The number of patients and events required to limit the risk of overestimation of intervention effects in meta-analysis--a simulation study

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The number of patients and events required to limit the risk of overestimation of intervention effects in meta-analysis--a simulation study is …
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scholarly articleQ13442814

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P819ADS bibcode2011PLoSO...625491T
P356DOI10.1371/JOURNAL.PONE.0025491
P932PMC publication ID3196500
P698PubMed publication ID22028777
P5875ResearchGate publication ID51746701

P50authorGordon GuyattQ5585214
Philip James DevereauxQ54067726
Georgina ImbergerQ114426379
Christian GluudQ26265142
Jørn WetterslevQ28037207
Lehana ThabaneQ28320748
Kristian ThorlundQ30089886
P2093author name stringMichael Walsh
Rong Chu
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Effect sizes in cumulative meta-analyses of mental health randomized trials evolved over time.Q51934574
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The fading of reported effectiveness. A meta-analysis of randomised controlled trialsQ30814884
Apparently conclusive meta-analyses may be inconclusive--Trial sequential analysis adjustment of random error risk due to repetitive testing of accumulating data in apparently conclusive neonatal meta-analysesQ33372680
Estimating required information size by quantifying diversity in random-effects model meta-analyses.Q33521365
How strong is the evidence for the use of perioperative beta blockers in non-cardiac surgery? Systematic review and meta-analysis of randomised controlled trialsQ36183773
Trial sequential analysis reveals insufficient information size and potentially false positive results in many meta-analysesQ37138228
Statistically significant meta-analyses of clinical trials have modest credibility and inflated effectsQ37859975
Cumulative meta-analysis of clinical trials builds evidence for exemplary medical care.Q40590984
Cumulating evidence from randomized trials: utilizing sequential monitoring boundaries for cumulative meta-analysisQ43471039
Can trial sequential monitoring boundaries reduce spurious inferences from meta-analyses?Q43707230
Updating meta-analyses leads to larger type I errors than publication biasQ43783542
Sequential meta-analysis: an efficient decision-making toolQ45771351
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue10
P407language of work or nameEnglishQ1860
P921main subjectpatientQ181600
meta-analysisQ815382
P304page(s)e25491
P577publication date2011-10-18
P1433published inPLOS OneQ564954
P1476titleThe number of patients and events required to limit the risk of overestimation of intervention effects in meta-analysis--a simulation study
P478volume6

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