| scholarly article | Q13442814 |
| P356 | DOI | 10.1074/JBC.M116.746164 |
| P8608 | Fatcat ID | release_nygug2djknggnbxdqvsfz5byby |
| P932 | PMC publication ID | 5034051 |
| P698 | PubMed publication ID | 27507812 |
| P2093 | author name string | Nicola M Heller | |
| Jessie X Fang | |||
| Nagaraj Gowda | |||
| Sarah M McCormick | |||
| P2860 | cites work | IL-10-producing monocytes differentiate to alternatively activated macrophages and are increased in atopic patients | Q79755073 |
| Lipoteichoic acid-related molecule derived from the streptococcal preparation, OK-432, which suppresses atopic dermatitis-like lesions in NC/Nga mice | Q79918364 | ||
| The expression of SOCS is altered in rheumatoid arthritis | Q80860169 | ||
| Characterization of relapsing-remitting and chronic forms of experimental autoimmune encephalomyelitis in C57BL/6 mice | Q84586594 | ||
| Efficacy and safety of an anti-IL-13 mAb in patients with severe asthma: a randomized trial | Q87384061 | ||
| APS, an adaptor protein containing Pleckstrin homology (PH) and Src homology-2 (SH2) domains inhibits the JAK-STAT pathway in collaboration with c-Cbl | Q22010142 | ||
| Inhibition of Stat1-mediated gene activation by PIAS1 | Q24310082 | ||
| A family of cytokine-inducible inhibitors of signalling | Q24313168 | ||
| A new protein containing an SH2 domain that inhibits JAK kinases | Q24313242 | ||
| Twenty proteins containing a C-terminal SOCS box form five structural classes | Q24317684 | ||
| Cloning and characterization of APS, an adaptor molecule containing PH and SH2 domains that is tyrosine phosphorylated upon B-cell receptor stimulation | Q24318912 | ||
| The JAK-binding protein JAB inhibits Janus tyrosine kinase activity through binding in the activation loop | Q24533774 | ||
| The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation | Q24654107 | ||
| Cytokine-inducible SH2 protein-3 (CIS3/SOCS3) inhibits Janus tyrosine kinase by binding through the N-terminal kinase inhibitory region as well as SH2 domain | Q28140535 | ||
| SOCS-1 and SOCS-3 block insulin signaling by ubiquitin-mediated degradation of IRS1 and IRS2 | Q28201656 | ||
| Deletion of skeletal muscle SOCS3 prevents insulin resistance in obesity | Q28274712 | ||
| Unique expression of suppressor of cytokine signaling 3 is essential for classical macrophage activation in rodents in vitro and in vivo | Q28574856 | ||
| Structure and function of a new STAT-induced STAT inhibitor | Q28584775 | ||
| Suppressor of cytokine signaling 1 (SOCS-1) and SOCS-3 cause insulin resistance through inhibition of tyrosine phosphorylation of insulin receptor substrate proteins by discrete mechanisms | Q28586863 | ||
| The SOCS box of suppressor of cytokine signaling-1 is important for inhibition of cytokine action in vivo | Q28588059 | ||
| True | Q29307566 | ||
| Macrophage activation and polarization: nomenclature and experimental guidelines | Q29620642 | ||
| A new look at the pathogenesis of asthma | Q33588457 | ||
| The role of allergy in the development of asthma | Q33787596 | ||
| Adoptive transfer of IL-4Rα+ macrophages is sufficient to enhance eosinophilic inflammation in a mouse model of allergic lung inflammation | Q34146922 | ||
| Combinatorial control of the specificity of protein tyrosine phosphatases | Q34180660 | ||
| SOCS3 deficiency promotes M1 macrophage polarization and inflammation. | Q34287544 | ||
| Protein tyrosine phosphatases in signal transduction. | Q34419522 | ||
| The alveolar macrophages in asthma: a double-edged sword | Q34641655 | ||
| The kinase inhibitory region of SOCS-1 is sufficient to inhibit T-helper 17 and other immune functions in experimental allergic encephalomyelitis | Q34645350 | ||
| IL-4/IL-13-dependent and independent expression of miR-124 and its contribution to M2 phenotype of monocytic cells in normal conditions and during allergic inflammation | Q35072554 | ||
| Mechanisms of asthma | Q35078587 | ||
| Suppressors of cytokine signaling 3 expression in eosinophils: regulation by PGE₂ and Th2 cytokines | Q35101723 | ||
| A SOCS-1 promoter variant is associated with total serum IgE levels | Q35175588 | ||
| Overexpression of suppressor of cytokine signaling-5 in T cells augments innate immunity during septic peritonitis | Q43459075 | ||
| Expression of activation markers on alveolar macrophages in allergic asthmatics after endobronchial or whole-lung allergen challenge | Q44078405 | ||
| A cytokine gene screen uncovers SOCS1 as genetic risk factor for multiple sclerosis | Q44596853 | ||
| Quantitative analysis of the suppressors of cytokine signaling 1 and 3 in peripheral blood leukocytes of patients with multiple sclerosis | Q44999655 | ||
| Therapeutic hope for psoriasis offered by SOCS (suppressor of cytokine signaling) mimetic peptide | Q45780399 | ||
| Detection of endogenous SOCS1 and SOCS3 proteins by immunoprecipitation and Western blot analysis | Q45845094 | ||
| Expression of SOCSs in human prostate cancer and their association in prognosis | Q46742441 | ||
| The comparative roles of suppressor of cytokine signaling-1 and -3 in the inhibition and desensitization of cytokine signaling | Q46941042 | ||
| Overexpression of suppressor of cytokine signaling 3 in adipose tissue causes local but not systemic insulin resistance | Q46966519 | ||
| SOCS-3 regulates onset and maintenance of T(H)2-mediated allergic responses | Q47777274 | ||
| Complex role of the IL-4 receptor alpha in a murine model of airway inflammation: expression of the IL-4 receptor alpha on nonlymphoid cells of bone marrow origin contributes to severity of inflammation | Q47914659 | ||
| Gene delivery of suppressors of cytokine signaling (SOCS) inhibits inflammation and atherosclerosis development in mice. | Q51016332 | ||
| SOCS3 is a modulator of human macrophage phagocytosis. | Q51360221 | ||
| Pulmonary suppressor of cytokine signaling-1 induced by IL-13 regulates allergic asthma phenotype. | Q51759144 | ||
| Suppressor of cytokine signaling (SOCS)1 is a key determinant of differential macrophage activation and function. | Q53243987 | ||
| Expression of SOCS1 and SOCS3 is altered in the nasal mucosa of patients with mild and moderate/severe persistent allergic rhinitis. | Q53381224 | ||
| The analysis of CIS, SOCS1, SOSC2 and SOCS3 transcript levels in peripheral blood mononuclear cells of systemic lupus erythematosus and rheumatoid arthritis patients. | Q53451202 | ||
| Suppressor of cytokine signaling-1 is an IL-4-inducible gene in macrophages and feedback inhibits IL-4 signaling. | Q53589182 | ||
| Functional Polymorphism in theSuppressor of Cytokine Signaling 1Gene Associated with Adult Asthma | Q57273099 | ||
| More alternative activation of macrophages in lungs of asthmatic patients | Q57891628 | ||
| Interactions between Innate Antiviral and Atopic Immunoinflammatory Pathways Precipitate and Sustain Asthma Exacerbations in Children | Q58385251 | ||
| SOCS-1 is a central mediator of steroid-increased thymocyte apoptosis and decreased survival following sepsis | Q60156750 | ||
| Multiple sclerosis-associated single-nucleotide polymorphisms in CLEC16A correlate with reduced SOCS1 and DEXI expression in the thymus | Q60445325 | ||
| Differential expression of suppressors of cytokine signaling-1 and -3 and related cytokines in central nervous system during remitting versus non-remitting forms of experimental autoimmune encephalomyelitis. | Q64948037 | ||
| Regulation of lipopolysaccharide sensitivity by IFN regulatory factor-2 | Q73419660 | ||
| Inadequate induction of suppressor of cytokine signaling-1 causes systemic autoimmune diseases | Q75303159 | ||
| Divergent expression patterns of IL-4 and IL-13 define unique functions in allergic immunity | Q35624378 | ||
| Suppression of cytokine signaling by SOCS3: characterization of the mode of inhibition and the basis of its specificity | Q35822851 | ||
| Signal transducer and activator of transcription-3/suppressor of cytokine signaling-3 (STAT3/SOCS3) axis in myeloid cells regulates neuroinflammation. | Q35882299 | ||
| Increased nuclear suppressor of cytokine signaling 1 in asthmatic bronchial epithelium suppresses rhinovirus induction of innate interferons | Q35971340 | ||
| The Interleukin-13 Receptor-α1 Chain Is Essential for Induction of the Alternative Macrophage Activation Pathway by IL-13 but Not IL-4. | Q36005808 | ||
| Regulation of Macrophage, Dendritic Cell, and Microglial Phenotype and Function by the SOCS Proteins. | Q36209324 | ||
| IL-4 and IL-13 employ discrete signaling pathways for target gene expression in alternatively activated monocytes/macrophages | Q36501243 | ||
| Characterization of macrophage phenotypes in three murine models of house-dust-mite-induced asthma | Q36692030 | ||
| A nuclear tyrosine phosphatase downregulates interferon-induced gene expression | Q36827566 | ||
| The cytokine network in asthma and chronic obstructive pulmonary disease | Q36955575 | ||
| Persistent activation of an innate immune response translates respiratory viral infection into chronic lung disease | Q36955908 | ||
| Phenotypic characterization of lung macrophages in asthmatic patients: overexpression of CCL17. | Q37246771 | ||
| Putting out the fire: coordinated suppression of the innate and adaptive immune systems by SOCS1 and SOCS3 proteins | Q37257006 | ||
| Suppression of cytokine signaling: the SOCS perspective | Q37278469 | ||
| The SOCS box encodes a hierarchy of affinities for Cullin5: implications for ubiquitin ligase formation and cytokine signalling suppression | Q37289267 | ||
| Type I IL-4Rs selectively activate IRS-2 to induce target gene expression in macrophages. | Q37337400 | ||
| Suppressors of cytokine signaling (SOCS) in T cell differentiation, maturation, and function | Q37455362 | ||
| A critical role for suppressor of cytokine signalling 3 in promoting M1 macrophage activation and function in vitro and in vivo | Q37486900 | ||
| Suppressors of cytokine signaling (SOCS) proteins and JAK/STAT pathways: regulation of T-cell inflammation by SOCS1 and SOCS3. | Q37867360 | ||
| Regulation of CD4+ T-cell polarization by suppressor of cytokine signalling proteins | Q37951621 | ||
| SOCS proteins in development and disease | Q38124037 | ||
| An update on biologic-based therapy in asthma | Q38159806 | ||
| Monoclonal antibodies for the treatment of refractory asthma | Q38166197 | ||
| SOCS signaling in autoimmune diseases: molecular mechanisms and therapeutic implications | Q38193362 | ||
| SOCS Proteins in Macrophage Polarization and Function. | Q38239660 | ||
| Anti-interleukin 4 and 13 for asthma treatment in the era of endotypes | Q38241884 | ||
| SOCS-3 inhibits insulin signaling and is up-regulated in response to tumor necrosis factor-alpha in the adipose tissue of obese mice | Q38295719 | ||
| Nedd4-induced monoubiquitination of IRS-2 enhances IGF signalling and mitogenic activity. | Q38886538 | ||
| Serine 307 on insulin receptor substrate 1 is required for SOCS3 and TNF-α signaling in the rMC-1 cell line | Q38944209 | ||
| High glucose induces suppression of insulin signalling and apoptosis via upregulation of endogenous IL-1beta and suppressor of cytokine signalling-1 in mouse pancreatic beta cells | Q39752996 | ||
| Suppressor of cytokine signalling-3 inhibits Tumor necrosis factor-alpha induced apoptosis and signalling in beta cells | Q39818820 | ||
| Interaction and functional interference of glucocorticoid receptor and SOCS1. | Q39975291 | ||
| Reciprocal regulation of SOCS 1 and SOCS3 enhances resistance to ionizing radiation in glioblastoma multiforme | Q40145078 | ||
| Suppressor of cytokine signalling (SOCS)-3 protects beta cells against IL-1beta-mediated toxicity through inhibition of multiple nuclear factor-kappaB-regulated proapoptotic pathways | Q40485152 | ||
| Reduced epithelial suppressor of cytokine signalling 1 in severe eosinophilic asthma. | Q40638790 | ||
| Suppressor of cytokine signaling-3 (SOCS-3), a potential mediator of interleukin-6-dependent insulin resistance in hepatocytes. | Q40673661 | ||
| The SOCS box of SOCS-1 accelerates ubiquitin-dependent proteolysis of TEL-JAK2. | Q40816941 | ||
| Regulation of SOCS-1 expression by translational repression | Q40886943 | ||
| Protein-tyrosine phosphatase Shp-1 is a negative regulator of IL-4- and IL-13-dependent signal transduction. | Q40988710 | ||
| The immunology of asthma | Q41673436 | ||
| The IFN-gamma-dependent suppressor of cytokine signaling 1 promoter activity is positively regulated by IFN regulatory factor-1 and Sp1 but repressed by growth factor independence-1b and Krüppel-like factor-4, and it is dysregulated in psoriatic ker | Q42474611 | ||
| P4510 | describes a project that uses | ImageJ | Q1659584 |
| P433 | issue | 39 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | phosphorylation | Q242736 |
| P1104 | number of pages | 14 | |
| P304 | page(s) | 20574-20587 | |
| P577 | publication date | 2016-08-09 | |
| P1433 | published in | Journal of Biological Chemistry | Q867727 |
| P1476 | title | Suppressor of Cytokine Signaling (SOCS)1 Regulates Interleukin-4 (IL-4)-activated Insulin Receptor Substrate (IRS)-2 Tyrosine Phosphorylation in Monocytes and Macrophages via the Proteasome | |
| P478 | volume | 291 |
| Q39022174 | Dupilumab for the treatment of asthma |
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| Q54977051 | IL-4 and IL-13 Receptor Signaling From 4PS to Insulin Receptor Substrate 2: There and Back Again, a Historical View. |
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