Flavanoids induce expression of the suppressor of cytokine signalling 3 (SOCS3) gene and suppress IL-6-activated signal transducer and activator of transcription 3 (STAT3) activation in vascular endothelial cells.

scientific article published on September 2013

Flavanoids induce expression of the suppressor of cytokine signalling 3 (SOCS3) gene and suppress IL-6-activated signal transducer and activator of transcription 3 (STAT3) activation in vascular endothelial cells. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1042/BJ20130481
P932PMC publication ID3749869
P698PubMed publication ID23782265

P50authorStephen J. YarwoodQ42398446
P2093author name stringJolanta Wiejak
Julia Dunlop
Simon P Mackay
P2860cites workPrinciples of interleukin (IL)-6-type cytokine signalling and its regulationQ24530173
Resveratrol ameliorates aging-related metabolic phenotypes by inhibiting cAMP phosphodiesterasesQ24608197
Inhibition of protein kinase CK2 by flavonoids and tyrphostins. A structural insightQ27681747
Selective inhibition of cytokine-activated extracellular signal-regulated kinase by cyclic AMP via Epac1-dependent induction of suppressor of cytokine signalling-3.Q45919876
The relationship between adipokines, metabolic parameters and insulin resistance in patients with metabolic syndrome and type 2 diabetes.Q51584134
Identification of CCAAT/enhancer-binding proteins as exchange protein activated by cAMP-activated transcription factors that mediate the induction of the SOCS-3 gene.Q53505333
Transsignaling of Interleukin-6 Crucially Contributes to Atherosclerosis in MiceQ62658826
Therapeutic and pharmacokinetic relationships of flavone acetic acid: an agent with activity against solid tumorsQ69687114
Intracellular protein therapy with SOCS3 inhibits inflammation and apoptosisQ80353010
Cytokine-inducible SH2 protein-3 (CIS3/SOCS3) inhibits Janus tyrosine kinase by binding through the N-terminal kinase inhibitory region as well as SH2 domainQ28140535
Flavonoids: antioxidants or signalling molecules?Q28250292
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The specificities of protein kinase inhibitors: an updateQ30014834
Exchange protein activated by cyclic AMP (Epac)-mediated induction of suppressor of cytokine signaling 3 (SOCS-3) in vascular endothelial cellsQ30445485
Plasma kinetics and urinary excretion of the flavanones naringenin and hesperetin in humans after ingestion of orange juice and grapefruit juiceQ33931727
Unregulated inflammation shortens human functional longevityQ34114689
Aging and proinflammatory cytokinesQ34219483
Antiatherogenic properties of flavonoids: implications for cardiovascular health.Q34618665
Suppressor of cytokine signalling protein SOCS3 expression is increased at sites of acute and chronic inflammationQ34762453
Interleukins in atherosclerosis: molecular pathways and therapeutic potentialQ35077444
IL-6 promotes acute and chronic inflammatory disease in the absence of SOCS3.Q35137626
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Autoregulation of pituitary corticotroph SOCS-3 expression: characterization of the murine SOCS-3 promoterQ36386744
SOCS proteins, cytokine signalling and immune regulationQ36831668
SOCS regulation of the JAK/STAT signalling pathwayQ37003892
The role of adiposity as a determinant of an inflammatory milieu.Q37135235
CK2 negatively regulates Galphas signalingQ37310767
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Antibody engineering to develop new antirheumatic therapiesQ37505420
Natural polyphenols that display anticancer properties through inhibition of kinase activityQ37692497
Unbiased identification of substrates for the Epac1-inducible E3 ubiquitin ligase component SOCS-3.Q37977181
New drug therapies on the horizon for IBD.Q38053028
Wogonin and related natural flavones are inhibitors of CDK9 that induce apoptosis in cancer cells by transcriptional suppression of Mcl-1.Q38798742
Estrogen receptor-alpha regulates SOCS-3 expression in human breast cancer cellsQ40391204
Inhibitory effects of naringenin on tumor growth in human cancer cell lines and sarcoma S-180-implanted mice.Q40451449
Sp3 is involved in the regulation of SOCS3 gene expressionQ40489948
Activation of protein kinase Calpha by EPAC1 is required for the ERK- and CCAAT/enhancer-binding protein beta-dependent induction of the SOCS-3 gene by cyclic AMP in COS1 cells.Q41774568
Quercetin inhibits a large panel of kinases implicated in cancer cell biologyQ42018542
The protein kinase C inhibitor, Ro-31-7459, is a potent activator of ERK and JNK MAP kinases in HUVECs and yet inhibits cyclic AMP-stimulated SOCS-3 gene induction through inactivation of the transcription factor c-Jun.Q42216011
Naringenin, a citrus flavonoid, increases muscle cell glucose uptake via AMPK.Q42473086
Extracellular signal-regulated kinase mitogen-activated protein kinase-dependent SOCS-3 gene induction requires c-Jun, signal transducer and activator of transcription 3, and specificity protein 3 transcription factorsQ42501717
Biphasic regulation of extracellular-signal-regulated protein kinase by leptin in macrophages: role in regulating STAT3 Ser727 phosphorylation and DNA bindingQ42522078
Naringin, the major grapefruit flavonoid, specifically affects atherosclerosis development in diet-induced hypercholesterolemia in miceQ42732172
Resveratrol suppresses tumorigenicity and enhances radiosensitivity in primary glioblastoma tumor initiating cells by inhibiting the STAT3 axis.Q42742420
Monitoring of the immunomodulatory effect of CP-690,550 by analysis of the JAK/STAT pathway in kidney transplant patientsQ43255330
Polyphenolic flavonoids differ in their antiapoptotic efficacy in hydrogen peroxide-treated human vascular endothelial cellsQ44388761
Impact of interleukin-6 on plaque development and morphology in experimental atherosclerosis.Q45158735
P275copyright licenseCreative Commons Attribution 3.0 UnportedQ14947546
P6216copyright statuscopyrightedQ50423863
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectendotheliumQ111140
P304page(s)283-293
P577publication date2013-09-01
P1433published inBiochemical JournalQ864221
P1476titleFlavanoids induce expression of the suppressor of cytokine signalling 3 (SOCS3) gene and suppress IL-6-activated signal transducer and activator of transcription 3 (STAT3) activation in vascular endothelial cells
P478volume454

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cites work (P2860)
Q38717326Altholactone Inhibits NF-κB and STAT3 Activation and Induces Reactive Oxygen Species-Mediated Apoptosis in Prostate Cancer DU145 Cells.
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Q59805361IFN-β Plays Both Pro- and Anti-inflammatory Roles in the Rat Cardiac Fibroblast Through Differential STAT Protein Activation
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Q38920986Naringenin Suppresses Neuroinflammatory Responses Through Inducing Suppressor of Cytokine Signaling 3 Expression
Q40976617Polarization of Monocytic Myeloid-Derived Suppressor Cells by Hepatitis B Surface Antigen Is Mediated via ERK/IL-6/STAT3 Signaling Feedback and Restrains the Activation of T Cells in Chronic Hepatitis B Virus Infection
Q37622040Quercetin Inhibits LPS-Induced Inflammation and ox-LDL-Induced Lipid Deposition
Q38290878Signaling and Immunoresolving Actions of Resolvin D1 in Inflamed Human Visceral Adipose Tissue
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Q90533200Targeted inhibition of STAT3 as a potential treatment strategy for atherosclerosis
Q37526079The citrus flavonoid naringenin confers protection in a murine endotoxaemia model through AMPK-ATF3-dependent negative regulation of the TLR4 signalling pathway
Q89556228Tryptanthrin promotes keratinocyte and fibroblast responses in vitro after infection with Trichophyton benhamiae DSM6916

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