| Q43283307 | A Comprehensive Survey of the Roles of Highly Disordered Proteins in Type 2 Diabetes. |
| Q38297454 | A mutant form of JAB/SOCS1 augments the cytokine-induced JAK/STAT pathway by accelerating degradation of wild-type JAB/CIS family proteins through the SOCS-box. |
| Q28218885 | A new high affinity binding site for suppressor of cytokine signaling-3 on the erythropoietin receptor |
| Q33726144 | A new polycythaemia vera-associated SOCS3 SH2 mutant (SOCS3F136L) cannot regulate erythropoietin responses |
| Q36109695 | A novel viral SOCS from infectious spleen and kidney necrosis virus: interacts with Jak1 and inhibits IFN-α induced Stat1/3 activation |
| Q42944831 | A role of suppressor of cytokine signaling 3 (SOCS3/CIS3/SSI3) in CD28-mediated interleukin 2 production |
| Q40965993 | A systems approach to understanding human rhinovirus and influenza virus infection |
| Q44391338 | A three-dimensional model of Suppressor Of Cytokine Signalling 1 (SOCS-1). |
| Q35594920 | Activation of signal transducer and activator of transcription (STAT) 1 in human chronic inflammatory bowel disease |
| Q40787375 | Activation of the transcription factor NF-kappaB by the erythropoietin receptor: structural requirements and biological significance |
| Q37377610 | Adiponectin inhibits pro-inflammatory signaling in human macrophages independent of interleukin-10 |
| Q33828925 | Advances in understanding the pathogenesis of primary familial and congenital polycythaemia |
| Q24529081 | Ankyrin repeat and SOCS box 3 (ASB3) mediates ubiquitination and degradation of tumor necrosis factor receptor II |
| Q28116068 | Autophosphorylation of JAK2 on tyrosines 221 and 570 regulates its activity |
| Q37146441 | Biology and significance of the JAK/STAT signalling pathways |
| Q83211663 | Bisphosphonates inhibit phosphorylation of signal transducer and activator of transcription 3 and expression of suppressor of cytokine signaling 3: implications for their effects on innate immune function and osteoclastogenesis |
| Q27473235 | Blocking of Interferon-Induced Jak-Stat Signaling by Japanese Encephalitis Virus NS5 through a Protein Tyrosine Phosphatase-Mediated Mechanism |
| Q28140132 | CIS3/SOCS-3 suppresses erythropoietin (EPO) signaling by binding the EPO receptor and JAK2 |
| Q36376179 | CIS3/SOCS3/SSI3 plays a negative regulatory role in STAT3 activation and intestinal inflammation |
| Q35643695 | CUEDC2 (CUE domain-containing 2) and SOCS3 (suppressors of cytokine signaling 3) cooperate to negatively regulate Janus kinase 1/signal transducers and activators of transcription 3 signaling. |
| Q35382471 | Cell-type-specific type I interferon antagonism influences organ tropism of murine coronavirus |
| Q37597696 | Chapter 3: Role of SOCS in allergic and innate immune responses |
| Q37075035 | Critical analysis of the potential for targeting STAT3 in human malignancy |
| Q36219805 | Deletion of the SOCS box of suppressor of cytokine signaling 3 (SOCS3) in embryonic stem cells reveals SOCS box-dependent regulation of JAK but not STAT phosphorylation |
| Q40563242 | Distinct activities of suppressor of cytokine signaling (SOCS) proteins and involvement of the SOCS box in controlling G-CSF signaling |
| Q40340377 | Divergent mechanisms utilized by SOCS3 to mediate interleukin-10 inhibition of tumor necrosis factor alpha and nitric oxide production by macrophages |
| Q37167952 | Drosophila SOCS36E negatively regulates JAK/STAT pathway signaling via two separable mechanisms. |
| Q37390882 | EPAC proteins transduce diverse cellular actions of cAMP. |
| Q34577551 | Elucidating the crosstalk mechanism between IFN-gamma and IL-6 via mathematical modelling |
| Q38903138 | Enhanced expression of suppresser of cytokine signaling 3 inhibits the IL-6-induced epithelial-to-mesenchymal transition and cholangiocarcinoma cell metastasis |
| Q34347958 | Epstein-barr virus-induced changes in B-lymphocyte gene expression |
| Q30445485 | Exchange protein activated by cyclic AMP (Epac)-mediated induction of suppressor of cytokine signaling 3 (SOCS-3) in vascular endothelial cells |
| Q50097560 | Expression and Purification of JAK1 and SOCS1 for Structural and Biochemical Studies. |
| Q46480919 | Expression of SOCS1-7 and CIS mRNA in porcine tissues |
| Q33897894 | Extended anti-inflammatory action of a degradation-resistant mutant of cell-penetrating suppressor of cytokine signaling 3. |
| Q37111982 | Flavanoids induce expression of the suppressor of cytokine signalling 3 (SOCS3) gene and suppress IL-6-activated signal transducer and activator of transcription 3 (STAT3) activation in vascular endothelial cells. |
| Q34342527 | Free fatty acid palmitate impairs the vitality and function of cultured human bladder smooth muscle cells |
| Q39190247 | Gene methylation and silencing of SOCS3 in mantle cell lymphoma |
| Q90725072 | Genome-Wide Mapping Defines a Role for C/EBPβ and c-Jun in Non-Canonical Cyclic AMP Signalling |
| Q41490661 | How Does the L884P Mutation Confer Resistance to Type-II Inhibitors of JAK2 Kinase: A Comprehensive Molecular Modeling Study. |
| Q35959846 | IFN-γ-induced JAK/STAT, but not NF-κB, signaling pathway is insensitive to glucocorticoid in airway epithelial cells |
| Q52148694 | Identification of STAT3 and STAT5 proteins in the rat suprachiasmatic nucleus and the Day/Night difference in astrocytic STAT3 phosphorylation in response to lipopolysaccharide. |
| Q36319044 | Identification of a Novel, Small Molecule Partial Agonist for the Cyclic AMP Sensor, EPAC1. |
| Q36714862 | Identification of steroid-sensitive gene-1/Ccdc80 as a JAK2-binding protein. |
| Q28366650 | Induction of the cytokine signal regulator SOCS3/CIS3 as a therapeutic strategy for treating inflammatory arthritis |
| Q37676036 | Inhibition of IL-6 family cytokines by SOCS3. |
| Q34103542 | Inhibition of insulin receptor catalytic activity by the molecular adapter Grb14. |
| Q24306070 | Insulin decreases hepatic acute phase protein levels in severely burned children |
| Q38305477 | Integrative signaling by minimal erythropoietin receptor forms and c-Kit |
| Q36573914 | Interaction between a Domain of the Negative Regulator of the Ras-ERK Pathway, SPRED1 Protein, and the GTPase-activating Protein-related Domain of Neurofibromin Is Implicated in Legius Syndrome and Neurofibromatosis Type 1. |
| Q48251193 | Interaction of suppressor of cytokine signalling 3 with cavin-1 links SOCS3 function and cavin-1 stability. |
| Q52319726 | Interferon Independent Non-Canonical STAT Activation and Virus Induced Inflammation. |
| Q35139231 | Interleukin-10 and immunity against prokaryotic and eukaryotic intracellular pathogens |
| Q37888027 | Interleukin-6: a multifunctional targetable cytokine in human prostate cancer |
| Q52656382 | Intracellular cAMP Sensor EPAC: Physiology, Pathophysiology, and Therapeutics Development. |
| Q36334963 | Intracellular signalling pathways activated by leptin |
| Q37810100 | JAK2V617F and beyond: role of genetics and aberrant signaling in the pathogenesis of myeloproliferative neoplasms |
| Q24806655 | Janus kinases and signal transducers and activators of transcription: their roles in cytokine signaling, development and immunoregulation |
| Q38530632 | Kinase inhibition, competitive binding and proteasomal degradation: resolving the molecular function of the suppressor of cytokine signaling (SOCS) proteins |
| Q38820725 | LIF signal in mouse embryonic stem cells |
| Q57038517 | Leptin Signaling in the Control of Metabolism and Appetite: Lessons from Animal Models |
| Q53594823 | Loss of SOCS3 gene expression converts STAT3 function from anti-apoptotic to pro-apoptotic. |
| Q33522778 | Mechanism of attenuation of leptin signaling under chronic ligand stimulation |
| Q40401298 | Mechanisms of SOCS3 phosphorylation upon interleukin-6 stimulation. Contributions of Src- and receptor-tyrosine kinases |
| Q33857008 | Mechanistic insights into activation and SOCS3-mediated inhibition of myeloproliferative neoplasm-associated JAK2 mutants from biochemical and structural analyses |
| Q41240274 | Methylation and microRNA-mediated epigenetic regulation of SOCS3. |
| Q37308106 | Methylation of SOCS3 is inversely associated with metabolic syndrome in an epigenome-wide association study of obesity |
| Q91447819 | MicroRNA gga-miR-455-5p suppresses Newcastle disease virus replication via targeting cellular suppressors of cytokine signaling 3 |
| Q42833029 | Modulation of host cell gene expression through activation of STAT transcription factors by Pasteurella multocida toxin |
| Q34898915 | Modulation of the central melanocortin system by leptin, insulin, and serotonin: co-ordinated actions in a dispersed neuronal network |
| Q33736438 | Molecular Signatures of Human Regulatory T Cells in Colorectal Cancer and Polyps |
| Q37172273 | Molecular and neural mediators of leptin action |
| Q40238236 | Mutational landscape of B-cell post-transplant lymphoproliferative disorders |
| Q36097785 | Negative regulation of FAK signaling by SOCS proteins |
| Q34246723 | Negative regulators of cytokine signaling |
| Q34979570 | Neuronal suppressor of cytokine signaling-3 deficiency enhances hypothalamic leptin-dependent phosphatidylinositol 3-kinase signaling |
| Q34099855 | New mimetic peptides of the kinase-inhibitory region (KIR) of SOCS1 through focused peptide libraries |
| Q40320402 | Oncostatin M receptor-mediated signal transduction is negatively regulated by SOCS3 through a receptor tyrosine-independent mechanism. |
| Q28585618 | PKD1 induces p21(waf1) and regulation of the cell cycle via direct activation of the JAK-STAT signaling pathway in a process requiring PKD2 |
| Q41493279 | Phosphorylation of JAK2 at serine 523: a negative regulator of JAK2 that is stimulated by growth hormone and epidermal growth factor. |
| Q89185950 | Post-Receptor Inhibitors of the GHR-JAK2-STAT Pathway in the Growth Hormone Signal Transduction |
| Q30873036 | Prediction and experimental validation of novel STAT3 target genes in human cancer cells |
| Q24530173 | Principles of interleukin (IL)-6-type cytokine signalling and its regulation |
| Q33858319 | Proinflammatory stem cell signaling in cardiac ischemia |
| Q42546799 | Protective effects of SOCS3 overexpression in high glucose‑induced lung epithelial cell injury through the JAK2/STAT3 pathway |
| Q36689092 | Proteomic applications of protein quantification by isotope-dilution mass spectrometry. |
| Q51188615 | Purification of SOCS (Suppressor of Cytokine Signaling) SH2 Domains for Structural and Functional Studies. |
| Q36739652 | Recent advances in growth hormone signaling |
| Q33857419 | Reconstruction of an active SOCS3-based E3 ubiquitin ligase complex in vitro: identification of the active components and JAK2 and gp130 as substrates |
| Q37951621 | Regulation of CD4+ T-cell polarization by suppressor of cytokine signalling proteins |
| Q24537294 | Regulation of Jak2 through the ubiquitin-proteasome pathway involves phosphorylation of Jak2 on Y1007 and interaction with SOCS-1. |
| Q37172111 | Regulation of Janus kinases by SOCS proteins |
| Q36209324 | Regulation of Macrophage, Dendritic Cell, and Microglial Phenotype and Function by the SOCS Proteins. |
| Q34830660 | Regulation of cytokine signaling and inflammation |
| Q36141189 | Regulation of multiple cytokine signalling pathways by SOCS3 is independent of SOCS2. |
| Q38214593 | Regulation of neurotrophin receptor (Trk) signaling: suppressor of cytokine signaling 2 (SOCS2) is a new player. |
| Q37965220 | Regulation of the inflammatory response of vascular endothelial cells by EPAC1. |
| Q38216732 | Role of Ubiquitylation in Controlling Suppressor of Cytokine Signalling 3 (SOCS3) Function and Expression. |
| Q26994711 | Role of suppressors of cytokine signaling 3 in bone inflammatory responses |
| Q40496539 | Role of tyrosine 441 of interferon-gamma receptor subunit 1 in SOCS-1-mediated attenuation of STAT1 activation |
| Q38349714 | SHP-2 Regulates SOCS-1-mediated Janus Kinase-2 Ubiquitination/Degradation Downstream of the Prolactin Receptor |
| Q28211408 | SHP2 and SOCS3 contribute to Tyr-759-dependent attenuation of interleukin-6 signaling through gp130 |
| Q36276638 | SLIM trims STATs: ubiquitin E3 ligases provide insights for specificity in the regulation of cytokine signaling. |
| Q47221711 | SOCS Proteins as Regulators of Inflammatory Responses Induced by Bacterial Infections: A Review. |
| Q64054763 | SOCS and Herpesviruses, With Emphasis on Cytomegalovirus Retinitis |
| Q38124037 | SOCS proteins in development and disease |
| Q38065534 | SOCS proteins in infectious diseases of mammals. |
| Q36831668 | SOCS proteins, cytokine signalling and immune regulation |
| Q37003892 | SOCS regulation of the JAK/STAT signalling pathway |
| Q38193362 | SOCS signaling in autoimmune diseases: molecular mechanisms and therapeutic implications |
| Q35927538 | SOCS, Inflammation, and Autoimmunity |
| Q50292456 | SOCS-1 and SOCS-3 binds to p-JAK2 |
| Q37527082 | SOCS-1 localizes to the microtubule organizing complex-associated 20S proteasome |
| Q39594973 | SOCS-3 antagonizes pro-apoptotic effects of TRAIL and resveratrol in prostate cancer cells |
| Q24537559 | SOCS-6 binds to insulin receptor substrate 4, and mice lacking the SOCS-6 gene exhibit mild growth retardation |
| Q39835229 | SOCS-mediated downregulation of mutant Jak2 (V617F, T875N and K539L) counteracts cytokine-independent signaling |
| Q50125557 | SOCS1: Regulator of T Cells in Autoimmunity and Cancer |
| Q40366547 | SOCS2 can enhance interleukin-2 (IL-2) and IL-3 signaling by accelerating SOCS3 degradation |
| Q35764207 | SOCS3 Drives Proteasomal Degradation of TBK1 and Negatively Regulates Antiviral Innate Immunity |
| Q27676669 | SOCS3 binds specific receptor–JAK complexes to control cytokine signaling by direct kinase inhibition |
| Q33338267 | SOCS3 inhibiting migration of A549 cells correlates with PYK2 signaling in vitro |
| Q47292718 | SOCS3 is a physiological negative regulator for granulopoiesis and granulocyte colony-stimulating factor receptor signaling. |
| Q35966972 | SOCS3 modulates interleukin-6R signaling preference in dermal fibroblasts |
| Q36700102 | SOCS3 promotor hypermethylation and STAT3-NF-κB interaction downregulate SOCS3 expression in human coronary artery smooth muscle cells |
| Q34022451 | SOCS3 regulates graft-versus-host disease |
| Q37592325 | SOCS3, a Major Regulator of Infection and Inflammation. |
| Q38140895 | SOCS3: A novel therapeutic target for cardioprotection |
| Q26853718 | SOCS3: An essential physiological inhibitor of signaling by interleukin-6 and G-CSF family cytokines |
| Q39698984 | SOCS3: an essential regulator of LIF receptor signaling in trophoblast giant cell differentiation |
| Q36731660 | SOCS5 is expressed in primary B and T lymphoid cells but is dispensable for lymphocyte production and function |
| Q43665317 | Selective inhibition of STAT3 induces apoptosis and G(1) cell cycle arrest in ALK-positive anaplastic large cell lymphoma |
| Q89820471 | Signal Transduction for TNFα-Induced Type II SOCS Expression and Its Functional Implication in Growth Hormone Resistance in Carp Hepatocytes |
| Q88460791 | Stat3 Regulates Liver Progenitor Cell-Driven Liver Regeneration in Zebrafish |
| Q64935699 | Structural insights into substrate recognition by the SOCS2 E3 ubiquitin ligase. |
| Q35822851 | Suppression of cytokine signaling by SOCS3: characterization of the mode of inhibition and the basis of its specificity |
| Q37278469 | Suppression of cytokine signaling: the SOCS perspective |
| Q31130829 | Suppressor of Cytokine Signaling (SOCS) 5 utilises distinct domains for regulation of JAK1 and interaction with the adaptor protein Shc-1. |
| Q41161742 | Suppressor of Cytokine Signaling (SOCS)1 Regulates Interleukin-4 (IL-4)-activated Insulin Receptor Substrate (IRS)-2 Tyrosine Phosphorylation in Monocytes and Macrophages via the Proteasome |
| Q34333533 | Suppressor of Cytokine Signaling 3 Inhibits LPS-induced IL-6 Expression in Osteoblasts by Suppressing CCAAT/Enhancer-binding Protein β Activity |
| Q34543450 | Suppressor of cytokine signaling 1 interacts with oncogenic lymphocyte-specific protein tyrosine kinase. |
| Q45345628 | Suppressor of cytokine signaling 1 regulates the immune response to infection by a unique inhibition of type I interferon activity |
| Q38336235 | Suppressor of cytokine signaling 3 expression in anaplastic large cell lymphoma. |
| Q36033134 | Suppressor of cytokine signaling 3 inhibits breast tumor kinase activation of STAT3. |
| Q40556038 | Suppressor of cytokine signaling 3 plays an important role in porcine circovirus type 2 subclinical infection by downregulating proinflammatory responses |
| Q35777741 | Suppressor of cytokine signaling-3 preferentially binds to the SHP-2-binding site on the shared cytokine receptor subunit gp130 |
| Q38177673 | Suppressors of cytokine signaling (SOCS) and type 2 diabetes |
| Q54576090 | Suppressors of cytokine signaling inhibit tubular epithelial cell-myofibroblast transdifferentiation. |
| Q35088551 | Suppressors of cytokine signalling: SOCS. |
| Q35134718 | TLR-induced negative regulatory circuits: role of suppressor of cytokine signaling (SOCS) proteins in innate immunity |
| Q51766789 | The Growth Hormone Receptor: Mechanism of Receptor Activation, Cell Signaling, and Physiological Aspects. |
| Q40686285 | The N-terminal truncated isoform of SOCS3 translated from an alternative initiation AUG codon under stress conditions is stable due to the lack of a major ubiquitination site, Lys-6. |
| Q48172039 | The Potential of a Novel Class of EPAC-Selective Agonists to Combat Cardiovascular Inflammation |
| Q27651007 | The SOCS Box Domain of SOCS3: Structure and Interaction with the ElonginBC-Cullin5 Ubiquitin Ligase |
| Q37289267 | The SOCS box encodes a hierarchy of affinities for Cullin5: implications for ubiquitin ligase formation and cytokine signalling suppression |
| Q35989418 | The SOCS box of suppressor of cytokine signaling-3 contributes to the control of G-CSF responsiveness in vivo |
| Q37987879 | The SOCS box-adapting proteins for ubiquitination and proteasomal degradation |
| Q40778041 | The Stat1 binding motif of the interferon-gamma receptor is sufficient to mediate Stat5 activation and its repression by SOCS3. |
| Q27003933 | The biology and mechanism of action of suppressor of cytokine signaling 3 |
| Q34465923 | The future of EPAC-targeted therapies: agonism versus antagonism |
| Q38313302 | The inhibition of interleukin-6-dependent STAT activation by mitogen-activated protein kinases depends on tyrosine 759 in the cytoplasmic tail of glycoprotein 130. |
| Q91864877 | The molecular details of cytokine signaling via the JAK/STAT pathway |
| Q33956113 | The molecular regulation of Janus kinase (JAK) activation |
| Q58575474 | The novel exchange protein activated by cyclic AMP 1 (EPAC1) agonist, I942, regulates inflammatory gene expression in human umbilical vascular endothelial cells (HUVECs) |
| Q34527668 | The pseudokinase domain is required for suppression of basal activity of Jak2 and Jak3 tyrosine kinases and for cytokine-inducible activation of signal transduction |
| Q36532544 | The role of SOCS3 in modulating leukaemia inhibitory factor signalling during murine placental development |
| Q90011439 | The role of SOCS3 in the hypothalamic paraventricular nucleus in rat model of inflammatory pain |
| Q26770682 | The role of small adaptor proteins in the control of oncogenic signaling driven by tyrosine kinases in human cancer |
| Q27026783 | The role of suppressors of cytokine signalling in human neoplasms |
| Q61807469 | Therapeutic Targeting of the Proinflammatory IL-6-JAK/STAT Signalling Pathways Responsible for Vascular Restenosis in Type 2 Diabetes Mellitus |
| Q45066357 | Thrombin induces expression of cytokine-induced SH2 protein (CIS) in rat brain astrocytes: involvement of phospholipase A2, cyclooxygenase, and lipoxygenase |
| Q33592962 | Transcriptional and Molecular Pathways Activated in Mesenteric Adipose Tissue and Intestinal Mucosa of Crohn's Disease Patients. |
| Q28186689 | Tyrosine-phosphorylated SOCS-3 inhibits STAT activation but binds to p120 RasGAP and activates Ras |
| Q37977181 | Unbiased identification of substrates for the Epac1-inducible E3 ubiquitin ligase component SOCS-3. |
| Q33828291 | Upregulation of SOCS3 in lung CD4+ T cells in a mouse model of chronic PA lung infection and suppression of Th17‑mediated neutrophil recruitment in exogenous SOCS3 transfer in vitro |
| Q38356597 | Vanadate enhances leptin-induced activation of JAK/STAT pathway in CHO cells |
| Q54255379 | Viral manipulation of STAT3: Evade, exploit, and injure. |
| Q64070093 | and digestive system cancers |