Trial sequential analysis reveals insufficient information size and potentially false positive results in many meta-analyses

scientific article published on 14 April 2008

Trial sequential analysis reveals insufficient information size and potentially false positive results in many meta-analyses is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.JCLINEPI.2007.10.007
P698PubMed publication ID18411040
P5875ResearchGate publication ID5441727

P50authorJørn WetterslevQ28037207
Kristian ThorlundQ30089886
Jesper Sune BrokQ97686044
Christian GluudQ26265142
P2860cites workWhy most published research findings are falseQ21092395
P433issue8
P921main subjectmeta-analysisQ815382
P304page(s)763-769
P577publication date2008-04-14
P1433published inJournal of Clinical EpidemiologyQ6294959
P1476titleTrial sequential analysis reveals insufficient information size and potentially false positive results in many meta-analyses
P478volume61

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cites work (P2860)
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Q47783772CDH1 promoter methylation in patients with cervical carcinoma: a systematic meta-analysis with trial sequential analysis
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Q37465301Carotid artery stenting versus no stenting assisting thrombectomy for acute ischaemic stroke: protocol for a systematic review of randomised clinical trials with meta-analyses and trial sequential analyses
Q38714410Cell therapy for heart disease: Trial sequential analyses of two Cochrane reviews
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Q26471135Central venous catheter (CVC) removal for patients of all ages with candidaemia
Q24201014Chinese herbal medicines for adverse events of transarterial chemoembolization in patients with primary liver cancer
Q49958853Cinacalcet versus Placebo for secondary hyperparathyroidism in chronic kidney disease patients: a meta-analysis of randomized controlled trials and trial sequential analysis.
Q94398304Citicoline for treating people with acute ischemic stroke
Q57389443Clevudine in people with chronic hepatitis B virus infection
Q89129563Closure, Anticoagulation, or Antiplatelet Therapy for Cryptogenic Stroke With Patent Foramen Ovale: Systematic Review of Randomized Trials, Sequential Meta-Analysis, and New Insights From the CLOSE Study
Q36203718Cognitive computer training in children with attention deficit hyperactivity disorder (ADHD) versus no intervention: study protocol for a randomized controlled trial
Q47997975Combination of Bone Graft and Resorbable Membrane for Alveolar Ridge Preservation: a Systematic Review, Meta-analysis and Trial Sequential Analysis.
Q26471711Combination of three-dimensional conformal radiotherapy and transcatheter arterial chemoembolisation versus transcatheter arterial chemoembolisation for primary hepatocellular carcinoma
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Q24185958Continued lamivudine for adults with lamivudine-resistant chronic hepatitis B virus infection
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Q24198839Diets for primary prevention of gallbladder stones in adults
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Q36133957Effects of Steroids on Quality of Recovery and Adverse Events after General Anesthesia: Meta-Analysis and Trial Sequential Analysis of Randomized Clinical Trials
Q37952446Effects of cognitive therapy versus interpersonal psychotherapy in patients with major depressive disorder: a systematic review of randomized clinical trials with meta-analyses and trial sequential analyses
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Q28070326Efficacy and safety of daptomycin for skin and soft tissue infections: a systematic review with trial sequential analysis
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Q38844123Efficacy of Short-Term Antiarrhythmic Drugs Use after Catheter Ablation of Atrial Fibrillation-A Systematic Review with Meta-Analyses and Trial Sequential Analyses of Randomized Controlled Trials
Q24202672Electro-coagulation for liver metastases
Q94328073Emtricitabine for adults with lamivudine‐resistant chronic hepatitis B virus infection
Q24200230Endoscopic injection of cyanoacrylate glue versus other endoscopic procedures for acute bleeding gastric varices in patients with portal hypertension
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Q33521365Estimating required information size by quantifying diversity in random-effects model meta-analyses.
Q33710053Evidence at a glance: error matrix approach for overviewing available evidence
Q26826957Exercise and BMI in Overweight and Obese Children and Adolescents: A Systematic Review and Trial Sequential Meta-Analysis
Q37187917Exercise for lower limb osteoarthritis: systematic review incorporating trial sequential analysis and network meta-analysis.
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Q94400191Exercise interventions for adults after liver transplantation
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Q94338143Extended‐release methylphenidate for attention deficit hyperactivity disorder (ADHD) in adults
Q24194024External beam radiotherapy for unresectable hepatocellular carcinoma
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Q24200171Fibrinogen concentrate in bleeding patients
Q24236341Fibrinogen concentrate in severely bleeding patients for acquired hypofibrinogenaemia
Q42074114Firm evidence of complete revascularization with culprit and target vessel revascularization only after ST-segment elevation myocardial infarction.
Q24201435Flow-regulated versus differential pressure-regulated shunt valves for adult patients with normal pressure hydrocephalus
Q24202666Flow-regulated versus differential pressure-regulated shunt valves for adult patients with normal pressure hydrocephalus
Q24200209Formal education of patients about to undergo laparoscopic cholecystectomy
Q36410996Gases for establishing pneumoperitoneum during laparoscopic abdominal surgery.
Q36406224Gastrointestinal adverse events during methylphenidate treatment of children and adolescents with attention deficit hyperactivity disorder: A systematic review with meta-analysis and Trial Sequential Analysis of randomised clinical trials
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Q57211742Gemcitabine-based chemotherapy for advanced biliary tract carcinomas
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Q24194975Glucocorticosteroid-free versus glucocorticosteroid-containing immunosuppression for liver transplanted patients
Q53279063Glucocorticosteroid-free versus glucocorticosteroid-containing immunosuppression for liver transplanted patients.
Q57689297Glucocorticosteroids for infants with biliary atresia following Kasai portoenterostomy
Q92967670Glucocorticosteroids for people with alcoholic hepatitis
Q26471655Glucocorticosteroids for people with alcoholic hepatitis
Q47548940Glucocorticosteroids for people with alcoholic hepatitis.
Q24197997Granulocyte-colony stimulating factor for acute liver failure or acute-on-chronic liver failure
Q94400582Granulocyte‐colony stimulating factor for acute liver failure or acute‐on‐chronic liver failure
Q60644249Hallucinations and other psychotic symptoms in response to methylphenidate in children and adolescents with attention-deficit/hyperactivity disorder: a Cochrane systematic review with meta-analysis and trial sequential analysis#
Q24202104Hepatitis A immunisation in persons not previously exposed to hepatitis A
Q24198922Hepatitis B immune globulin for preventing hepatitis B recurrence after liver transplantation
Q37854837Hepato-biliary clinical trials and their inclusion in the Cochrane Hepato-Biliary Group register and reviews
Q24200256Herbal medicines for fatty liver diseases
Q24236298Herbal medicines for fatty liver diseases
Q58040893Higher versus lower inspiratory oxygen fraction or targets of arterial oxygenation for adult intensive care patients
Q26991636Holmium laser enucleation versus transurethral resection in patients with benign prostate hyperplasia: an updated systematic review with meta-analysis and trial sequential analysis
Q24186605Homocysteine-lowering interventions for preventing cardiovascular events
Q24201783Homocysteine-lowering interventions for preventing cardiovascular events
Q38620630Homocysteine-lowering interventions for preventing cardiovascular events.
Q24234575Hormone replacement for osteoporosis in women with primary biliary cirrhosis
Q24202128Human recombinant protein C for severe sepsis and septic shock in adult and paediatric patients
Q22306541Hydroxyethyl starch 130/0.38-0.45 versus crystalloid or albumin in patients with sepsis: systematic review with meta-analysis and trial sequential analysis
Q24197641Illness management and recovery programme for people with severe mental illness
Q38271502Impact of closed versus open tracheal suctioning systems for mechanically ventilated adults: a systematic review and meta-analysis.
Q47177161Impact of heterogeneity and effect size on the estimation of the optimal information size: analysis of recently published meta-analyses
Q37943221In deep cavities stepwise excavation of caries can preserve the pulp
Q92802225Incidence and Risk of Fatal Adverse Events in Cancer Patients Treated With Vascular Endothelial Growth Factor Receptor 2-Targeted Agents: A Meta-Analysis With Trial Sequential Analysis of Randomized Controlled Trials
Q92343154Incidences of obstetric outcomes and sample size calculations: A Danish national registry study based on all deliveries from 2008 to 2015
Q24234177Inhaled nitric oxide for acute respiratory distress syndrome (ARDS) and acute lung injury in children and adults
Q92286721Intensive follow-up strategies after radical surgery for nonmetastatic colorectal cancer: A systematic review and meta-analysis of randomized controlled trials
Q34083400Intensive glycaemic control for patients with type 2 diabetes: systematic review with meta-analysis and trial sequential analysis of randomised clinical trials
Q24187640Interferon alpha versus any other drug for chronic hepatitis D
Q24201588Interferon for interferon nonresponding and relapsing patients with chronic hepatitis C
Q24185973Interferon for people with lamivudine-resistant chronic hepatitis B virus infection
Q55095941Intermittent furosemide administration in patients with or at risk for acute kidney injury: Meta-analysis of randomized trials.
Q39834471Interpreting meta-analysis according to the adequacy of sample size. An example using isoniazid chemoprophylaxis for tuberculosis in purified protein derivative negative HIV-infected individuals
Q40468855Interpreting trial sequential analysis.
Q92547410Interventional radiology versus operative management for splenic injuries: a study protocol for a systematic review and meta-analysis
Q50104614Interventions for paracetamol (acetaminophen) overdose
Q24187279Interventions for treating intrahepatic cholestasis in people with sickle cell disease
Q24200803Interventions for treating intrahepatic cholestasis in people with sickle cell disease
Q38651517Interventions for treating intrahepatic cholestasis in people with sickle cell disease.
Q99561499Interventions for treatment of COVID-19: A living systematic review with meta-analyses and trial sequential analyses (The LIVING Project)
Q94585433Interventions for treatment of COVID-19: a protocol for a living systematic review with network meta-analysis including individual patient data (The LIVING Project)
Q24198254Interventions to increase physical activity for people with congenital heart disease
Q36309524Intra-articular Steroid Injection for Frozen Shoulder: A Systematic Review and Meta-analysis of Randomized Controlled Trials With Trial Sequential Analysis
Q40187092Intraoperative ketamine for prevention of postoperative delirium or pain after major surgery in older adults: an international, multicentre, double-blind, randomised clinical trial
Q24197964Intraperitoneal local anaesthetic instillation versus no intraperitoneal local anaesthetic instillation for laparoscopic cholecystectomy
Q24198851Isoprinosine for chronic hepatitis B
Q24198159Isoprinosine versus other antiviral drugs for chronic hepatitis B
Q35766551Issues in assessing products for the treatment of hemophilia - the intersection between efficacy, economics, and ethics.
Q61804635Ivabradine for coronary artery disease and/or heart failure-a protocol for a systematic review of randomised clinical trials with meta-analysis and Trial Sequential Analysis
Q24198134Laparoscopic surgical box model training for surgical trainees with limited prior laparoscopic experience
Q24198218Laparoscopic surgical box model training for surgical trainees with limited prior laparoscopic experience
Q24198149Laparoscopic surgical box model training for surgical trainees with no prior laparoscopic experience
Q24201098Laparoscopic surgical box model training for surgical trainees with no prior laparoscopic experience
Q24200196Laparoscopic versus open liver resection for benign and malignant hepatic lesions in adults
Q24202912Laparoscopic versus open liver resection for benign and malignant hepatic lesions in adults
Q24198100Laparoscopic-endoscopic rendezvous versus preoperative endoscopic sphincterotomy for common bile duct stones in patients undergoing laparoscopic cholecystectomy
Q53279390Laparoscopic-endoscopic rendezvous versus preoperative endoscopic sphincterotomy in people undergoing laparoscopic cholecystectomy for stones in the gallbladder and bile duct.
Q64104076Leukodepleted Packed Red Blood Cells Transfusion in Patients Undergoing Major Cardiovascular Surgical Procedure: Systematic Review and Meta-Analysis
Q24236771Levamisole for chronic hepatitis B
Q38752412Long-term cardiovascular mortality after radiotherapy for breast cancer: A systematic review and meta-analysis
Q24197916Low pressure versus standard pressure pneumoperitoneum in laparoscopic cholecystectomy
Q64949560Low-Dose Aspirin for the Primary Prevention of Cardiovascular Disease in Diabetic Individuals: A Meta-Analysis of Randomized Control Trials and Trial Sequential Analysis.
Q64247185Low-Volume Polyethylene Glycol Improved Patient Attendance in Bowel Preparation Before Colonoscopy: A Meta-Analysis With Trial Sequential Analysis
Q37696578Lower pill burden and once-daily antiretroviral treatment regimens for HIV infection: A meta-analysis of randomized controlled trials
Q38637757Lower vs. higher fluid volumes in sepsis-protocol for a systematic review with meta-analysis
Q41841188Mesh fixation methods in open inguinal hernia repair: a protocol for network meta-analysis and trial sequential analysis of randomised controlled trials
Q35610008Meta- analysis and meta-regression analysis of the associations between sex and the operative outcomes of carotid endarterectomy
Q51737212Meta-analysis of CDKN2A methylation to find its role in prostate cancer development and progression, and also to find the effect of CDKN2A expression on disease-free survival (PRISMA).
Q49671805Meta-analysis of sutureless technology versus standard aortic valve replacement and transcatheter aortic valve replacement
Q42700715Meta-analysis reveals gender difference in the association of liver cancer incidence and excess BMI.
Q21090716Meta-regression analyses, meta-analyses, and trial sequential analyses of the effects of supplementation with beta-carotene, vitamin A, and vitamin E singly or in different combinations on all-cause mortality: do we have evidence for lack of harm?
Q37788646Meta‐analysis: ribavirin plus interferon vs. interferon monotherapy for chronic hepatitic C – an updated Cochrane review
Q24197870Methods of intraperitoneal local anaesthetic instillation for laparoscopic cholecystectomy
Q24198063Methods of preventing bacterial sepsis and wound complications after liver transplantation
Q24198192Methylphenidate for attention deficit hyperactivity disorder (ADHD) in children and adolescents
Q27007856Methylphenidate for attention-deficit/hyperactivity disorder in children and adolescents: Cochrane systematic review with meta-analyses and trial sequential analyses of randomised clinical trials
Q22061981Methylphenidate for children and adolescents with attention deficit hyperactivity disorder (ADHD)
Q24197493Microwave coagulation for liver metastases
Q24199085Microwave coagulation for liver metastases
Q24200630Miniports versus standard ports for laparoscopic cholecystectomy
Q94327375Modified dietary fat intake for treatment of gallstone disease
Q24186061N-acetylcysteine for non-paracetamol (acetaminophen)-related acute liver failure
Q47352340New FIGO and Swedish intrapartum cardiotocography classification systems incorporated in the fetal ECG ST analysis (STAN) interpretation algorithm: agreements and discrepancies in cardiotocography classification and evaluation of significant ST even
Q24197485Nitazoxanide for chronic hepatitis C
Q24234215Nitazoxanide for chronic hepatitis C virus infection
Q24186673Non-acute percutaneous coronary intervention versus medical therapy in patients with ischaemic heart disease
Q24186648Non-invasive positive pressure ventilation for acute asthma in children
Q34541515Non-invasive positive pressure ventilation for acute asthma in children.
Q35650348Non-vitamin K antagonist oral anticoagulants and major bleeding-related fatality in patients with atrial fibrillation and venous thromboembolism: a systematic review and meta-analysis.
Q47918560Non-vitamin K antagonist oral anticoagulants in patients with atrial fibrillation and valvular heart disease: systematic review and meta-analysis
Q24187602Nutrition support in hospitalised adults at nutritional risk
Q36376463Nutrition support in hospitalised adults at nutritional risk.
Q24197811Nutritional support for liver disease
Q24240249Nutritional support for liver disease
Q24202688Omega-3 polyunsaturated fatty acids for non-alcoholic fatty liver disease
Q38808716Ondansetron for neuraxial morphine-induced pruritus: A meta-analysis of randomized controlled trials
Q51167432Open versus endovascular stent graft repair of abdominal aortic aneurysms: do we need more randomized clinical trials?
Q24241082Open, small-incision, or laparoscopic cholecystectomy for patients with symptomatic cholecystolithiasis. An overview of Cochrane Hepato-Biliary Group reviews
Q35739731Oral Motor Intervention Improved the Oral Feeding in Preterm Infants: Evidence Based on a Meta-Analysis With Trial Sequential Analysis.
Q38730748Patient-controlled analgesia with remifentanil versus alternative parenteral methods for pain management in labour
Q34100819Peginterferon alpha-2a is associated with higher sustained virological response than peginterferon alfa-2b in chronic hepatitis C: systematic review of randomized trials
Q24200197Peginterferon alpha-2a versus peginterferon alpha-2b for chronic hepatitis C
Q24200189Peginterferon plus ribavirin versus interferon plus ribavirin for chronic hepatitis C
Q24240315Pegylated interferon alpha 2a versus pegylated interferon alpha 2b for chronic hepatitis C
Q24241360Pegylated interferon plus ribavirin versus non-pegylated interferon plus ribavirin for chronic hepatitis C
Q24240223Pentoxifylline for alcoholic hepatitis
Q24200456Percutaneous cholecystostomy for high-risk surgical patients with acute calculous cholecystitis
Q47164618Percutaneous coronary intervention versus cardiac bypass surgery for left main coronary artery disease: A trial sequential analysis
Q24202714Percutaneous ethanol injection for liver metastases
Q89527361Percutaneous ethanol injection for liver metastases
Q24186496Percutaneous ethanol injection or percutaneous acetic acid injection for early hepatocellular carcinoma
Q94400195Perioperative antioxidants for adults undergoing elective non‐cardiac surgery
Q37326885Perioperative beta blockers in patients having non-cardiac surgery: a meta-analysis
Q39206633Perioperative intravenous glucocorticoids can decrease postoperative nausea and vomiting and pain in total joint arthroplasty: A meta-analysis and trial sequence analysis
Q37010831Perioperative oxygen fraction - effect on surgical site infection and pulmonary complications after abdominal surgery: a randomized clinical trial. Rationale and design of the PROXI-Trial
Q59129247Perioperative statin therapy in cardiac and non-cardiac surgery: a systematic review and meta-analysis of randomized controlled trials
Q38786993Perioperative statin therapy in cardiac surgery: a meta-analysis of randomized controlled trials
Q24186909Pharmacological interventions for benzodiazepine discontinuation in chronic benzodiazepine users
Q57689410Pharmacological interventions for benzodiazepine discontinuation in chronic benzodiazepine users
Q36214472Pharmacological interventions for delirium in intensive care patients: a protocol for an overview of reviews
Q94348315Pharmacological interventions for people with borderline personality disorder
Q24197827Pharmacological interventions for prevention or treatment of postoperative pain in people undergoing laparoscopic cholecystectomy
Q24198275Pharmacological interventions for the primary prevention of gallbladder stones in adults
Q24186750Pharmacotherapy for hypertension-induced left ventricular hypertrophy
Q24197858Phyllanthus species versus antiviral drugs for chronic hepatitis B virus infection
Q35686476Plasmakinetic resection technology for the treatment of benign prostatic hyperplasia: evidence from a systematic review and meta-analysis
Q24194031Positive end-expiratory pressure (PEEP) during anaesthesia for prevention of mortality and postoperative pulmonary complications
Q24235298Positive end-expiratory pressure (PEEP) during anaesthesia for the prevention of mortality and postoperative pulmonary complications
Q24240820Positive end-expiratory pressure (PEEP) during anaesthesia for the prevention of mortality and postoperative pulmonary complications
Q24187631Postdischarge interventions for depression
Q24236024Postexposure vaccines for hepatitis A
Q94336862Postoperative adjuvant chemotherapy for resectable cholangiocarcinoma
Q24202070Postoperative adjuvant transarterial (chemo)embolisation after liver resection for hepatocellular carcinoma
Q24200759Pre-operative biliary drainage for obstructive jaundice
Q24236361Preexposure vaccines for hepatitis A
Q24201164Preoperative physical exercise training for patients scheduled for major abdominal surgery
Q89998540Preoperative short-course radiotherapy and long-course radiochemotherapy for locally advanced rectal cancer: Meta-analysis with trial sequential analysis of long-term survival data
Q47142541Probiotics for Preventing Ventilator-Associated Pneumonia in Mechanically Ventilated Patients: A Meta-Analysis with Trial Sequential Analysis.
Q93336628Probiotics for treating eczema
Q61453118Prognostic Value of CD133 and SOX2 in Advanced Cancer
Q61798737Prognostic Value of CD44 and Its Isoforms in Advanced Cancer: A Systematic Meta-Analysis With Trial Sequential Analysis
Q64107263Prognostic value of ALDH1 and Nestin in advanced cancer: a systematic meta-analysis with trial sequential analysis
Q43462756Prognostic value of p16 promoter hypermethylation in colorectal cancer: a meta-analysis
Q24186513Prolonged storage of packed red blood cells for blood transfusion
Q90423242Prompt closure versus gradual weaning of extraventricular drainage for hydrocephalus in adult patients with aneurysmal subarachnoid haemorrhage: a systematic review protocol with meta-analysis and trial sequential analysis
Q39044129Prophylactic mesh to prevent parastomal hernia after end colostomy: a meta-analysis and trial sequential analysis.
Q57808968Prothrombin complex concentrate versus placebo, no intervention, or other interventions in critically bleeding patients associated with oral anticoagulant administration: a protocol for a systematic review of randomised clinical trials with meta-anal
Q64078467Protocol for a systematic review, meta-analysis, and trial sequential analysis of clinical outcomes following accelerated versus conventional corneal collagen cross-linking for corneal ectasia
Q47758867RASSF1A promoter methylation was associated with the development, progression and metastasis of cervical carcinoma: a meta-analysis with trial sequential analysis.
Q24201669Radiofrequency (thermal) ablation versus no intervention or other interventions for hepatocellular carcinoma
Q92808416Radix Sophorae flavescentis versus no intervention or placebo for chronic hepatitis B
Q24187818Reduction of dialysate temperature for intradialytic hypotension during haemodialysis
Q56972678Reply: To PMID 22095893
Q24240057Ribavirin monotherapy for chronic hepatitis C
Q24240879Ribavirin plus interferon versus interferon for chronic hepatitis C
Q24187627Rifaximin for people with hepatic encephalopathy
Q37406894Robustness assessments are needed to reduce bias in meta-analyses that include zero-event randomized trials
Q36262503Role of genetic mutations in folate-related enzyme genes on Male Infertility
Q24198238Routine abdominal drainage versus no abdominal drainage for uncomplicated laparoscopic cholecystectomy
Q24188235S-adenosyl-L-methionine for people with alcoholic liver disease
Q37471423SSRIs for hot flashes: a systematic review and meta-analysis of randomized trials
Q58778098Safety and efficacy of ultrathin strut biodegradable polymer sirolimus-eluting stent versus durable polymer drug-eluting stents: a meta-analysis of randomized trials
Q42386185Sample size and power considerations in network meta-analysis
Q38778992Scandinavian clinical practice guideline on fluid and drug therapy in adults with acute respiratory distress syndrome.
Q90058438Sclerotherapy versus sham or no intervention for primary prophylaxis of oesophageal variceal bleeding in children with chronic liver disease or portal vein thrombosis
Q94321541Screening for reducing morbidity and mortality in malignant melanoma
Q28736049Selective serotonin reuptake inhibitors versus placebo in patients with major depressive disorder. A systematic review with meta-analysis and Trial Sequential Analysis
Q24234739Selective vasopressin type 2 receptor antagonist for patients with cirrhosis
Q94347992Selective versus routine intraoperative cholangiography for cholecystectomy
Q49909861Sequential analysis in neonatal research-systematic review
Q24289522Sequential methods for random-effects meta-analysis
Q91849916Short-term versus long-term psychotherapy for adult psychiatric disorders: a protocol for a systematic review with meta-analysis and trial sequential analysis
Q24234231Social skills training for Attention Deficit Hyperactivity Disorder (ADHD) in children aged 5 to 18 years
Q24239933Social skills training for children with attention deficit hyperactivity disorder (ADHD)
Q24187238Statins for primary prevention of venous thromboembolism
Q34099242Statistical multiplicity in systematic reviews of anaesthesia interventions: a quantification and comparison between Cochrane and non-Cochrane reviews
Q42554270Stress ulcer prophylaxis in adult neurocritical care patients--no firm evidence for benefit or harm
Q33831121Stress ulcer prophylaxis versus placebo or no prophylaxis in adult hospitalised acutely ill patients-protocol for a systematic review with meta-analysis and trial sequential analysis.
Q57170856Surgical portosystemic shunts versus devascularisation procedures for prevention of variceal rebleeding in people with hepatosplenic schistosomiasis
Q24188170Surgical portosystemic shunts versus devascularisation procedures for variceal bleeding due to hepatosplenic schistosomiasis
Q24187528Surgical portosystemic shunts versus transjugular intrahepatic portosystemic shunt for variceal haemorrhage
Q58087379Surgical portosystemic shunts versus transjugular intrahepatic portosystemic shunt for variceal haemorrhage in people with cirrhosis
Q24201773Surgical resection versus liver transplant for patients with hepatocellular carcinoma
Q24198229Surgical versus endoscopic treatment of bile duct stones
Q24201837Surgical versus endoscopic treatment of bile duct stones
Q24201871T-tube drainage versus primary closure after laparoscopic common bile duct exploration
Q24201876T-tube drainage versus primary closure after open common bile duct exploration
Q89986320Tai Chi for Essential Hypertension: a Systematic Review of Randomized Controlled Trials
Q42565408Targeted temperature management after out-of-hospital cardiac arrest: certainties and uncertainties
Q24186667Targeting intensive glycaemic control versus targeting conventional glycaemic control for type 2 diabetes mellitus
Q24202505Targeting intensive glycaemic control versus targeting conventional glycaemic control for type 2 diabetes mellitus
Q24236456Targeting intensive glycaemic control versus targeting conventional glycaemic control for type 2 diabetes mellitus
Q24241529Targeting intensive glycaemic control versus targeting conventional glycaemic control for type 2 diabetes mellitus
Q34071861Targeting intensive versus conventional glycaemic control for type 1 diabetes mellitus: a systematic review with meta-analyses and trial sequential analyses of randomised clinical trials
Q92730078Temporal Instability of Evidence Base: A Threat to Policy Making?
Q24188350Terlipressin versus other vasoactive drugs for hepatorenal syndrome
Q26777807The Effects of Intravenous Immunoglobulins in Women with Recurrent Miscarriages: A Systematic Review of Randomised Trials with Meta-Analyses and Trial Sequential Analyses Including Individual Patient Data
Q39525458The antimicrobial effect of apical box versus apical cone preparation using iodine potassium iodide as root canal dressing: a pilot study
Q35017639The cardiovascular effects of glucagon-like peptide-1 receptor agonists: a trial sequential analysis of randomized controlled trials.
Q64970003The clinical outcomes of selenium supplementation on critically ill patients: A meta-analysis of randomized controlled trials.
Q33893924The effect of interpersonal psychotherapy and other psychodynamic therapies versus 'treatment as usual' in patients with major depressive disorder
Q28741656The effects of cognitive therapy versus 'no intervention' for major depressive disorder
Q33988593The effects of cognitive therapy versus 'treatment as usual' in patients with major depressive disorder
Q24187017The effects of high perioperative inspiratory oxygen fraction for adult surgical patients
Q24236075The effects of high perioperative inspiratory oxygen fraction for adult surgical patients
Q30843055The effects of immunotherapy with intravenous immunoglobulins versus no intervention, placebo, or usual care in patients with recurrent miscarriages: a protocol for a systematic review with meta-analyses, trial sequential analyses, and [...]
Q44824832The effects of rhythm control strategies versus rate control strategies for atrial fibrillation and atrial flutter: A systematic review with meta-analysis and Trial Sequential Analysis
Q37684261The effects of rhythm control strategies versus rate control strategies for atrial fibrillation and atrial flutter: a protocol for a systematic review with meta-analysis and Trial Sequential Analysis
Q42136549The efficacy of gabapentin in reducing pain intensity and postoperative nausea and vomiting following laparoscopic cholecystectomy: A meta-analysis
Q36721160The impact of study size on meta-analyses: examination of underpowered studies in Cochrane reviews
Q34058272The number of patients and events required to limit the risk of overestimation of intervention effects in meta-analysis--a simulation study
Q90446294The prognostic value of hypoxia-inducible factor-1α in advanced cancer survivors: a meta-analysis with trial sequential analysis
Q47750410Therapeutic bronchoscopy vs. standard of care in acute respiratory failure: a systematic review
Q34071751Third-wave cognitive therapy versus mentalisation-based treatment for major depressive disorder: a randomised clinical trial
Q24288962Thresholds for statistical and clinical significance in systematic reviews with meta-analytic methods
Q24240465Thrombelastography (TEG) or Thrombelastometry (ROTEM) to monitor haemotherapy versus usual care in patients with massive transfusion
Q24235742Thrombelastography (TEG) or thromboelastometry (ROTEM) to monitor haemotherapy versus usual care in patients with massive transfusion
Q24185948Thrombolysis for acute upper extremity deep vein thrombosis
Q47332295Thrombolysis for acute upper extremity deep vein thrombosis.
Q38744960Thromboprophylaxis With Apixaban in Patients Undergoing Major Orthopedic Surgery: Meta-Analysis and Trial-Sequential Analysis
Q91736691Traditional Chinese herbal medicine for treating novel coronavirus (COVID-19) pneumonia: protocol for a systematic review and meta-analysis
Q55382946Training, executive, attention and motor skills (TEAMS) training versus standard treatment for preschool children with attention deficit hyperactivity disorder: a randomised clinical trial.
Q24235977Transarterial (chemo)embolisation for unresectable hepatocellular carcinoma
Q94336541Transarterial (chemo)embolisation versus chemotherapy for colorectal cancer liver metastases
Q90260464Transarterial (chemo)embolisation versus no intervention or placebo for liver metastases
Q24197776Transarterial (chemo)embolisation versus no intervention or placebo intervention for liver metastases
Q24200851Transarterial (chemo)embolisation versus no intervention or placebo intervention for liver metastases
Q24202458Transarterial (chemo)embolisation versus other nonsurgical ablation methods for liver metastases
Q91676153Transcatheter arterial chemoembolisation followed by three-dimensional conformal radiotherapy versus transcatheter arterial chemoembolisation alone for primary hepatocellular carcinoma in adults
Q92324425Transepithelial versus epithelium-off corneal collagen cross-linking for corneal ectasia: protocol for a systematic review, meta-analysis and trial sequential analysis of randomised controlled trials
Q24198269Transjugular intrahepatic portosystemic shunts for hepatorenal syndrome
Q36298738Trial Sequential Analysis in systematic reviews with meta-analysis
Q87389709Trial sequence meta-analysis can reject false-positive result calculated from conventional meta-analysis
Q64092361Trial sequential analysis suggested the potential overestimated effect of carbonic anhydrase inhibitor for respiratory failure and metabolic alkalosis
Q38520058Trial sequential methods for meta-analysis
Q85382249Trials on stress ulcer prophylaxis: finding the balance between benefit and harm
Q24187730Tyrosine kinase inhibitors for unresectable hepatocellular carcinoma in adults
Q24202184Ursodeoxycholic acid for primary biliary cirrhosis
Q38523769Use of quality control charts for detection of outliers and temporal trends in cumulative meta-analysis
Q24236134Use versus avoidance of neuromuscular blocking agent for improving conditions during tracheal intubation or direct laryngoscopy in adults and adolescents
Q39128511Using conditional power of network meta-analysis (NMA) to inform the design of future clinical trials.
Q37681321Vasopressor use following traumatic injury: protocol for a systematic review
Q24200226Virtual reality training for surgical trainees in laparoscopic surgery
Q36124402Viscoelastic testing for hepatic surgery: a systematic review with meta-analysis-a protocol
Q47663614Vitamin D supplementation for chronic liver diseases in adults.
Q24193850Vitamin D supplementation for prevention of cancer in adults
Q24201160Vitamin D supplementation for prevention of mortality in adults
Q24235390Vitamin D supplementation for prevention of mortality in adults
Q24200416Vitamin K for upper gastrointestinal bleeding in patients with acute or chronic liver diseases
Q24187239Vitamin K for upper gastrointestinal bleeding in people with acute or chronic liver diseases
Q30234655Weekend versus weekday admission and short-term mortality: A meta-analysis of 88 cohort studies including 56,934,649 participants
Q24197980Wound infiltration with local anaesthetic agents for laparoscopic cholecystectomy
Q24186130Yttrium-90 microsphere radioembolisation for unresectable hepatocellular carcinoma
Q24194017Yttrium-90 microsphere radioembolisation for unresectable hepatocellular carcinoma
Q53528273[Trial sequential analysis : Sample size calculation for reliable meta-analyses].
Q60300637promoter methylation correlates development, progression, and poor cancer-specific survival of renal cell carcinoma: trial sequential analysis

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