Synergistic effect of the PDZ and p85β-binding domains of the NS1 protein on virulence of an avian H5N1 influenza A virus

scientific article published on 13 February 2013

Synergistic effect of the PDZ and p85β-binding domains of the NS1 protein on virulence of an avian H5N1 influenza A virus is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1128/JVI.02608-12
P932PMC publication ID3624326
P698PubMed publication ID23408626
P5875ResearchGate publication ID235621638

P50authorYoshihiro KawaokaQ2600945
Gabriele NeumannQ98952221
Hualan ChenQ107321893
Catherine MackenQ117540617
P2093author name stringChengjun Li
Chairul A Nidom
Makoto Ozawa
Hideo Goto
Shufang Fan
N F N Iswahyudi
P2860cites workInfluenza A virus NS1 protein binds p85beta and activates phosphatidylinositol-3-kinase signalingQ24302191
Inhibition of retinoic acid-inducible gene I-mediated induction of beta interferon by the NS1 protein of influenza A virusQ24311228
New genotype of avian influenza H5N1 viruses isolated from tree sparrows in ChinaQ24534704
The evolution of H5N1 influenza viruses in ducks in southern ChinaQ24564166
Role of PDZ proteins in regulating trafficking, signaling, and function of GPCRs: means, motif, and opportunityQ27015870
Structural insights into phosphoinositide 3-kinase activation by the influenza A virus NS1 proteinQ27659586
PDlim2 Selectively Interacts with the PDZ Binding Motif of Highly Pathogenic Avian H5N1 Influenza A Virus NS1Q27668086
Marburg Virus VP35 Can Both Fully Coat the Backbone and Cap the Ends of dsRNA for Interferon AntagonismQ27673907
Efficient selection for high-expression transfectants with a novel eukaryotic vectorQ27860810
RIG-I-mediated antiviral responses to single-stranded RNA bearing 5'-phosphatesQ27861007
Oncogenic function for the Dlg1 mammalian homolog of the Drosophila discs-large tumor suppressorQ28571122
Influenza A Virus Lacking the NS1 Gene Replicates in Interferon-Deficient SystemsQ29039793
Establishment of multiple sublineages of H5N1 influenza virus in Asia: Implications for pandemic controlQ29301392
Generation of influenza A viruses entirely from cloned cDNAsQ29616768
Molecular basis for high virulence of Hong Kong H5N1 influenza A virusesQ29619144
Mechanism of influenza A virus NS1 protein interaction with the p85beta, but not the p85alpha, subunit of phosphatidylinositol 3-kinase (PI3K) and up-regulation of PI3K activityQ30157667
SH3 binding motif 1 in influenza A virus NS1 protein is essential for PI3K/Akt signaling pathway activationQ30157758
Influenza A virus NS1 protein activates the phosphatidylinositol 3-kinase (PI3K)/Akt pathway by direct interaction with the p85 subunit of PI3K.Q30159525
Continued evolution of H5N1 influenza viruses in wild birds, domestic poultry, and humans in China from 2004 to 2009.Q30227119
H5N1 influenza viruses isolated from geese in Southeastern China: evidence for genetic reassortment and interspecies transmission to ducks.Q30233542
Emergence of multiple genotypes of H5N1 avian influenza viruses in Hong Kong SAR.Q30330486
Genesis of a highly pathogenic and potentially pandemic H5N1 influenza virus in eastern Asia.Q30342179
Effect of the phosphatidylinositol 3-kinase/Akt pathway on influenza A virus propagationQ40166064
IFNbeta induction by influenza A virus is mediated by RIG-I which is regulated by the viral NS1 proteinQ40202119
Bivalent role of the phosphatidylinositol-3-kinase (PI3K) during influenza virus infection and host cell defenceQ40249148
A molecular-properties-based approach to understanding PDZ domain proteins and PDZ ligandsQ40258028
Evolution of highly pathogenic avian H5N1 influenza viruses and the emergence of dominant variantsQ43174213
Low pathogenicity H5N2 avian influenza outbreak in Japan during the 2005-2006.Q43176181
Avian flu: H5N1 virus outbreak in migratory waterfowl.Q43177297
Highly pathogenic H5N1 influenza virus infection in migratory birdsQ43177302
Pathogenicity and diagnosis of H5N2 Mexican avian influenza viruses in chickensQ43976680
Avian influenza A virus subtype H5N2 in a red-lored Amazon parrot.Q44952723
Pathobiology of H5N2 Mexican avian influenza virus infections of chickens.Q45759088
Origin and molecular changes associated with emergence of a highly pathogenic H5N2 influenza virus in MexicoQ45790630
Heterogeneity in the haemagglutinin gene and emergence of the highly pathogenic phenotype among recent H5N2 avian influenza viruses from MexicoQ48062663
Large-scale sequence analysis of avian influenza isolates.Q30352711
Genotype turnover by reassortment of replication complex genes from avian influenza A virus.Q30356764
Evolutionary dynamics and emergence of panzootic H5N1 influenza viruses.Q30372285
Evolutionarily conserved bias of amino-acid usage refines the definition of PDZ-binding motifQ31017084
A specificity map for the PDZ domain familyQ33373127
Phylogenetic characterization of H5N1 avian influenza viruses isolated in Indonesia from 2003-2007Q33451413
Novel genotypes of H9N2 influenza A viruses isolated from poultry in Pakistan containing NS genes similar to highly pathogenic H7N3 and H5N1 virusesQ33466049
The role of interferon in influenza virus tissue tropismQ33785192
Activation of interferon regulatory factor 3 is inhibited by the influenza A virus NS1 proteinQ33810694
Species-specific contribution of the four C-terminal amino acids of influenza A virus NS1 protein to virulenceQ33990505
Virulence Determinants of Avian H5N1 Influenza A Virus in Mammalian and Avian Hosts: Role of the C-Terminal ESEV Motif in the Viral NS1 ProteinQ34178292
The ESEV PDZ-binding motif of the avian influenza A virus NS1 protein protects infected cells from apoptosis by directly targeting ScribbleQ34190628
Novel roles of TLR3 tyrosine phosphorylation and PI3 kinase in double-stranded RNA signalingQ34361655
Genome-wide analysis of PDZ domain binding reveals inherent functional overlap within the PDZ interaction networkQ34516482
Properties and dissemination of H5N1 viruses isolated during an influenza outbreak in migratory waterfowl in western ChinaQ34651554
The distinct binding properties between avian/human influenza A virus NS1 and Postsynaptic density protein-95 (PSD-95), and inhibition of nitric oxide productionQ35122232
The NS1 gene contributes to the virulence of H5N1 avian influenza virusesQ35139698
Emerging theme: cellular PDZ proteins as common targets of pathogenic virusesQ35531181
Influenza A virus NS1 protein activates the PI3K/Akt pathway to mediate antiapoptotic signaling responsesQ35785139
F1Fo-ATPase, F-type proton-translocating ATPase, at the plasma membrane is critical for efficient influenza virus buddingQ35849742
Inability of NS1 protein from an H5N1 influenza virus to activate PI3K/Akt signaling pathway correlates to the enhanced virus replication upon PI3K inhibitionQ36156616
Selective PDZ protein-dependent stimulation of phosphatidylinositol 3-kinase by the adenovirus E4-ORF1 oncoproteinQ36410968
A naturally occurring deletion in its NS gene contributes to the attenuation of an H5N1 swine influenza virus in chickensQ36423951
A single-amino-acid substitution in the NS1 protein changes the pathogenicity of H5N1 avian influenza viruses in miceQ36424206
A new influenza virus virulence determinant: the NS1 protein four C-terminal residues modulate pathogenicityQ36670254
The development and genetic diversity of H5N1 influenza virus in China, 1996-2006.Q37119149
A new player in a deadly game: influenza viruses and the PI3K/Akt signalling pathwayQ37416250
Interplay between influenza A virus and the innate immune signalingQ37603801
The avian influenza virus NS1 ESEV PDZ binding motif associates with Dlg1 and Scribble to disrupt cellular tight junctionsQ38632014
Phosphatidylinositol-3-kinase (PI3K) is activated by influenza virus vRNA via the pathogen pattern receptor Rig-I to promote efficient type I interferon productionQ39478013
Analysis of the PDZ binding specificities of Influenza A virus NS1 proteins.Q39605811
Influenza A virus polymerase inhibits type I interferon induction by binding to interferon beta promoter stimulator 1.Q39669004
Loss of function of the influenza A virus NS1 protein promotes apoptosis but this is not due to a failure to activate phosphatidylinositol 3-kinase (PI3K).Q39780931
Binding of influenza A virus NS1 protein to the inter-SH2 domain of p85 suggests a novel mechanism for phosphoinositide 3-kinase activationQ40047113
P433issue9
P407language of work or nameEnglishQ1860
P921main subjectinfluenza A virusQ834390
P304page(s)4861-4871
P577publication date2013-02-13
P1433published inJournal of VirologyQ1251128
P1476titleSynergistic effect of the PDZ and p85β-binding domains of the NS1 protein on virulence of an avian H5N1 influenza A virus
P478volume87

Reverse relations

cites work (P2860)
Q39156048A Review of Functional Motifs Utilized by Viruses.
Q34593967Amino acid changes in the influenza A virus PA protein that attenuate avian H5N1 viruses in mammals
Q42218004Analysis of the phylogeny of Chinese H9N2 avian influenza viruses and their pathogenicity in mice
Q42724653Avian influenza virus NS1: A small protein with diverse and versatile functions
Q55555164Diversity of Influenza A(H5N1) Viruses in Infected Humans, Northern Vietnam, 2004-2010.
Q41614528Effects of different NS genes of avian influenza viruses and amino acid changes on pathogenicity of recombinant A/Puerto Rico/8/34 viruses
Q41140967Expected Effect of Deleterious Mutations on Within-Host Adaptation of Pathogens
Q38826570Genetic characterization of H5N2 influenza viruses isolated from wild birds in Japan suggests multiple reassortment
Q35203091Genetic dynamic analysis of the influenza A H5N1 NS1 gene in China
Q38937423H5N1 influenza virulence, pathogenicity and transmissibility: what do we know?
Q40099812Influenza A Virus-Host Protein Interactions Control Viral Pathogenesis.
Q30364868Molecular determinants of influenza virus pathogenesis in mice.
Q21245146Mutations within the conserved NS1 nuclear export signal lead to inhibition of influenza A virus replication
Q52721229NS Segment of a 1918 Influenza A Virus-Descendent Enhances Replication of H1N1pdm09 and Virus-Induced Cellular Immune Response in Mammalian and Avian Systems.
Q92237170Rule-based meta-analysis reveals the major role of PB2 in influencing influenza A virus virulence in mice
Q40811320Stop-codon variations in non-structural protein NS1 of avian influenza viruses
Q38621502Structure-Guided Functional Annotation of the Influenza A Virus NS1 Protein Reveals Dynamic Evolution of the p85β-Binding Site During Circulation in Humans
Q35635868Synergistic Effect of S224P and N383D Substitutions in the PA of H5N1 Avian Influenza Virus Contributes to Mammalian Adaptation
Q48329656Synthesis of hemithioindigo-based chromopeptides by using the Tmb auxiliary in native chemical ligation studies.
Q57007054The Cellular DExD/H-Box RNA Helicase UAP56 Co-localizes With the Influenza A Virus NS1 Protein
Q28538376The human adenovirus E4-ORF1 protein subverts discs large 1 to mediate membrane recruitment and dysregulation of phosphatidylinositol 3-kinase
Q46241896Unexpected Functional Divergence of Bat Influenza Virus NS1 Proteins
Q59349302Upsetting the Balance: When Viruses Manipulate Cell Polarity Control
Q37643802Virulence-affecting amino acid changes in the PA protein of H7N9 influenza A viruses
Q57093653Zoonotic Potential of Influenza A Viruses: A Comprehensive Overview

Search more.