Cloning of the late genes in the ergosterol biosynthetic pathway of Saccharomyces cerevisiae--a review

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Cloning of the late genes in the ergosterol biosynthetic pathway of Saccharomyces cerevisiae--a review is …
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scholarly articleQ13442814
review articleQ7318358

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P6179Dimensions Publication ID1008729820
P356DOI10.1007/BF02537824
P698PubMed publication ID7791529

P2093author name stringBard M
Lees ND
Kirsch DR
Skaggs B
P2860cites workConservation between human and fungal squalene synthetases: similarities in structure, function, and regulationQ24324408
Isolation of an Arabidopsis thaliana gene encoding cycloartenol synthase by functional expression in a yeast mutant lacking lanosterol synthase by the use of a chromatographic screenQ24563711
Molecular cloning and characterization of the yeast gene for squalene synthetaseQ24564387
Isolation and primary structure of the ERG9 gene of Saccharomyces cerevisiae encoding squalene synthetaseQ27931092
Cloning, disruption and sequence of the gene encoding yeast C-5 sterol desaturase.Q27931197
Cloning, sequencing, and disruption of the gene encoding sterol C-14 reductase in Saccharomyces cerevisiaeQ27931513
The yeast gene ERG6 is required for normal membrane function but is not essential for biosynthesis of the cell-cycle-sparking sterolQ27936224
The identification of a gene family in the Saccharomyces cerevisiae ergosterol biosynthesis pathwayQ27936276
Construction and growth properties of a yeast strain defective in sterol 14-reductaseQ27938171
ESR determinations of membrane permeability in a yeast sterol mutantQ28322566
Yeast mutants blocked in removing the methyl group of lanosterol at C-14. Separation of sterols by high-pressure liquid chromatographyQ28324250
Regulation of the mevalonate pathwayQ29547763
Fission yeast sts1+ gene encodes a protein similar to the chicken lamin B receptor and is implicated in pleiotropic drug-sensitivity, divalent cation-sensitivity, and osmoregulationQ31161014
The gene encoding squalene epoxidase from Saccharomyces cerevisiae: cloning and characterizationQ33282125
In vitro and in vivo effects of the antimycotic drug ketoconazole on sterol synthesisQ33729638
The lamin B receptor of the nuclear envelope inner membrane: a polytopic protein with eight potential transmembrane domainsQ33942800
Genetic characterization of pathogenic Saccharomyces cerevisiae isolates.Q33962722
Essential role for mevalonate synthesis in DNA replicationQ34036343
Total enzymic synthesis of cholesterol from lanosterol. Cytochrome b5-dependence of 4-methyl sterol oxidaseQ34282078
A protein kinase antigenically related to pp60v-src possibly involved in yeast cell cycle control: positive in vivo regulation by sterolQ34630739
Molecular cloning, characterization, and overexpression of ERG7, the Saccharomyces cerevisiae gene encoding lanosterol synthaseQ35099990
Azole susceptibility and hyphal formation in a cytochrome P-450-deficient mutant of Candida albicansQ35253807
Structural discrimination in the sparking function of sterols in the yeast Saccharomyces cerevisiaeQ36184389
Requirement for a second sterol biosynthetic mutation for viability of a sterol C-14 demethylation defect in Saccharomyces cerevisiaeQ36331125
Isolation of a cytochrome P-450 structural gene from Saccharomyces cerevisiaeQ36463806
The polyene macrolide antibioticsQ36715860
Inhibitors of 2,3-oxidosqualene lanosterol-cyclase as potential antifungal agentsQ37919460
In vivo effects of fenpropimorph on the yeast Saccharomyces cerevisiae and determination of the molecular basis of the antifungal propertyQ39816093
Strategies in prevention of invasive pulmonary aspergillosis in immunosuppressed or neutropenic patientsQ39866778
Differences in crystal violet uptake and cation-induced death among yeast sterol mutantsQ39991038
ESR determination of membrane order parameter in yeast sterol mutantsQ40236298
Human mycoses: drugs and targets for emerging pathogensQ40737322
Inactivation of antibiotics and the dissemination of resistance genesQ40737331
Defective sterol C5-6 desaturation and azole resistance: a new hypothesis for the mode of action of azole antifungalsQ41273819
Nucleotide sequence of the gene encoding yeast C-8 sterol isomeraseQ42618301
The YGL022 gene encodes a putative transport proteinQ42623113
Primary structure of the P450 lanosterol demethylase gene from Saccharomyces cerevisiaeQ42657157
Membrane fluidity alterations in a cytochrome P-450-deficient mutant of Candida albicansQ43521194
Accumulation of 14-methyl sterols and defective hyphal growth in Candida albicansQ44330166
Accumulation of 14 alpha-methylergosta-8,24(28)-dien-3 beta,6 alpha-diol in 14 alpha-demethylation mutants of Candida albicans: genetic evidence for the involvement of 5-desaturaseQ46591619
SED6 is identical to ERG6, and encodes a putative methyltransferase required for ergosterol synthesisQ48085182
Cloning and disruption of the yeast C-8 sterol isomerase geneQ52480974
Multiple functions for sterols in Saccharomyces cerevisiae.Q52656230
Cloning and characterization of the 2,3-oxidosqualene cyclase-coding gene of Candida albicansQ68506832
Cholesterol in mycoplasma membranes. Composition, ultrastructure and biological properties of membranes from Mycoplasma mycoides var. capri cells adapted to grow with low cholesterol concentrationsQ68673028
Stereochemical specificity for sterols in Saccharomyces cerevisiaeQ70246345
Stereochemically distinct roles for sterol in SaccharomycescerevisiaeQ70249486
Structural and physiological features of sterols necessary to satisfy bulk membrane and sparking requirements in yeast sterol auxotrophsQ70288224
The dual role of mevalonate in the cell cycleQ71728058
Reviving the antibiotic miracle?Q72353506
Sterol synthesis and viability of erg11 (cytochrome P450 lanosterol demethylase) mutations in Saccharomyces cerevisiae and Candida albicansQ72697440
P433issue3
P921main subjectSaccharomyces cerevisiaeQ719725
P304page(s)221-226
P577publication date1995-03-01
P1433published inLipidsQ15756668
P1476titleCloning of the late genes in the ergosterol biosynthetic pathway of Saccharomyces cerevisiae--a review
P478volume30

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cites work (P2860)
Q34473860A genetic and pharmacological analysis of isoprenoid pathway by LC-MS/MS in fission yeast
Q40277991A newly identified amino acid substitution T123I in the 14α-demethylase (Erg11p) of Candida albicans confers azole resistance
Q41774705A nonsense mutation in the ERG6 gene leads to reduced susceptibility to polyenes in a clinical isolate of Candida glabrata
Q57362291A sterol 14α-demethylase is required for conidiation, virulence and for mediating sensitivity to sterol demethylation inhibitors by the rice blast fungus Magnaporthe oryzae
Q36588959A yeast sterol auxotroph (erg25) is rescued by addition of azole antifungals and reduced levels of heme
Q49537989Abnormal Ergosterol Biosynthesis Activates Transcriptional Responses to Antifungal Azoles
Q42052002Accelerated molecular evolution of insect orthologues of ERG28/C14orf1: a link with ecdysteroid metabolism?
Q38882171Activation of the silent secondary metabolite production by introducing neomycin-resistance in a marine-derived Penicillium purpurogenum G59.
Q42173257An integrated approach for identification and target validation of antifungal compounds active against Erg11p
Q41692037Analysis of the ergosterol biosynthesis pathway cloning, molecular characterization and phylogeny of lanosterol 14 α-demethylase (ERG11) gene of Moniliophthora perniciosa
Q27930059Biochemical characterization and subcellular localization of the sterol C-24(28) reductase, erg4p, from the yeast saccharomyces cerevisiae.
Q28744002Biosynthesis of cholesterol and other sterols
Q28548587Changes in the Sterol Composition of the Plasma Membrane Affect Membrane Potential, Salt Tolerance and the Activity of Multidrug Resistance Pumps in Saccharomyces cerevisiae
Q46667714Characterizing sterol defect suppressors uncovers a novel transcriptional signaling pathway regulating zymosterol biosynthesis
Q33721804Clinical, cellular, and molecular factors that contribute to antifungal drug resistance.
Q28679167Cloning and characterization of ERG25, the Saccharomyces cerevisiae gene encoding C-4 sterol methyl oxidase
Q47889782Cloning and characterization of the Yarrowia lipolytica squalene synthase (SQS1) gene and functional complementation of the Saccharomyces cerevisiae erg9 mutation
Q74640260Cloning of cDNAs or genes encoding enzymes of sterol biosynthesis from plants and other eukaryotes: heterologous expression and complementation analysis of mutations for functional characterization
Q27933748Cofilin-mediated sorting and export of specific cargo from the Golgi apparatus in yeast
Q34061093Compound prioritization methods increase rates of chemical probe discovery in model organisms
Q34101223Conservation of eukaryotic sterol homeostasis: new insights from studies in budding yeast
Q34133774Current and future approaches to antimycotic treatment in the era of resistant fungi and immunocompromised hosts
Q33980488Depletion of the squalene synthase (ERG9) gene does not impair growth of Candida glabrata in mice
Q42774768Differential gene expression by Moniliophthora roreri while overcoming cacao tolerance in the field.
Q28238338Discovering modes of action for therapeutic compounds using a genome-wide screen of yeast heterozygotes
Q41816687Disruption of ergosterol biosynthesis confers resistance to amphotericin B in Candida lusitaniae
Q39671060Drug susceptibilities of yeast cells are affected by membrane lipid composition
Q27935535Dual localization of squalene epoxidase, Erg1p, in yeast reflects a relationship between the endoplasmic reticulum and lipid particles
Q37532159Dyclonine and alverine citrate enhance the cytotoxic effects of proteasome inhibitor MG132 on breast cancer cells
Q39826627Dynamic Lipidomic Insights into the Adaptive Responses ofSaccharomyces cerevisiaeto the Repeated Vacuum Fermentation
Q40565750ERG6 gene deletion modifies Kluyveromyces lactis susceptibility to various growth inhibitors.
Q38827511Effects of genome duplication on phenotypes and industrial applications of Saccharomyces cerevisiae strains
Q47675174Elimination of the last reactions in ergosterol biosynthesis alters the resistance of Saccharomyces cerevisiae to multiple stresses
Q34297450Ergosterol biosynthesis: a fungal pathway for life on land?
Q28345077Ergosterol is required for the Sec18/ATP-dependent priming step of homotypic vacuole fusion
Q30819999Expression deconvolution: a reinterpretation of DNA microarray data reveals dynamic changes in cell populations
Q37787891Feedback regulation of proteasome gene expression and its implications in cancer therapy
Q32039563Functional analysis of ADP-ribosylation factor (ARF) guanine nucleotide exchange factors Gea1p and Gea2p in yeast.
Q35025988High affinity of sigma 1-binding sites for sterol isomerization inhibitors: evidence for a pharmacological relationship with the yeast sterol C8-C7 isomerase
Q48071131Homology modeling and site-directed mutagenesis reveal catalytic key amino acids of 3beta-hydroxysteroid-dehydrogenase/C4-decarboxylase from Arabidopsis
Q40148508Identification and Mode of Action of a Plant Natural Product Targeting Human Fungal Pathogens.
Q24321851Identification and molecular characterization of TM7SF2 in the FAUNA gene cluster on human chromosome 11q13
Q27934131Identification of yeast deletion strains that are hypersensitive to brefeldin A or monensin, two drugs that affect intracellular transport
Q33983303In vitro and in vivo effects of 14alpha-demethylase (ERG11) depletion in Candida glabrata
Q35124001Inhibition of 2,3-oxidosqualene-lanosterol cyclase in Candida albicans by pyridinium ion-based inhibitors
Q84932845Involvement of FgERG4 in ergosterol biosynthesis, vegetative differentiation and virulence in Fusarium graminearum
Q38192931Lipid integration in neurodegeneration: an overview of Alzheimer's disease
Q64917292Mevalonate Diphosphate Decarboxylase MVD/Erg19 Is Required for Ergosterol Biosynthesis, Growth, Sporulation and Stress Tolerance in Aspergillus oryzae.
Q48086127Molecular and enzymatic characterizations of novel bifunctional 3beta-hydroxysteroid dehydrogenases/C-4 decarboxylases from Arabidopsis thaliana.
Q36969703Molecular mechanisms of drug resistance in clinical Candida species isolated from Tunisian hospitals
Q27936376Mot3 is a transcriptional repressor of ergosterol biosynthetic genes and is required for normal vacuolar function in Saccharomyces cerevisiae
Q28373535PF1163A and B, new antifungal antibiotics produced by Penicillium sp. I. Taxonomy of producing strain, fermentation, isolation and biological activities
Q36198245Parallel genetic changes and nonparallel gene-environment interactions characterize the evolution of drug resistance in yeast
Q39140952Photoactivatable GFP tagging cassettes for protein-tracking studies in the budding yeast Saccharomyces cerevisiae
Q33358036Preservation of genes involved in sterol metabolism in cholesterol auxotrophs: facts and hypotheses
Q42948674Reduced susceptibility to polyenes associated with a missense mutation in the ERG6 gene in a clinical isolate of Candida glabrata with pseudohyphal growth
Q39189843Regulation of ERG3, ERG6, and ERG11 Genes in Antifungal-Resistant isolates of Candida parapsilosis
Q36940667Specific sterols required for the internalization step of endocytosis in yeast
Q36882388Sterol C-22 Desaturase ERG5 Mediates the Sensitivity to Antifungal Azoles in Neurospora crassa and Fusarium verticillioides
Q44456021Sterol biosynthesis by symbiotes: cytochrome P450 sterol C-22 desaturase genes from yeastlike symbiotes of rice planthoppers and anobiid beetles
Q39932402Sterol metabolism
Q39565383Sterol uptake in Saccharomyces cerevisiae heme auxotrophic mutants is affected by ergosterol and oleate but not by palmitoleate or by sterol esterification
Q36176013Studies on biosynthetic genes and enzymes of isoprenoids produced by actinomycetes
Q27335565The SUN protein Mps3 is required for spindle pole body insertion into the nuclear membrane and nuclear envelope homeostasis
Q27933743The Saccharomyces cerevisiae mevalonate diphosphate decarboxylase is essential for viability, and a single Leu-to-Pro mutation in a conserved sequence leads to thermosensitivity
Q92035433The anti-aflatoxigenic mechanism of cinnamaldehyde in Aspergillus flavus
Q36626677The contribution of systematic approaches to characterizing the proteins and functions of the endoplasmic reticulum
Q36560018The immunosuppressant SR 31747 blocks cell proliferation by inhibiting a steroid isomerase in Saccharomyces cerevisiae
Q77343314Transcriptional regulation of the squalene synthase gene (ERG9) in the yeast Saccharomyces cerevisiae
Q48066094Transformation of Saccharomyces cerevisiae with a cDNA encoding a sterol C-methyltransferase from Arabidopsis thaliana results in the synthesis of 24-ethyl sterols
Q28344744Upregulation of ERG genes in Candida species by azoles and other sterol biosynthesis inhibitors
Q27500429Vitamin D in plants: a review of occurrence, analysis, and biosynthesis
Q28818537Widespread Genetic Incompatibilities between First-Step Mutations during Parallel Adaptation of Saccharomyces cerevisiae to a Common Environment
Q97535789Yeast as a promising heterologous host for steroid bioproduction
Q27937083Yeast oxidosqualene cyclase (Erg7p) is a major component of lipid particles
Q48618374hydra Mutants of Arabidopsis are defective in sterol profiles and auxin and ethylene signaling

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