| P50 | author | Giulia Sita | Q57202990 |
| | Fabiana Morroni | Q57209261 |
| | Agnese Graziosi | Q59831981 |
| | Patrizia Hrelia | Q43097748 |
| P2860 | cites work | Nanotherapeutic systems for local treatment of brain tumors | Q39330269 |
| | Effect of sulforaphane on growth inhibition in human brain malignant glioma GBM 8401 cells by means of mitochondrial- and MEK/ERK-mediated apoptosis pathway. | Q39352280 |
| | Temozolomide: mechanisms of action, repair and resistance | Q39436413 |
| | A major inducer of anticarcinogenic protective enzymes from broccoli: isolation and elucidation of structure | Q24562666 |
| | Cruciferous vegetables and human cancer risk: epidemiologic evidence and mechanistic basis | Q24641921 |
| | Onto better TRAILs for cancer treatment | Q26768160 |
| | Cytotoxic and Antitumor Activity of Sulforaphane: The Role of Reactive Oxygen Species | Q26799560 |
| | Mechanisms of tumor development and anti-angiogenic therapy in glioblastoma multiforme | Q26999917 |
| | Cancer prevention with promising natural products: mechanisms of action and molecular targets | Q27006530 |
| | Gliomas and the vascular fragility of the blood brain barrier | Q28081953 |
| | Dangerous liaisons: STAT3 and NF-kappaB collaboration and crosstalk in cancer | Q28267996 |
| | Hypoxia in cancer: significance and impact on clinical outcome | Q28298305 |
| | Sulforaphane protects against ethanol-induced oxidative stress and apoptosis in neural crest cells by the induction of Nrf2-mediated antioxidant response | Q28382864 |
| | Metabolism and tissue distribution of sulforaphane in Nrf2 knockout and wild-type mice | Q28395388 |
| | Induction of phase 2 antioxidant enzymes by broccoli sulforaphane: perspectives in maintaining the antioxidant activity of vitamins a, C, and e | Q28395954 |
| | Tumor metastasis: molecular insights and evolving paradigms | Q29615908 |
| | CBTRUS Statistical Report: Primary Brain and Central Nervous System Tumors Diagnosed in the United States in 2008-2012. | Q30373363 |
| | Increased seizure susceptibility and other toxicity symptoms following acute sulforaphane treatment in mice. | Q50443779 |
| | Pharmacological targeting of the transcription factor Nrf2 at the basal ganglia provides disease modifying therapy for experimental parkinsonism. | Q50547983 |
| | Preclinical and clinical evaluation of sulforaphane for chemoprevention in the breast. | Q53335967 |
| | Sulforaphane suppresses oral cancer cell migration by regulating cathepsin S expression. | Q54113625 |
| | Sulforaphane induces apoptosis in human hepatic cancer cells through inhibition of 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase4, mediated by hypoxia inducible factor-1-dependent pathway. | Q54585085 |
| | Hemidesmus indicus induces immunogenic death in human colorectal cancer cells. | Q55422081 |
| | The Role of Curcumin in Prevention and Management of Metastatic Disease. | Q55629415 |
| | Neuroprotective Effect of Caffeic Acid Phenethyl Ester in A Mouse Model of Alzheimer's Disease Involves Nrf2/HO-1 Pathway | Q56350501 |
| | Sulforaphane as a promising molecule for fighting cancer | Q56656827 |
| | Sulforaphane regulates apoptosis- and proliferation‑related signaling pathways and synergizes with cisplatin to suppress human ovarian cancer | Q58760539 |
| | Glioblastoma Chemoresistance: The Double Play by Microenvironment and Blood-Brain Barrier | Q59134092 |
| | Cellular and molecular mechanisms of glioblastoma malignancy: Implications in resistance and therapeutic strategies | Q60196442 |
| | Sulforaphane potentiates oxaliplatin-induced cell growth inhibition in colorectal cancer cells via induction of different modes of cell death | Q61908025 |
| | Safety, Tolerance, and Metabolism of Broccoli Sprout Glucosinolates and Isothiocyanates: A Clinical Phase I Study | Q63433163 |
| | Inhibition of matrix metalloproteinase-9 reduces in vitro invasion and angiogenesis in human microvascular endothelial cells | Q64379249 |
| | Chemoprevention of colonic aberrant crypt foci in Fischer rats by sulforaphane and phenethyl isothiocyanate | Q73336084 |
| | Sulforaphane, a naturally occurring isothiocyanate, induces cell cycle arrest and apoptosis in HT29 human colon cancer cells | Q73574350 |
| | Shikonin circumvents cancer drug resistance by induction of a necroptotic death | Q80358241 |
| | Cancer chemoprevention of intestinal polyposis in ApcMin/+ mice by sulforaphane, a natural product derived from cruciferous vegetable | Q83288938 |
| | 4,2',5'-trihydroxy-4'-methoxychalcone from Dalbergia odorifera exhibits anti-inflammatory properties by inducing heme oxygenase-1 in murine macrophages | Q86558495 |
| | miR-21 induces myofibroblast differentiation and promotes the malignant progression of breast phyllodes tumors | Q88187415 |
| | Isothiocyanates from Brassica Vegetables-Effects of Processing, Cooking, Mastication, and Digestion | Q89091248 |
| | Sulforaphane modulates telomerase activity via epigenetic regulation in prostate cancer cell lines. | Q38828585 |
| | The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary | Q38829244 |
| | Sulforaphane inhibits invasion by phosphorylating ERK1/2 to regulate E-cadherin and CD44v6 in human prostate cancer DU145 cells | Q38857913 |
| | Sulforaphane enhances temozolomide-induced apoptosis because of down-regulation of miR-21 via Wnt/β-catenin signaling in glioblastoma | Q38873014 |
| | Changes in pyruvate metabolism detected by magnetic resonance imaging are linked to DNA damage and serve as a sensor of temozolomide response in glioblastoma cells. | Q38947387 |
| | RRAD promotes EGFR-mediated STAT3 activation and induces temozolomide resistance of malignant glioblastoma | Q38948087 |
| | Sulforaphane induces apoptosis in T24 human urinary bladder cancer cells through a reactive oxygen species-mediated mitochondrial pathway: the involvement of endoplasmic reticulum stress and the Nrf2 signaling pathway | Q38978206 |
| | Crude extract of Euphorbia formosana inhibits the migration and invasion of DU145 human prostate cancer cells: The role of matrix metalloproteinase-2/9 inhibition via the MAPK signaling pathway | Q39176393 |
| | Growth inhibition and apoptosis of neuroblastoma cells through ROS-independent MEK/ERK activation by sulforaphane | Q39192899 |
| | Human chorionic gonadotropin β induces cell motility via ERK1/2 and MMP-2 activation in human glioblastoma U87MG cells | Q39227664 |
| | Epithelial-mesenchymal transition, a novel target of sulforaphane via COX-2/MMP2, 9/Snail, ZEB1 and miR-200c/ZEB1 pathways in human bladder cancer cells | Q39243628 |
| | Sulforaphane potentiates the efficacy of imatinib against chronic leukemia cancer stem cells through enhanced abrogation of Wnt/β-catenin function | Q39329452 |
| | Chemoresistance to temozolomide in human glioma cell line U251 is associated with increased activity of O6-methylguanine-DNA methyltransferase and can be overcome by metronomic temozolomide regimen | Q39479445 |
| | Sulforaphane inhibits oral carcinoma cell migration and invasion in vitro | Q39574872 |
| | Differential effects of sulforaphane on histone deacetylases, cell cycle arrest and apoptosis in normal prostate cells versus hyperplastic and cancerous prostate cells | Q39581417 |
| | MiR-21 protected human glioblastoma U87MG cells from chemotherapeutic drug temozolomide induced apoptosis by decreasing Bax/Bcl-2 ratio and caspase-3 activity | Q39679824 |
| | Sulforaphane induces DNA single strand breaks in cultured human cells. | Q39699012 |
| | Sulforaphane as an inducer of glutathione prevents oxidative stress-induced cell death in a dopaminergic-like neuroblastoma cell line | Q39795340 |
| | Patterns of MMP-2 and MMP-9 expression in human cancer cell lines | Q39862025 |
| | Sulforaphane inhibited expression of hypoxia-inducible factor-1alpha in human tongue squamous cancer cells and prostate cancer cells | Q39971360 |
| | The diet-derived sulforaphane inhibits matrix metalloproteinase-9-activated human brain microvascular endothelial cell migration and tubulogenesis. | Q39988573 |
| | Sulforaphane induces cell type-specific apoptosis in human breast cancer cell lines | Q40163040 |
| | Sulforaphane increases the efficacy of doxorubicin in mouse fibroblasts characterized by p53 mutations | Q40255489 |
| | Activation of multiple molecular mechanisms for apoptosis in human malignant glioblastoma T98G and U87MG cells treated with sulforaphane | Q40269357 |
| | Sulforaphane enhances TRAIL-induced apoptosis through the induction of DR5 expression in human osteosarcoma cells | Q40298559 |
| | Sulforaphane sensitizes tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-resistant hepatoma cells to TRAIL-induced apoptosis through reactive oxygen species-mediated up-regulation of DR5. | Q40321960 |
| | Sulforaphane inhibits hypoxia-induced HIF-1α and VEGF expression and migration of human colon cancer cells | Q40395712 |
| | The antitumor effects of Angelica sinensis on malignant brain tumors in vitro and in vivo | Q40427909 |
| | The dietary isothiocyanate sulforaphane targets pathways of apoptosis, cell cycle arrest, and oxidative stress in human pancreatic cancer cells and inhibits tumor growth in severe combined immunodeficient mice | Q40503935 |
| | Genistein induces Ca2+ -mediated, calpain/caspase-12-dependent apoptosis in breast cancer cells | Q40517158 |
| | Pseudopalisades in glioblastoma are hypoxic, express extracellular matrix proteases, and are formed by an actively migrating cell population | Q40590816 |
| | Sulforaphane: a naturally occurring mammary carcinoma mitotic inhibitor, which disrupts tubulin polymerization | Q40623161 |
| | Sulforaphane induces caspase-mediated apoptosis in cultured PC-3 human prostate cancer cells and retards growth of PC-3 xenografts in vivo | Q40630814 |
| | Estrogen attenuates oxidative stress-induced apoptosis in C6 glial cells. | Q40653560 |
| | Inhibition of constitutively active Stat3 suppresses proliferation and induces apoptosis in glioblastoma multiforme cells | Q40685493 |
| | p53 stabilization is decreased upon NFkappaB activation: a role for NFkappaB in acquisition of resistance to chemotherapy | Q40717571 |
| | Tumoricidal activity of tumor necrosis factor-related apoptosis-inducing ligand in vivo. | Q40975748 |
| | Basal levels and patterns of anticancer drug-induced activation of nuclear factor-kappaB (NF-kappaB), and its attenuation by tamoxifen, dexamethasone, and curcumin in carcinoma cells | Q42521263 |
| | Neuroprotective effect of sulforaphane in 6-hydroxydopamine-lesioned mouse model of Parkinson's disease | Q42712361 |
| | Quantitative determination of dithiocarbamates in human plasma, serum, erythrocytes and urine: pharmacokinetics of broccoli sprout isothiocyanates in humans | Q43828349 |
| | Induction of medulloblastoma cell apoptosis by sulforaphane, a dietary anticarcinogen from Brassica vegetables | Q44689802 |
| | Nuclear factor E2-related factor 2-dependent antioxidant response element activation by tert-butylhydroquinone and sulforaphane occurring preferentially in astrocytes conditions neurons against oxidative insult. | Q44755335 |
| | In vivo pharmacokinetics and regulation of gene expression profiles by isothiocyanate sulforaphane in the rat. | Q44779436 |
| | A novel mechanism of chemoprotection by sulforaphane: inhibition of histone deacetylase. | Q45020400 |
| | Novel MSH6 mutations in treatment-naïve glioblastoma and anaplastic oligodendroglioma contribute to temozolomide resistance independently of MGMT promoter methylation | Q45066546 |
| | Sulforaphane induces p53‑deficient SW480 cell apoptosis via the ROS‑MAPK signaling pathway | Q46301324 |
| | Sulforaphane suppresses the growth of glioblastoma cells, glioblastoma stem cell-like spheroids, and tumor xenografts through multiple cell signaling pathways | Q46436321 |
| | Comparison of Adaptive Neuroprotective Mechanisms of Sulforaphane and its Interconversion Product Erucin in in Vitro and in Vivo Models of Parkinson's Disease | Q47226804 |
| | P-glycoprotein (ABCB1) and Oxidative Stress: Focus on Alzheimer's Disease | Q47873232 |
| | CBTRUS Statistical Report: Primary brain and other central nervous system tumors diagnosed in the United States in 2010-2014. | Q47979443 |
| | The effects of NRF2 modulation on the initiation and progression of chemically and genetically induced lung cancer. | Q48246199 |
| | Neuroprotection by 6-(methylsulfinyl)hexyl isothiocyanate in a 6-hydroxydopamine mouse model of Parkinson׳s disease. | Q48513976 |
| | Matrix metalloproteinase-9 is associated with blood-brain barrier opening and brain edema formation after cortical contusion in rats. | Q48557413 |
| | Paeoniflorin Inhibits Migration and Invasion of Human Glioblastoma Cells via Suppression Transforming Growth Factor β-Induced Epithelial-Mesenchymal Transition | Q50103939 |
| | The worldwide incidence and prevalence of primary brain tumors: a systematic review and meta-analysis | Q30382505 |
| | Drug delivery strategies to enhance the permeability of the blood-brain barrier for treatment of glioma | Q30413487 |
| | Hypoxia is important in the biology and aggression of human glial brain tumors. | Q31137856 |
| | A phase II study of sulforaphane-rich broccoli sprout extracts in men with recurrent prostate cancer | Q33390657 |
| | Galectins and gliomas | Q33588438 |
| | Effectiveness of temozolomide for primary glioblastoma multiforme in routine clinical practice | Q33599200 |
| | CXCL12 modulation of CXCR4 and CXCR7 activity in human glioblastoma stem-like cells and regulation of the tumor microenvironment | Q33677057 |
| | Antioxidant functions of sulforaphane: a potent inducer of Phase II detoxication enzymes | Q33763068 |
| | Discordant in vitro and in vivo chemopotentiating effects of the PARP inhibitor veliparib in temozolomide-sensitive versus -resistant glioblastoma multiforme xenografts | Q33953822 |
| | Disruption of astrocyte-vascular coupling and the blood-brain barrier by invading glioma cells. | Q34023246 |
| | Sulforaphane induces apoptosis in rhabdomyosarcoma and restores TRAIL-sensitivity in the aggressive alveolar subtype leading to tumor elimination in mice | Q34028460 |
| | Sulforaphane controls TPA-induced MMP-9 expression through the NF-κB signaling pathway, but not AP-1, in MCF-7 breast cancer cells | Q34049460 |
| | MicroRNA-21 promotes glioblastoma tumorigenesis by down-regulating insulin-like growth factor-binding protein-3 (IGFBP3). | Q34139065 |
| | Therapy targets in glioblastoma and cancer stem cells: lessons from haematopoietic neoplasms | Q34154786 |
| | DGKI methylation status modulates the prognostic value of MGMT in glioblastoma patients treated with combined radio-chemotherapy with temozolomide | Q34215037 |
| | An allograft glioma model reveals the dependence of aquaporin-4 expression on the brain microenvironment | Q34270834 |
| | Glucosinolates and isothiocyanates in health and disease. | Q34274313 |
| | A miRNA signature for defining aggressive phenotype and prognosis in gliomas | Q34287223 |
| | Curcumin confers radiosensitizing effect in prostate cancer cell line PC-3. | Q34301331 |
| | Increased radiation sensitivity of an eosinophilic cell line following treatment with epigallocatechin-gallate, resveratrol and curcuma | Q34384058 |
| | Notch activation is dispensable for D, L-sulforaphane-mediated inhibition of human prostate cancer cell migration | Q34412867 |
| | Effects of co-treatment with sulforaphane and autophagy modulators on uridine 5'-diphospho-glucuronosyltransferase 1A isoforms and cytochrome P450 3A4 expression in Caco-2 human colon cancer cells. | Q34427344 |
| | Glioblastoma multiforme: Pathogenesis and treatment. | Q34475149 |
| | How melanoma cells evade trail-induced apoptosis. | Q34572097 |
| | Human chorionic gonadotropin β induces migration and invasion via activating ERK1/2 and MMP-2 in human prostate cancer DU145 cells | Q34592525 |
| | A Chinese herbal formula, Yi-Qi-Fu-Sheng, inhibits migration/invasion of colorectal cancer by down-regulating MMP-2/9 via inhibiting the activation of ERK/MAPK signaling pathways | Q34626644 |
| | Are isothiocyanates potential anti-cancer drugs? | Q34979394 |
| | The role of matrix metalloproteinases in glioma invasion | Q35011171 |
| | Botanicals in cancer chemoprevention | Q35054151 |
| | Targeting the STAT3 signaling pathway in cancer: role of synthetic and natural inhibitors. | Q35081777 |
| | Sulforaphane inhibits invasion via activating ERK1/2 signaling in human glioblastoma U87MG and U373MG cells | Q35109117 |
| | Molecular mechanisms of glioma invasiveness: the role of proteases | Q35166808 |
| | Invasion as limitation to anti-angiogenic glioma therapy | Q35553151 |
| | Enhancement of therapeutic potential of TRAIL by cancer chemotherapy and irradiation: mechanisms and clinical implications | Q35781710 |
| | Sulforaphane reduces molecular response to hypoxia in ovarian tumor cells independently of their resistance to chemotherapy | Q35798547 |
| | On the TRAIL to successful cancer therapy? Predicting and counteracting resistance against TRAIL-based therapeutics | Q35853714 |
| | Matrix metalloproteinase gelatinase B (MMP-9) is associated with leaking glaucoma filtering blebs | Q35928395 |
| | Sulforaphane induces apoptosis and inhibits invasion in U251MG glioblastoma cells | Q35973580 |
| | Angiogenesis in gliomas: biology and molecular pathophysiology | Q36359221 |
| | Angiogenesis in malignant glioma--a target for antitumor therapy? | Q36543994 |
| | The redox regulation of thiol dependent signaling pathways in cancer. | Q36683582 |
| | Molecular basis for chemoprevention by sulforaphane: a comprehensive review. | Q36775326 |
| | Efficacy of protracted temozolomide dosing is limited in MGMT unmethylated GBM xenograft models | Q36866006 |
| | Antiproliferative activity of sulforaphane in Akt-overexpressing ovarian cancer cells | Q36975191 |
| | Asymmetric focal adhesion disassembly in motile cells. | Q37033437 |
| | Sulforaphane, a natural component of broccoli, inhibits vestibular schwannoma growth in vitro and in vivo. | Q37386177 |
| | Potential application of temozolomide in mesenchymal stem cell-based TRAIL gene therapy against malignant glioma | Q37585453 |
| | Targeting transcription factor NF-kappaB to overcome chemoresistance and radioresistance in cancer therapy. | Q37676478 |
| | Survival signalling and apoptosis resistance in glioblastomas: opportunities for targeted therapeutics | Q37761935 |
| | Phytochemicals resveratrol and sulforaphane as potential agents for enhancing the anti-tumor activities of conventional cancer therapies | Q37861769 |
| | The definition of primary and secondary glioblastoma | Q38064831 |
| | Blood-brain barrier structure and function and the challenges for CNS drug delivery | Q38100970 |
| | Review: molecular mechanism of microglia stimulated glioblastoma invasion | Q38128099 |
| | Modulation of mitochondrial functions by the indirect antioxidant sulforaphane: a seemingly contradictory dual role and an integrative hypothesis | Q38133725 |
| | Exploring the effects of isothiocyanates on chemotherapeutic drugs | Q38148572 |
| | Pharmacological and dietary agents for colorectal cancer chemoprevention: effects on polyamine metabolism (review). | Q38239601 |
| | The future of glioblastoma therapy: synergism of standard of care and immunotherapy | Q38255481 |
| | Natural compounds to overcome cancer chemoresistance: toxicological and clinical issues | Q38262078 |
| | Glioblastoma stem-like cells: at the root of tumor recurrence and a therapeutic target. | Q38287518 |
| | Glioblastoma: pathology, molecular mechanisms and markers | Q38460865 |
| | Applicable advances in the molecular pathology of glioblastoma | Q38528700 |
| | Factors controlling permeability of the blood-brain barrier | Q38592449 |
| | Hypoxia Is the Driving Force Behind GBM and Could Be a New Tool in GBM Treatment | Q38630796 |
| | Sulforaphane-cysteine induces apoptosis by sustained activation of ERK1/2 and caspase 3 in human glioblastoma U373MG and U87MG cells | Q38708323 |
| | d,l-Sulforaphane Induces ROS-Dependent Apoptosis in Human Gliomablastoma Cells by Inactivating STAT3 Signaling Pathway | Q38722856 |
| | Sulforaphane-cysteine suppresses invasion via downregulation of galectin-1 in human prostate cancer DU145 and PC3 cells | Q38757393 |
| | Autophagic down-regulation in motor neurons remarkably prolongs the survival of ALS mice | Q38779776 |
| | Sulforaphane reverses chemo-resistance to temozolomide in glioblastoma cells by NF-κB-dependent pathway downregulating MGMT expression | Q38813379 |
| P275 | copyright license | Creative Commons Attribution | Q6905323 |
| P6216 | copyright status | copyrighted | Q50423863 |
| P433 | issue | 11 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | glioblastoma | Q282142 |
| | isothiocyanate | Q416049 |
| | vegetable | Q11004 |
| | Brassica | Q58677 |
| | phytogenic antineoplastic agents | Q50377200 |
| P5008 | on focus list of Wikimedia project | ScienceSource | Q55439927 |
| P304 | page(s) | 1755 | |
| P577 | publication date | 2018-11-14 | |
| P1433 | published in | Nutrients | Q7070485 |
| P1476 | title | Sulforaphane from Cruciferous Vegetables: Recent Advances to Improve Glioblastoma Treatment | |
| P478 | volume | 10 | |