Co-activation of ERK, NF-kappaB, and GADD45beta in response to ionizing radiation

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Co-activation of ERK, NF-kappaB, and GADD45beta in response to ionizing radiation is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M410982200
P932PMC publication ID4130153
P698PubMed publication ID15642734

P2093author name stringDavid Gius
Qian Gao
Jian Jian Li
Ming Fan
Shaozhong Dong
Daniel Tamae
Munetaka Ozeki
Tieli Wang
Yu-Chang Hu
P2860cites workImmediate-early gene induction by the stresses anisomycin and arsenite in human osteosarcoma cells involves MAPK cascade signaling to Elk-1, CREB and SRFQ24298595
CR6-interacting factor 1 interacts with Gadd45 family proteins and modulates the cell cycleQ24300586
Overexpression of manganese superoxide dismutase selectively modulates the activity of Jun-associated transcription factors in fibrosarcoma cellsQ24311827
The NF-kappa B and I kappa B proteins: new discoveries and insightsQ24313579
Meaningful relationships: the regulation of the Ras/Raf/MEK/ERK pathway by protein interactionsQ24532168
Induction by ionizing radiation of the gadd45 gene in cultured human cells: lack of mediation by protein kinase CQ24605002
NF-kappaB is a target of AKT in anti-apoptotic PDGF signallingQ28144330
Identification of a functional domain in a GADD45-mediated G2/M checkpointQ28145438
NF-kappaB regulation in the immune systemQ28205043
GADD45b and GADD45g are cdc2/cyclinB1 kinase inhibitors with a role in S and G2/M cell cycle checkpoints induced by genotoxic stressQ28215088
Regulation of the gadd45beta promoter by NF-kappaBQ28216901
Gadd45 beta mediates the NF-kappa B suppression of JNK signalling by targeting MKK7/JNKK2Q28240600
The DNA-dependent protein kinase participates in the activation of NF kappa B following DNA damageQ28274456
Hypoxia--a key regulatory factor in tumour growthQ29547318
TNF- and cancer therapy-induced apoptosis: potentiation by inhibition of NF-kappaBQ29614706
A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasiaQ29615437
Visualization of interactions among bZIP and Rel family proteins in living cells using bimolecular fluorescence complementationQ29616037
Cell cycle control and cancerQ29617536
Effector genes altered in MCF-7 human breast cancer cells after exposure to fractionated ionizing radiationQ30984038
Redox regulation of cellular signallingQ33595625
Intracellular oxidation/reduction status in the regulation of transcription factors NF-kappaB and AP-1.Q33686149
The complexity of radiation stress responses: analysis by informatics and functional genomics approaches.Q33706935
Control of apoptosis by Rel/NF-kappaB transcription factorsQ33797163
p53-mediated DNA repair responses to UV radiation: studies of mouse cells lacking p53, p21, and/or gadd45 genesQ33963455
Manganese superoxide dismutase-mediated gene expression in radiation-induced adaptive responsesQ34784364
The role of NF-kappaB in the regulation of cell stress responsesQ34998147
MAPK pathways in radiation responsesQ35208830
Metabolic oxidation/reduction reactions and cellular responses to ionizing radiation: a unifying concept in stress response biology.Q35805264
Tumor necrosis factor alpha and interleukin-1beta regulate the murine manganese superoxide dismutase gene through a complex intronic enhancer involving C/EBP-beta and NF-kappaB.Q36573870
Reconstitution of the Raf-1-MEK-ERK signal transduction pathway in vitroQ36824645
A role for NF-kappaB-dependent gene transactivation in sunburn.Q37202396
Genes regulated in human breast cancer cells overexpressing manganese-containing superoxide dismutaseQ38304457
An intronic NF-kappaB element is essential for induction of the human manganese superoxide dismutase gene by tumor necrosis factor-alpha and interleukin-1betaQ38320388
Induction of gene expression as a monitor of exposure to ionizing radiationQ38496962
Subcellular localization determines the protective effects of activated ERK2 against distinct apoptogenic stimuli in myeloid leukemia cells.Q40549982
Sensitization of breast cancer cells to radiation by trastuzumabQ40616367
Activation of the nuclear transcription factor kappaB (NFkappaB) and differential gene expression in U87 glioma cells after exposure to the cytoprotector amifostineQ40732463
Induction of gadd45beta by NF-kappaB downregulates pro-apoptotic JNK signalling.Q40767950
Redox modulation of the pro-fibrogenic mediator plasminogen activator inhibitor-1 following ionizing radiation.Q40792388
Extremely low-dose ionizing radiation causes activation of mitogen-activated protein kinase pathway and enhances proliferation of normal human diploid cells.Q40792437
Activation of NFkappaB and MnSOD gene expression by free radical scavengers in human microvascular endothelial cellsQ40801438
Fluorescent cDNA microarray hybridization reveals complexity and heterogeneity of cellular genotoxic stress responses.Q40946010
Effects of propranolol on phosphatidate phosphohydrolase and mitogen-activated protein kinase activities in A7r5 vascular smooth muscle cellsQ41012556
The p53-dependent gamma-ray response of GADD45.Q41467956
Inhibition by cAMP of Ras-Dependent Activation of RafQ41514458
Inhibition of NF-kappaB, clonogenicity, and radiosensitivity of human cancer cellsQ41702875
p53 activation in chronic radiation-treated breast cancer cells: regulation of MDM2/p14ARF.Q42455717
Activation of nuclear factor kappaB in radioresistance of TP53-inactive human keratinocytes.Q42517823
Attenuation of radiation-induced genomic instability by free radical scavengers and cellular proliferationQ43652963
Profiling of cancer cells using protein microarrays: discovery of novel radiation-regulated proteinsQ43770341
Indomethacin-induced radiosensitization and inhibition of ionizing radiation-induced NF-kappaB activation in HeLa cells occur via a mechanism involving p38 MAP kinase.Q43770354
Inhibition of JNK activation through NF-kappaB target genesQ43802523
The c-Rel transcription factor can both induce and inhibit apoptosis in the same cells via the upregulation of MnSOD.Q44039029
MEK/ERK pathway protects ionizing radiation-induced loss of mitochondrial membrane potential and cell death in lymphocytic leukemia cellsQ44104450
ERK inhibitor PD98059 enhances docetaxel-induced apoptosis of androgen-independent human prostate cancer cells.Q44594549
Inhibition of the Raf/MEK/ERK pathway up-regulates expression of the coxsackievirus and adenovirus receptor in cancer cellsQ46016751
In vivo evidence for binding of p53 to consensus binding sites in the p21 and GADD45 genes in response to ionizing radiationQ46059520
Ras promotes cell survival in Drosophila by downregulating hid expressionQ47070193
Cyclin B1 overexpression and resistance to radiotherapy in head and neck squamous cell carcinoma.Q53950165
Activation of Raf by ionizing radiationQ59095906
Requirement of Erk, but not JNK, for arsenite-induced cell transformationQ63561118
Control of inducible chemoresistance: enhanced anti-tumor therapy through increased apoptosis by inhibition of NF-kappaBQ64381570
Different structural requirements within the switch II region of the Ras protein for interactions with specific downstream targetsQ71946178
Nuclear factor-kappaB activation by the photochemotherapeutic agent verteporfinQ73295216
Regulation of death receptor expression and TRAIL/Apo2L-induced apoptosis by NF-kappaBQ73704115
NF-kappa B activation results in rapid inactivation of JNK in TNF alpha-treated Ewing sarcoma cells: a mechanism for the anti-apoptotic effect of NF-kappa BQ74244990
Ionizing radiation activates c-Jun NH2-terminal kinase (JNK/SAPK) via a PKC-dependent pathway in human thyroid cellsQ74353014
Overexpression of manganese superoxide dismutase suppresses tumor necrosis factor-induced apoptosis and activation of nuclear transcription factor-kappaB and activated protein-1Q74531790
Gadd45beta is important for perpetuating cognate and inflammatory signals in T cellsQ75202056
Phorbol ester-induced mononuclear cell differentiation is blocked by the mitogen-activated protein kinase kinase (MEK) inhibitor PD98059Q77844396
Expression of a dominant-negative mutant inhibitor-kappaBalpha of nuclear factor-kappaB in human head and neck squamous cell carcinoma inhibits survival, proinflammatory cytokine expression, and tumor growth in vivoQ78029734
Heat shock inhibits radiation-induced activation of NF-kappaB via inhibition of I-kappaB kinaseQ78101684
P433issue13
P407language of work or nameEnglishQ1860
P921main subjectNF-κBQ411114
P1104number of pages9
P304page(s)12593-12601
P577publication date2005-01-10
P1433published inJournal of Biological ChemistryQ867727
P1476titleCo-activation of ERK, NF-kappaB, and GADD45beta in response to ionizing radiation
P478volume280

Reverse relations

cites work (P2860)
Q36907054ATM-NFκB axis-driven TIGAR regulates sensitivity of glioma cells to radiomimetics in the presence of TNFα.
Q37875377Beyond ATM: the protein kinase landscape of the DNA damage response
Q33345889Bimolecular fluorescence complementation (BiFC) analysis as a probe of protein interactions in living cells
Q39867836Coactivation of ATM/ERK/NF-kappaB in the low-dose radiation-induced radioadaptive response in human skin keratinocytes.
Q39951699Cyclin D1 in low-dose radiation-induced adaptive resistance.
Q37687728Distinct biological effects of low-dose radiation on normal and cancerous human lung cells are mediated by ATM signaling
Q52668557Down-regulation of GADD45A enhances chemosensitivity in melanoma.
Q40119822Dual targeting of IGF-1R and PDGFR inhibits proliferation in high-grade gliomas cells and induces radiosensitivity in JNK-1 expressing cells.
Q37593377Enhanced radiation response in radioresistant MCF-7 cells by targeting peroxiredoxin II.
Q63384184Expression of mTert in primary murine cells links the growth-promoting effects of telomerase to transforming growth factor-β signaling
Q28388105Gadd45 proteins as critical signal transducers linking NF-kappaB to MAPK cascades
Q34131115Hepatocyte proliferation/growth arrest balance in the liver of mice during E. multilocularis infection: a coordinated 3-stage course
Q54490483Low-dose, low-dose-rate proton radiation modulates CD4(+) T cell gene expression.
Q36868559Many faces of NF-kappaB signaling induced by genotoxic stress
Q36696163Matrix metalloproteinase-9 inhibition down-regulates radiation-induced nuclear factor-kappa B activity leading to apoptosis in breast tumors
Q38808755Modeling cell response to low doses of photon irradiation: Part 2--application to radiation-induced chromosomal aberrations in human carcinoma cells.
Q55497904Molecular Mechanisms and Treatment of Radiation-Induced Lung Fibrosis.
Q34142102Molecular mechanisms and treatment of radiation-induced lung fibrosis
Q92069747NF-kB as a key player in regulation of cellular radiation responses and identification of radiation countermeasures
Q36493029NF-kappa B-mediated adaptive resistance to ionizing radiation
Q30486628NF-kappaB-mediated HER2 overexpression in radiation-adaptive resistance
Q34415133Neurokinin-1 receptor antagonist treatment in polymicrobial sepsis: molecular insights
Q30466128Noise-induced changes in gene expression in the cochleae of mice differing in their susceptibility to noise damage
Q33770167Phosphoproteomics profiling of human skin fibroblast cells reveals pathways and proteins affected by low doses of ionizing radiation
Q92022772QTL Mapping of Intestinal Neutrophil Variation in Threespine Stickleback Reveals Possible Gene Targets Connecting Intestinal Inflammation and Systemic Health
Q28577758Radiation-induced molecular changes in rat mammary tissue: possible implications for radiation-induced carcinogenesis
Q35065235Radiation-triggered tumor necrosis factor (TNF) alpha-NFkappaB cross-signaling favors survival advantage in human neuroblastoma cells
Q39986725Rapid activation of Stat3 and ERK1/2 by nicotine modulates cell proliferation in human bladder cancer cells.
Q55238574Regulator of calcineurin 1 differentially regulates TLR-dependent MyD88 and TRIF signaling pathways.
Q41837398Shigatoxin-induced endothelin-1 expression in cultured podocytes autocrinally mediates actin remodeling
Q35217017Tumor cells switch to mitochondrial oxidative phosphorylation under radiation via mTOR-mediated hexokinase II inhibition--a Warburg-reversing effect
Q37183903Tyrosine nitration of IkappaBalpha: a novel mechanism for NF-kappaB activation.
Q50849341cIAP-2 protects cardiac fibroblasts from oxidative damage: an obligate regulatory role for ERK1/2 MAPK and NF-κB.

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