Activation of c-jun N-terminal kinase upon influenza A virus (IAV) infection is independent of pathogen-related receptors but dependent on amino acid sequence variations of IAV NS1.

scientific article

Activation of c-jun N-terminal kinase upon influenza A virus (IAV) infection is independent of pathogen-related receptors but dependent on amino acid sequence variations of IAV NS1. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1128/JVI.00424-14
P932PMC publication ID4136289
P698PubMed publication ID24872593

P50authorAhmed MostafaQ39624650
Stephan LudwigQ39997705
Wolfgang NackenQ91228786
Stephan PleschkaQ123614404
P2093author name stringChristina Ehrhardt
Darisuren Anhlan
Thorsten Wolff
Eike R Hrincius
Anne Sadewasser
P2860cites workIPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon inductionQ24318426
Epstein-Barr virus-encoded latent membrane protein 1 activates the JNK pathway through its extreme C terminus via a mechanism involving TRADD and TRAF2Q24516975
Toll-like receptor signallingQ24570126
Structural basis for suppression of a host antiviral response by influenza A virusQ27651800
Innate immune recognitionQ27860721
Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-kappaB and IRF 3Q27861127
Regulation of the type I IFN induction: a current viewQ28276339
The multifunctional NS1 protein of influenza A virusesQ28294201
Influenza virus NS1 protein interacts with the cellular 30 kDa subunit of CPSF and inhibits 3'end formation of cellular pre-mRNAsQ28609836
Cell type-specific involvement of RIG-I in antiviral responseQ29615914
A DNA transfection system for generation of influenza A virus from eight plasmidsQ29642855
CRK adaptor protein expression is required for efficient replication of avian influenza A viruses and controls JNK-mediated apoptotic responsesQ30156990
Improved dual promotor-driven reverse genetics system for influenza viruses.Q30352337
The CPSF30 binding site on the NS1A protein of influenza A virus is a potential antiviral target.Q30353557
Apoptosis, cytokine and chemokine induction by non-structural 1 (NS1) proteins encoded by different influenza subtypesQ30410882
Small molecule inhibitors of the c-Jun N-terminal kinase (JNK) possess antiviral activity against highly pathogenic avian and human pandemic influenza A virusesQ30417228
The NS segment of an H5N1 highly pathogenic avian influenza virus (HPAIV) is sufficient to alter replication efficiency, cell tropism, and host range of an H7N1 HPAIVQ33614553
Structure and function of the interferon-beta enhanceosomeQ33671579
Association of RIG-I with innate immunity of ducks to influenzaQ33778227
Reovirus infection activates JNK and the JNK-dependent transcription factor c-JunQ33849552
The 3' untranslated regions of influenza genomic sequences are 5'PPP-independent ligands for RIG-IQ34206087
Activation of type I and III interferon signalling pathways occurs in lung epithelial cells infected with low pathogenic avian influenza virusesQ34217456
The NS1 protein of influenza A virus interacts with heat shock protein Hsp90 in human alveolar basal epithelial cells: implication for virus-induced apoptosisQ34993004
The virulence of 1997 H5N1 influenza viruses in the mouse model is increased by correcting a defect in their NS1 proteinsQ35077820
Double-stranded RNA-induced activation of activating protein-1 promoter is differentially regulated by the non-structural protein 1 of avian influenza A viruses.Q35731419
Strain-specific contribution of NS1-activated phosphoinositide 3-kinase signaling to influenza A virus replication and virulenceQ35943755
Influenza a virus polymerase is an integral component of the CPSF30-NS1A protein complex in infected cellsQ37099780
MAVS self-association mediates antiviral innate immune signalingQ37145207
RNA recognition and signal transduction by RIG-I-like receptorsQ37361441
A new player in a deadly game: influenza viruses and the PI3K/Akt signalling pathwayQ37416250
Interplay between influenza A virus and the innate immune signalingQ37603801
RIG-I like receptors and their signaling crosstalk in the regulation of antiviral immunity.Q37939129
Broad action of Hsp90 as a host chaperone required for viral replicationQ37966479
Phosphatidylinositol-3-kinase (PI3K) is activated by influenza virus vRNA via the pathogen pattern receptor Rig-I to promote efficient type I interferon productionQ39478013
Activation of cJUN N-terminal kinase by herpes simplex virus type 1 enhances viral replicationQ39595937
The influenza A virus NS1 protein inhibits activation of Jun N-terminal kinase and AP-1 transcription factorsQ39685168
Bivalent role of the phosphatidylinositol-3-kinase (PI3K) during influenza virus infection and host cell defenceQ40249148
ORF36 protein kinase of Kaposi's sarcoma herpesvirus activates the c-Jun N-terminal kinase signaling pathway.Q40537026
p38 mitogen-activated protein kinase and c-jun-NH2-terminal kinase regulate RANTES production by influenza virus-infected human bronchial epithelial cellsQ40895310
Inhibitory effect of bafilomycin A1, a specific inhibitor of vacuolar-type proton pump, on the growth of influenza A and B viruses in MDCK cellsQ41315096
NS reassortment of an H7-type highly pathogenic avian influenza virus affects its propagation by altering the regulation of viral RNA production and antiviral host responseQ41821502
Influenza virus sequence feature variant type analysis: evidence of a role for NS1 in influenza virus host range restriction.Q42096408
P433issue16
P407language of work or nameEnglishQ1860
P921main subjectinfluenza A virusQ834390
P304page(s)8843-8852
P577publication date2014-05-28
P1433published inJournal of VirologyQ1251128
P1476titleActivation of c-jun N-terminal kinase upon influenza A virus (IAV) infection is independent of pathogen-related receptors but dependent on amino acid sequence variations of IAV NS1.
P478volume88

Reverse relations

cites work (P2860)
Q40844952Anti-inflammatory effects of indirubin derivatives on influenza A virus-infected human pulmonary microvascular endothelial cells
Q47204425Bacterial ribonuclease binase exerts an intra-cellular anti-viral mode of action targeting viral RNAs in influenza a virus-infected MDCK-II cells
Q35758591Fluorescence-Activated Cell Sorting-Based Analysis Reveals an Asymmetric Induction of Interferon-Stimulated Genes in Response to Seasonal Influenza A Virus
Q38937423H5N1 influenza virulence, pathogenicity and transmissibility: what do we know?
Q60954913Influenza A Virus NS1 Protein Suppresses JNK1-Dependent Autophagosome Formation Mediated by Rab11a Recycling Endosomes
Q40376490Influenza A virus NS1 protein-induced JNK activation and apoptosis are not functionally linked
Q36564475JNK1 Derived from Orange-Spotted Grouper, Epinephelus coioides, Involving in the Evasion and Infection of Singapore Grouper Iridovirus (SGIV).
Q37640922Mitogen-activated protein kinases (MAPKs) regulate IL-6 over-production during concomitant influenza virus and Staphylococcus aureus infection
Q92081412Molecular and Cellular Mechanisms for PRRSV Pathogenesis and Host Response to Infection
Q39530544Phosphoproteomics to Characterize Host Response During Influenza A Virus Infection of Human Macrophages
Q90191935Role of TGF-β-activated kinase 1 (TAK1) activation in H5N1 influenza A virus-induced c-Jun terminal kinase activation and virus replication
Q57479310Role of c-Jun terminal kinase (JNK) activation in influenza A virus-induced autophagy and replication
Q90026649Signaling pathways involved in regulating apoptosis induction in host cells upon PRRSV infection
Q52671141Targeting intracellular signaling as an antiviral strategy: aerosolized LASAG for the treatment of influenza in hospitalized patients.

Search more.