Updated efficacy and toxicity analysis of irinotecan and oxaliplatin (IROX) : intergroup trial N9741 in first-line treatment of metastatic colorectal cancer

scientific article published on 01 August 2007

Updated efficacy and toxicity analysis of irinotecan and oxaliplatin (IROX) : intergroup trial N9741 in first-line treatment of metastatic colorectal cancer is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1002/CNCR.22831
P698PubMed publication ID17559146

P50authorDaniel J. SargentQ43055483
Charles S. FuchsQ88762246
Steven R AlbertsQ88846398
Axel GrotheyQ92828335
Stephen WilliamsonQ98617101
Henry C PitotQ107054204
Roscoe F MortonQ117264216
Ramesh K RamanathanQ117264217
Brian P FindlayQ117264218
P2093author name stringRichard M Goldberg
Megan E Campbell
Amanda C Ashley
P2860cites workCancer statistics, 2006Q29615133
Combination of oxaliplatin plus irinotecan in patients with gastrointestinal tumors: results of two independent phase I studies with pharmacokineticsQ33330597
Pooled analysis of safety and efficacy of oxaliplatin plus fluorouracil/leucovorin administered bimonthly in elderly patients with colorectal cancerQ33372496
Chemotherapy in elderly patients with colorectal cancerQ34277764
A randomized controlled trial of fluorouracil plus leucovorin, irinotecan, and oxaliplatin combinations in patients with previously untreated metastatic colorectal cancer.Q34282412
Treatment of colorectal cancer in the elderly: a review of the literatureQ36335597
Elderly patients with fluoropyrimidine and thymidylate synthase inhibitor-resistant advanced colorectal cancer derive similar benefit without excessive toxicity when treated with irinotecan monotherapyQ36695795
A pooled analysis of adjuvant chemotherapy for resected colon cancer in elderly patientsQ43763447
Combination of irinotecan (CPT-11) plus oxaliplatin (L-OHP) as first-line treatment in locally advanced or metastatic gastric cancer: a multicentre phase II trialQ44995389
5-Fluorouracil-based chemotherapy for advanced colorectal cancer in elderly patients: a north central cancer treatment group studyQ45233228
Chemotherapy permits resection of metastatic colorectal cancer: experience from Intergroup N9741.Q45242224
INK4/ARF germline alterations in pancreatic cancer patients.Q54737226
Combined irinotecan and oxaliplatin plus granulocyte colony-stimulating factor in patients with advanced fluoropyrimidine/leucovorin-pretreated colorectal cancerQ74593436
A multicenter, phase II trial of weekly irinotecan (CPT-11) in patients with previously treated colorectal carcinomaQ74635392
P433issue3
P921main subjectcolorectal cancerQ188874
irinotecanQ412197
oxaliplatinQ422327
colorectal carcinomaQ25493920
metastatic colon cancerQ108566365
P304page(s)670-677
P577publication date2007-08-01
P1433published inCancerQ326041
P1476titleUpdated efficacy and toxicity analysis of irinotecan and oxaliplatin (IROX) : intergroup trial N9741 in first-line treatment of metastatic colorectal cancer
P478volume110

Reverse relations

cites work (P2860)
Q37422341Adjuvant colon cancer chemotherapy: Is there an Indian standard of care?
Q99612013Amifostine protects from the peripheral sensory neuropathy induced by oxaliplatin in mice
Q50041173An Update on Randomized Clinical Trials in Metastatic Colorectal Carcinoma
Q33693186Effect of glutathione combined with cisplatin and oxaliplatin on the proliferation and apoptosis of lung carcinoma cell line
Q34048515Leveraging learning from a phase III colorectal cancer clinical trial: outcomes, methodology, meta-analysis and pharmacogenetics
Q34050521NCCTG Study N9741: leveraging learning from an NCI Cooperative Group phase III trial.
Q82032854Phase III trial of irinotecan plus infusional 5-fluorouracil/folinic acid versus irinotecan plus oxaliplatin as first-line treatment of advanced colorectal cancer
Q33384513Pilot study of irinotecan/oxalipltin (IROX) combination chemotherapy for patients with gemcitabine- and 5-fluorouracil- refractory pancreatic cancer
Q37118862Platinum neurotoxicity pharmacogenetics
Q27021105Review of systemic therapies for locally advanced and metastatic rectal cancer
Q37663255Selective use of adjuvant chemotherapy for rectal cancer patients with ypN0.
Q36061168Tegafur-uracil is a safe alternative for the treatment of colorectal cancer in patients with partial dihydropyrimidine dehydrogenase deficiency: a proof of principle.
Q37402459UGT1A1 gene polymorphism: impact on toxicity and efficacy of irinotecan-based regimens in metastatic colorectal cancer

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