NCCTG Study N9741: leveraging learning from an NCI Cooperative Group phase III trial.

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NCCTG Study N9741: leveraging learning from an NCI Cooperative Group phase III trial. is …
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scholarly articleQ13442814

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P356DOI10.1634/THEONCOLOGIST.2009-0175
P932PMC publication ID2917613
P698PubMed publication ID19828593
P5875ResearchGate publication ID38011072

P50authorDaniel J. SargentQ43055483
Hanna K SanoffQ89113920
P2093author name stringHoward McLeod
Richard M Goldberg
Erin Green
Roscoe F Morton
Jan Buckner
P2860cites workEarly detection of toxicity and adjustment of ongoing clinical trials: the history and performance of the North Central Cancer Treatment Group's real-time toxicity monitoring programQ35009894
Racial differences in advanced colorectal cancer outcomes and pharmacogenetics: a subgroup analysis of a large randomized clinical trial.Q37325078
A phase I study of sequential irinotecan and 5-fluorouracil/leucovorinQ44177901
Survival of patients with advanced colorectal cancer improves with the availability of fluorouracil-leucovorin, irinotecan, and oxaliplatin in the course of treatmentQ44820379
Cost-effectiveness projections of oxaliplatin and infusional fluorouracil versus irinotecan and bolus fluorouracil in first-line therapy for metastatic colorectal carcinomaQ44913737
Impact of complete response to chemotherapy on overall survival in advanced colorectal cancer: results from Intergroup N9741.Q44916555
Mortality associated with daily bolus 5-fluorouracil/leucovorin administered in combination with either irinotecan or oxaliplatin: results from Intergroup Trial N9741.Q45095320
Chemotherapy permits resection of metastatic colorectal cancer: experience from Intergroup N9741.Q45242224
Response-independent survival benefit in metastatic colorectal cancer: a comparative analysis of N9741 and AVF2107.Q46817228
Associations between plasma insulin-like growth factor proteins and C-peptide and quality of life in patients with metastatic colorectal cancerQ53294514
Randomized controlled trial of reduced-dose bolus fluorouracil plus leucovorin and irinotecan or infused fluorouracil plus leucovorin and oxaliplatin in patients with previously untreated metastatic colorectal cancer: a North American Intergroup TriQ79930433
Updated efficacy and toxicity analysis of irinotecan and oxaliplatin (IROX) : intergroup trial N9741 in first-line treatment of metastatic colorectal cancerQ80455371
Irinotecan fluorouracil plus leucovorin is not superior to fluorouracil plus leucovorin alone as adjuvant treatment for stage III colon cancer: results of CALGB 89803Q80768425
UGT1A1*28 genotype and irinotecan-induced neutropenia: dose mattersQ80865711
Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancerQ27860681
FOLFIRI followed by FOLFOX6 or the reverse sequence in advanced colorectal cancer: a randomized GERCOR studyQ28189472
Dealing with a deluge of data: an assessment of adverse event data on North Central Cancer Treatment Group trialsQ31026840
Rapid reporting and review of an increased incidence of a known adverse eventQ33180566
Pooled analysis of safety and efficacy of oxaliplatin plus fluorouracil/leucovorin administered bimonthly in elderly patients with colorectal cancerQ33372496
Five-year data and prognostic factor analysis of oxaliplatin and irinotecan combinations for advanced colorectal cancer: N9741Q33383727
Pooled safety and efficacy analysis examining the effect of performance status on outcomes in nine first-line treatment trials using individual data from patients with metastatic colorectal cancerQ33414068
Plasma insulin-like growth factors, insulin-like binding protein-3, and outcome in metastatic colorectal cancer: results from intergroup trial N9741.Q33791812
Phase III multicenter randomized trial of oxaliplatin added to chronomodulated fluorouracil-leucovorin as first-line treatment of metastatic colorectal cancerQ33810043
Cost implications of new treatments for advanced colorectal cancer.Q33874203
Leucovorin and fluorouracil with or without oxaliplatin as first-line treatment in advanced colorectal cancerQ33913953
Evaluation of the optimal number of lesions needed for tumor evaluation using the response evaluation criteria in solid tumors: a north central cancer treatment group investigation.Q34049406
A randomized controlled trial of fluorouracil plus leucovorin, irinotecan, and oxaliplatin combinations in patients with previously untreated metastatic colorectal cancer.Q34282412
Mortality associated with irinotecan plus bolus fluorouracil/leucovorin: summary findings of an independent panelQ34371152
Irinotecan plus fluorouracil and leucovorin for metastatic colorectal cancer. Irinotecan Study GroupQ34511070
P433issue10
P921main subjectphase III clinical trialQ42824827
P304page(s)970-978
P577publication date2009-10-14
P13046publication type of scholarly workreview articleQ7318358
P1433published inOncologistQ2122327
P1476titleNCCTG Study N9741: leveraging learning from an NCI Cooperative Group phase III trial
P478volume14

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cites work (P2860)
Q35689948Adding a treatment arm to an ongoing clinical trial: a review of methodology and practice
Q39628955Beyond Composite Endpoints Analysis: Semicompeting Risks as an Underutilized Framework for Cancer Research
Q35623336Chemoresistant colorectal cancer cells and cancer stem cells mediate growth and survival of bystander cells
Q30416509Data for cancer comparative effectiveness research: past, present, and future potential
Q47257299Mortality within 30 days of receiving systemic anti-cancer therapy at a regional oncology unit: what have we learned?
Q37325674Patient-Reported Outcome Measures in Safety Event Reporting: PROSPER Consortium guidance
Q34716556Resampling the N9741 trial to compare tumor dynamic versus conventional end points in randomized phase II trials
Q48522724Use of Patient-Reported Outcomes to Improve the Predictive Accuracy of Clinician-Reported Adverse Events

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