
Q37683419Interleukin-6 (IL-6) trans signaling drives a STAT3-dependent pathway that leads to hyperactive transforming growth factor-β (TGF-β) signaling promoting SMAD3 activation and fibrosis via Gremlin protein.
Q45278539Microsatellite scanning of the immunogenome associates MAPK14 and ELTD1 with graft-versus-host disease in hematopoietic stem cell transplantation
Q90360119SMG1 heterozygosity exacerbates haematopoietic cancer development in Atm null mice by increasing persistent DNA damage and oxidative stress
Q35226610SOCS1 and SOCS3 are expressed in mononuclear cells in human cytomegalovirus viremia after allogeneic hematopoietic stem cell transplantation
Q37592325SOCS3, a Major Regulator of Infection and Inflammation.
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Q37989141The role of chemokines in mediating graft versus host disease: opportunities for novel therapeutics.
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