| scholarly article | Q13442814 |
| review article | Q7318358 |
| P50 | author | Michael G Tomlinson | Q56999433 |
| Jasmeet S Reyat | Q87685217 | ||
| Peter J Noy | Q42581857 | ||
| P2093 | author name string | Alexandra L Matthews | |
| P2860 | cites work | Platelet glycoprotein VI binds to polymerized fibrin and promotes thrombin generation | Q48186665 |
| Homozygous loss of mouse tetraspanin CD82 enhances integrin αIIbβ3 expression and clot retraction in platelets | Q48717426 | ||
| CD151, the first member of the tetraspanin (TM4) superfamily detected on erythrocytes, is essential for the correct assembly of human basement membranes in kidney and skin. | Q50335739 | ||
| CD9 negatively regulates integrin alphaIIbbeta3 activation and could thus prevent excessive platelet recruitment at sites of vascular injury. | Q51812701 | ||
| Differentially regulated GPVI ectodomain shedding by multiple platelet-expressed proteinases. | Q53311584 | ||
| Regulated shedding of transmembrane chemokines by the disintegrin and metalloproteinase 10 facilitates detachment of adherent leukocytes. | Q53548573 | ||
| Analysis of a Finnish family confirms RHBDF2 mutations as the underlying factor in tylosis with esophageal cancer | Q57567427 | ||
| An essential role for ectodomain shedding in mammalian development | Q77544828 | ||
| ADAM10 is a principal 'sheddase' of the low-affinity immunoglobulin E receptor CD23 | Q79314167 | ||
| Platelet tetraspanins: small but interesting | Q84533740 | ||
| Evidence for a role of ADAM17 (TACE) in the regulation of platelet glycoprotein V | Q24293698 | ||
| Rhomboid family pseudoproteases use the ER quality control machinery to regulate intercellular signaling | Q24298141 | ||
| The TspanC8 subgroup of tetraspanins interacts with A disintegrin and metalloprotease 10 (ADAM10) and regulates its maturation and cell surface expression | Q24300299 | ||
| TspanC8 tetraspanins regulate ADAM10/Kuzbanian trafficking and promote Notch activation in flies and mammals | Q24301578 | ||
| RHBDF2 mutations are associated with tylosis, a familial esophageal cancer syndrome | Q24302343 | ||
| The disintegrin/metalloprotease ADAM 10 is essential for Notch signalling but not for alpha-secretase activity in fibroblasts | Q24307875 | ||
| Identification of Tspan9 as a novel platelet tetraspanin and the collagen receptor GPVI as a component of tetraspanin microdomains | Q24313296 | ||
| TSPAN12 regulates retinal vascular development by promoting Norrin- but not Wnt-induced FZD4/beta-catenin signaling | Q24336628 | ||
| Tetraspanin12 regulates ADAM10-dependent cleavage of amyloid precursor protein | Q24642700 | ||
| Mammary ductal morphogenesis requires paracrine activation of stromal EGFR via ADAM17-dependent shedding of epithelial amphiregulin | Q24646364 | ||
| Membrane-proximal domain of a disintegrin and metalloprotease-17 represents the putative molecular switch of its shedding activity operated by protein-disulfide isomerase | Q27684263 | ||
| Current state and novel approaches of antiplatelet therapy | Q28082251 | ||
| Impaired "outside-in" integrin alphaIIbbeta3 signaling and thrombus stability in TSSC6-deficient mice | Q28241986 | ||
| Distinct roles for ADAM10 and ADAM17 in ectodomain shedding of six EGFR ligands | Q30443463 | ||
| A critical role for tetraspanin CD151 in alpha3beta1 and alpha6beta4 integrin-dependent tumor cell functions on laminin-5 | Q30477393 | ||
| Tetraspanin CD151 regulates alpha6beta1 integrin adhesion strengthening | Q30478308 | ||
| CD151 restricts the α6 integrin diffusion mode | Q30513779 | ||
| Epidermal ADAM17 maintains the skin barrier by regulating EGFR ligand-dependent terminal keratinocyte differentiation | Q30515730 | ||
| Platelet receptor expression and shedding: glycoprotein Ib-IX-V and glycoprotein VI. | Q33414254 | ||
| KUZ, a conserved metalloprotease-disintegrin protein with two roles in Drosophila neurogenesis | Q48060932 | ||
| A platelet tetraspanin superfamily member, CD151, is required for regulation of thrombus growth and stability in vivo | Q33501327 | ||
| Next-generation sequencing of a 40 Mb linkage interval reveals TSPAN12 mutations in patients with familial exudative vitreoretinopathy | Q33645942 | ||
| Mutations in TSPAN12 cause autosomal-dominant familial exudative vitreoretinopathy | Q33645980 | ||
| CD81 gene defect in humans disrupts CD19 complex formation and leads to antibody deficiency | Q33755327 | ||
| ADAM10 mediates E-cadherin shedding and regulates epithelial cell-cell adhesion, migration, and beta-catenin translocation. | Q33878896 | ||
| iRHOM2-dependent regulation of ADAM17 in cutaneous disease and epidermal barrier function | Q33947954 | ||
| Critical role of the disintegrin metalloprotease ADAM17 for intestinal inflammation and regeneration in mice | Q34044458 | ||
| Downregulation of Notch modulators, tetraspanin 5 and 10, inhibits osteoclastogenesis in vitro | Q34071113 | ||
| CD63 is an essential cofactor to leukocyte recruitment by endothelial P-selectin | Q34204995 | ||
| Tumor necrosis factor signaling requires iRhom2 to promote trafficking and activation of TACE | Q34247194 | ||
| iRhom2 regulation of TACE controls TNF-mediated protection against Listeria and responses to LPS | Q34247201 | ||
| iRhom2 is required for the secretion of mouse TNFα | Q34272237 | ||
| The first comprehensive and quantitative analysis of human platelet protein composition allows the comparative analysis of structural and functional pathways | Q34368551 | ||
| Membrane-enabled dimerization of the intrinsically disordered cytoplasmic domain of ADAM10. | Q34526248 | ||
| TACE activation by MAPK-mediated regulation of cell surface dimerization and TIMP3 association. | Q34626693 | ||
| A complex of EpCAM, claudin-7, CD44 variant isoforms, and tetraspanins promotes colorectal cancer progression | Q34639345 | ||
| ADAM10 is the constitutive functional sheddase of CD44 in human melanoma cells. | Q34868956 | ||
| Metalloprotease ADAM10 is required for Notch1 site 2 cleavage. | Q35000965 | ||
| Defective valvulogenesis in HB-EGF and TACE-null mice is associated with aberrant BMP signaling | Q35032897 | ||
| The sheddase ADAM10 is a potent modulator of prion disease. | Q35137829 | ||
| The cytoplasmic domain of a disintegrin and metalloproteinase 10 (ADAM10) regulates its constitutive activity but is dispensable for stimulated ADAM10-dependent shedding | Q35199342 | ||
| A Staphylococcus aureus pore-forming toxin subverts the activity of ADAM10 to cause lethal infection in mice | Q35332249 | ||
| The Functional Maturation of A Disintegrin and Metalloproteinase (ADAM) 9, 10, and 17 Requires Processing at a Newly Identified Proprotein Convertase (PC) Cleavage Site | Q35583121 | ||
| Ceramide kinase regulates the production of tumor necrosis factor α (TNFα) via inhibition of TNFα-converting enzyme | Q35604572 | ||
| Regulated surface expression and shedding support a dual role for semaphorin 4D in platelet responses to vascular injury | Q35616359 | ||
| iRhoms 1 and 2 are essential upstream regulators of ADAM17-dependent EGFR signaling | Q35616369 | ||
| Inside-out Regulation of Ectodomain Cleavage of Cluster-of-Differentiation-44 (CD44) and of Neuregulin-1 Requires Substrate Dimerization | Q35837076 | ||
| Distinct Intracellular Domain Substrate Modifications Selectively Regulate Ectodomain Cleavage of NRG1 or CD44. | Q36033357 | ||
| Fibrin activates GPVI in human and mouse platelets | Q36091308 | ||
| Structural basis for tetraspanin functions as revealed by the cryo-EM structure of uroplakin complexes at 6-A resolution. | Q36117676 | ||
| Synergistic Action of Staphylococcus aureus α-Toxin on Platelets and Myeloid Lineage Cells Contributes to Lethal Sepsis | Q36274821 | ||
| CD151 accelerates breast cancer by regulating alpha 6 integrin function, signaling, and molecular organization | Q36609212 | ||
| TspanC8 tetraspanins differentially regulate the cleavage of ADAM10 substrates, Notch activation and ADAM10 membrane compartmentalization. | Q36762907 | ||
| Identification of a calmodulin-binding domain in Sema4D that regulates its exodomain shedding in platelets | Q36850859 | ||
| Endothelial adhesion receptors are recruited to adherent leukocytes by inclusion in preformed tetraspanin nanoplatforms | Q36955726 | ||
| iRhom2 controls the substrate selectivity of stimulated ADAM17-dependent ectodomain shedding. | Q37010654 | ||
| Deficiency of the tetraspanin CD63 associated with kidney pathology but normal lysosomal function | Q37099908 | ||
| Regulation of mature ADAM17 by redox agents for L-selectin shedding | Q37122083 | ||
| Active metalloproteases of the A Disintegrin and Metalloprotease (ADAM) family: biological function and structure. | Q37789733 | ||
| The "A Disintegrin And Metalloproteases" ADAM10 and ADAM17: novel drug targets with therapeutic potential? | Q37824931 | ||
| Tetraspanin microdomains: fine-tuning platelet function | Q37856391 | ||
| Emerging role of rhomboid family proteins in mammalian biology and disease | Q38096675 | ||
| Metalloproteinases and their natural inhibitors in inflammation and immunity. | Q38130854 | ||
| Tetraspanin proteins promote multiple cancer stages | Q38186043 | ||
| Function of the tetraspanin molecule CD81 in B and T cells | Q38187573 | ||
| The rhomboid-like superfamily: molecular mechanisms and biological roles | Q38233962 | ||
| Tetraspanins at a glance. | Q38240344 | ||
| Of von Willebrand factor and platelets | Q38258281 | ||
| ADAM-family metalloproteinases in lung inflammation: potential therapeutic targets | Q38283936 | ||
| TspanC8 Tetraspanins and A Disintegrin and Metalloprotease 10 (ADAM10) Interact via Their Extracellular Regions: EVIDENCE FOR DISTINCT BINDING MECHANISMS FOR DIFFERENT TspanC8 PROTEINS. | Q38377767 | ||
| Understanding intramembrane proteolysis: from protein dynamics to reaction kinetics | Q38459056 | ||
| Deletions in the cytoplasmic domain of iRhom1 and iRhom2 promote shedding of the TNF receptor by the protease ADAM17. | Q38822173 | ||
| The tetraspanin web revisited by super-resolution microscopy | Q38852168 | ||
| Regulated proteolysis of NOTCH2 and NOTCH3 receptors by ADAM10 and presenilins | Q38993482 | ||
| The SLAM family member CD84 is regulated by ADAM10 and calpain in platelets | Q39268482 | ||
| Thiol isomerases negatively regulate the cellular shedding activity of ADAM17. | Q39722344 | ||
| Selective use of ADAM10 and ADAM17 in activation of Notch1 signaling | Q39808768 | ||
| Tetraspanins regulate ADAM10-mediated cleavage of TNF-alpha and epidermal growth factor | Q39921892 | ||
| Controlled shedding of platelet glycoprotein (GP)VI and GPIb-IX-V by ADAM family metalloproteinases. | Q40143775 | ||
| Tumor necrosis factor-alpha-converting enzyme (TACE/ADAM-17) mediates the ectodomain cleavage of intercellular adhesion molecule-1 (ICAM-1). | Q40342802 | ||
| A disintegrin-metalloproteinase prevents amyloid plaque formation and hippocampal defects in an Alzheimer disease mouse model | Q40841974 | ||
| Functional analysis of the domain structure of tumor necrosis factor-alpha converting enzyme | Q40881816 | ||
| ADAM10 cleavage of N-cadherin and regulation of cell-cell adhesion and beta-catenin nuclear signalling | Q41107179 | ||
| ADAM10 regulates endothelial permeability and T-Cell transmigration by proteolysis of vascular endothelial cadherin. | Q41840639 | ||
| Mammalian iRhoms have distinct physiological functions including an essential role in TACE regulation. | Q41936018 | ||
| iRHOM2 is a critical pathogenic mediator of inflammatory arthritis | Q42056708 | ||
| Copy number analysis of the murine platelet proteome spanning the complete abundance range | Q42209721 | ||
| ADAM17 is regulated by a rapid and reversible mechanism that controls access to its catalytic site | Q42382724 | ||
| A disintegrin and metalloprotease 10 is a novel mediator of vascular endothelial growth factor-induced endothelial cell function in angiogenesis and is associated with atherosclerosis. | Q42674129 | ||
| Inflammatory skin and bowel disease linked to ADAM17 deletion | Q43484128 | ||
| Tumor necrosis factor-alpha-converting enzyme (ADAM17) mediates GPIbalpha shedding from platelets in vitro and in vivo | Q45042577 | ||
| Tetraspanin CD151 regulates glycosylation of (alpha)3(beta)1 integrin. | Q46318751 | ||
| Tetraspanin15 regulates cellular trafficking and activity of the ectodomain sheddase ADAM10. | Q47984887 | ||
| P275 | copyright license | Creative Commons Attribution 4.0 International | Q20007257 |
| P6216 | copyright status | copyrighted | Q50423863 |
| P433 | issue | 4 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | peptide | Q172847 |
| membrane protein | Q423042 | ||
| enzyme | Q8047 | ||
| carbohydrate | Q11358 | ||
| P304 | page(s) | 333-341 | |
| P577 | publication date | 2016-06-02 | |
| P1433 | published in | Platelets | Q1573582 |
| P1476 | title | Regulation of A disintegrin and metalloproteinase (ADAM) family sheddases ADAM10 and ADAM17: The emerging role of tetraspanins and rhomboids | |
| P478 | volume | 28 |
| Q40178318 | ADAM10-Interacting Tetraspanins Tspan5 and Tspan17 Regulate VE-Cadherin Expression and Promote T Lymphocyte Transmigration |
| Q38990156 | Basic mechanisms of platelet receptor shedding |
| Q60190673 | Bisphenol-A and Nonylphenol Induce Apoptosis in Reproductive Tract Cancer Cell Lines by the Activation of ADAM17 |
| Q49228637 | CD9 Regulates Major Histocompatibility Complex Class II Trafficking in Monocyte-Derived Dendritic Cells. |
| Q61809339 | CD9 regulates keratinocyte migration by negatively modulating the sheddase activity of ADAM17 |
| Q92257614 | Differences in Shedding of the Interleukin-11 Receptor by the Proteases ADAM9, ADAM10, ADAM17, Meprin α, Meprin β and MT1-MMP |
| Q60950078 | Dynamics of Axl Receptor Shedding in Hepatocellular Carcinoma and Its Implication for Theranostics |
| Q33599723 | Ectodomain Shedding by ADAM17: Its Role in Neutrophil Recruitment and the Impairment of This Process during Sepsis |
| Q55260461 | Exploring the roles of urinary HAI-1, EpCAM & EGFR in bladder cancer prognosis & risk stratification. |
| Q51735123 | In vivo regulation of the A disintegrin and metalloproteinase 10 (ADAM10) by the tetraspanin 15. |
| Q89965577 | Modulation of Immune Responses by Platelet-Derived ADAM10 |
| Q64059020 | Novel Contribution of Secreted Amyloid-β Precursor Protein to White Matter Brain Enlargement in Autism Spectrum Disorder |
| Q89433901 | Proteolytic ectodomain shedding of membrane proteins in mammals-hardware, concepts, and recent developments |
| Q90692861 | Proteomic Analysis of Blood Exosomes from Healthy Females and Breast Cancer Patients Reveals an Association between Different Exosomal Bioactivity on Non-tumorigenic Epithelial Cell and Breast Cancer Cell Migration in Vitro |
| Q55718031 | Regulation of Leukocytes by TspanC8 Tetraspanins and the "Molecular Scissor" ADAM10. |
| Q92606408 | Relation between Tetraspanin- Associated and Tetraspanin- Non- Associated Exosomal Proteases and Metabolic Syndrome in Colorectal Cancer Patients |
| Q39376860 | Scissor sisters: regulation of ADAM10 by the TspanC8 tetraspanins. |
| Q52603837 | Sorting nexin 9 (SNX9) regulates levels of the transmembrane disintegrin and metalloproteinase (ADAM)-9 at the cell surface. |
| Q52602016 | Structural and mechanistic aspects influencing the ADAM10-mediated shedding of the prion protein. |
| Q57293856 | Synthesis and in vitro Evaluation of ADAM10 and ADAM17 Highly Selective Bioimaging Probes |
| Q55047515 | Tetraspanin CD9: A Key Regulator of Cell Adhesion in the Immune System. |
| Q47103597 | Tetraspanin Tspan9 regulates platelet collagen receptor GPVI lateral diffusion and activation. |
| Q37739091 | Tetraspanins Function as Regulators of Cellular Signaling. |
| Q90725986 | The Many and Varied Roles of Tetraspanins in Immune Cell Recruitment and Migration |
| Q91640081 | The emerging role of ADAM metalloproteinases in immunity |
| Q50047940 | The metalloprotease ADAM10 (a disintegrin and metalloprotease 10) undergoes rapid, postlysis autocatalytic degradation. |
| Q89947236 | The tetraspanin Tspan15 is an essential subunit of an ADAM10 scissor complex |
| Q46457656 | The xenoestrogens biphenol-A and nonylphenol differentially regulate metalloprotease-mediated shedding of EGFR ligands |
| Q89511180 | Tspan8-Tumor Extracellular Vesicle-Induced Endothelial Cell and Fibroblast Remodeling Relies on the Target Cell-Selective Response |
| Q57611689 | What is currently known about the genetics of venous thromboembolism at the dawn of next generation sequencing technologies |
| Q52655486 | Xenopus ADAM19 regulates Wnt signaling and neural crest specification by stabilizing ADAM13. |
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