Novel residues in avian influenza virus PB2 protein affect virulence in mammalian hosts

scientific article published on 7 October 2014

Novel residues in avian influenza virus PB2 protein affect virulence in mammalian hosts is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode2014NatCo...5.5021F
P356DOI10.1038/NCOMMS6021
P932PMC publication ID5841464
P698PubMed publication ID25289523

P50authorYoshihiro KawaokaQ2600945
Masaki ImaiQ91452505
Peter J HalfmannQ92339952
Shufang FanQ92533949
Gabriele NeumannQ98952221
Masato HattaQ114403073
Catherine MackenQ117540617
P2093author name stringTung Nguyen
Jin Hyun Kim
Mai Quynh Le
P2860cites workA single mutation in the PB1-F2 of H5N1 (HK/97) and 1918 influenza A viruses contributes to increased virulenceQ21089626
phyloXML: XML for evolutionary biology and comparative genomicsQ21284370
The evolution of H5N1 influenza viruses in ducks in southern ChinaQ24564166
The structural basis for cap binding by influenza virus polymerase subunit PB2Q27650520
Biological and Structural Characterization of a Host-Adapting Amino Acid in Influenza VirusQ27664029
Structural and Functional Characterization of K339T Substitution Identified in the PB2 Subunit Cap-binding Pocket of Influenza A VirusQ27676615
Clustal W and Clustal X version 2.0Q27860517
RAxML-VI-HPC: maximum likelihood-based phylogenetic analyses with thousands of taxa and mixed modelsQ27860746
Efficient selection for high-expression transfectants with a novel eukaryotic vectorQ27860810
Generation of influenza A viruses entirely from cloned cDNAsQ29616768
Emergence and pandemic potential of swine-origin H1N1 influenza virusQ29619003
Molecular basis for high virulence of Hong Kong H5N1 influenza A virusesQ29619144
In vitro and in vivo characterization of new swine-origin H1N1 influenza virusesQ29619174
Continued evolution of H5N1 influenza viruses in wild birds, domestic poultry, and humans in China from 2004 to 2009.Q30227119
The viral polymerase mediates adaptation of an avian influenza virus to a mammalian host.Q30352150
PB2-588I enhances 2009 H1N1 pandemic influenza virus virulence by increasing viral replication and exacerbating PB2 inhibition of beta interferon expression.Q30356762
Growth of H5N1 influenza A viruses in the upper respiratory tracts of mice.Q30365053
Expression of the 1918 influenza A virus PB1-F2 enhances the pathogenesis of viral and secondary bacterial pneumoniaQ30365855
Adaptive strategies of the influenza virus polymerase for replication in humansQ30383307
Identification of amino acids in HA and PB2 critical for the transmission of H5N1 avian influenza viruses in a mammalian hostQ30383968
PB2 residue 271 plays a key role in enhanced polymerase activity of influenza A viruses in mammalian host cells.Q30385995
Avian-to-human transmission of the PB1 gene of influenza A viruses in the 1957 and 1968 pandemicsQ30396327
Impact of amino acid mutations in PB2, PB1-F2, and NS1 on the replication and pathogenicity of pandemic (H1N1) 2009 influenza virusesQ30399775
Genetic characterization and pathogenicity assessment of highly pathogenic H5N1 avian influenza viruses isolated from migratory wild birds in 2011, South KoreaQ30405129
Role of host-specific amino acids in the pathogenicity of avian H5N1 influenza viruses in miceQ33885412
Molecular basis of replication of duck H5N1 influenza viruses in a mammalian mouse modelQ33987340
Avian influenza (H5N1) viruses isolated from humans in Asia in 2004 exhibit increased virulence in mammalsQ33987458
Lethal H5N1 influenza viruses escape host anti-viral cytokine responsesQ34146021
Mouse-adapted H9N2 influenza A virus PB2 protein M147L and E627K mutations are critical for high virulenceQ34342367
Influenza A virus NS1 gene mutations F103L and M106I increase replication and virulenceQ34547254
Pathogenicity of highly pathogenic avian H5N1 influenza A viruses isolated from humans between 2003 and 2008 in northern VietnamQ34641895
Properties and dissemination of H5N1 viruses isolated during an influenza outbreak in migratory waterfowl in western ChinaQ34651554
The NS1 gene contributes to the virulence of H5N1 avian influenza virusesQ35139698
New avian influenza virus (H5N1) in wild birds, Qinghai, China.Q35484103
Indications that live poultry markets are a major source of human H5N1 influenza virus infection in ChinaQ35599445
A naturally occurring deletion in its NS gene contributes to the attenuation of an H5N1 swine influenza virus in chickensQ36423951
A single-amino-acid substitution in the NS1 protein changes the pathogenicity of H5N1 avian influenza viruses in miceQ36424206
A new influenza virus virulence determinant: the NS1 protein four C-terminal residues modulate pathogenicityQ36670254
A single amino acid in the PB2 gene of influenza A virus is a determinant of host range.Q36685680
Characterization of avian influenza viruses A (H5N1) from wild birds, Hong Kong, 2004-2008.Q37152132
Sequence requirements for cleavage activation of influenza virus hemagglutinin expressed in mammalian cellsQ37481771
Influence of PB2 host-range determinants on the intranuclear mobility of the influenza A virus polymeraseQ38325400
Adaptive mutations in NEP compensate for defective H5N1 RNA replication in cultured human cellsQ39355418
Evolution of highly pathogenic avian H5N1 influenza viruses and the emergence of dominant variantsQ43174213
Two amino acid residues in the matrix protein M1 contribute to the virulence difference of H5N1 avian influenza viruses in miceQ43175209
Homology modeling and examination of the effect of the D92E mutation on the H5N1 nonstructural protein NS1 effector domainQ44494533
Mx proteins: mediators of innate resistance to RNA virusesQ47932415
P407language of work or nameEnglishQ1860
P921main subjectavian influenzaQ43987
P304page(s)5021
P577publication date2014-10-07
P1433published inNature CommunicationsQ573880
P1476titleNovel residues in avian influenza virus PB2 protein affect virulence in mammalian hosts
P478volume5