Myosin VI mediates the movement of NHE3 down the microvillus in intestinal epithelial cells

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Myosin VI mediates the movement of NHE3 down the microvillus in intestinal epithelial cells is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1242/JCS.149930
P932PMC publication ID4132392
P698PubMed publication ID24928903
P5875ResearchGate publication ID263096900

P2093author name stringJianbo Yang
Mark Donowitz
Boyoung Cha
Rafiquel Sarker
Tiane Chen
Ann Hubbard
Jennifer Price
Rakhilya Murtazina
P2860cites workMyosin VI is an actin-based motor that moves backwardsQ22010643
Myosin VI isoform localized to clathrin-coated vesicles with a role in clathrin-mediated endocytosisQ24291429
Proteomic analysis of the enterocyte brush borderQ24293478
Myosin VI binds to and localises with Dab2, potentially linking receptor-mediated endocytosis and the actin cytoskeletonQ24294845
Optineurin links myosin VI to the Golgi complex and is involved in Golgi organization and exocytosisQ24300284
Myo6 facilitates the translocation of endocytic vesicles from cell peripheriesQ24307920
A millennial myosin censusQ24633678
T6BP and NDP52 are myosin VI binding partners with potential roles in cytokine signalling and cell adhesionQ24650918
Myosin VI: two distinct roles in endocytosisQ28191412
Na+-H+ exchanger 3 (NHE3) is present in lipid rafts in the rabbit ileal brush border: a role for rafts in trafficking and rapid stimulation of NHE3Q28365699
Binding of internalized receptors to the PDZ domain of GIPC/synectin recruits myosin VI to endocytic vesiclesQ28511953
Structural and functional relationship between the membrane and the cytoskeleton in brush border microvilliQ70826423
Synaptotagmin I binds intestinal epithelial NHE3 and mediates cAMP- and Ca2+-induced endocytosis by recruitment of AP2 and clathrinQ79792981
Defective CFTR apical endocytosis and enterocyte brush border in myosin VI-deficient miceQ80445304
Tissue-specific regulation of sodium/proton exchanger isoform 3 activity in Na(+)/H(+) exchanger regulatory factor 1 (NHERF1) null mice. cAMP inhibition is differentially dependent on NHERF1 and exchange protein directly activated by cAMP in ileum vQ80502556
Quantitative colocalization analysis of confocal fluorescence microscopy imagesQ84904541
Redistribution of myosin VI from top to base of proximal tubule microvilli during acute hypertensionQ28575058
Expression of myosin VI within the early endocytic pathway in adult and developing proximal tubulesQ28579268
Effects of dietary salt on renal Na+ transporter subcellular distribution, abundance, and phosphorylation statusQ28583444
Dynasore, a cell-permeable inhibitor of dynaminQ29619881
Autophagy receptors link myosin VI to autophagosomes to mediate Tom1-dependent autophagosome maturation and fusion with the lysosomeQ30525665
The lateral mobility of NHE3 on the apical membrane of renal epithelial OK cells is limited by the PDZ domain proteins NHERF1/2, but is dependent on an intact actin cytoskeleton as determined by FRAP.Q33204357
Requirements for efficient production and transduction of human immunodeficiency virus type 1-based vectors.Q33652758
PLC-γ directly binds activated c-Src, which is necessary for carbachol-mediated inhibition of NHE3 activity in Caco-2/BBe cellsQ33816681
Glucocorticoids acutely increase cell surface Na+/H+ exchanger-3 (NHE3) by activation of NHE3 exocytosisQ33818285
Alpha-AP-2 directs myosin VI-dependent endocytosis of cystic fibrosis transmembrane conductance regulator chloride channels in the intestineQ33883196
Myosin-1a: A motor for microvillar membrane movement and mechanicsQ33895781
A myosin family tree.Q33917616
Rho GTPases dictate the mobility of the Na/H exchanger NHE3 in epithelia: role in apical retention and targetingQ33922759
NHE3 mobility in brush borders increases upon NHERF2-dependent stimulation by lyophosphatidic acidQ34116039
NHE3 serves as a molecular tool for cAMP-mediated regulation of receptor-mediated endocytosisQ34143409
Characterization of an epithelial approximately 460-kDa protein that facilitates endocytosis of intrinsic factor-vitamin B12 and binds receptor-associated proteinQ34442584
The NHE3 juxtamembrane cytoplasmic domain directly binds ezrin: dual role in NHE3 trafficking and mobility in the brush borderQ34661729
NHERF1 and NHERF2 are necessary for multiple but usually separate aspects of basal and acute regulation of NHE3 activityQ34782190
Myosin Ia is required for CFTR brush border membrane trafficking and ion transport in the mouse small intestineQ36094961
Nucleated polymerization of actin from the membrane-associated ends of microvillar filaments in the intestinal brush borderQ36206923
Casein kinase 2 binds to the C terminus of Na+/H+ exchanger 3 (NHE3) and stimulates NHE3 basal activity by phosphorylating a separate site in NHE3Q36854915
Regulatory binding partners and complexes of NHE3.Q36872214
Renal NHE3 and NaPi2 partition into distinct membrane domainsQ37162385
Structural and functional features of protein handling in the kidney proximal tubule.Q37498346
Myosin VI and its cargo adaptors - linking endocytosis and autophagyQ38115519
Actin binding proteins of the brush borderQ40137726
The cytoskeletal apparatus of the intestinal brush border.Q40197330
Na+/H+ exchanger NHE3 activity and trafficking are lipid Raft-dependentQ40285754
Characterization and ultrastructural role of the major components of the intestinal microvillus cytoskeletonQ40335956
Ca2+-dependent inhibition of NHE3 requires PKC alpha which binds to E3KARP to decrease surface NHE3 containing plasma membrane complexesQ40637935
Acute regulation of Na+/H+ exchanger NHE3 by parathyroid hormone via NHE3 phosphorylation and dynamin-dependent endocytosisQ40871739
A high-titer lentiviral production system mediates efficient transduction of differentiated cells including beating cardiac myocytesQ40913258
Subcellular redistribution is involved in acute regulation of the brush border Na+/H+ exchanger isoform 3 in human colon adenocarcinoma cell line Caco-2. Protein kinase C-mediated inhibition of the exchangerQ41043721
Kinetics and regulation of three cloned mammalian Na+/H+ exchangers stably expressed in a fibroblast cell line.Q41509579
Actin microfilaments play a critical role in endocytosis at the apical but not the basolateral surface of polarized epithelial cellsQ41576870
Myosin VI targeting to clathrin-coated structures and dimerization is mediated by binding to Disabled-2 and PtdIns(4,5)P2.Q42155473
Myosin VI is required for maintenance of brush border structure, composition, and membrane trafficking functions in the intestinal epithelial cellQ42192580
Basic fibroblast growth factor stimulates surface expression and activity of Na(+)/H(+) exchanger NHE3 via mechanism involving phosphatidylinositol 3-kinaseQ42484860
The Wilcoxon-Mann-Whitney test under scrutinyQ43969500
Carbachol regulation of rabbit ileal brush border Na+-H+ exchanger 3 (NHE3) occurs through changes in NHE3 trafficking and complex formation and is Src dependentQ44772868
Release of extracellular membrane vesicles from microvilli of epithelial cells is enhanced by depleting membrane cholesterol.Q46080391
The cytoskeleton of intestinal microvilli contains two polypeptides immunologically related to proteins of striated muscle.Q64999087
P433issuePt 16
P407language of work or nameEnglishQ1860
P304page(s)3535-3545
P577publication date2014-06-13
P1433published inJournal of Cell ScienceQ1524177
P1476titleMyosin VI mediates the movement of NHE3 down the microvillus in intestinal epithelial cells
P478volume127

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cites work (P2860)
Q48003997Apical cytoskeletons and junctional complexes as a combined system in epithelial cell sheets
Q91044918Clathrin light chain A drives selective myosin VI recruitment to clathrin-coated pits under membrane tension
Q39141494Mechanisms of Cell Polarity-Controlled Epithelial Homeostasis and Immunity in the Intestine
Q64083816Molecular transport through primary human small intestinal monolayers by culture on a collagen scaffold with a gradient of chemical cross-linking
Q42365129Myosin-7b Promotes Distal Tip Localization of the Intermicrovillar Adhesion Complex
Q87929283Myosin-Driven Intracellular Transport
Q38720389Plasticity of the brush border - the yin and yang of intestinal homeostasis
Q39155176Regulation of Transporters and Channels by Membrane-Trafficking Complexes in Epithelial Cells
Q43085145Restoration of cytoskeletal and membrane tethering defects but not defects in membrane trafficking in the intestinal brush border of mice lacking both myosin Ia and myosin VI.
Q89396658Restoration of mucosal integrity and epithelial transport function by concomitant anti-TNFα treatment in chronic DSS-induced colitis
Q36184681The NHERF2 sequence adjacent and upstream of the ERM-binding domain affects NHERF2-ezrin binding and dexamethasone stimulated NHE3 activity.

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