Enhanced expression of suppresser of cytokine signaling 3 inhibits the IL-6-induced epithelial-to-mesenchymal transition and cholangiocarcinoma cell metastasis

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Enhanced expression of suppresser of cytokine signaling 3 inhibits the IL-6-induced epithelial-to-mesenchymal transition and cholangiocarcinoma cell metastasis is …
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scholarly articleQ13442814

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P6179Dimensions Publication ID1009370653
P356DOI10.1007/S12032-015-0553-7
P698PubMed publication ID25744243

P2093author name stringZhi-Dong Wang
Qing-Xin Zhou
Yun-Fu Cui
Chun-Long Li
Xing-Ming Jiang
P2860cites workThe basics of epithelial-mesenchymal transitionQ24652992
Suppressor of cytokine signaling-3 antagonizes cAMP effects on proliferation and apoptosis and is expressed in human prostate cancerQ24677026
SOCS, inflammation, and cancerQ26991808
Cytokine-inducible SH2 protein-3 (CIS3/SOCS3) inhibits Janus tyrosine kinase by binding through the N-terminal kinase inhibitory region as well as SH2 domainQ28140535
SOCS-3 is frequently silenced by hypermethylation and suppresses cell growth in human lung cancerQ33715489
Cholangiocarcinoma: Current concepts and insightsQ33965702
Serum and bile markers for cholangiocarcinomaQ33979059
Loss of expression and function of SOCS3 is an early event in HNSCC: altered subcellular localization as a possible mechanism involved in proliferation, migration and invasionQ34428326
Cholangiocarcinoma: thirty-one-year experience with 564 patients at a single institutionQ34578979
Pathogenesis, diagnosis, and management of cholangiocarcinomaQ34656747
Over-expression of interleukin-6 enhances cell survival and transformed cell growth in human malignant cholangiocytesQ34881846
Metformin inhibits the IL-6-induced epithelial-mesenchymal transition and lung adenocarcinoma growth and metastasisQ35161856
Sustained IL-6/STAT-3 signaling in cholangiocarcinoma cells due to SOCS-3 epigenetic silencingQ36388792
SOCS regulation of the JAK/STAT signalling pathwayQ37003892
Cross talk of signals between EGFR and IL-6R through JAK2/STAT3 mediate epithelial-mesenchymal transition in ovarian carcinomas.Q37080992
Inflammation and EMT: an alliance towards organ fibrosis and cancer progressionQ37668231
Inflammatory cytokines in cancer: tumour necrosis factor and interleukin 6 take the stageQ37845554
Current therapy of hilar cholangiocarcinomaQ37976498
Cancer-related inflammation and treatment effectivenessQ38256601
Role of crosstalk between interleukin-6 and transforming growth factor-beta 1 in epithelial-mesenchymal transition and chemoresistance in biliary tract cancerQ39214336
IL-6 promotes head and neck tumor metastasis by inducing epithelial-mesenchymal transition via the JAK-STAT3-SNAIL signaling pathwayQ39462532
Interleukin-6 induces an epithelial-mesenchymal transition phenotype in human breast cancer cells.Q39828317
Expression of SOCS1 and SOCS3 genes is differentially regulated in breast cancer cells in response to proinflammatory cytokine and growth factor signals.Q40227613
Interleukin 6 upregulates myeloid cell leukemia-1 expression through a STAT3 pathway in cholangiocarcinoma cellsQ40345898
Methylation silencing of SOCS-3 promotes cell growth and migration by enhancing JAK/STAT and FAK signalings in human hepatocellular carcinomaQ40399429
Growth control of human biliary epithelial cells by interleukin 6, hepatocyte growth factor, transforming growth factor beta1, and activin A: comparison of a cholangiocarcinoma cell line with primary cultures of non-neoplastic biliary epithelial celQ40871475
Inflammation and cancer: IL-6 and STAT3 complete the link.Q41957513
IL-6/STAT3/TFF3 signaling regulates human biliary epithelial cell migration and wound healing in vitroQ46752331
Human biliary epithelial cells secrete and respond to cytokines and hepatocyte growth factors in vitro: interleukin-6, hepatocyte growth factor and epidermal growth factor promote DNA synthesis in vitroQ72094183
SOCS-3 is frequently methylated in head and neck squamous cell carcinoma and its precursor lesions and causes growth inhibitionQ80353124
P433issue4
P921main subjectcholangiocarcinomaQ124292
P304page(s)105
P577publication date2015-03-06
P1433published inMedical OncologyQ2152666
P1476titleEnhanced expression of suppresser of cytokine signaling 3 inhibits the IL-6-induced epithelial-to-mesenchymal transition and cholangiocarcinoma cell metastasis
P478volume32

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cites work (P2860)
Q40978616Allicin inhibits the invasion of lung adenocarcinoma cells by altering tissue inhibitor of metalloproteinase/matrix metalloproteinase balance via reducing the activity of phosphoinositide 3-kinase/AKT signaling
Q52673450Desmoplastic Tumor Microenvironment and Immunotherapy in Cholangiocarcinoma.
Q26771988Epithelial-to-Mesenchymal Transition and Cancer Invasiveness: What Can We Learn from Cholangiocarcinoma?
Q40635240Inhibition of NF-kappaB with Dehydroxymethylepoxyquinomicin modifies the function of human peritoneal mesothelial cells
Q91876340MiR-30a-5p promotes cholangiocarcinoma cell proliferation through targeting SOCS3
Q47603972Molecular mechanisms driving cholangiocarcinoma invasiveness: an overview.
Q57115352Systematic literature review of IL-6 as a biomarker or treatment target in patients with gastric, bile duct, pancreatic and colorectal cancer
Q35814659The Prognostic Role of SOCS3 and A20 in Human Cholangiocarcinoma
Q36856915e-Cadherin in 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-Induced Parkinson Disease