A mutant form of JAB/SOCS1 augments the cytokine-induced JAK/STAT pathway by accelerating degradation of wild-type JAB/CIS family proteins through the SOCS-box.

scientific article published on 24 August 2001

A mutant form of JAB/SOCS1 augments the cytokine-induced JAK/STAT pathway by accelerating degradation of wild-type JAB/CIS family proteins through the SOCS-box. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M106139200
P698PubMed publication ID11522790
P5875ResearchGate publication ID11822626

P50authorIchiko KinjyoQ58883938
P2093author name stringS Kato
T Yoshida
Y Nomura
A Yoshimura
M Kubo
T Hanada
H Yasukawa
Y Seki
H Mimata
S Minoguchi
P2860cites workA new protein containing an SH2 domain that inhibits JAK kinasesQ24313242
Cloning and characterization of novel CIS family genesQ24321480
cul-1 is required for cell cycle exit in C. elegans and identifies a novel gene familyQ24336422
Inhibition of Transcription Elongation by the VHL Tumor Suppressor ProteinQ24336629
Elongin (SIII): A Multisubunit Regulator of Elongation by RNA Polymerase IIQ24336681
Binding of the von Hippel-Lindau Tumor Suppressor Protein to Elongin B and CQ24336712
The JAK-binding protein JAB inhibits Janus tyrosine kinase activity through binding in the activation loopQ24533774
STAT5 as a molecular regulator of proliferation, differentiation and apoptosis in hematopoietic cellsQ24534351
The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradationQ24654107
CIS3/SOCS-3 suppresses erythropoietin (EPO) signaling by binding the EPO receptor and JAK2Q28140132
Cytokine-inducible SH2 protein-3 (CIS3/SOCS3) inhibits Janus tyrosine kinase by binding through the N-terminal kinase inhibitory region as well as SH2 domainQ28140535
Gigantism in mice lacking suppressor of cytokine signalling-2Q28140549
SOCS1 deficiency causes a lymphocyte-dependent perinatal lethalityQ28144528
SOCS3 is essential in the regulation of fetal liver erythropoiesisQ28144536
Negative regulation of cytokine signaling pathwaysQ28145643
Rbx1, a component of the VHL tumor suppressor complex and SCF ubiquitin ligaseQ28506124
STATs and gene regulationQ29547796
Accelerated apoptosis of lymphocytes by augmented induction of Bax in SSI-1 (STAT-induced STAT inhibitor-1) deficient miceQ31949951
Control of B cell development by Ras-mediated activation of Raf.Q33887809
Suppression of STAT5 functions in liver, mammary glands, and T cells in cytokine-inducible SH2-containing protein 1 transgenic miceQ33959559
The Elongin BC complex interacts with the conserved SOCS-box motif present in members of the SOCS, ras, WD-40 repeat, and ankyrin repeat familiesQ35211894
CIS3/SOCS3/SSI3 plays a negative regulatory role in STAT3 activation and intestinal inflammationQ36376179
Three distinct domains of SSI-1/SOCS-1/JAB protein are required for its suppression of interleukin 6 signalingQ36638911
Liver degeneration and lymphoid deficiencies in mice lacking suppressor of cytokine signaling-1.Q36735213
Expression of constitutively active IkappaB beta in T cells of transgenic mice: persistent NF-kappaB activity is required for T-cell immune responsesQ39631389
The SOCS box of SOCS-1 accelerates ubiquitin-dependent proteolysis of TEL-JAK2.Q40816941
Augmentation of Valpha14 NKT cell-mediated cytotoxicity by interleukin 4 in an autocrine mechanism resulting in the development of concanavalin A-induced hepatitisQ42157047
The influence of the MAPK pathway on T cell lineage commitmentQ46660975
SOCS1 is a critical inhibitor of interferon gamma signaling and prevents the potentially fatal neonatal actions of this cytokine.Q52174469
Interferon gamma plays a critical role in T cell-dependent liver injury in mice initiated by concanavalin AQ71215744
CIS3 and JAB have different regulatory roles in interleukin-6 mediated differentiation and STAT3 activation in M1 leukemia cellsQ77540472
One ring to rule a superfamily of E3 ubiquitin ligasesQ77752816
P433issue44
P407language of work or nameEnglishQ1860
P304page(s)40746-40754
P577publication date2001-08-24
P1433published inJournal of Biological ChemistryQ867727
P1476titleA mutant form of JAB/SOCS1 augments the cytokine-induced JAK/STAT pathway by accelerating degradation of wild-type JAB/CIS family proteins through the SOCS-box
P478volume276

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cites work (P2860)
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