Sulforaphane suppresses the growth of glioblastoma cells, glioblastoma stem cell-like spheroids, and tumor xenografts through multiple cell signaling pathways

scientific article published on 6 January 2017

Sulforaphane suppresses the growth of glioblastoma cells, glioblastoma stem cell-like spheroids, and tumor xenografts through multiple cell signaling pathways is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.3171/2016.8.JNS161197
P8608Fatcat IDrelease_ndl7b2qhtfh4nm6eb3y6ygastq
P932PMC publication ID6086125
P698PubMed publication ID28059653

P50authorKhadijeh Bijangi-VishehsaraeiQ87417010
Stacey L. HalumQ93819249
Aaron A. Cohen-GadolQ60780622
Karen E. PollokQ64589654
P2093author name stringHaiyan Wang
Jann N Sarkaria
Ahmad R Safa
M Reza Saadatzadeh
Wenjing Cai
Malgorzata M Kamocka
Angie Nguyen
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The transcription factor Nrf2 is a therapeutic target against brain inflammationQ39970287
Suppression of NF-kappaB and NF-kappaB-regulated gene expression by sulforaphane and PEITC through IkappaBalpha, IKK pathway in human prostate cancer PC-3 cells.Q40430279
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Sulforaphane enhances the therapeutic potential of TRAIL in prostate cancer orthotopic model through regulation of apoptosis, metastasis, and angiogenesisQ46267077
Sulforaphane induces DNA double strand breaks predominantly repaired by homologous recombination pathway in human cancer cellsQ46317528
Sulforaphane induces apoptosis in human hepatic cancer cells through inhibition of 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase4, mediated by hypoxia inducible factor-1-dependent pathway.Q54585085
Use of an orthotopic xenograft model for assessing the effect of epidermal growth factor receptor amplification on glioblastoma radiation response.Q55470277
Selective cytostatic and cytotoxic effects of glucosinolates hydrolysis products on human colon cancer cells in vitroQ74337652
Anti-carcinogenic effects of sulforaphane in association with its apoptosis-inducing and anti-inflammatory properties in human cervical cancer cellsQ85213795
Cytotoxic and Antitumor Activity of Sulforaphane: The Role of Reactive Oxygen SpeciesQ26799560
Cellular stress responses, hormetic phytochemicals and vitagenes in aging and longevityQ27024064
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Taxol induces caspase-10-dependent apoptosisQ28285037
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Bioactive dietary supplements reactivate ER expression in ER-negative breast cancer cells by active chromatin modificationsQ34291226
Sulforaphane as a promising molecule for fighting cancerQ34376869
Sulforaphane suppresses polycomb group protein level via a proteasome-dependent mechanism in skin cancer cellsQ35415785
4-(4-Chloro-2-methylphenoxy)-N-hydroxybutanamide (CMH) targets mRNA of the c-FLIP variants and induces apoptosis in MCF-7 human breast cancer cellsQ35668904
Glioblastoma stem cells (GSCs) epigenetic plasticity and interconversion between differentiated non-GSCs and GSCs.Q35794896
DNA damage by drugs and radiation: what is important and how is it measured?Q36022419
Reactive oxygen species-mediated therapeutic response and resistance in glioblastomaQ36347143
Deadly teamwork: neural cancer stem cells and the tumor microenvironmentQ36386525
Sulforaphane retards the growth of human PC-3 xenografts and inhibits HDAC activity in human subjects.Q36496614
Emerging targets for glioblastoma stem cell therapyQ36502009
Wnt/β-catenin signaling is a key downstream mediator of MET signaling in glioblastoma stem cellsQ36544112
Gamma-H2AX - a novel biomarker for DNA double-strand breaks.Q37210367
HDAC turnover, CtIP acetylation and dysregulated DNA damage signaling in colon cancer cells treated with sulforaphane and related dietary isothiocyanatesQ37378670
Survival signalling and apoptosis resistance in glioblastomas: opportunities for targeted therapeuticsQ37761935
Targeting cancer stem cells with sulforaphane, a dietary component from broccoli and broccoli sproutsQ38125500
Modulation of mitochondrial functions by the indirect antioxidant sulforaphane: a seemingly contradictory dual role and an integrative hypothesisQ38133725
Stem cell signature in glioblastoma: therapeutic development for a moving targetQ38268185
Mitochondrial energy metabolism and apoptosis regulation in glioblastomaQ38275798
Glioblastoma stem-like cells: at the root of tumor recurrence and a therapeutic target.Q38287518
Mitochondrial reactive oxygen species and cancer.Q38351698
Sulforaphane enhances caspase-dependent apoptosis through inhibition of cyclooxygenase-2 expression in human oral squamous carcinoma cells and nude mouse xenograft modelQ38498804
Sulforaphane sensitizes tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis through downregulation of ERK and Akt in lung adenocarcinoma A549 cellsQ38507607
How to train glioma cells to die: molecular challenges in cell deathQ38626416
Hypoxia Is the Driving Force Behind GBM and Could Be a New Tool in GBM TreatmentQ38630796
P433issue6
P407language of work or nameEnglishQ1860
P921main subjectglioblastomaQ282142
xenograftQ64148587
tumour xenograftQ112042499
P304page(s)1219-1230
P577publication date2017-01-06
P1433published inJournal of NeurosurgeryQ15708886
P1476titleSulforaphane suppresses the growth of glioblastoma cells, glioblastoma stem cell-like spheroids, and tumor xenografts through multiple cell signaling pathways
P478volume127

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cites work (P2860)
Q90711255Gomisin M2 from Baizuan suppresses breast cancer stem cell proliferation in a zebrafish xenograft model
Q93018164Human bronchial carcinoid tumor initiating cells are targeted by the combination of acetazolamide and sulforaphane
Q59807366Sulforaphane from Cruciferous Vegetables: Recent Advances to Improve Glioblastoma Treatment

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