H5N1 influenza virulence, pathogenicity and transmissibility: what do we know?

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H5N1 influenza virulence, pathogenicity and transmissibility: what do we know? is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.2217/FVL.15.62
P932PMC publication ID4658657
P698PubMed publication ID26617665

P2093author name stringGabriele Neumann
P2860cites workSynergistic effect of the PDZ and p85β-binding domains of the NS1 protein on virulence of an avian H5N1 influenza A virusQ36760030
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H5N1 hybrid viruses bearing 2009/H1N1 virus genes transmit in guinea pigs by respiratory dropletQ39156660
The influenza virus PB1-F2 protein has interferon antagonistic activityQ39448668
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Influenza A virus protein PB1-F2 exacerbates IFN-beta expression of human respiratory epithelial cells.Q39655511
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Influenza virus PB1-F2 protein induces cell death through mitochondrial ANT3 and VDAC1.Q21090537
PB1-F2, an influenza A virus-encoded proapoptotic mitochondrial protein, creates variably sized pores in planar lipid membranesQ24563255
The H5N1 influenza virus NS genes selected after 1998 enhance virus replication in mammalian cellsQ24676166
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The viral polymerase mediates adaptation of an avian influenza virus to a mammalian host.Q30352150
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Expression of the 1918 influenza A virus PB1-F2 enhances the pathogenesis of viral and secondary bacterial pneumoniaQ30365855
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PB1-F2 expression by the 2009 pandemic H1N1 influenza virus has minimal impact on virulence in animal modelsQ30385984
PB2 residue 271 plays a key role in enhanced polymerase activity of influenza A viruses in mammalian host cells.Q30385995
PB1-F2 proteins from H5N1 and 20 century pandemic influenza viruses cause immunopathologyQ30391867
Differential effects of NS1 proteins of human pandemic H1N1/2009, avian highly pathogenic H5N1, and low pathogenic H5N2 influenza A viruses on cellular pre-mRNA polyadenylation and mRNA translation.Q30397559
Effect of receptor binding domain mutations on receptor binding and transmissibility of avian influenza H5N1 virusesQ30400680
Differential contribution of PB1-F2 to the virulence of highly pathogenic H5N1 influenza A virus in mammalian and avian speciesQ30406151
In vitro evolution of H5N1 avian influenza virus toward human-type receptor specificity.Q30409010
The changing nature of avian influenza A virus (H5N1).Q30410441
Small molecule inhibitors of the c-Jun N-terminal kinase (JNK) possess antiviral activity against highly pathogenic avian and human pandemic influenza A virusesQ30417228
Influenza virus protein PB1-F2 inhibits the induction of type I interferon by binding to MAVS and decreasing mitochondrial membrane potentialQ30417679
Interaction of polymerase subunit PB2 and NP with importin alpha1 is a determinant of host range of influenza A virusQ33318082
The NS segment of an H5N1 highly pathogenic avian influenza virus (HPAIV) is sufficient to alter replication efficiency, cell tropism, and host range of an H7N1 HPAIVQ33614553
The HA and NS Genes of Human H5N1 Influenza A Virus Contribute to High Virulence in FerretsQ33700611
The influenza virus protein PB1-F2 inhibits the induction of type I interferon at the level of the MAVS adaptor proteinQ33939684
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Transcriptomic analysis of host immune and cell death responses associated with the influenza A virus PB1-F2 proteinQ34013619
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Differential localization and function of PB1-F2 derived from different strains of influenza A virusQ34120921
Lethal H5N1 influenza viruses escape host anti-viral cytokine responsesQ34146021
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The ESEV PDZ-binding motif of the avian influenza A virus NS1 protein protects infected cells from apoptosis by directly targeting ScribbleQ34190628
Seroprevalence of antibodies to avian influenza A (H5) and A (H9) viruses among market poultry workers, Hanoi, Vietnam, 2001.Q34396105
A single N66S mutation in the PB1-F2 protein of influenza A virus increases virulence by inhibiting the early interferon response in vivoQ34485350
Influenza A virus NS1 gene mutations F103L and M106I increase replication and virulenceQ34547254
Properties and dissemination of H5N1 viruses isolated during an influenza outbreak in migratory waterfowl in western ChinaQ34651554
Influenza virus primes mice for pneumonia from Staphylococcus aureus.Q34763964
The virulence of 1997 H5N1 influenza viruses in the mouse model is increased by correcting a defect in their NS1 proteinsQ35077820
Reassortant highly pathogenic influenza A(H5N6) virus in Laos.Q35130361
Identification, characterization, and natural selection of mutations driving airborne transmission of A/H5N1 virusQ35146036
A recommended numbering scheme for influenza A HA subtypesQ35415045
Avian influenza A(H5N1) and A(H9N2) seroprevalence and risk factors for infection among Egyptians: a prospective, controlled seroepidemiological studyQ35715601
Influenza A virus NS1 protein activates the PI3K/Akt pathway to mediate antiapoptotic signaling responsesQ35785139
A single-amino-acid substitution in the NS1 protein changes the pathogenicity of H5N1 avian influenza viruses in miceQ36424206
A new influenza virus virulence determinant: the NS1 protein four C-terminal residues modulate pathogenicityQ36670254
A single amino acid in the PB2 gene of influenza A virus is a determinant of host range.Q36685680
P433issue8
P304page(s)971-980
P577publication date2015-01-01
P1433published inFuture VirologyQ15751230
P1476titleH5N1 influenza virulence, pathogenicity and transmissibility: what do we know?
P478volume10

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cites work (P2860)
Q90319185Design and synthesis of heteroaromatic-based benzenesulfonamide derivatives as potent inhibitors of H5N1 influenza A virus
Q40061293Insights into genetic diversity and biological propensities of potentially zoonotic avian influenza H9N2 viruses circulating in Egypt
Q90736243Key Role of the Influenza A Virus PA Gene Segment in the Emergence of Pandemic Viruses
Q103024230Long-lasting heterologous antibody responses after sequential vaccination with A/Indonesia/5/2005 and A/Vietnam/1203/2004 pre-pandemic influenza A(H5N1) virus vaccines
Q57245963Robustness of Eco-Epidemiological Capture-Recapture Parameter Estimates to Variation in Infection State Uncertainty
Q92237170Rule-based meta-analysis reveals the major role of PB2 in influencing influenza A virus virulence in mice

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