| scholarly article | Q13442814 |
| P50 | author | Markus Neurath | Q1750078 |
| Stefan Schreiber | Q2337595 | ||
| Jürgen Scheller | Q89252289 | ||
| Robert Häsler | Q90700457 | ||
| Nina Adam | Q114563639 | ||
| Joanna Cichy | Q21260616 | ||
| Philip Rosenstiel | Q30089872 | ||
| Christoph Becker | Q39738752 | ||
| Stefan Rose-John | Q47812749 | ||
| P2093 | author name string | Olga Gavrilova | |
| Judith Lehmann-Koch | |||
| Vance Matthews | |||
| Dieter Hartmann | |||
| Paul Saftig | |||
| Peter Schirmacher | |||
| Athena Chalaris | |||
| Christian Sina | |||
| Thomas Jostock | |||
| Karina Reiss | |||
| P2860 | cites work | Requirement of STAT3 activation for maximal collagenase-1 (MMP-1) induction by epidermal growth factor and malignant characteristics in T24 bladder cancer cells. | Q50335893 |
| gp130-mediated Stat3 activation in enterocytes regulates cell survival and cell-cycle progression during colitis-associated tumorigenesis. | Q53418407 | ||
| Treatment of Crohn's disease with anti-tumor necrosis factor chimeric monoclonal antibody (cA2). | Q54005785 | ||
| Blockade of interleukin 6 trans signaling suppresses T-cell resistanceagainst apoptosis in chronic intestinal inflammation: Evidence in Crohn diseaseand experimental colitis in vivo | Q57079498 | ||
| Apoptosis is a natural stimulus of IL6R shedding and contributes to the proinflammatory trans-signaling function of neutrophils | Q62658841 | ||
| Mice lacking transforming growth factor alpha have an increased susceptibility to dextran sulfate-induced colitis | Q73675999 | ||
| An essential role for ectodomain shedding in mammalian development | Q77544828 | ||
| Cutting edge: TNF-alpha-converting enzyme (TACE/ADAM17) inactivation in mouse myeloid cells prevents lethality from endotoxin shock | Q80819547 | ||
| Mammary ductal morphogenesis requires paracrine activation of stromal EGFR via ADAM17-dependent shedding of epithelial amphiregulin | Q24646364 | ||
| Systematic determination of genetic network architecture | Q28138580 | ||
| Adam meets Eph: an ADAM substrate recognition module acts as a molecular switch for ephrin cleavage in trans | Q28278222 | ||
| Inducible gene targeting in mice | Q29614544 | ||
| IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer | Q29614594 | ||
| High-efficiency deleter mice show that FLPe is an alternative to Cre-loxP | Q29615159 | ||
| The importance of shedding of membrane proteins for cytokine biology | Q33855623 | ||
| Conditional inactivation of TACE by a Sox9 promoter leads to osteoporosis and increased granulopoiesis via dysregulation of IL-17 and G-CSF. | Q34076325 | ||
| Inhibition of Thl responses prevents inflammatory bowel disease in scid mice reconstituted with CD45RBhi CD4+ T cells | Q34299001 | ||
| Multiple mechanisms are responsible for transactivation of the epidermal growth factor receptor in mammary epithelial cells. | Q34824747 | ||
| Interleukin-6 biology is coordinated by membrane-bound and soluble receptors: role in inflammation and cancer | Q36481367 | ||
| TACE: a new target in epidermal growth factor receptor dependent tumors | Q36869357 | ||
| Tracking the inflammatory response in stroke in vivo by sensing the enzyme myeloperoxidase | Q36985114 | ||
| Drug insight: tumor necrosis factor-converting enzyme as a pharmaceutical target for rheumatoid arthritis | Q37139284 | ||
| The ADAMs: signalling scissors in the tumour microenvironment | Q37324256 | ||
| The epidermal growth factor receptor: a link between inflammation and liver cancer. | Q37476452 | ||
| Reduced susceptibility of mice overexpressing transforming growth factor alpha to dextran sodium sulphate induced colitis | Q41820837 | ||
| STAT3 links IL-22 signaling in intestinal epithelial cells to mucosal wound healing | Q41953828 | ||
| Chemically induced mouse models of intestinal inflammation | Q42510602 | ||
| Transforming growth factor beta induced FoxP3+ regulatory T cells suppress Th1 mediated experimental colitis. | Q42844822 | ||
| Genetic control of global gene expression levels in the intestinal mucosa: a human twin study | Q45824536 | ||
| P433 | issue | 8 | |
| P407 | language of work or name | English | Q1860 |
| P304 | page(s) | 1617-1624 | |
| P577 | publication date | 2010-07-05 | |
| P1433 | published in | Journal of Experimental Medicine | Q3186912 |
| P1476 | title | Critical role of the disintegrin metalloprotease ADAM17 for intestinal inflammation and regeneration in mice | |
| P478 | volume | 207 |
| Q37234144 | A Lactobacillus rhamnosus GG-derived soluble protein, p40, stimulates ligand release from intestinal epithelial cells to transactivate epidermal growth factor receptor |
| Q28658714 | A disintegrin and metalloprotease 17 dynamic interaction sequence, the sweet tooth for the human interleukin 6 receptor |
| Q35571359 | A disintegrin and metalloprotease 17 promotes microglial cell survival via epidermal growth factor receptor signalling following spinal cord injury |
| Q39363398 | A novel bispecific single-chain antibody for ADAM17 and CD3 induces T-cell-mediated lysis of prostate cancer cells |
| Q28585962 | ACE2 links amino acid malnutrition to microbial ecology and intestinal inflammation |
| Q37052477 | ADAM Proteases and Gastrointestinal Function |
| Q93185172 | ADAM10 controls the differentiation of the coronary arterial endothelium |
| Q35691781 | ADAM17 Promotes Motility, Invasion, and Sprouting of Lymphatic Endothelial Cells. |
| Q40912652 | ADAM17 controls IL-6 signaling by cleavage of the murine IL-6Rα from the cell surface of leukocytes during inflammatory responses |
| Q37122908 | ADAM17 controls endochondral ossification by regulating terminal differentiation of chondrocytes |
| Q52584359 | ADAM17 inhibition enhances platinum efficiency in ovarian cancer. |
| Q37424039 | ADAM17 is a survival factor for microglial cells in vitro and in vivo after spinal cord injury in mice. |
| Q52689175 | ADAM17 is required for EGF-R-induced intestinal tumors via IL-6 trans-signaling. |
| Q64067287 | ADAM17 selectively activates the IL-6 trans-signaling/ERK MAPK axis in KRAS-addicted lung cancer |
| Q89721924 | ADAM17 stabilizes its interacting partner inactive Rhomboid 2 (iRhom2) but not inactive Rhomboid 1 (iRhom1) |
| Q37262336 | ADAM17 substrate release in proximal tubule drives kidney fibrosis |
| Q90050597 | ADAM17-Mediated Reduction in CD14++CD16+ Monocytes ex vivo and Reduction in Intermediate Monocytes With Immune Paresis in Acute Pancreatitis and Acute Alcoholic Hepatitis |
| Q92783310 | ADAM17: An Emerging Therapeutic Target for Lung Cancer |
| Q34018620 | Anti-inflammatory effects of Lactococcus lactis NCDO 2118 during the remission period of chemically induced colitis |
| Q28551557 | Characterization of CD200 Ectodomain Shedding |
| Q39326946 | Circulating Soluble IL-6R but Not ADAM17 Activation Drives Mononuclear Cell Migration in Tissue Inflammation |
| Q38430546 | Clinical implications of compounds designed to inhibit ECM-modifying metalloproteinases. |
| Q50495797 | Considerations on inhibition approaches for proinflammatory functions of ADAM proteases. |
| Q41430763 | Control of ADAM17 activity by regulation of its cellular localisation |
| Q38810631 | Cytokine secretion and NK cell activity in human ADAM17 deficiency |
| Q55331908 | Diabetes-associated dysregulated cytokines and cancer. |
| Q39735298 | Different Soluble Forms of the Interleukin-6 Family Signal Transducer gp130 Fine-tune the Blockade of Interleukin-6 Trans-signaling |
| Q42455189 | Differential expression of transcription factors and inflammation-, ROS-, and cell death-related genes in organotypic cultures in the modiolus, the organ of Corti and the stria vascularis of newborn rats |
| Q36129113 | Differentiation-induced skin cancer suppression by FOS, p53, and TACE/ADAM17. |
| Q49861198 | EGFR in Tumor-Associated Myeloid Cells Promotes Development of Colorectal Cancer in Mice and Associates With Outcomes of Patients |
| Q33599723 | Ectodomain Shedding by ADAM17: Its Role in Neutrophil Recruitment and the Impairment of This Process during Sepsis |
| Q38196724 | Ectoenzymes in leukocyte migration and their therapeutic potential |
| Q36756262 | Endothelial deletion of ADAM17 in mice results in defective remodeling of the semilunar valves and cardiac dysfunction in adults |
| Q30515730 | Epidermal ADAM17 maintains the skin barrier by regulating EGFR ligand-dependent terminal keratinocyte differentiation |
| Q39761331 | Epithelial Cell-Derived a Disintegrin and Metalloproteinase-17 Confers Resistance to Colonic Inflammation Through EGFR Activation. |
| Q54322345 | Exoming into rare skin disease: EGFR deficiency. |
| Q56889930 | FRMD8 promotes inflammatory and growth factor signalling by stabilising the iRhom/ADAM17 sheddase complex |
| Q91795790 | Functional Characterization of Colon Cancer-Associated Mutations in ADAM17: Modifications in the Pro-Domain Interfere with Trafficking and Maturation |
| Q47742575 | GRP78 protects a disintegrin and metalloprotease 17 against protein-disulfide isomerase A6 catalyzed inactivation |
| Q38928508 | Growth Factors in the Pathogenesis of Retinal Neurodegeneration in Diabetes Mellitus |
| Q36677090 | HVEM: An unusual TNF receptor family member important for mucosal innate immune responses to microbes |
| Q35992493 | IBC's 22nd Annual Antibody Engineering and 9th Annual Antibody Therapeutics International Conferences and the 2011 Annual Meeting of The Antibody Society, December 5-8, 2011, San Diego, CA. |
| Q57244550 | IL-1β and ADAM17 are central regulators of β-defensin expression in Candida esophagitis |
| Q38241232 | IL-6 biology: implications for clinical targeting in rheumatic disease |
| Q41525669 | Increased Potency of a Bi-specific TL1A-ADAM17 (TACE) Inhibitor by Cell Surface Targeting. |
| Q34181792 | Interleukin-1 stimulates ADAM17 through a mechanism independent of its cytoplasmic domain or phosphorylation at threonine 735 |
| Q36581303 | Intravitreal injection of TIMP3 or the EGFR inhibitor erlotinib offers protection from oxygen-induced retinopathy in mice. |
| Q90685529 | Intriguing Roles for Endothelial ADAM10/Notch Signaling in the Development of Organ-Specific Vascular Beds |
| Q58694456 | Involvement of Cell Proliferation Induced by Dual Intracellular Signaling of HB-EGF in the Development of Colitis-Associated Cancer during Ulcerative Colitis |
| Q39393617 | Late acute graft-versus-host disease: a prospective analysis of clinical outcomes and circulating angiogenic factors |
| Q39111812 | Leukocyte adhesion molecules in diabetic retinopathy |
| Q36109388 | Loss of ADAM17-Mediated Tumor Necrosis Factor Alpha Signaling in Intestinal Cells Attenuates Mucosal Atrophy in a Mouse Model of Parenteral Nutrition |
| Q47220619 | Loss of PACS-2 delays regeneration in DSS-induced colitis but does not affect the ApcMin model of colorectal cancer |
| Q41847844 | Lung endothelial ADAM17 regulates the acute inflammatory response to lipopolysaccharide |
| Q92575076 | MMPs and ADAMs in neurological infectious diseases and multiple sclerosis |
| Q50113156 | Macrocyclic θ-defensins suppress tumor necrosis factor-α (TNF-α) shedding by inhibition of TNF-α converting enzyme |
| Q36071413 | Maintaining intestinal health: the genetics and immunology of very early onset inflammatory bowel disease |
| Q37577712 | Making sense of the cause of Crohn's - a new look at an old disease |
| Q38182526 | Mapping orphan proteases by proteomics: meprin metalloproteases deciphered as potential therapeutic targets |
| Q37975970 | Mass spectrometry-based proteomics strategies for protease cleavage site identification. |
| Q41447018 | Mechanistic insights into a TIMP3-sensitive pathway constitutively engaged in the regulation of cerebral hemodynamics |
| Q37690147 | Meprin Metalloproteases Generate Biologically Active Soluble Interleukin-6 Receptor to Induce Trans-Signaling |
| Q38130854 | Metalloproteinases and their natural inhibitors in inflammation and immunity. |
| Q38160763 | Monogenic diseases associated with intestinal inflammation: implications for the understanding of inflammatory bowel disease |
| Q50864972 | Mouse neutrophils express the decoy type 2 interleukin-1 receptor (IL-1R2) constitutively and in acute inflammatory conditions. |
| Q92912576 | Mutagenesis of the ADAM17-phosphatidylserine-binding motif leads to embryonic lethality in mice |
| Q34358637 | MyD88 signaling in nonhematopoietic cells protects mice against induced colitis by regulating specific EGF receptor ligands |
| Q36111349 | Nardilysin and ADAM proteases promote gastric cancer cell growth by activating intrinsic cytokine signalling via enhanced ectodomain shedding of TNF-α. |
| Q41687175 | Nardilysin is involved in autoimmune arthritis via the regulation of tumour necrosis factor alpha secretion |
| Q89068457 | Neutrophil and Macrophage Cell Surface Colony-Stimulating Factor 1 Shed by ADAM17 Drives Mouse Macrophage Proliferation in Acute and Chronic Inflammation |
| Q55166889 | New insights into the role and signalling processes of gp130. |
| Q34251045 | Novel regulatory mechanisms for generation of the soluble leptin receptor: implications for leptin action |
| Q37961473 | Physiological functions of the amyloid precursor protein secretases ADAM10, BACE1, and presenilin |
| Q38211365 | Pleiotropic functions of TNF-α in the regulation of the intestinal epithelial response to inflammation |
| Q41903115 | Polo-like kinase 2, a novel ADAM17 signaling component, regulates tumor necrosis factor α ectodomain shedding |
| Q27022976 | Prevention of colitis-associated cancer: natural compounds that target the IL-6 soluble receptor |
| Q45338276 | Redox Regulation of Inflammatory Processes Is Enzymatically Controlled. |
| Q38852399 | Regulation of A disintegrin and metalloproteinase (ADAM) family sheddases ADAM10 and ADAM17: The emerging role of tetraspanins and rhomboids. |
| Q35115474 | Regulation of CXCR2 expression and function by a disintegrin and metalloprotease-17 (ADAM17). |
| Q35899475 | Reparative inflammation takes charge of tissue regeneration |
| Q52680713 | Role of iRhom2 in intestinal ischemia-reperfusion-mediated acute lung injury. |
| Q41114856 | Savior or not: ADAM17 inhibitors overcome radiotherapy-resistance in non-small cell lung cancer |
| Q38836137 | Shedding of Endogenous Interleukin-6 Receptor (IL-6R) Is Governed by A Disintegrin and Metalloproteinase (ADAM) Proteases while a Full-length IL-6R Isoform Localizes to Circulating Microvesicles |
| Q42722712 | Species specificity of ADAM10 and ADAM17 proteins in interleukin-6 (IL-6) trans-signaling and novel role of ADAM10 in inducible IL-6 receptor shedding |
| Q57792395 | Structural and Functional Analyses of the Shedding Protease ADAM17 in HoxB8-Immortalized Macrophages and Dendritic-like Cells |
| Q41863389 | Structural basis for inflammation-driven shedding of CD163 ectodomain and tumor necrosis factor-α in macrophages |
| Q89903812 | Substrate-selective protein ectodomain shedding by ADAM17 and iRhom2 depends on their juxtamembrane and transmembrane domains |
| Q34626693 | TACE activation by MAPK-mediated regulation of cell surface dimerization and TIMP3 association. |
| Q35159615 | TNF-α converting enzyme-mediated ErbB4 transactivation by TNF promotes colonic epithelial cell survival |
| Q43077204 | TNFα cleavage beyond TACE/ADAM17: matrix metalloproteinase 13 is a potential therapeutic target in sepsis and colitis |
| Q55177212 | The EGFR-ADAM17 Axis in Chronic Obstructive Pulmonary Disease and Cystic Fibrosis Lung Pathology. |
| Q39268482 | The SLAM family member CD84 is regulated by ADAM10 and calpain in platelets |
| Q34537041 | The apolipoprotein E-mimetic peptide COG112 inhibits NF-kappaB signaling, proinflammatory cytokine expression, and disease activity in murine models of colitis |
| Q52645849 | The enhanced susceptibility of ADAM-17 hypomorphic mice to DSS-induced colitis is not ameliorated by loss of RIPK3, revealing an unexpected function of ADAM-17 in necroptosis. |
| Q89514254 | The enigma of soluble LDLR: could inflammation be the key? |
| Q38961857 | The role of ADAM17 in tumorigenesis and progression of breast cancer |
| Q38725223 | The role of IL-6 in host defence against infections: immunobiology and clinical implications |
| Q38860417 | The sorting protein PACS-2 promotes ErbB signalling by regulating recycling of the metalloproteinase ADAM17. |
| Q45968948 | XIAP variants in male Crohn's disease. |
| Q87424004 | [New biologics for treatment of chronic inflammatory bowel diseases] |
| Q42056708 | iRHOM2 is a critical pathogenic mediator of inflammatory arthritis |
| Q33947954 | iRHOM2-dependent regulation of ADAM17 in cutaneous disease and epidermal barrier function |
| Q37010654 | iRhom2 controls the substrate selectivity of stimulated ADAM17-dependent ectodomain shedding. |
| Q34272237 | iRhom2 is required for the secretion of mouse TNFα |
| Q35616369 | iRhoms 1 and 2 are essential upstream regulators of ADAM17-dependent EGFR signaling |
| Q55711821 | iTAP, a novel iRhom interactor, controls TNF secretion by policing the stability of iRhom/TACE. |
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