Hypoxia: A Double-Edged Sword in Cancer Therapy

scientific article published on 8 November 2016

Hypoxia: A Double-Edged Sword in Cancer Therapy is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

External links are
P356DOI10.1080/07357907.2016.1245317
P698PubMed publication ID27824512

P50authorRezvan NajafiQ56635642
Saeid AfsharQ56855046
Hamed ManoochehriQ90818950
P2093author name stringHamed Manoochehri Khoshinani
Rezvan Najafi
Saeid Afshar
P2860cites workMyeloid-derived suppressor cells: linking inflammation and cancerQ24641811
Targeting the hypoxic fraction of tumours using hypoxia-activated prodrugsQ26774750
Hypoxia-inducible factor 1-mediated characteristic features of cancer cells for tumor radioresistanceQ26779535
Progress toward overcoming hypoxia-induced resistance to solid tumor therapyQ26796405
Defining normoxia, physoxia and hypoxia in tumours-implications for treatment responseQ27009437
Targeting HIF-1 for cancer therapyQ27860504
Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesisQ28279053
Targeting hypoxia in cancer therapyQ29615491
Blockade of B7-H1 improves myeloid dendritic cell–mediated antitumor immunityQ33186765
PD-L1 is a novel direct target of HIF-1α, and its blockade under hypoxia enhanced MDSC-mediated T cell activationQ33569771
Exploiting the hypoxic cancer cell: mechanisms and therapeutic strategiesQ33877024
Hypoxia, clonal selection, and the role of HIF-1 in tumor progressionQ33924693
Macrophage Expression of Hypoxia-Inducible Factor-1α Suppresses T-Cell Function and Promotes Tumor ProgressionQ34168497
Molecular and cellular pharmacology of the hypoxia-activated prodrug TH-302.Q34238898
Clostridia in cancer therapyQ34307573
Tumor hypoxia: causative factors, compensatory mechanisms, and cellular responseQ34375447
Role of oxygen radicals in DNA damage and cancer incidence.Q34383781
The role of hypoxia-activated prodrugs in cancer therapyQ34571883
Treatment resistance of solid tumors: role of hypoxia and anemiaQ34579410
Targeting tumors with hypoxia-activated cytotoxinsQ34626133
Hypoxia-inducible regulation of a prodrug-activating enzyme for tumor-specific gene therapyQ34775024
Tumor hypoxia: a target for selective cancer therapyQ35602696
Tumour hypoxia: impact on biology, prognosis and treatment of solid malignant tumoursQ35685078
Mechanisms regulating the recruitment of macrophages into hypoxic areas of tumors and other ischemic tissues.Q35825254
New anticancer strategies targeting HIF-1.Q35864024
Anticancer efficacy of systemically delivered anaerobic bacteria as gene therapy vectors targeting tumor hypoxia/necrosisQ43918986
Hsp90 regulates a von Hippel Lindau-independent hypoxia-inducible factor-1 alpha-degradative pathwayQ44019897
2ME2 inhibits tumor growth and angiogenesis by disrupting microtubules and dysregulating HIF.Q44426540
Development of a hypoxia-responsive vector for tumor-specific gene therapyQ45866583
Suppression of tumor growth through disruption of hypoxia-inducible transcriptionQ45872806
Expression of hypoxia-inducible factor 1alpha by macrophages in the rheumatoid synovium: implications for targeting of therapeutic genes to the inflamed jointQ45878755
A randomized double-blind phase III study of nimorazole as a hypoxic radiosensitizer of primary radiotherapy in supraglottic larynx and pharynx carcinoma. Results of the Danish Head and Neck Cancer Study (DAHANCA) Protocol 5-85.Q50561584
Transition metal complexes with bioactive ligands: mechanisms for selective ligand release and applications for drug delivery.Q50803523
Hypoxia inhibition of apoptosis induced by tumor necrosis factor-related apoptosis-inducing ligand (TRAIL).Q52594169
AK-2123 (Sanazol) as a radiation sensitizer in the treatment of stage III cervical cancer: results of an IAEA multicentre randomised trial.Q53245269
Cancer cells that survive radiation therapy acquire HIF-1 activity and translocate towards tumour blood vesselsQ35916654
Tumor-activated prodrugs--a new approach to cancer therapyQ35964429
Nitroimidazole adducts as markers for tissue hypoxia: mechanistic studies in aerobic normal tissues and tumour cellsQ35994664
Hypoxia and anemia: effects on tumor biology and treatment resistanceQ36090924
Negative and positive regulation of HIF-1: a complex networkQ36182360
Efficacy and safety of the hypoxia-activated prodrug TH-302 in combination with gemcitabine and nab-paclitaxel in human tumor xenograft models of pancreatic cancerQ36214623
Clostridium spores as anti-tumour agents.Q36405753
HIF-1 and tumour radiosensitivityQ36493239
Phase I and pharmacologic study of the novel indoloquinone bioreductive alkylating cytotoxic drug E09.Q36751567
Targeting hypoxia cell signaling for cancer therapyQ36784388
Hypoxia-driven selection of the metastatic phenotypeQ36801461
Detection and characterization of tumor hypoxia using pO2 histographyQ36834948
Tirapazamine: from bench to clinical trials.Q37230218
Hypoxia-specific gene expression for ischemic disease gene therapyQ37460109
Role of hypoxia in the hallmarks of human cancerQ37500308
Hypoxia-activated prodrugs in cancer therapy: progress to the clinicQ37707385
Bacteria in cancer therapy: a novel experimental strategyQ37717794
Hypoxia and hypoxia-inducible factors: master regulators of metastasisQ37801762
Hypoxia-mediated drug resistance: novel insights on the functional interaction of HIFs and cell death pathwaysQ37861928
Hypoxia-regulated microRNAs in human cancerQ38078802
Microenvironment and radiation therapyQ38091084
Bioreductive prodrugs as cancer therapeutics: targeting tumor hypoxiaQ38120850
Design of optimized hypoxia-activated prodrugs using pharmacokinetic/pharmacodynamic modeling.Q38177279
Hypoxia-inducible factors in regulation of immune responses in tumour microenvironmentQ38246724
Prolyl hydroxylase inhibitors act as agents to enhance the efficiency of cell therapyQ38577907
Selective tumor hypoxia targeting by hypoxia-activated prodrug TH-302 inhibits tumor growth in preclinical models of cancer.Q39425368
Hypoxia induces escape from innate immunity in cancer cells via increased expression of ADAM10: role of nitric oxideQ39456593
Introduction of hypoxia-targeting p53 fusion protein for the selective therapy of non-small cell lung cancerQ39605499
Suppression of hypoxia-inducible factor 2alpha restores p53 activity via Hdm2 and reverses chemoresistance of renal carcinoma cellsQ39773550
Significance of HIF-1-active cells in angiogenesis and radioresistanceQ40120839
Hypoxia-selective targeting by the bioreductive prodrug AQ4N in patients with solid tumors: results of a phase I studyQ40123047
Bystander effects of bioreductive drugs: potential for exploiting pathological tumor hypoxia with dinitrobenzamide mustards.Q40128344
Mechanism of hypoxia-specific cytotoxicity of procaspase-3 fused with a VHL-mediated protein destruction motif of HIF-1alpha containing Pro564.Q40225838
Bioreducible mustards: a paradigm for hypoxia-selective prodrugs of diffusible cytotoxins (HPDCs).Q40848113
Breast cancer angiogenesis--new approaches to therapy via antiangiogenesis, hypoxic activated drugs, and vascular targetingQ40958050
Targeting hypoxia at the forefront of anticancer immune responsesQ41819433
Phase 1 study of the safety, tolerability, and pharmacokinetics of TH-302, a hypoxia-activated prodrug, in patients with advanced solid malignanciesQ42745781
Henry S. Kaplan Distinguished Scientist Award Lecture 2007. The remarkable yin and yang of tumour hypoxiaQ43009524
New antimetastatic hypoxic cell radiosensitizers: design, synthesis, and biological activities of 2-nitroimidazole-acetamide, TX-1877, and its analoguesQ43542768
P433issue10
P921main subjecthypoxiaQ105688
P304page(s)536-545
P577publication date2016-11-08
P1433published inCancer InvestigationQ325953
P1476titleHypoxia: A Double-Edged Sword in Cancer Therapy
P478volume34

Reverse relations

cites work (P2860)
Q91830459B7-H3 Induces Ovarian Cancer Drugs Resistance Through An PI3K/AKT/BCL-2 Signaling Pathway
Q50025483Baicalin induces cellular senescence in human colon cancer cells via upregulation of DEPP and the activation of Ras/Raf/MEK/ERK signaling
Q90195204Cellular Stress Responses in Radiotherapy
Q92557315Colon cancer cells secrete exosomes to promote self-proliferation by shortening mitosis duration and activation of STAT3 in a hypoxic environment
Q92703023Energy Metabolism in Cancer: The Roles of STAT3 and STAT5 in the Regulation of Metabolism-Related Genes
Q90678032Exercise as Adjunct Therapy in Cancer
Q98463685Flavagline synthetic derivative induces senescence in glioblastoma cancer cells without being toxic to healthy astrocytes
Q112284336Network Pharmacology-Based Study on the Active Component and Mechanism of the Anti-Non-Invasive and Invasive Bladder Urothelial Carcinoma Effects of Zhuling Jisheng Decoction
Q90221767PO2-based biodosimetry evaluation using an EPR technique acts as a sensitive index for chemotherapy
Q64071649Prognostic role of diffusion weighted and dynamic contrast-enhanced MRI in loco-regionally advanced head and neck cancer treated with concomitant chemoradiotherapy
Q90341495Roles of Ceramides and Other Sphingolipids in Immune Cell Function and Inflammation
Q90732409Saikosaponin-d Inhibits the Hepatoma Cells and Enhances Chemosensitivity Through SENP5-Dependent Inhibition of Gli1 SUMOylation Under Hypoxia
Q38644800The Many Faces of Long Noncoding RNAs in Cancer
Q94552664Upregulation of lncRNA AGAP2-AS1 is an independent predictor of poor survival in patients with clear cell renal carcinoma

Search more.