Sulforaphane induces apoptosis in rhabdomyosarcoma and restores TRAIL-sensitivity in the aggressive alveolar subtype leading to tumor elimination in mice

scientific article

Sulforaphane induces apoptosis in rhabdomyosarcoma and restores TRAIL-sensitivity in the aggressive alveolar subtype leading to tumor elimination in mice is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.4161/CBT.29684
P932PMC publication ID4128864
P698PubMed publication ID24971463
P5875ResearchGate publication ID263515082

P50authorPatrizia HreliaQ43097748
Giorgio Cantelli-FortiQ43098665
Andrea PessionQ54643363
P2093author name stringRoberto Tonelli
Giorgio Cantelli-Forti
Cristina Nanni
Carmelo Quarta
Stefano Fanti
Elisa Bergantin
P2860cites workSulforaphane as a promising molecule for fighting cancerQ56656827
Safety, Tolerance, and Metabolism of Broccoli Sprout Glucosinolates and Isothiocyanates: A Clinical Phase I StudyQ63433163
MYCN expression in human rhabdomyosarcoma cell lines and tumour samplesQ77839834
The PAX3-FKHR fusion protein created by the t(2;13) translocation in alveolar rhabdomyosarcomas is a more potent transcriptional activator than PAX3Q24313754
PAX3-FKHR and PAX7-FKHR gene fusions are prognostic indicators in alveolar rhabdomyosarcoma: a report from the children's oncology groupQ28201860
Differential regulation of the TRAIL death receptors DR4 and DR5 by the signal recognition particleQ33206588
Reproducibility of 18F-FDG microPET studies in mouse tumor xenograftsQ34164724
Sulforaphane Increases Drug-mediated Cytotoxicity Toward Cancer Stem-like Cells of Pancreas and ProstateQ34473316
Isothiocyanates as cancer chemopreventive agents: their biological activities and metabolism in rodents and humansQ34706257
Molecular pathogenesis of rhabdomyosarcomaQ34779149
TRAIL signaling and synergy mechanisms used in TRAIL-based combination therapiesQ37974875
Sulforaphane inhibits histone deacetylase in vivo and suppresses tumorigenesis in Apc-minus miceQ38268094
Antitumor activity of sustained N-myc reduction in rhabdomyosarcomas and transcriptional block by antigene therapyQ39446630
p21 Downregulation is an important component of PAX3/FKHR oncogenicity and its reactivation by HDAC inhibitors enhances combination treatment.Q39706036
FDG small animal PET permits early detection of malignant cells in a xenograft murine model.Q40198035
Identification of a PAX-FKHR gene expression signature that defines molecular classes and determines the prognosis of alveolar rhabdomyosarcomasQ40254065
Inhibition of angiogenesis and endothelial cell functions are novel sulforaphane-mediated mechanisms in chemoprevention.Q40302650
Sulforaphane sensitizes tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-resistant hepatoma cells to TRAIL-induced apoptosis through reactive oxygen species-mediated up-regulation of DR5.Q40321960
Phase I dose-escalation study of recombinant human Apo2L/TRAIL, a dual proapoptotic receptor agonist, in patients with advanced cancerQ40359028
The dietary isothiocyanate sulforaphane targets pathways of apoptosis, cell cycle arrest, and oxidative stress in human pancreatic cancer cells and inhibits tumor growth in severe combined immunodeficient miceQ40503935
Sulforaphane induces caspase-mediated apoptosis in cultured PC-3 human prostate cancer cells and retards growth of PC-3 xenografts in vivoQ40630814
Nuclear factor kappa B is a molecular target for sulforaphane-mediated anti-inflammatory mechanisms.Q40798546
Validation of met as a therapeutic target in alveolar and embryonal rhabdomyosarcoma.Q42802665
Modulation of phase II enzymes by sulforaphane: implications for its cardioprotective potentialQ45014174
P433issue9
P921main subjectrhabdomyosarcomaQ1898141
P304page(s)1219-1225
P577publication date2014-06-27
P1433published inCancer Biology and TherapyQ2544651
P1476titleSulforaphane induces apoptosis in rhabdomyosarcoma and restores TRAIL-sensitivity in the aggressive alveolar subtype leading to tumor elimination in mice
P478volume15

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cites work (P2860)
Q37564708Alveolar rhabdomyosarcoma: morphoproteomics and personalized tumor graft testing further define the biology of PAX3-FKHR(FOXO1) subtype and provide targeted therapeutic options
Q58750953Chemopreventive activity of sulforaphane
Q39136514DNA Microarray Profiling Highlights Nrf2-Mediated Chemoprevention Targeted by Wasabi-Derived Isothiocyanates in HepG2 Cells
Q39045906Nrf2 targeting by sulforaphane: A potential therapy for cancer treatment
Q59807366Sulforaphane from Cruciferous Vegetables: Recent Advances to Improve Glioblastoma Treatment
Q36413327Sulforaphane inhibits thyroid cancer cell growth and invasiveness through the reactive oxygen species-dependent pathway
Q37330410Thapsigargin sensitizes human esophageal cancer to TRAIL-induced apoptosis via AMPK activation.
Q38780660The effects of sulforaphane on canine osteosarcoma proliferation and invasion.

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