Sulforaphane reduces molecular response to hypoxia in ovarian tumor cells independently of their resistance to chemotherapy

scientific article published on 5 May 2015

Sulforaphane reduces molecular response to hypoxia in ovarian tumor cells independently of their resistance to chemotherapy is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.3892/IJO.2015.2987
P932PMC publication ID4485648
P698PubMed publication ID25955133

P50authorFranck DequiedtQ39200814
P2093author name stringJan Sedlak
Olga Krizanova
Silvia Pastorekova
Sona Hudecova
Martina Takacova
Maria Bartosova
Luba Hunakova
Monika Barathova
Veronika Simko
Michal Pastorek
Olga Sedlakova
P2860cites workExpression of hypoxia-inducible factor 1alpha in epithelial ovarian tumors: its impact on prognosis and on response to chemotherapyQ28202355
Hypoxia upregulates ovarian cancer invasiveness via the binding of HIF-1α to a hypoxia-induced, methylation-free hypoxia response element of S100A4 geneQ83353256
Co-expression of VEGF and CA9 in ovarian high-grade serous carcinoma and relationship to survivalQ84380481
Cloning and characterization of MN, a human tumor-associated protein with a domain homologous to carbonic anhydrase and a putative helix-loop-helix DNA binding segmentQ28247998
Exploiting tumour hypoxia in cancer treatmentQ28264146
Hypoxia-inducible expression of tumor-associated carbonic anhydrasesQ28647603
Hypoxia--a key regulatory factor in tumour growthQ29547318
Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathwayQ29617805
Sulforaphane induces cell cycle arrest by protecting RB-E2F-1 complex in epithelial ovarian cancer cellsQ33728766
Hypoxia induces chemoresistance in ovarian cancer cells by activation of signal transducer and activator of transcription 3.Q33945427
Frequent loss of heterozygosity at the interferon regulatory factor-1 gene locus in breast cancerQ34139499
Adaptation to hypoxia and acidosis in carcinogenesis and tumor progressionQ34192789
The hypoxic microenvironment upgrades stem-like properties of ovarian cancer cellsQ34285178
Role of hypoxia and glycolysis in the development of multi-drug resistance in human tumor cells and the establishment of an orthotopic multi-drug resistant tumor model in nude mice using hypoxic pre-conditioningQ34610733
Combination of carbonic anhydrase inhibitor, acetazolamide, and sulforaphane, reduces the viability and growth of bronchial carcinoid cell linesQ34911416
Reciprocal influence of the p53 and the hypoxic pathwaysQ35065006
Anti-tumor activity and signaling events triggered by the isothiocyanates, sulforaphane and phenethyl isothiocyanate, in multiple myelomaQ35143496
Sulforaphane induction of p21(Cip1) cyclin-dependent kinase inhibitor expression requires p53 and Sp1 transcription factors and is p53-dependentQ35956502
Hypoxia-inducible factors: mediators of cancer progression and targets for cancer therapyQ36220497
Prognostic Relevance of the Expression of CA IX, GLUT-1, and VEGF in Ovarian Epithelial CancersQ36518752
Keap1-nrf2 signaling: a target for cancer prevention by sulforaphaneQ36557973
DNA damage is a prerequisite for p53-mediated proteasomal degradation of HIF-1alpha in hypoxic cells and downregulation of the hypoxia marker carbonic anhydrase IX.Q36732878
Hypoxia and adaptive landscapes in the evolution of carcinogenesisQ36778738
Antiproliferative activity of sulforaphane in Akt-overexpressing ovarian cancer cellsQ36975191
Generating specificity and diversity in the transcriptional response to hypoxiaQ37626406
Hypoxia-mediated drug resistance: novel insights on the functional interaction of HIFs and cell death pathwaysQ37861928
Carbonic anhydrase IX, a hypoxia-induced catalytic component of the pH regulating machinery in tumorsQ38177264
Sulforaphane inhibits histone deacetylase in vivo and suppresses tumorigenesis in Apc-minus miceQ38268094
Sulforaphane blocks hypoxia-mediated resistance to TRAIL-induced tumor cell deathQ38475327
Nrf2 activation supports cell survival during hypoxia and hypoxia/reoxygenation in cardiomyoblasts; the roles of reactive oxygen and nitrogen speciesQ39143886
Hyperactivated JNK is a therapeutic target in pVHL-deficient renal cell carcinomaQ39197614
Hypoxia-inducible factor 1 alpha mediates epidermal growth factor-induced down-regulation of E-cadherin expression and cell invasion in human ovarian cancer cells.Q39246943
Sulforaphane, a cruciferous vegetable-derived isothiocyanate, inhibits protein synthesis in human prostate cancer cellsQ39341072
Phosphorylation of carbonic anhydrase IX controls its ability to mediate extracellular acidification in hypoxic tumors.Q39450874
Activation of several concurrent proapoptic pathways by sulforaphane in human colon cancer cells SW620.Q39831526
Role of aryl hydrocarbon receptor in modulation of the expression of the hypoxia marker carbonic anhydrase IX.Q39893439
Sulforaphane inhibited expression of hypoxia-inducible factor-1alpha in human tongue squamous cancer cells and prostate cancer cellsQ39971360
Expression of MRP1 and GSTP1-1 modulate the acute cellular response to treatment with the chemopreventive isothiocyanate, sulforaphaneQ40023339
Hypoxia contributes to development of recurrent endometrial carcinoma.Q40159415
Inhibition of angiogenesis and endothelial cell functions are novel sulforaphane-mediated mechanisms in chemoprevention.Q40302650
Enhanced sensitivity of human ovarian carcinoma cell lines A2780 and A2780/CP to the combination of cisplatin and synthetic isothiocyanate ethyl 4-isothiocyanatobutanoate.Q40351970
Hypoxia activates the capacity of tumor-associated carbonic anhydrase IX to acidify extracellular pH.Q40489574
Cell surface phenotype and increased penetration of human multidrug-resistant ovarian carcinoma cells into in vitro collagen-fibroblasts matrixQ41243719
Enhancement of Cisplatin-Mediated Apoptosis in Ovarian Cancer Cells through Potentiating G2/M Arrest and p21 Upregulation by Combinatorial Epigallocatechin Gallate and SulforaphaneQ41610999
Cross-talk between the aryl hydrocarbon receptor and hypoxia inducible factor signaling pathways. Demonstration of competition and compensationQ41646529
Sulforaphane induced cell cycle arrest in the G2/M phase via the blockade of cyclin B1/CDC2 in human ovarian cancer cells.Q42538234
c-Jun NH2-terminal kinase activation contributes to hypoxia-inducible factor 1alpha-dependent P-glycoprotein expression in hypoxiaQ45190273
A microenvironmental model of carcinogenesis.Q53326346
Expression of hypoxia-inducible factor 1alpha gene affects the outcome in patients with ovarian cancer.Q54533143
The dietary isothiocyanate sulforaphane is an antagonist of the human steroid and xenobiotic nuclear receptor.Q54577544
Sulforaphane induces apoptosis in human hepatic cancer cells through inhibition of 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase4, mediated by hypoxia inducible factor-1-dependent pathway.Q54585085
Sulforaphane potentiates oxaliplatin-induced cell growth inhibition in colorectal cancer cells via induction of different modes of cell deathQ61908025
Transcriptional regulation of the MN/CA 9 gene coding for the tumor-associated carbonic anhydrase IX. Identification and characterization of a proximal silencer elementQ73157272
VEGF and HIF-1alpha expression are increased in advanced stages of epithelial ovarian cancerQ79366831
Expression of transmembrane carbonic anhydrases IX and XII in ovarian tumoursQ79428232
P433issue1
P921main subjectchemotherapyQ974135
P304page(s)51-60
P577publication date2015-05-05
P1433published inInternational Journal of OncologyQ6051527
P1476titleSulforaphane reduces molecular response to hypoxia in ovarian tumor cells independently of their resistance to chemotherapy
P478volume47

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cites work (P2860)
Q55492494Anticancer Activity of Sulforaphane: The Epigenetic Mechanisms and the Nrf2 Signaling Pathway.
Q90662863Brassicaceae-Derived Anticancer Agents: Towards a Green Approach to Beat Cancer
Q33914234Combination therapy in combating cancer
Q93018164Human bronchial carcinoid tumor initiating cells are targeted by the combination of acetazolamide and sulforaphane
Q38794896Hypoxic conditions increases H₂S-induced ER stress in A2870 cells.
Q95270493Sulforaphane Potentiates Anticancer Effects of Doxorubicin and Cisplatin and Mitigates Their Toxic Effects
Q59807366Sulforaphane from Cruciferous Vegetables: Recent Advances to Improve Glioblastoma Treatment
Q35973580Sulforaphane induces apoptosis and inhibits invasion in U251MG glioblastoma cells
Q37709114Sulforaphane inhibits proliferation and invasive activity of everolimus-resistant kidney cancer cells in vitro
Q58579152The Chemoprevention of Ovarian Cancer: the Need and the Options

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