scholarly article | Q13442814 |
review article | Q7318358 |
P50 | author | Thorsten Cramer | Q52902687 |
P2093 | author name string | Nadine Rohwer | |
P2860 | cites work | Mitochondrial autophagy is an HIF-1-dependent adaptive metabolic response to hypoxia | Q28586744 |
Anthracycline chemotherapy inhibits HIF-1 transcriptional activity and tumor-induced mobilization of circulating angiogenic cells | Q33402834 | ||
The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis | Q22009936 | ||
P433 | issue | 3 | |
P921 | main subject | hypoxia | Q105688 |
cell death | Q2383867 | ||
drug resistance | Q12147416 | ||
P304 | page(s) | 191-201 | |
P577 | publication date | 2011-04-03 | |
P1433 | published in | Drug Resistance Updates | Q3040081 |
P1476 | title | Hypoxia-mediated drug resistance: novel insights on the functional interaction of HIFs and cell death pathways | |
P478 | volume | 14 |
Q42371604 | 7-ketocholesterol and 27-hydroxycholesterol decreased doxorubicin sensitivity in breast cancer cells: estrogenic activity and mTOR pathway |
Q90264066 | A Pharmacological Overview of Alpinumisoflavone, a Natural Prenylated Isoflavonoid |
Q92424237 | A close relationship between HIF-1α expression and bone metastases in advanced NSCLC, a retrospective analysis |
Q91559728 | A lncRNA coordinates with Ezh2 to inhibit HIF-1α transcription and suppress cancer cell adaption to hypoxia |
Q39185534 | A three-dimensional microenvironment alters protein expression and chemosensitivity of epithelial ovarian cancer cells in vitro |
Q38853225 | AMPK and HIF signaling pathways regulate both longevity and cancer growth: the good news and the bad news about survival mechanisms |
Q38933079 | An outline of main factors of drug resistance influencing cancer therapy |
Q36916313 | Annexin A1 sustains tumor metabolism and cellular proliferation upon stable loss of HIF1A. |
Q89407909 | Anti-tumor activity of wogonin, an extract from Scutellaria baicalensis, through regulating different signaling pathways |
Q39038881 | Anti-tumor effect of the mammalian target of rapamycin inhibitor everolimus in oral squamous cell carcinoma. |
Q96304689 | Antineoplastic Agents Targeting Sphingolipid Pathways |
Q26822640 | Ascorbate as a co-factor for fe- and 2-oxoglutarate dependent dioxygenases: physiological activity in tumor growth and progression |
Q36069245 | Association of Hypoxia-Inducible Factor-2 Alpha Gene Polymorphisms with the Risk of Hepatitis B Virus-Related Liver Disease in Guangxi Chinese: A Case-Control Study |
Q60912923 | Autophagy and Its Role in Protein Secretion: Implications for Cancer Therapy |
Q37694333 | Benzimidazole analogs as potent hypoxia inducible factor inhibitors: synthesis, biological evaluation, and profiling drug-like properties |
Q91954814 | Blocking Triggering Receptor Expressed on Myeloid Cells-1-Positive Tumor-Associated Macrophages Induced by Hypoxia Reverses Immunosuppression and Anti-Programmed Cell Death Ligand 1 Resistance in Liver Cancer |
Q90395581 | CXCR4-targeted PET imaging using 64Cu-AMD3100 for detection of Waldenström Macroglobulinemia |
Q39132859 | Cancer cell bioenergetics and pH regulation influence breast cancer cell resistance to paclitaxel and doxorubicin. |
Q97643522 | Cancer cells grown in 3D under fluid flow exhibit an aggressive phenotype and reduced responsiveness to the anti-cancer treatment doxorubicin |
Q38154554 | Carbonic anhydrase IX as an imaging and therapeutic target for tumors and metastases |
Q38611440 | Cariporide Enhances the DNA Damage and Apoptosis in Acid-tolerable Malignant Mesothelioma H-2452 Cells |
Q90308038 | Catalase-Functionalized Iron Oxide Nanoparticles Reverse Hypoxia-Induced Chemotherapeutic Resistance |
Q92467948 | Cell Membrane-Coated Magnetic Nanocubes with a Homotypic Targeting Ability Increase Intracellular Temperature due to ROS Scavenging and Act as a Versatile Theranostic System for Glioblastoma Multiforme |
Q38754112 | Cell type-dependent HIF1 α-mediated effects of hypoxia on proliferation, migration and metastatic potential of human tumor cells |
Q35828103 | Cellular plasticity regulated cancer stem cell niche: a possible new mechanism of chemoresistance |
Q90571077 | Chemoresistance of Cancer Cells: Requirements of Tumor Microenvironment-mimicking In Vitro Models in Anti-Cancer Drug Development |
Q35125058 | Clinical and prognostic significance of HIF-1α, PTEN, CD44v6, and survivin for gastric cancer: a meta-analysis |
Q90610869 | Clinical significance and prognostic role of hypoxia-induced microRNA 382 in gastric adenocarcinoma |
Q92557315 | Colon cancer cells secrete exosomes to promote self-proliferation by shortening mitosis duration and activation of STAT3 in a hypoxic environment |
Q36396999 | Combining Optical Reporter Proteins with Different Half-lives to Detect Temporal Evolution of Hypoxia and Reoxygenation in Tumors. |
Q46417081 | Comparative studies of oxaliplatin-based platinum(iv) complexes in different in vitro and in vivo tumor models |
Q37351778 | Cross-talk between HIF and p53 as mediators of molecular responses to physiological and genotoxic stresses |
Q47836759 | Deciphering metabolic rewiring in breast cancer subtypes |
Q51060486 | Dendritic cells phenotype fitting under hypoxia or lipopolysaccharide; adenosine 5'-triphosphate-binding cassette transporters far beyond an efflux pump. |
Q37723274 | Development of Inhibitors Targeting Hypoxia-Inducible Factor 1 and 2 for Cancer Therapy |
Q64953998 | Development of an in vitro cell-sheet cancer model for chemotherapeutic screening. |
Q39149491 | Development of an oxygen-sensitive degradable peptide probe for the imaging of hypoxia-inducible factor-1-active regions in tumors. |
Q39921071 | Dihydroartemisinin is a Hypoxia-Active Anti-Cancer Drug in Colorectal Carcinoma Cells |
Q38777339 | Downregulation of HIF-1a sensitizes U251 glioma cells to the temozolomide (TMZ) treatment |
Q92431484 | Dynamic characterization of intestinal metaplasia in the gastric corpus mucosa of Atp4a-deficient mice |
Q38628352 | Dynamic regulation of stem cell specification and maintenance by hypoxia-inducible factors |
Q48149214 | E2F is involved in radioresistance of carbon ion induced apoptosis via Bax/caspase 3 signal pathway in human hepatoma cell |
Q92512140 | ENO1 silencing impaires hypoxia-induced gemcitabine chemoresistance associated with redox modulation in pancreatic cancer cells |
Q37301032 | Effects of copper sulfate-oxidized or myeloperoxidase-modified LDL on lipid loading and programmed cell death in macrophages under hypoxia |
Q34799788 | Effects of hypoxia on human cancer cell line chemosensitivity |
Q39668588 | Efficient Protocol for the Identification of Hypoxic Cell Radiosensitisers. |
Q40167291 | Egr-1 promotes hypoxia-induced autophagy to enhance chemo-resistance of hepatocellular carcinoma cells |
Q100490624 | Emerging role of tumor cell plasticity in modifying therapeutic response |
Q36303571 | Emerging roles of PKM2 in cell metabolism and cancer progression |
Q42835560 | Engineered Breast Cancer Cell Spheroids Reproduce Biologic Properties of Solid Tumors |
Q34536008 | Examining the polymorphisms in the hypoxia pathway genes in relation to outcome in colorectal cancer |
Q90678032 | Exercise as Adjunct Therapy in Cancer |
Q98463685 | Flavagline synthetic derivative induces senescence in glioblastoma cancer cells without being toxic to healthy astrocytes |
Q92445423 | Functional Interaction of Hypoxia-Inducible Factor 2-Alpha and Autophagy Mediates Drug Resistance in Colon Cancer Cells |
Q37745415 | Functional inhibition of acid sphingomyelinase by Fluphenazine triggers hypoxia-specific tumor cell death |
Q38935057 | Gene expression alterations in chronic hypoxic MCF7 breast cancer cell line |
Q26765869 | Glioblastoma Stem Cells Microenvironment: The Paracrine Roles of the Niche in Drug and Radioresistance |
Q64273668 | Glutaminase 1 expression in colorectal cancer cells is induced by hypoxia and required for tumor growth, invasion, and metastatic colonization |
Q37504324 | HAF drives the switch of HIF-1α to HIF-2α by activating the NF-κB pathway, leading to malignant behavior of T24 bladder cancer cells |
Q38112399 | HIF expression and the role of hypoxic microenvironments within primary tumours as protective sites driving cancer stem cell renewal and metastatic progression |
Q36070195 | HIF-1 at the crossroads of hypoxia, inflammation, and cancer |
Q33688459 | HIF-1α activates hypoxia-induced BCL-9 expression in human colorectal cancer cells |
Q39324644 | HIF-1α induced by β-elemene protects human osteosarcoma cells from undergoing apoptosis |
Q33717131 | HIF-1α inhibition reverses multidrug resistance in colon cancer cells via downregulation of MDR1/P-glycoprotein |
Q90396000 | HIF-1α-derived cell-penetrating peptides inhibit ERK-dependent activation of HIF-1 and trigger apoptosis of cancer cells under hypoxia |
Q91655677 | HIF-2α upregulation mediated by hypoxia promotes NAFLD-HCC progression by activating lipid synthesis via the PI3K-AKT-mTOR pathway |
Q26764740 | Hedgehog signaling: modulation of cancer properies and tumor mircroenvironment |
Q37702131 | Hemoglobin level trajectories in the early treatment period are related with survival outcomes in patients with breast cancer. |
Q39404697 | Hsp90 inhibitor NVP-AUY922 enhances radiation sensitivity of tumor cell lines under hypoxia. |
Q93091117 | Hypoxia Imaging and Adaptive Radiotherapy: A State-of-the-Art Approach in the Management of Glioma |
Q64095235 | Hypoxia induced hERG trafficking defect linked to cell cycle arrest in SH-SY5Y cells |
Q31118586 | Hypoxia induced impairment of NK cell cytotoxicity against multiple myeloma can be overcome by IL-2 activation of the NK cells. |
Q38097867 | Hypoxia inducible factor pathway inhibitors as anticancer therapeutics. |
Q39271109 | Hypoxia inducible factor-1α induces chemoresistance phenotype in non-Hodgkin lymphoma cell line via up-regulation of Bcl-xL. |
Q37418248 | Hypoxia modulates the activity of a series of clinically approved tyrosine kinase inhibitors |
Q58778161 | Hypoxia promotes acquisition of aggressive phenotypes in human malignant mesothelioma |
Q39456881 | Hypoxia-Inducible Factors: Master Regulators of Cancer Progression |
Q60920177 | Hypoxia-induced Slug SUMOylation enhances lung cancer metastasis |
Q28484877 | Hypoxia-induced modulation of apoptosis and BCL-2 family proteins in different cancer cell types |
Q35915363 | Hypoxia-inducible factor-1α induces multidrug resistance protein in colon cancer |
Q37301011 | Hypoxia-inducible factor-mediated induction of WISP-2 contributes to attenuated progression of breast cancer |
Q34752692 | Hypoxia-inducible factors are required for chemotherapy resistance of breast cancer stem cells |
Q36220497 | Hypoxia-inducible factors: mediators of cancer progression and targets for cancer therapy |
Q39214063 | Hypoxia-mediated sorafenib resistance can be overcome by EF24 through Von Hippel-Lindau tumor suppressor-dependent HIF-1α inhibition in hepatocellular carcinoma. |
Q54354000 | Hypoxia-regulated gene network in drug resistance and cancer progression. |
Q39002822 | Hypoxia: A Double-Edged Sword in Cancer Therapy |
Q38395896 | Hypoxic tumor microenvironment in advanced retinoblastoma. |
Q61449688 | Identification of imatinib-resistant long non-coding RNAs in gastrointestinal stromal tumors |
Q58771197 | Impact of the hypoxic phenotype on the uptake and efflux of nanoparticles by human breast cancer cells |
Q38040787 | Implication of tumor microenvironment in chemoresistance: tumor-associated stromal cells protect tumor cells from cell death |
Q39202459 | In vitro hypoxic cytotoxicity and hypoxic radiosensitization. Efficacy of the novel 2-nitroimidazole N,N,N-tris[2-(2-nitro-1H-imidazol-1-yl)ethyl]amine |
Q26798210 | Increased Oxidative Stress as a Selective Anticancer Therapy |
Q37550889 | Increased Tumor Ascorbate is Associated with Extended Disease-Free Survival and Decreased Hypoxia-Inducible Factor-1 Activation in Human Colorectal Cancer |
Q33842748 | Increased drug resistance is associated with reduced glucose levels and an enhanced glycolysis phenotype. |
Q38794892 | Induction of hypoxia-inducible factor-1α by BDNF protects retinoblastoma cells against chemotherapy-induced apoptosis |
Q35686894 | Inhibition of Aerobic Glycolysis Represses Akt/mTOR/HIF-1α Axis and Restores Tamoxifen Sensitivity in Antiestrogen-Resistant Breast Cancer Cells |
Q36070321 | Inhibition of JNK Sensitizes Hypoxic Colon Cancer Cells to DNA-Damaging Agents |
Q39925876 | Inhibition of hypoxia inducible factor 1 and topoisomerase with acriflavine sensitizes perihilar cholangiocarcinomas to photodynamic therapy. |
Q39052864 | Inhibition of hypoxia-induced gene transcription by substituted pyrazolyl oxadiazoles: initial lead generation and structure-activity relationships |
Q92488692 | Inhibition of hypoxia-inducible factor 1α accumulation by glyceryl trinitrate and cyclic guanosine monophosphate |
Q39326747 | Inhibition of the vacuolar ATPase induces Bnip3-dependent death of cancer cells and a reduction in tumor burden and metastasis |
Q55285485 | Intermittent Hypoxia Is Associated With High Hypoxia Inducible Factor-1α but Not High Vascular Endothelial Growth Factor Cell Expression in Tumors of Cutaneous Melanoma Patients. |
Q48435274 | Investigation of hypoxia-inducible factor-1α in hippocampal sclerosis: a postmortem study |
Q51779398 | Isotopologous Organotellurium Probes Reveal Dynamic Hypoxia In Vivo with Cellular Resolution. |
Q38769076 | JNK1 Inhibition Attenuates Hypoxia-Induced Autophagy and Sensitizes to Chemotherapy |
Q92052767 | Lipid metabolism in cancer cells under metabolic stress |
Q38932870 | Lipocalin2 as a plasma marker for tumors with hypoxic regions. |
Q36095051 | Long noncoding RNA expression profiles of the doxorubicin-resistant human osteosarcoma cell line MG63/DXR and its parental cell line MG63 as ascertained by microarray analysis |
Q91525731 | Long-term monitoring in a microfluidic system to study tumour spheroid response to chronic and cycling hypoxia |
Q38827940 | Macrophages as Active Nanocarriers for Targeted Early and Adjuvant Cancer Chemotherapy. |
Q36083614 | Marine spongean polybrominated diphenyl ethers, selective growth inhibitors against the cancer cells adapted to glucose starvation, inhibits mitochondrial complex II. |
Q48179985 | Metabolic regulation of glioma stem-like cells in the tumor micro-environment |
Q93064626 | Metabolic targeting of HIF-1α potentiates the therapeutic efficacy of oxaliplatin in colorectal cancer |
Q35849597 | Metformin Radiosensitizes p53-Deficient Colorectal Cancer Cells through Induction of G2/M Arrest and Inhibition of DNA Repair Proteins |
Q37352852 | Metformin sensitizes the response of oral squamous cell carcinoma to cisplatin treatment through inhibition of NF-κB/HIF-1α signal axis |
Q38881607 | MicroRNA-210 and its theranostic potential. |
Q42932576 | Microenvironment-a role in tumour progression and prognosis |
Q91436230 | Microvascular density, macrophages, and mast cells in human clear cell renal carcinoma with and without bevacizumab treatment |
Q90102261 | Microvesicles derived from human bone marrow mesenchymal stem cells promote U2OS cell growth under hypoxia: the role of PI3K/AKT and HIF-1α |
Q33599243 | Modeling nasopharyngeal carcinoma in three dimensions |
Q57806985 | Modulation of Hypoxia-Induced Chemoresistance to Polymeric Micellar Cisplatin: The Effect of Ligand Modification of Micellar Carrier Versus Inhibition of the Mediators of Drug Resistance |
Q38832323 | Molecular diagnosis and molecular profiling to detect treatment-resistant ovarian cancer |
Q93193962 | Molecular mechanism of mammary gland involution: An update |
Q33888179 | N-(3-oxododecanoyl)-L-homoserine lactone interactions in the breast tumor microenvironment: Implications for breast cancer viability and proliferation in vitro. |
Q89537177 | New Aspects of Ultrasound-Mediated Targeted Delivery and Therapy for Cancer |
Q35660112 | Non-Toxic Metabolic Management of Metastatic Cancer in VM Mice: Novel Combination of Ketogenic Diet, Ketone Supplementation, and Hyperbaric Oxygen Therapy |
Q37690655 | Nonhypoxic regulation and role of hypoxia-inducible factor 1 in aromatase inhibitor resistant breast cancer |
Q48515386 | Notch signaling molecule is involved in the invasion of MiaPaCa2 cells induced by CoCl2 via regulating epithelial‑mesenchymal transition |
Q92646362 | Overcoming hypoxia-induced chemoresistance to cisplatin through tumor oxygenation monitored by optical imaging |
Q57798467 | Overexpression of HIF-1α contributes to melphalan resistance in multiple myeloma cells by activation of ERK1/2, Akt, and NF-κB |
Q38530352 | Oxygen-Sensing Methods in Biomedicine from the Macroscale to the Microscale |
Q39169265 | P2Y12 receptor inhibition augments cytotoxic effects of cisplatin in breast cancer. |
Q41694212 | PGC1α induced by reactive oxygen species contributes to chemoresistance of ovarian cancer cells |
Q40088702 | PLC-β2 is modulated by low oxygen availability in breast tumor cells and plays a phenotype dependent role in their hypoxia-related malignant potential. |
Q90221767 | PO2-based biodosimetry evaluation using an EPR technique acts as a sensitive index for chemotherapy |
Q41897007 | Paclitaxel and Its Evolving Role in the Management of Ovarian Cancer. |
Q27012236 | Persistent activation of pancreatic stellate cells creates a microenvironment favorable for the malignant behavior of pancreatic ductal adenocarcinoma |
Q36743392 | Porphyromonas gingivalis: keeping the pathos out of the biont. |
Q59799842 | Protective role of all-trans retinoic acid (ATRA) against hypoxia-induced malignant potential of non-invasive breast tumor derived cells |
Q42677471 | Rapid Generation and Detection of Biomimetic Oxygen Concentration Gradients In Vitro |
Q36190013 | Reference Genes for Addressing Gene Expression of Bladder Cancer Cell Models under Hypoxia: A Step Towards Transcriptomic Studies |
Q38592681 | Regulation of the breast cancer stem cell phenotype by hypoxia-inducible factors |
Q28486174 | Retracted: Zoledronic Acid Restores Doxorubicin Chemosensitivity and Immunogenic Cell Death in Multidrug-Resistant Human Cancer Cells |
Q41829972 | Reversal of multidrug resistance in human lung cancer cells by delivery of 3-octadecylcarbamoylacrylic acid-cisplatin-based liposomes |
Q41869840 | Ritonavir inhibits HIF-1α-mediated VEGF expression in retinal pigment epithelial cells in vitro |
Q38951517 | Role of three-dimensional matrix stiffness in regulating the chemoresistance of hepatocellular carcinoma cells |
Q43499055 | STAT3 but Not HIF-1α Is Important in Mediating Hypoxia-Induced Chemoresistance in MDA-MB-231, a Triple Negative Breast Cancer Cell Line |
Q89460186 | Secalonic acid D as a selective cytotoxic substance on the cancer cells adapted to nutrient starvation |
Q38814004 | Selective Intracellular Delivery of Recombinant Arginine Deiminase (ADI) Using pH-Sensitive Cell Penetrating Peptides To Overcome ADI Resistance in Hypoxic Breast Cancer Cells |
Q96685929 | Selective cytotoxicity of marine-derived fungal metabolite (3S,6S)-3,6-dibenzylpiperazine-2,5-dione against cancer cells adapted to nutrient starvation |
Q33868512 | Selinexor Overcomes Hypoxia-Induced Drug Resistance in Multiple Myeloma |
Q35273402 | Silencing erythropoietin receptor on glioma cells reinforces efficacy of temozolomide and X-rays through senescence and mitotic catastrophe |
Q28833656 | Small Molecule Inhibition of miR-544 Biogenesis Disrupts Adaptive Responses to Hypoxia by Modulating ATM-mTOR Signaling |
Q35798547 | Sulforaphane reduces molecular response to hypoxia in ovarian tumor cells independently of their resistance to chemotherapy |
Q47769995 | Targeting Hypoxia to Improve Non-Small Cell Lung Cancer Outcome |
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Q35870450 | Targeting hypoxia-inducible factor-2α enhances sorafenib antitumor activity via β-catenin/C-Myc-dependent pathways in hepatocellular carcinoma |
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Q90449093 | The Different Routes to Metastasis via Hypoxia-Regulated Programs |
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Q34805346 | The antioxidant N-acetylcysteine prevents HIF-1 stabilization under hypoxia in vitro but does not affect tumorigenesis in multiple breast cancer models in vivo |
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Q28542639 | The histone deacetylase inhibitor, Vorinostat, represses hypoxia inducible factor 1 alpha expression through translational inhibition |
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