The implications of DNA methylation for toxicology: toward toxicomethylomics, the toxicology of DNA methylation

scientific article

The implications of DNA methylation for toxicology: toward toxicomethylomics, the toxicology of DNA methylation is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1093/TOXSCI/KFR024
P932PMC publication ID3061486
P698PubMed publication ID21297083
P5875ResearchGate publication ID49813391

P2093author name stringMoshe Szyf
P2860cites workPromoter-wide hypermethylation of the ribosomal RNA gene promoter in the suicide brainQ21144321
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Targeted mutation of the DNA methyltransferase gene results in embryonic lethalityQ28131773
DNA methyltransferase Dnmt1 associates with histone deacetylase activityQ28141500
MBD2 is a transcriptional repressor belonging to the MeCP1 histone deacetylase complexQ28143627
Mi-2 complex couples DNA methylation to chromatin remodelling and histone deacetylationQ28143634
The oncoprotein Set/TAF-1beta, an inhibitor of histone acetyltransferase, inhibits active demethylation of DNA, integrating DNA methylation and transcriptional silencingQ28215929
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Dynamic DNA methylation programs persistent adverse effects of early-life stressQ28264120
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Persistent epigenetic differences associated with prenatal exposure to famine in humansQ28298905
Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cellsQ28366303
Association of arsenic-induced malignant transformation with DNA hypomethylation and aberrant gene expressionQ28379242
Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specificationQ28504641
Cloning and characterization of a family of novel mammalian DNA (cytosine-5) methyltransferasesQ28507226
Covalent modification of DNA regulates memory formationQ28576256
MeCP2 is a transcriptional repressor with abundant binding sites in genomic chromatinQ28576622
Meiotic catastrophe and retrotransposon reactivation in male germ cells lacking Dnmt3LQ28585211
Molecular enzymology of mammalian DNA methyltransferasesQ28646064
Derepression of BDNF Transcription Involves Calcium-Dependent Phosphorylation of MeCP2Q28941210
Environmental epigenomics and disease susceptibilityQ29547452
Epigenetic transgenerational actions of endocrine disruptors and male fertilityQ29547704
Conserved role of intragenic DNA methylation in regulating alternative promotersQ29616289
Brain-specific phosphorylation of MeCP2 regulates activity-dependent Bdnf transcription, dendritic growth, and spine maturationQ29616327
Maternal care, hippocampal glucocorticoid receptors, and hypothalamic-pituitary-adrenal responses to stressQ29616820
Nongenomic transmission across generations of maternal behavior and stress responses in the ratQ29618867
Hypomethylation distinguishes genes of some human cancers from their normal counterpartsQ29619217
The dynamics of myogenin site-specific demethylation is strongly correlated with its expression and with muscle differentiation.Q31628887
GADD45A does not promote DNA demethylationQ33325901
The site specific demethylation in the 5'-regulatory area of NMDA receptor 2B subunit gene associated with CIE-induced up-regulation of transcriptionQ33526324
Epigenetic transgenerational actions of vinclozolin on promoter regions of the sperm epigenomeQ33711986
A mammalian protein with specific demethylase activity for mCpG DNA.Q33853552
Organ and gestational age effects of maternal nutrient restriction on global methylation in fetal baboonsQ33858489
DNA hypermethylation in tumorigenesis: epigenetics joins geneticsQ33870798
Active demethylation of the paternal genome in the mouse zygoteQ33901068
X inactivation, differentiation, and DNA methylationQ33999850
Dnmt1 and Dnmt3a maintain DNA methylation and regulate synaptic function in adult forebrain neurons.Q34103901
Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylationQ22003769
DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian developmentQ22010765
Translating the Histone CodeQ22065840
The nuclear DNA base 5-hydroxymethylcytosine is present in Purkinje neurons and the brainQ22065852
DNMT1 binds HDAC2 and a new co-repressor, DMAP1, to form a complex at replication fociQ22254582
The Polycomb group protein EZH2 directly controls DNA methylationQ24299020
Methylation of tRNAAsp by the DNA methyltransferase homolog Dnmt2Q24301514
Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complexQ24324026
UHRF1 plays a role in maintaining DNA methylation in mammalian cellsQ24336152
Reelin and glutamic acid decarboxylase67 promoter remodeling in an epigenetic methionine-induced mouse model of schizophreniaQ24530247
Reelin promoter hypermethylation in schizophreniaQ24531469
Maternal care effects on the hippocampal transcriptome and anxiety-mediated behaviors in the offspring that are reversible in adulthoodQ24541484
An epigenetic mouse model for molecular and behavioral neuropathologies related to schizophrenia vulnerabilityQ24544035
In psychosis, cortical interneurons overexpress DNA-methyltransferase 1Q24556666
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Lasting epigenetic influence of early-life adversity on the BDNF geneQ24600763
Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuseQ24602512
Human DNA methylomes at base resolution show widespread epigenomic differencesQ24633677
The DNMT3B DNA methyltransferase gene is mutated in the ICF immunodeficiency syndromeQ24647294
Developmental exposure to estradiol and bisphenol A increases susceptibility to prostate carcinogenesis and epigenetically regulates phosphodiesterase type 4 variant 4Q24648201
Epigenetic regulation of PPARGC1A in human type 2 diabetic islets and effect on insulin secretionQ24650896
Clozapine and sulpiride but not haloperidol or olanzapine activate brain DNA demethylationQ24652480
Transposable elements: targets for early nutritional effects on epigenetic gene regulationQ24681243
Maternal nutrient supplementation counteracts bisphenol A-induced DNA hypomethylation in early developmentQ24681489
Histone hyperacetylation induces demethylation of reelin and 67-kDa glutamic acid decarboxylase promotersQ24682629
Antithetic effects of MBD2a on gene regulationQ24684982
TACC3 mediates the association of MBD2 with histone acetyltransferases and relieves transcriptional repression of methylated promotersQ25255820
Broad epigenetic signature of maternal care in the brain of adult ratsQ27314001
Epigenetic programming by maternal behaviorQ27860466
DNA methylation, insulin resistance, and blood pressure in offspring determined by maternal periconceptional B vitamin and methionine statusQ36288582
In vitro methylation of the hamster adenine phosphoribosyltransferase gene inhibits its expression in mouse L cellsQ36297565
Nuclear extracts of chicken embryos promote an active demethylation of DNA by excision repair of 5-methyldeoxycytidineQ36311707
Acetylation-induced transcription is required for active DNA demethylation in methylation-silenced genes.Q36315629
Epigenetic tête-à-tête: the bilateral relationship between chromatin modifications and DNA methylationQ36579350
DNA methylation and histone acetylation work in concert to regulate memory formation and synaptic plasticityQ36726961
Metastable epialleles, imprinting, and the fetal origins of adult diseasesQ36783165
Complex disease, gender and epigeneticsQ36793656
The developmental origins of health and disease: current theories and epigenetic mechanisms.Q36816569
Role of S-adenosylmethionine, folate, and betaine in the treatment of alcoholic liver disease: summary of a symposiumQ36872665
DNA methylation and systemic lupus erythematosusQ36951024
Report on the IASO Stock Conference 2006: early and lifelong environmental epigenomic programming of metabolic syndrome, obesity and type II diabetesQ36975977
Environmental epigenomics in human health and diseaseQ37049211
A human B cell methylome at 100-base pair resolutionQ37052486
DNA demethylation in zebrafish involves the coupling of a deaminase, a glycosylase, and gadd45.Q37068711
Developmental origins of health and disease: new insights.Q37069352
DNA methylation is a reversible biological signalQ37197626
Towards a new developmental synthesis: adaptive developmental plasticity and human diseaseQ37475772
Epigenetic mechanisms that underpin metabolic and cardiovascular diseasesQ37504694
Cellular and viral DNA hypomethylation associated with induction of Epstein-Barr virus lytic cycleQ37557036
Alteration of the methylation status of tumor-promoting genes decreases prostate cancer cell invasiveness and tumorigenesis in vitro and in vivo.Q38309516
CpG methylation inhibits binding of several sequence-specific DNA-binding proteins from pea, wheat, soybean and cauliflowerQ38334537
Reversal of the hypomethylation status of urokinase (uPA) promoter blocks breast cancer growth and metastasisQ38341003
Uteroplacental insufficiency alters DNA methylation, one-carbon metabolism, and histone acetylation in IUGR ratsQ38462433
Effects of specific DNMT gene depletion on cancer cell transformation and breast cancer cell invasion; toward selective DNMT inhibitorsQ39639196
Transient cyclical methylation of promoter DNA.Q40005345
Cigarette smoke induces demethylation of prometastatic oncogene synuclein-gamma in lung cancer cells by downregulation of DNMT3B.Q40157240
Complete inactivation of DNMT1 leads to mitotic catastrophe in human cancer cellsQ40166601
Gene body-specific methylation on the active X chromosomeQ40166744
Gadd45a promotes epigenetic gene activation by repair-mediated DNA demethylation.Q40176354
DNA methylation patterns. Formation and functionQ40186833
Role of T cell DNA methylation in lupus syndromesQ40399385
DNA methylation as an epigenetic regulator of neural 5-lipoxygenase expression: evidence in human NT2 and NT2-N cells.Q40580678
Role of promoter methylation in regulation of the mammalian heparanase geneQ40621407
Valproate induces replication-independent active DNA demethylationQ40647716
The methyl-CpG-binding protein MeCP2 links DNA methylation to histone methylationQ40690782
Demethylase activity is directed by histone acetylationQ40783486
DNA demethylation and pericentromeric rearrangements of chromosome 1.Q41087672
Induction of myogenic differentiation by an expression vector encoding the DNA methyltransferase cDNA sequence in the antisense orientation.Q41126074
Hypomethylation of hepatic nuclear DNA in rats fed with a carcinogenic methyl-deficient dietQ41888615
High frequency mutagenesis by a DNA methyltransferaseQ41917002
Rapid appearance of hypomethylated DNA in livers of rats fed cancer-promoting, methyl-deficient dietsQ41956709
Cellular differentiation, cytidine analogs and DNA methylationQ42242732
Epigenetic programming of the rRNA promoter by MBD3.Q42412828
Global DNA methylation in the mouse liver is affected by methyl deficiency and arsenic in a sex-dependent mannerQ42846409
Enzyme-mediated cytosine deamination by the bacterial methyltransferase M.MspI.Q42990671
Loss of human ribosomal gene CpG methylation enhances cryptic RNA polymerase II transcription and disrupts ribosomal RNA processingQ43283756
Ethanol consumption inhibits fetal DNA methylation in mice: implications for the fetal alcohol syndromeQ44086079
Selective, stable demethylation of the interleukin-2 gene enhances transcription by an active processQ44291577
The methyl donor S-Adenosylmethionine inhibits active demethylation of DNA: a candidate novel mechanism for the pharmacological effects of S-AdenosylmethionineQ44391318
Monozygotic twins exhibit numerous epigenetic differences: clues to twin discordance?Q44543032
DNA methylation models histone acetylationQ44585032
DNA methylation affects the formation of active chromatinQ44614953
Changes in methylation pattern of NMDA receptor NR2B gene in cortical neurons after chronic ethanol treatment in miceQ44768246
Parental imprinting of genesQ45294626
N-methyl-D-aspartate 2b receptor subtype (NR2B) promoter methylation in patients during alcohol withdrawalQ46059215
Hypermethylation of hepatic Gck promoter in ageing rats contributes to diabetogenic potentialQ46581862
Hepatic S-adenosylmethionine after maternal alcohol exposure on offspring ratsQ46726314
On the mechanism of demethylation of 5-methylcytosine in DNA.Q46830714
Uteroplacental insufficiency affects epigenetic determinants of chromatin structure in brains of neonatal and juvenile IUGR rats.Q46870106
Lowered DNA methyltransferase (DNMT-3b) mRNA expression is associated with genomic DNA hypermethylation in patients with chronic alcoholismQ46931693
Evidence that DNA (cytosine-5) methyltransferase regulates synaptic plasticity in the hippocampus.Q48587952
Dnmt3L and the establishment of maternal genomic imprintsQ48874297
Genome-wide analysis of DNA methylation and gene expression changes in the mouse lung following subchronic arsenate exposure.Q51550316
Transcript levels of DNA methyltransferases DNMT1, DNMT3A and DNMT3B in CD4+ T cells from patients with systemic lupus erythematosus.Q54551006
Substrate and sequence specificity of a eukaryotic DNA methylaseQ59062029
Canalization of Development and Genetic Assimilation of Acquired CharactersQ59065949
The onset of oncogene hypomethylation in the livers of rats fed methyl-deficient, amino acid-defined dietsQ67505743
A 10-year perspective of motherless-mother monkey behaviorQ67525435
Effects of alcohol consumption on DNA methylation reactions and gene expression: implications for increased cancer riskQ67968856
Hydralazine and procainamide inhibit T cell DNA methylation and induce autoreactivityQ68092023
Tissue-specific hypomethylation and expression of rat phosphoenolpyruvate carboxykinase gene induced by in vivo treatment of fetuses and neonates with 5-azacytidineQ68949344
Effects of prolonged ethanol feeding on methionine metabolism in rat liverQ69015074
Methylation of CpG sequences in eukaryotic DNAQ70725576
Ras induces a general DNA demethylation activity in mouse embryonal P19 cellsQ72259850
Gene Regulation in Higher CellsQ72537045
DNA methylation properties: consequences for pharmacologyQ72755740
Increased cytosine DNA-methyltransferase activity during colon cancer progressionQ72832112
Alterations in hepatic p53 gene methylation patterns during tumor progression with folate/methyl deficiency in the ratQ73212017
The host defence function of genomic methylation patternsQ74588154
Impaired methionine synthesis and hypomethylation in rats exposed to valproate during gestationQ74608086
Histone deacetylase inhibitor Trichostatin A induces global and gene-specific DNA demethylation in human cancer cell linesQ79716913
Transcript overexpression of the MBD2 and MBD4 genes in CD4+ T cells from systemic lupus erythematosus patientsQ79953563
Using LUMA: a Luminometric-based assay for global DNA-methylationQ81590977
Promoter-specific activation and demethylation by MBD2/demethylaseQ34144453
The transcription factor nerve growth factor-inducible protein a mediates epigenetic programming: altering epigenetic marks by immediate-early genes.Q34180593
Aberrant patterns of DNA methylation, chromatin formation and gene expression in cancerQ34188991
Genome-wide erasure of DNA methylation in mouse primordial germ cells is affected by AID deficiency.Q34249450
Occurrence of 5-methylcytosine in nucleic acidsQ34352684
Reversal of maternal programming of stress responses in adult offspring through methyl supplementation: altering epigenetic marking later in life.Q34469960
Assignment of candidate DNA methyltransferase gene (DNMT2) to human chromosome band 10p15.1 by in situ hybridizationQ34474330
Maternal genistein alters coat color and protects Avy mouse offspring from obesity by modifying the fetal epigenomeQ34508191
Valproate induces widespread epigenetic reprogramming which involves demethylation of specific genesQ34570313
The role of DNA methylation in the central nervous system and neuropsychiatric disordersQ34613653
Early demethylation of non-CpG, CpC-rich, elements in the myogenin 5'-flanking region: a priming effect on the spreading of active demethylation.Q34619602
Peptidyl argininedeiminase 2 CpG island in multiple sclerosis white matter is hypomethylatedQ34624154
The social environment and the epigenomeQ34728015
DNA hypomethylation leads to elevated mutation ratesQ34752442
DNA methylation in cancer: too much, but also too littleQ34770545
The quantitative separation of purines, pyrimidines, and nucleosides by paper chromatography.Q34854256
Valproic acid in pregnancy: how much are we endangering the embryo and fetus?Q34984538
Distribution of 5-methylcytosine in chromatinQ35034058
From epigenesis to epigenetics: the case of C. H. WaddingtonQ35053504
Effects of vitamin B12 and folate deficiencies on DNA methylation and carcinogenesis in rat liverQ35215615
An estrogen-dependent demethylation at the 5′ end of the chicken vitellogenin gene is independent of DNA synthesisQ35260743
HIDden targets of microRNAs for growth controlQ35296027
The ICF syndrome, a DNA methyltransferase 3B deficiency and immunodeficiency diseaseQ35571262
Replacement of 5-methylcytosine by cytosine: a possible mechanism for transient DNA demethylation during differentiationQ35602033
Dnmt2 functions in the cytoplasm to promote liver, brain, and retina development in zebrafishQ35616001
The concept of epigenetics and its role in the development of cardiovascular disease: commentary on "new and emerging theories of cardiovascular disease".Q35798449
CpG methylation inhibits proenkephalin gene expression and binding of the transcription factor AP-2Q35848528
Variations in DNA methylation during mouse cell differentiation in vivo and in vitroQ36256690
Trichostatin A causes selective loss of DNA methylation in NeurosporaQ36260468
P433issue2
P921main subjectDNA methylationQ874745
P304page(s)235-255
P577publication date2011-02-04
P1433published inToxicological SciencesQ2446966
P1476titleThe implications of DNA methylation for toxicology: toward toxicomethylomics, the toxicology of DNA methylation
P478volume120

Reverse relations

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