Exploring the effects of isothiocyanates on chemotherapeutic drugs

scientific article published on 03 October 2013

Exploring the effects of isothiocyanates on chemotherapeutic drugs is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1517/17425255.2013.843668
P8608Fatcat IDrelease_v5kguaveyva5rcteg4qkmysstm
P698PubMed publication ID24087843

P50authorEleonora TurriniQ43245394
Carmela FimognariQ43245399
Anna MinariniQ57078501
P2093author name stringVincenzo Tumiatti
Elena Simoni
Andrea Milelli
P2860cites workRole of Notch signaling in cell-fate determination of human mammary stem/progenitor cellsQ21195157
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Synergistic effect of paclitaxel and epigenetic agent phenethyl isothiocyanate on growth inhibition, cell cycle arrest and apoptosis in breast cancer cellsQ28397373
Sulforaphane potentiates RNA damage induced by different xenobioticsQ28482480
Modulation of the metabolism of airborne pollutants by glucoraphanin-rich and sulforaphane-rich broccoli sprout beverages in Qidong, ChinaQ28732170
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Cisplatin: mode of cytotoxic action and molecular basis of resistanceQ29615385
Reversibility of apoptosis in cancer cellsQ30485754
Molecular mechanism of rapid cellular accumulation of anticarcinogenic isothiocyanatesQ32128748
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A critical evaluation of the mechanisms of action proposed for the antitumor effects of the anthracycline antibiotics adriamycin and daunorubicinQ33540751
Allyl isothiocyanate as a cancer chemopreventive phytochemical.Q33622654
Phenethyl isothiocyanate sensitizes androgen-independent human prostate cancer cells to docetaxel-induced apoptosis in vitro and in vivoQ33724512
Chemoprevention of cancerQ33846248
The chemical diversity and distribution of glucosinolates and isothiocyanates among plantsQ33934528
High levels of Nrf2 determine chemoresistance in type II endometrial cancerQ33959077
Phenethyl isothiocyanate inhibits oxidative phosphorylation to trigger reactive oxygen species-mediated death of human prostate cancer cellsQ34074470
Sensitization of non-small cell lung cancer cells to cisplatin by naturally occurring isothiocyanatesQ34076604
Inhibition of carcinogenesis by isothiocyanatesQ34119188
Selective depletion of mutant p53 by cancer chemopreventive isothiocyanates and their structure-activity relationshipsQ34159403
Cancer epidemiology in the last century and the next decadeQ34253597
Glucosinolates and isothiocyanates in health and disease.Q34274313
Sulforaphane Increases Drug-mediated Cytotoxicity Toward Cancer Stem-like Cells of Pancreas and ProstateQ34473316
Signal transduction pathways of taxanes-induced apoptosisQ34534026
Isothiocyanates as cancer chemopreventive agents: their biological activities and metabolism in rodents and humansQ34706257
Multi-targeted prevention of cancer by sulforaphaneQ34781826
Are isothiocyanates potential anti-cancer drugs?Q34979394
Doxorubicin pathways: pharmacodynamics and adverse effectsQ35048393
Anti-tumor activity and signaling events triggered by the isothiocyanates, sulforaphane and phenethyl isothiocyanate, in multiple myelomaQ35143496
Gemcitabine in cervical cancerQ35202990
Proteins as binding targets of isothiocyanates in cancer preventionQ35230296
Oral azathioprine leads to higher incorporation of 6-thioguanine in DNA of skin than liver: the protective role of the Keap1/Nrf2/ARE pathway.Q35283173
The molecular basis that unifies the metabolism, cellular uptake and chemopreventive activities of dietary isothiocyanates.Q35747310
Protection of humans by plant glucosinolates: efficiency of conversion of glucosinolates to isothiocyanates by the gastrointestinal microfloraQ36201654
Metformin and phenethyl isothiocyanate combined treatment in vitro is cytotoxic to ovarian cancer culturesQ36226632
Etoposide, topoisomerase II and cancerQ36230274
Signaling pathways and intracellular targets of sulforaphane mediating cell cycle arrest and apoptosisQ36418052
Telomerase therapeutics for cancer: challenges and new directionsQ36506309
Phenethyl isothiocyanate sensitizes human cervical cancer cells to apoptosis induced by cisplatinQ36580055
hTERT phosphorylation by PKC is essential for telomerase holoprotein integrity and enzyme activity in head neck cancer cellsQ36614496
Enhanced cytotoxicity of mitomycin C in human tumour cells with inducers of DT-diaphoraseQ36618045
Effective elimination of fludarabine-resistant CLL cells by PEITC through a redox-mediated mechanismQ36843744
Targeting multiple signal pathways by chemopreventive agents for cancer prevention and therapyQ36920745
Metformin attenuates ovarian cancer cell growth in an AMP-kinase dispensable mannerQ37293802
Aldehyde dehydrogenase as a marker for stem cellsQ37347494
NRF2 and KEAP1 mutations: permanent activation of an adaptive response in cancerQ37423465
Biosynthesis of glucosinolates--gene discovery and beyondQ37715312
Anti-angiogenic effects of dietary isothiocyanates: Mechanisms of action and implications for human healthQ37801027
Nrf2: control of sensitivity to carcinogensQ37849195
Pharmacokinetics and pharmacodynamics of isothiocyanates.Q37873490
Differential effects of sulforaphane on histone deacetylases, cell cycle arrest and apoptosis in normal prostate cells versus hyperplastic and cancerous prostate cellsQ39581417
Effects of phenylethyl isothiocyanate and its metabolite on cell-cycle arrest and apoptosis in LNCaP human prostate cancer cellsQ39713370
Targeting protein kinase C (PKC) and telomerase by phenethyl isothiocyanate (PEITC) sensitizes PC-3 cells towards chemotherapeutic drug-induced apoptosisQ39747791
Isothiocyanates sensitize the effect of chemotherapeutic drugs via modulation of protein kinase C and telomerase in cervical cancer cellsQ39861400
Synergistic inhibitory effect of sulforaphane and 5-fluorouracil in high and low metastasis cell lines of salivary gland adenoid cystic carcinomaQ39930973
The role of protein binding in induction of apoptosis by phenethyl isothiocyanate and sulforaphane in human non-small lung cancer cellsQ40110170
Induction of p21 protein protects against sulforaphane-induced mitotic arrest in LNCaP human prostate cancer cell lineQ40130426
Combination of doxorubicin and sulforaphane for reversing doxorubicin-resistant phenotype in mouse fibroblasts with p53Ser220 mutationQ40150731
Sulforaphane increases the efficacy of doxorubicin in mouse fibroblasts characterized by p53 mutationsQ40255489
p53-independent G1 cell cycle arrest of human colon carcinoma cells HT-29 by sulforaphane is associated with induction of p21CIP1 and inhibition of expression of cyclin D1.Q40371664
Effect of NQO1 induction on the antitumor activity of RH1 in human tumors in vitro and in vivoQ40426261
Sulforaphane-induced cell death in human prostate cancer cells is initiated by reactive oxygen species.Q40447260
Redox-cycling of anthracyclines by thioredoxin system: increased superoxide generation and DNA damageQ40529202
Role of MRP2 and GSH in intrahepatic cycling of toxinsQ40780576
Cellular pharmacology of quinone bioreductive alkylating agentsQ40848126
Synergistic activity of sorafenib and sulforaphane abolishes pancreatic cancer stem cell characteristicsQ43041593
Reactive oxygen species-related induction of multidrug resistance-associated protein 2 expression in primary hepatocytes exposed to sulforaphaneQ43550903
High-performance liquid chromatography-based determination of total isothiocyanate levels in human plasma: application to studies with 2-phenethyl isothiocyanateQ43636434
Protein kinase C modulates telomerase activity in human cervical cancer cellsQ43772323
Dose-dependent promotion by phenylethyl isothiocyanate, a known chemopreventer, of two-stage rat urinary bladder and liver carcinogenesisQ43965273
Effect of organic isothiocyanates on the P-glycoprotein- and MRP1-mediated transport of daunomycin and vinblastineQ44211838
Determination of phenethyl isothiocyanate in human plasma and urine by ammonia derivatization and liquid chromatography–tandem mass spectrometryQ44658811
A novel mechanism of chemoprotection by sulforaphane: inhibition of histone deacetylase.Q45020400
Effect of organic isothiocyanates on breast cancer resistance protein (ABCG2)-mediated transportQ45222334
Sulforaphane targets pancreatic tumour-initiating cells by NF-kappaB-induced antiapoptotic signallingQ46336155
ERK and JNK signaling pathways are involved in the regulation of activator protein 1 and cell death elicited by three isothiocyanates in human prostate cancer PC-3 cells.Q46792290
Inhibition of EGFR signaling in human prostate cancer PC-3 cells by combination treatment with beta-phenylethyl isothiocyanate and curcumin.Q46813473
Design, synthesis and biological evaluation of new naphtalene diimides bearing isothiocyanate functionality.Q50791285
Studies on the mechanism of the inhibition of human leukaemia cell growth by dietary isothiocyanates and their cysteine adducts in vitro.Q51080568
Enhancement of cisplatin cytotoxicity by benzyl isothiocyanate in HL-60 cells.Q54313490
ABC Transporters and IsothiocyanatesQ58005850
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectchemotherapyQ974135
P304page(s)25-38
P577publication date2013-10-03
P1433published inExpert Opinion on Drug Metabolism & ToxicologyQ5421205
P1476titleExploring the effects of isothiocyanates on chemotherapeutic drugs
P478volume10

Reverse relations

cites work (P2860)
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Q38262078Natural compounds to overcome cancer chemoresistance: toxicological and clinical issues
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