The role of SOCS3 in modulating leukaemia inhibitory factor signalling during murine placental development

scientific article published on 3 April 2007

The role of SOCS3 in modulating leukaemia inhibitory factor signalling during murine placental development is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1016/J.JRI.2007.02.003
P932PMC publication ID2289801
P698PubMed publication ID17408753
P5875ResearchGate publication ID6412714

P2093author name stringLorraine Robb
Kristy Boyle
P2860cites workTwenty proteins containing a C-terminal SOCS box form five structural classesQ24317684
Placental defects and embryonic lethality in mice lacking suppressor of cytokine signaling 3Q24555816
Central role of suppressors of cytokine signaling proteins in hepatic steatosis, insulin resistance, and the metabolic syndrome in the mouseQ24564225
The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradationQ24654107
CIS3/SOCS-3 suppresses erythropoietin (EPO) signaling by binding the EPO receptor and JAK2Q28140132
SOCS3 mediates feedback inhibition of the leptin receptor via Tyr985Q28140351
Cytokine-inducible SH2 protein-3 (CIS3/SOCS3) inhibits Janus tyrosine kinase by binding through the N-terminal kinase inhibitory region as well as SH2 domainQ28140535
SOCS3 exerts its inhibitory function on interleukin-6 signal transduction through the SHP2 recruitment site of gp130Q28142716
SOCS3 is essential in the regulation of fetal liver erythropoiesisQ28144536
Identification of suppressors of cytokine signaling (SOCS) proteins in human gestational tissues: differential regulation is associated with the onset of laborQ28206330
SOCS-3 inhibits IL-12-induced STAT4 activation by binding through its SH2 domain to the STAT4 docking site in the IL-12 receptor β2 subunitQ28209831
Localization of leukemia inhibitory factor and its receptor in human placenta throughout pregnancyQ28294991
Induction of the cytokine signal regulator SOCS3/CIS3 as a therapeutic strategy for treating inflammatory arthritisQ28366650
Suppressor of cytokine signaling 1 (SOCS-1) and SOCS-3 cause insulin resistance through inhibition of tyrosine phosphorylation of insulin receptor substrate proteins by discrete mechanismsQ28586863
Genetic reduction of embryonic leukemia-inhibitory factor production rescues placentation in SOCS3-null embryos but does not prevent inflammatory diseaseQ28592478
Enhanced leptin sensitivity and attenuation of diet-induced obesity in mice with haploinsufficiency of Socs3.Q34329517
Comparative developmental anatomy of the murine and human definitive placentae.Q34546263
SOCS-3 negatively regulates innate and adaptive immune mechanisms in acute IL-1-dependent inflammatory arthritisQ34619592
The Elongin BC complex interacts with the conserved SOCS-box motif present in members of the SOCS, ras, WD-40 repeat, and ankyrin repeat familiesQ35211894
The role of suppressors of cytokine signaling (SOCS) proteins in regulation of the immune responseQ35698515
Growth in utero, blood pressure in childhood and adult life, and mortality from cardiovascular diseaseQ35709253
Suppressor of cytokine signaling-3 preferentially binds to the SHP-2-binding site on the shared cytokine receptor subunit gp130Q35777741
Determinants of trophoblast lineage and cell subtype specification in the mouse placentaQ36166995
Attenuation of leptin and insulin signaling by SOCS proteinsQ36607776
SOCS3 regulates the plasticity of gp130 signalingQ38354507
SOCS3 negatively regulates IL-6 signaling in vivoQ38354512
SOCS3: an essential regulator of LIF receptor signaling in trophoblast giant cell differentiationQ39698984
Reciprocal regulation of gastrointestinal homeostasis by SHP2 and STAT-mediated trefoil gene activation in gp130 mutant miceQ40705435
Suppressor of cytokine signaling-3 is recruited to the activated granulocyte-colony stimulating factor receptor and modulates its signal transductionQ40716523
Identification of the Y985 and Y1077 motifs as SOCS3 recruitment sites in the murine leptin receptorQ40838534
SOCS-3 is an insulin-induced negative regulator of insulin signalingQ42801701
Absence of suppressor of cytokine signalling 3 reduces self-renewal and promotes differentiation in murine embryonic stem cells.Q42803086
IL-6 induces an anti-inflammatory response in the absence of SOCS3 in macrophagesQ46376203
Socs3 deficiency in the brain elevates leptin sensitivity and confers resistance to diet-induced obesityQ47314567
Trophoblast stem cells rescue placental defect in SOCS3-deficient mice.Q50737501
SOCS3 is a critical physiological negative regulator of G-CSF signaling and emergency granulopoiesis.Q51027830
Targeted disruption of the low-affinity leukemia inhibitory factor receptor gene causes placental, skeletal, neural and metabolic defects and results in perinatal death.Q52510633
Suppressors of cytokine signaling proteins in human preterm placental tissuesQ81023202
P433issue1
P921main subjectleukemiaQ29496
P304page(s)1-6
P577publication date2007-04-03
P1433published inJournal of Reproductive ImmunologyQ15755932
P1476titleThe role of SOCS3 in modulating leukaemia inhibitory factor signalling during murine placental development
P478volume77

Reverse relations

cites work (P2860)
Q38184164Development of the hemochorial maternal vascular spaces in the placenta through endothelial and vasculogenic mimicry
Q36785052FoxO1 in embryonic development
Q35931177In vitro culture of mouse embryos reduces differential gene expression between inner cell mass and trophectoderm
Q91947175Increased expression of STAT3 and SOCS3 in placenta from hyperglycemic rats
Q90303896Insights into the Evolution of the Suppressors of Cytokine Signaling (SOCS) Gene Family in Vertebrates
Q38153210Interaction of Notch and gp130 signaling in the maintenance of neural stem and progenitor cells
Q55617573Leukemia inhibitory factor: roles in embryo implantation and in nonhormonal contraception.
Q39599326NDRG2-mediated Modulation of SOCS3 and STAT3 Activity Inhibits IL-10 Production
Q47104530Relationship of SOCS3 and TGF-β with IDO expression in early pregnancy chorionic villi and decidua
Q48316137Screening for embryonic loss during in utero development of mice with a human 1.5 Tesla clinical MRI scanner

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