Bone morphogenetic protein regulation of early osteoblast genes in human marrow stromal cells is mediated by extracellular signal-regulated kinase and phosphatidylinositol 3-kinase signaling

scientific article

Bone morphogenetic protein regulation of early osteoblast genes in human marrow stromal cells is mediated by extracellular signal-regulated kinase and phosphatidylinositol 3-kinase signaling is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1210/EN.2005-0303
P932PMC publication ID1237031
P698PubMed publication ID15905316
P5875ResearchGate publication ID7836889

P50authorAnna M OsyczkaQ99576390
P2093author name stringPhoebe S Leboy
P2860cites workEssential requirement of BMPs-2/4 for both osteoblast and osteoclast formation in murine bone marrow cultures from adult mice: antagonism by nogginQ22253980
Smad-dependent and Smad-independent pathways in TGF-beta family signallingQ28208250
Opposing BMP and EGF signalling pathways converge on the TGF-beta family mediator Smad1Q28251731
In vivo convergence of BMP and MAPK signaling pathways: impact of differential Smad1 phosphorylation on development and homeostasisQ28508517
A phylogenetically conserved cis-regulatory module in the Msx2 promoter is sufficient for BMP-dependent transcription in murine and Drosophila embryosQ28593486
Clinical applications of recombinant human BMPs: early experience and future developmentQ30977277
Bone morphogenetic proteins: an update on basic biology and clinical relevanceQ33604511
Bone morphogenetic proteins in human bone regenerationQ33816117
Cbfa1: a molecular switch in osteoblast biologyQ34085710
Delivering on the promise of bone morphogenetic proteinsQ34286186
Regulation of BMP-induced transcription in cultured human bone marrow stromal cellsQ34313048
One strategy for cell and gene therapy: harnessing the power of adult stem cells to repair tissues.Q34582606
Clinical evaluation of recombinant human bone morphogenetic protein-2.Q34591409
Different effects of BMP-2 on marrow stromal cells from human and rat boneQ34620442
Alkaline phosphatase knock-out mice recapitulate the metabolic and skeletal defects of infantile hypophosphatasiaQ34628935
Building a consensus regarding the nature and origin of mesenchymal stem cells.Q34669038
Impaired calcification around matrix vesicles of growth plate and bone in alkaline phosphatase-deficient miceQ35094674
Differentiation of human marrow stromal precursor cells: bone morphogenetic protein-2 increases OSF2/CBFA1, enhances osteoblast commitment, and inhibits late adipocyte maturationQ38321083
Smad4 and β-Catenin Co-activators Functionally Interact with Lymphoid-enhancing Factor to Regulate Graded Expression of Msx2Q38349379
Isolation and characterization of osteoblast precursor cells from human bone marrowQ38360786
Runx2 induces osteoblast and chondrocyte differentiation and enhances their migration by coupling with PI3K-Akt signalingQ40540364
Continuous inhibition of MAPK signaling promotes the early osteoblastic differentiation and mineralization of the extracellular matrixQ40699220
Modulation of Smad2-mediated signaling by extracellular signal-regulated kinaseQ40709028
Requirement of BMP-2-induced phosphatidylinositol 3-kinase and Akt serine/threonine kinase in osteoblast differentiation and Smad-dependent BMP-2 gene transcription.Q40722201
Effects of cortisol and bone morphogenetic protein-2 on stromal cell differentiation: correlation with CCAAT-enhancer binding protein expressionQ40733646
Involvement of ERK in BMP-2 induced osteoblastic differentiation of mesenchymal progenitor cell line C3H10T1/2.Q40899668
Effects of BMP-2, BMP-4, and BMP-6 on osteoblastic differentiation of bone marrow-derived stromal cell lines, ST2 and MC3T3-G2/PA6.Q41214960
Recombinant human bone morphogenetic protein-2 induces osteoblastic differentiation in W-20-17 stromal cellsQ41638851
Differential activation of ERK1,2 MAP kinase signaling pathway in mesenchymal stem cell from control and osteoporotic postmenopausal womenQ42463582
Adult human mesenchymal stem cell differentiation to the osteogenic or adipogenic lineage is regulated by mitogen-activated protein kinaseQ42485565
Signal transductions induced by bone morphogenetic protein-2 and transforming growth factor-beta in normal human osteoblastic cellsQ42818438
Bone morphogenetic proteins, extracellular matrix, and mitogen-activated protein kinase signaling pathways are required for osteoblast-specific gene expression and differentiation in MC3T3-E1 cellsQ42820375
Osteopontin gene regulation by oscillatory fluid flow via intracellular calcium mobilization and activation of mitogen-activated protein kinase in MC3T3-E1 osteoblastsQ42830581
Stimulation of Smad1 transcriptional activity by Ras-extracellular signal-regulated kinase pathway: a possible mechanism for collagen-dependent osteoblastic differentiationQ43866537
Inhibition of phosphatidylinositol 3-kinase and p70S6 kinase blocks osteogenic protein-1 induction of alkaline phosphatase activity in fetal rat calvaria cellsQ44369009
Cross-talk between ERK MAP kinase and Smad signaling pathways enhances TGF-beta-dependent responses in human mesangial cellsQ44489915
BMP responsiveness in human mesenchymal stem cellsQ44571257
Dexamethasone, BMP-2, and 1,25-dihydroxyvitamin D enhance a more differentiated osteoblast phenotype: validation of an in vitro model for human bone marrow-derived primary osteoblastsQ44926479
Inhibition of growth and differentiation of osteoprogenitors in mouse bone marrow stromal cell cultures by increased donor age and glucocorticoid treatmentQ44944983
Regulation of bone matrix protein expression and induction of differentiation of human osteoblasts and human bone marrow stromal cells by bone morphogenetic protein-2.Q46292279
Recombinant human bone morphogenetic protein-2 for treatment of open tibial fractures: a prospective, controlled, randomized study of four hundred and fifty patientsQ46954545
Mechanical strain differentially regulates endothelial nitric-oxide synthase and receptor activator of nuclear kappa B ligand expression via ERK1/2 MAPK.Q47807554
Global amplification polymerase chain reaction reveals novel transitional stages during osteoprogenitor differentiation.Q52107333
Insulin and IGF-I binding and tyrosine kinase activity in fish heartQ71748286
Induction of rapid osteoblast differentiation in rat bone marrow stromal cell cultures by dexamethasone and BMP-2Q72737893
Stimulatory effects of basic fibroblast growth factor and bone morphogenetic protein-2 on osteogenic differentiation of rat bone marrow-derived mesenchymal stem cellsQ73794638
Species-divergent regulation of human and mouse osteocalcin genes by calciotropic hormonesQ74008099
Osteoprogenitor cells in cell populations derived from mouse and rat calvaria differ in their response to corticosterone, cortisol, and cortisoneQ77079030
P433issue8
P407language of work or nameEnglishQ1860
P921main subjectmorphogenesisQ815547
osteoblastQ917177
P304page(s)3428-3437
P577publication date2005-05-19
P1433published inEndocrinologyQ3054009
P1476titleBone morphogenetic protein regulation of early osteoblast genes in human marrow stromal cells is mediated by extracellular signal-regulated kinase and phosphatidylinositol 3-kinase signaling
P478volume146

Reverse relations

cites work (P2860)
Q917140103D Human Periodontal Stem Cells and Endothelial Cells Promote Bone Development in Bovine Pericardium-Based Tissue Biomaterial
Q986127843D-HA Scaffold Functionalized by Extracellular Matrix of Stem Cells Promotes Bone Repair
Q57148183A biological study establishing the endotoxin limit for osteoblast and adipocyte differentiation of human mesenchymal stem cells
Q42030325A comparative analysis of the osteogenic effects of BMP-2, FGF-2, and VEGFA in a calvarial defect model.
Q51547914A single short session of media perfusion induces osteogenesis in hBMSCs cultured in porous scaffolds, dependent on cell differentiation stage.
Q36105778A specific role for phosphoinositide 3-kinase and AKT in osteoblasts?
Q34001960Age and skeletal sites affect BMP-2 responsiveness of human bone marrow stromal cells
Q34623930Akt activation is required for TGF-β1-induced osteoblast differentiation of MC3T3-E1 pre-osteoblasts
Q28511143Akt promotes BMP2-mediated osteoblast differentiation and bone development
Q34402832Atherogenic phospholipids attenuate osteogenic signaling by BMP-2 and parathyroid hormone in osteoblasts.
Q58689102Attachment and Proliferation of Human-Adipose-Tissue-Derived Stem Cells on Bioactive Glass/PVA Hybrid Scaffolds
Q37133071Avenanthramides Prevent Osteoblast and Osteocyte Apoptosis and Induce Osteoclast Apoptosis in Vitro in an Nrf2-Independent Manner
Q24328930BMP-2/4 and BMP-6/7 differentially utilize cell surface receptors to induce osteoblastic differentiation of human bone marrow-derived mesenchymal stem cells
Q47117787Bone marrow stem cells-derived extracellular matrix is a promising material
Q42003155Bone morphogenetic protein receptor in the osteogenic differentiation of rat bone marrow stromal cells
Q42314932Bone morphogenetic protein-2 enhances the osteogenic differentiation capacity of mesenchymal stromal cells derived from human bone marrow and umbilical cord.
Q50899736Bromopropane compounds inhibit osteogenesis by ERK-dependent Runx2 inhibition in C2C12 cells.
Q33749536Calcium Supplement Derived from Gallus gallus domesticus Promotes BMP-2/RUNX2/SMAD5 and Suppresses TRAP/RANK Expression through MAPK Signaling Activation
Q54658297Catechin stimulates osteogenesis by enhancing PP2A activity in human mesenchymal stem cells
Q40308276Chondrocytes utilize a cholesterol-dependent lipid translocator to externalize phosphatidylserine
Q34676851Conditional deletion of gremlin causes a transient increase in bone formation and bone mass
Q35910519Culture & differentiation of mesenchymal stem cell into osteoblast on degradable biomedical composite scaffold: In vitro study.
Q33871094Degradation, bioactivity, and osteogenic potential of composites made of PLGA and two different sol-gel bioactive glasses.
Q35748909Deletion of RBPJK in Mesenchymal Stem Cells Enhances Osteogenic Activity by Up-Regulation of BMP Signaling
Q37235621Differential alkaline phosphatase responses of rat and human bone marrow derived mesenchymal stem cells to 45S5 bioactive glass
Q35129460Distinct actions of akt1 on skeletal architecture and function
Q24314684Distinct roles for mitogen-activated protein kinase phosphatase-1 (MKP-1) and ERK-MAPK in PTH1R signaling during osteoblast proliferation and differentiation
Q34347325Effect of phosphatidyl inositol 3-kinase, extracellular signal-regulated kinases 1/2, and p38 mitogen-activated protein kinase inhibition on osteogenic differentiation of muscle-derived stem cells
Q36474269Effects of growth factors and cytokines on osteoblast differentiation.
Q38544771Enamel matrix proteins exhibit growth factor activity: A review of evidence at the cellular and molecular levels
Q42511847Enhanced osteogenesis by collagen-binding peptide from bone sialoprotein in vitro and in vivo
Q36738099Er-Xian Decoction Stimulates Osteoblastic Differentiation of Bone Mesenchymal Stem Cells in Ovariectomized Mice and Its Gene Profile Analysis.
Q35156067Estrogens attenuate oxidative stress and the differentiation and apoptosis of osteoblasts by DNA-binding-independent actions of the ERalpha
Q39899713Fibroblast growth factor receptor 2 promotes osteogenic differentiation in mesenchymal cells via ERK1/2 and protein kinase C signaling
Q36532502Function of BMPs and BMP antagonists in adult bone
Q28513627Gain-of-function mutation in FGFR3 in mice leads to decreased bone mass by affecting both osteoblastogenesis and osteoclastogenesis
Q42218264Guiding the osteogenic fate of mouse and human mesenchymal stem cells through feedback system control.
Q35563597Inhibited Wnt signaling causes age-dependent abnormalities in the bone matrix mineralization in the Apert syndrome FGFR2(S252W/+) mice
Q35229856Insulin-like growth factor 2 (IGF-2) potentiates BMP-9-induced osteogenic differentiation and bone formation
Q46740122Insulin-like growth factor-II regulates bone sialoprotein gene transcription
Q36629298Insulin-like growth factor-binding protein-5 inhibits osteoblast differentiation and skeletal growth by blocking insulin-like growth factor actions
Q38964544Involvement of the phosphoinositide 3-kinase/Akt signaling pathway in bone morphogenetic protein 9-stimulated osteogenic differentiation and stromal cell-derived factor 1 production in human periodontal ligament fibroblasts.
Q39786755Limited but heterogeneous osteogenic response of human bone marrow mesenchymal stem cells to bone morphogenetic protein-2 and serum
Q35423697Lung tumor-associated osteoblast-derived bone morphogenetic protein-2 increased epithelial-to-mesenchymal transition of cancer by Runx2/Snail signaling pathway
Q38958525Magnesium Ions Promote the Biological Behaviour of Rat Calvarial Osteoblasts by Activating the PI3K/Akt Signalling Pathway
Q42374637Multipathway kinase signatures of multipotent stromal cells are predictive for osteogenic differentiation: tissue-specific stem cells
Q35051315Multiple signaling pathways converge to regulate bone-morphogenetic-protein-dependent glial gene expression
Q47156422Negative pressure wound therapy promotes muscle-derived stem cell osteogenic differentiation through MAPK pathway.
Q28302174Nephroblastoma overexpressed (Nov) inhibits osteoblastogenesis and causes osteopenia
Q50540613Neurotrophin-3 Induces BMP-2 and VEGF Activities and Promotes the Bony Repair of Injured Growth Plate Cartilage and Bone in Rats.
Q34323226O45-regulation of osteoblast differentiation and ECM remodeling by Bmp2/4 in vitro
Q36804660Osteogenic differentiation of human marrow-derived mesenchymal stem cells
Q34937131Osteoinductive activity of insulin-functionalized cell culture surfaces obtained using diazonium chemistry
Q42472286Osteoporosis-associated alteration in the signalling status of BMP-2 in human MSCs under adipogenic conditions
Q39926569PI3K/Akt-dependent transcriptional regulation and activation of BMP-2-Smad signaling by NF-kappaB in metastatic prostate cancer cells
Q38816459Pathogenesis of ligaments ossification in spondyloarthritis: insights and doubts
Q92348210Phloretin Suppresses Bone Morphogenetic Protein-2-Induced Osteoblastogenesis and Mineralization via Inhibition of Phosphatidylinositol 3-kinases/Akt Pathway
Q50051115Photocrosslinked ultrathin anionic polysaccharide supports for accelerated growth of human mesenchymal stem cells
Q47120342Piezo type mechanosensitive ion channel component 1 functions as a regulator of the cell fate determination of mesenchymal stem cells.
Q34579496Preconditioning Human Mesenchymal Stem Cells with a Low Concentration of BMP2 Stimulates Proliferation and Osteogenic Differentiation In Vitro
Q39616703Proliferative and mineralogenic effects of insulin, IGF-1, and vanadate in fish osteoblast-like cells
Q54651402Protective effect of quercitrin against hydrogen peroxide-induced dysfunction in osteoblastic MC3T3-E1 cells
Q50995238Proteomic identification of differently expressed proteins responsible for osteoblast differentiation from human mesenchymal stem cells.
Q36025982Regulation of Immunity via Multipotent Mesenchymal Stromal Cells
Q38884628Regulation of Osteoblast Migration Involving Receptor Activator of Nuclear Factor-kappa B (RANK) Signaling.
Q35665655Selective signaling by Akt1 controls osteoblast differentiation and osteoblast-mediated osteoclast development
Q33887388Shear stress induces osteogenic differentiation of human mesenchymal stem cells
Q38515510Simulated microgravity inhibits the proliferation and osteogenesis of rat bone marrow mesenchymal stem cells
Q49621194TNF-α inhibits SATB2 expression and osteoblast differentiation through NF-κB and MAPK pathways
Q37778399Targeting miRNAs in osteoblast differentiation and bone formation
Q92862832Taurine Activates BMP-2/Wnt3a-Mediated Osteoblast Differentiation and Mineralization via Akt and MAPK Signaling
Q48214627The Effects of BMP-2, miR-31, miR-106a, and miR-148a on Osteogenic Differentiation of MSCs Derived from Amnion in Comparison with MSCs Derived from the Bone Marrow
Q37588577The insulin-like growth factor (IGF) receptor type 1 (IGF1R) as an essential component of the signalling network regulating neurogenesis
Q42321250The osteogenic differentiation of human bone marrow MSCs on HUVEC-derived ECM and β-TCP scaffold
Q38316849Transcriptional regulation of the osterix (Osx, Sp7) promoter by tumor necrosis factor identifies disparate effects of mitogen-activated protein kinase and NF kappa B pathways
Q34787325p85alpha regulates osteoblast differentiation by cross-talking with the MAPK pathway

Search more.