The structural basis for cap binding by influenza virus polymerase subunit PB2

scientific article

The structural basis for cap binding by influenza virus polymerase subunit PB2 is …
instance of (P31):
scholarly articleQ13442814

External links are
P6179Dimensions Publication ID1026955344
P356DOI10.1038/NSMB.1421
P8608Fatcat IDrelease_5txhh4upzbbb5flzmvobj5v3da
P3181OpenCitations bibliographic resource ID690764
P698PubMed publication ID18454157
P5875ResearchGate publication ID5329836

P50authorStephen Anthony CusackQ19914199
Patricia Resa-InfanteQ47087609
Darren J HartQ54837819
Thibaut CrépinQ59401298
P2093author name stringRob W H Ruigrok
Delphine Guilligay
Joe Lewis
Peter Sehr
Patricia Resa-Infante
Franck Tarendeau
Juan Ortin
Rocío Coloma
P2860cites workActivation of influenza virus-associated RNA polymerase by cap-1 structure (m7GpppNm).Q45828066
Molecular cloning and sequencing of influenza virus A/Victoria/3/75 polymerase genes: sequence evolution and prediction of possible functional domainsQ45843152
Characterization of a temperature-sensitive mutant in the RNA polymerase PB2 subunit gene of influenza A/WSN/33 virusQ45850106
Genetic variability of Hong Kong (H3N2) influenza viruses: spontaneous mutations and their location in the viral genome.Q54546412
Capped mRNAs may stimulate the influenza virion polymerase by allosteric modulationQ70771602
Large-scale induced fit recognition of an m(7)GpppG cap analogue by the human nuclear cap-binding complexQ24310463
Analysis of mutation in human cells by using an Epstein-Barr virus shuttle systemQ24628961
Biophysical studies of eIF4E cap-binding protein: recognition of mRNA 5' cap structure and synthetic fragments of eIF4G and 4E-BP1 proteinsQ27639133
Structure and nuclear import function of the C-terminal domain of influenza virus polymerase PB2 subunitQ27643860
Cocrystal structure of the messenger RNA 5' cap-binding protein (eIF4E) bound to 7-methyl-GDPQ27739838
Structural Basis for Sequence-Nonspecific Recognition of 5′-Capped mRNA by a Cap-Modifying EnzymeQ27760566
Automated protein model building combined with iterative structure refinementQ27860506
Structure validation by Calpha geometry: phi,psi and Cbeta deviationQ27860657
Atomic structures of the human immunophilin FKBP-12 complexes with FK506 and rapamycinQ27860688
Protein structure comparison by alignment of distance matricesQ27860798
Refinement of macromolecular structures by the maximum-likelihood methodQ27861011
Two separate sequences of PB2 subunit constitute the RNA cap-binding site of influenza virus RNA polymeraseQ27863658
The active sites of the influenza cap-dependent endonuclease are on different polymerase subunitsQ27863698
3D structure of the influenza virus polymerase complex: localization of subunit domains.Q27863781
A unique cap(m7GpppXm)-dependent influenza virion endonuclease cleaves capped RNAs to generate the primers that initiate viral RNA transcriptionQ27865288
RNA-dependent activation of primer RNA production by influenza virus polymerase: different regions of the same protein subunit constitute the two required RNA-binding sitesQ27867719
Generation of influenza A viruses entirely from cloned cDNAsQ29616768
Influenza: lessons from past pandemics, warnings from current incidents.Q30351160
Antiviral agents active against influenza A viruses.Q30358429
Global patterns of influenza a virus in wild birdsQ33995214
Recognition of mRNA cap structures by viral and cellular proteinsQ36098747
Both the 7-methyl and the 2'-O-methyl groups in the cap of mRNA strongly influence its ability to act as primer for influenza virus RNA transcriptionQ36396943
Defective RNA replication and late gene expression in temperature-sensitive influenza viruses expressing deleted forms of the NS1 proteinQ37093452
Differential effect of modified capped RNA substrates on influenza virus transcriptionQ38344450
Quantitative analysis of influenza virus RNP interaction with RNA cap structures and comparison to human cap binding protein eIF4E.Q38354500
Two aromatic residues in the PB2 subunit of influenza A RNA polymerase are crucial for cap bindingQ38356589
Ultrastructural and functional analyses of recombinant influenza virus ribonucleoproteins suggest dimerization of nucleoprotein during virus amplificationQ39588564
A single amino acid mutation in the PA subunit of the influenza virus RNA polymerase inhibits endonucleolytic cleavage of capped RNAsQ39684553
Three-dimensional model for the isolated recombinant influenza virus polymerase heterotrimerQ40129576
Inhibition of influenza viral polymerases by minimal viral RNA decoysQ41091374
Specificity of recognition of mRNA 5' cap by human nuclear cap-binding complexQ41833043
Three-dimensional reconstruction of a recombinant influenza virus ribonucleoprotein particleQ42724088
Amino acid residues in the N-terminal region of the PA subunit of influenza A virus RNA polymerase play a critical role in protein stability, endonuclease activity, cap binding, and virion RNA promoter bindingQ43156905
P433issue5
P921main subjectvirusQ808
P304page(s)500-6
P577publication date2008-05-01
P1433published inNature Structural & Molecular BiologyQ1071739
P1476titleThe structural basis for cap binding by influenza virus polymerase subunit PB2
P478volume15

Reverse relations

cites work (P2860)
Q61449744A Comprehensive Review on the Interaction Between the Host GTPase Rab11 and Influenza A Virus
Q35674905A complete map of potential pathogenicity markers of avian influenza virus subtype H5 predicted from 11 expressed proteins
Q91227505A convenient in vivo cap donor delivery system to investigate the cap snatching of plant bunyaviruses
Q57031885A multisubstrate reductase from Plantago major: structure-function in the short chain reductase superfamily
Q34139013A novel functional site in the PB2 subunit of influenza A virus essential for acetyl-CoA interaction, RNA polymerase activity, and viral replication.
Q38766044A novel small-molecule compound disrupts influenza A virus PB2 cap-binding and inhibits viral replication.
Q36666497A novel small-molecule inhibitor of influenza A virus acts by suppressing PA endonuclease activity of the viral polymerase.
Q98733614A prion-like domain in ELF3 functions as a thermosensor in Arabidopsis
Q37416358A quantitative strategy to detect changes in accessibility of protein regions to chemical modification on heterodimerization
Q64116821A review of H5Nx avian influenza viruses
Q36414388A small-RNA enhancer of viral polymerase activity
Q47788104A structural organization for the Disrupted in Schizophrenia 1 protein, identified by high-throughput screening, reveals distinctly folded regions, which are bisected by mental illness-related mutations
Q30429748Adaptation of Avian Influenza A Virus Polymerase in Mammals To Overcome the Host Species Barrier
Q39355418Adaptive mutations in NEP compensate for defective H5N1 RNA replication in cultured human cells
Q38111647Adaptive mutations in the H5N1 polymerase complex
Q41359819Adaptive mutations resulting in enhanced polymerase activity contribute to high virulence of influenza A virus in mice
Q30395645All that glitters is not gold--founder effects complicate associations of flu mutations to disease severity
Q38348049An N-terminal region of Lassa virus L protein plays a critical role in transcription but not replication of the virus genome
Q40362747An in vitro fluorescence based study of initiation of RNA synthesis by influenza B polymerase
Q39136001Antiviral activity of Jinchai capsule against influenza virus
Q26738562Antiviral therapies on the horizon for influenza
Q38011755Antivirals Targeting Influenza A Virus
Q34286309Architecture and regulation of negative-strand viral enzymatic machinery
Q33769326Artificial Hybrids of Influenza A Virus RNA Polymerase Reveal PA Subunit Modulates Its Thermal Sensitivity
Q34055461Association of the influenza virus RNA polymerase subunit PB2 with the host chaperonin CCT.
Q28550239Atomic Structure and Biochemical Characterization of an RNA Endonuclease in the N Terminus of Andes Virus L Protein
Q41919256Biochemical characterization of recombinant influenza A polymerase heterotrimer complex: Polymerase activity and mechanisms of action of nucleotide analogs
Q39319904Biochemical principles and inhibitors to interfere with viral capping pathways
Q38117553Biogenesis, assembly, and export of viral messenger ribonucleoproteins in the influenza A virus infected cell
Q30395393Biological characterization of highly pathogenic avian influenza H5N1 viruses that infected humans in Egypt in 2014-2015.
Q27664646Bunyaviridae RNA Polymerases (L-Protein) Have an N-Terminal, Influenza-Like Endonuclease Domain, Essential for Viral Cap-Dependent Transcription
Q39248221Bunyaviridae RdRps: structure, motifs, and RNA synthesis machinery
Q37940415Cap and cap-binding proteins in the control of gene expression
Q27665958Cap binding and immune evasion revealed by Lassa nucleoprotein structure
Q41922860Cap snatching of yeast L-A double-stranded RNA virus can operate in trans and requires viral polymerase actively engaging in transcription
Q35471074Cap-snatching mechanism in yeast L-A double-stranded RNA virus
Q47569878Capped RNA primer binding to influenza polymerase and implications for the mechanism of cap-binding inhibitors.
Q38959504Cellular human CLE/C14orf166 protein interacts with influenza virus polymerase and is required for viral replication.
Q34440497Cellular protein HAX1 interacts with the influenza A virus PA polymerase subunit and impedes its nuclear translocation
Q30426032Characterization in vitro and in vivo of a pandemic H1N1 influenza virus from a fatal case.
Q42284370Characterization of PA-N terminal domain of Influenza A polymerase reveals sequence specific RNA cleavage
Q55426854Characterization of influenza virus variants induced by treatment with the endonuclease inhibitor baloxavir marboxil.
Q26799938Cloned Defective Interfering Influenza RNA and a Possible Pan-Specific Treatment of Respiratory Virus Diseases
Q33834096CoESPRIT: a library-based construct screening method for identification and expression of soluble protein complexes
Q27001753Common and unique features of viral RNA-dependent polymerases
Q28550279Comparative Structural and Functional Analysis of Bunyavirus and Arenavirus Cap-Snatching Endonucleases
Q27681434Comparative structural and functional analysis of orthomyxovirus polymerase cap-snatching domains
Q34448295Competition between influenza A virus genome segments
Q64078428Comprehensive mapping of adaptation of the avian influenza polymerase protein PB2 to humans
Q41811018Computational Studies on the Substrate Interactions of Influenza A Virus PB2 Subunit
Q47259261Computational analysis of the effect of polymerase acidic (PA) gene mutation F35L in the 2009 pandemic influenza A (H1N1) virus on binding aspects of mononucleotides in the endonuclease domain
Q27680799Conformational polymorphism of m7GTP in crystal structure of the PB2 middle domain from human influenza A virus
Q36946991Conserved Endonuclease Function of Hantavirus L Polymerase
Q37964471Conventional and unconventional mechanisms for capping viral mRNA.
Q39730929Correlation between polymerase activity and pathogenicity in two duck H5N1 influenza viruses suggests that the polymerase contributes to pathogenicity
Q27678055Crimean-Congo hemorrhagic fever virus nucleoprotein reveals endonuclease activity in bunyaviruses
Q38234789Crucial role of PA in virus life cycle and host adaptation of influenza A virus
Q27668161Crystal Structure and Functional Analysis of the SARS-Coronavirus RNA Cap 2′-O-Methyltransferase nsp10/nsp16 Complex
Q27653656Crystal structure of an avian influenza polymerase PA(N) reveals an endonuclease active site
Q27315161Crystal structure of the RNA-dependent RNA polymerase from influenza C virus
Q27651109Crystal structure of the polymerase PA(C)-PB1(N) complex from an avian influenza H5N1 virus
Q36711056Crystallization and X-ray crystallographic analysis of the cap-binding domain of influenza A virus H1N1 polymerase subunit PB2
Q37083804Crystallization and X-ray diffraction analysis of the RNA primer/promoter-binding domain of influenza A virus RNA-dependent RNA polymerase PB2.
Q27681317Crystallization and preliminary X-ray diffraction studies of a surface mutant of the middle domain of PB2 from human influenza A (H1N1) virus
Q42578086Crystallization studies of the keratin-like domain from Arabidopsis thaliana SEPALLATA 3.
Q38473543Deep sequencing reveals the eight facets of the influenza A/HongKong/1/1968 (H3N2) virus cap-snatching process
Q42107951Detection and characterization of influenza A virus PA-PB2 interaction through a bimolecular fluorescence complementation assay
Q36482772Development of Live-Attenuated Influenza Vaccines against Outbreaks of H5N1 Influenza
Q43173299Differential host gene responses in mice infected with two highly pathogenic avian influenza viruses of subtype H5N1 isolated from wild birds in Thailand
Q30398601Discovery of Novel, Orally Bioavailable β-Amino Acid Azaindole Inhibitors of Influenza PB2.
Q91800691Diversity of A(H5N1) clade 2.3.2.1c avian influenza viruses with evidence of reassortment in Cambodia, 2014-2016
Q34595028DnaJA1/Hsp40 is co-opted by influenza A virus to enhance its viral RNA polymerase activity
Q33599838Dynamical insight into Caenorhabditis elegans eIF4E recognition specificity for mono-and trimethylated structures of mRNA 5' cap.
Q51021243ESPRIT: A Method for Defining Soluble Expression Constructs in Poorly Understood Gene Sequences
Q30356291Effects of different polymerases of avian influenza viruses on the growth and pathogenicity of A/Puerto Rico/8/1934 (H1N1)-derived reassorted viruses.
Q34269400Emerging antiviral resistant strains of influenza A and the potential therapeutic targets within the viral ribonucleoprotein (vRNP) complex
Q30376907Emerging antiviral targets for influenza A virus.
Q24567974Enzymology of RNA cap synthesis
Q38061423Evasion of influenza A viruses from innate and adaptive immune responses.
Q64129782Evolution of canine and equine influenza (H3N8) viruses co-circulating between 2005 and 2008
Q28603187Evolution of the Plant Reproduction Master Regulators LFY and the MADS Transcription Factors: The Role of Protein Structure in the Evolutionary Development of the Flower
Q36409349Evolutionary conservation of influenza A PB2 sequences reveals potential target sites for small molecule inhibitors
Q33965724Experimental mapping of soluble protein domains using a hierarchical approach
Q33399907Expression of Helicobacter pylori CagA domains by library-based construct screening
Q33684517Expression of soluble, active fragments of the morphogenetic protein SpoIIE from Bacillus subtilis using a library-based construct screen
Q30356104Extreme evolutionary conservation of functionally important regions in H1N1 influenza proteome.
Q27683683First structural evidence of sequestration of mRNA cap structures by type 1 ribosome inactivating protein from Momordica balsamina
Q38184248Flavivirus RNA methylation
Q90949938Flupyranochromene, a novel inhibitor of influenza virus cap-dependent endonuclease, from Penicillium sp. f28743
Q35680145Functional Constraint Profiling of a Viral Protein Reveals Discordance of Evolutionary Conservation and Functionality
Q36736639Functional Genomics Reveals Linkers Critical for Influenza Virus Polymerase
Q30406897Gene Composerin a structural genomics environment
Q28118085Generation and comprehensive analysis of an influenza virus polymerase cellular interaction network
Q40075092Genetic and codon usage bias analyses of polymerase genes of equine influenza virus and its relation to evolution.
Q33455562Genetic trans-complementation establishes a new model for influenza virus RNA transcription and replication.
Q42276887Genomic and evolutionary characterization of a novel influenza-C-like virus from swine
Q33955342Genomic and protein structural maps of adaptive evolution of human influenza A virus to increased virulence in the mouse
Q42919340Genomic diversity of oseltamivir-resistant influenza virus A (H1N1), Luxembourg, 2007-08.
Q90434393Hantavirus RdRp Requires a Host Cell Factor for Cap Snatching
Q33799724Hantavirus nucleocapsid protein has distinct m7G cap- and RNA-binding sites
Q28477264Heat shock protein 70 inhibits the activity of Influenza A virus ribonucleoprotein and blocks the replication of virus in vitro and in vivo
Q38268262Heat shock protein 70 modulates influenza A virus polymerase activity
Q27681674High-Resolution Structure of the N-Terminal Endonuclease Domain of the Lassa Virus L Polymerase in Complex with Magnesium Ions
Q27651972Host Determinant Residue Lysine 627 Lies on the Surface of a Discrete, Folded Domain of Influenza Virus Polymerase PB2 Subunit
Q36736357Host Protein Moloney Leukemia Virus 10 (MOV10) Acts as a Restriction Factor of Influenza A Virus by Inhibiting the Nuclear Import of the Viral Nucleoprotein
Q39451190Host immune-related gene responses against highly pathogenic avian influenza virus infection in vitro differ among chicken cell lines established from different organs
Q34022729Identification of BPR3P0128 as an inhibitor of cap-snatching activities of influenza virus.
Q30574395Identification of Influenza Endonuclease Inhibitors Using a Novel Fluorescence Polarization Assay
Q30370990Identification of PB2 mutations responsible for the efficient replication of H5N1 influenza viruses in human lung epithelial cells
Q28476315Identification of a PA-binding peptide with inhibitory activity against influenza A and B virus replication
Q28118856Identification of gemin5 as a novel 7-methylguanosine cap-binding protein
Q28743238Identification of high-affinity PB1-derived peptides with enhanced affinity to the PA protein of influenza A virus polymerase
Q38325400Influence of PB2 host-range determinants on the intranuclear mobility of the influenza A virus polymerase
Q56981340Influenza A Virus Cell Entry, Replication, Virion Assembly and Movement
Q39224928Influenza A polymerase subunit PB2 possesses overlapping binding sites for polymerase subunit PB1 and human MAVS proteins.
Q39669004Influenza A virus polymerase inhibits type I interferon induction by binding to interferon beta promoter stimulator 1.
Q34121115Influenza A virus polymerase: structural insights into replication and host adaptation mechanisms
Q36286466Influenza A virus preferentially snatches noncoding RNA caps
Q33953132Influenza A virus-generated small RNAs regulate the switch from transcription to replication
Q35879897Influenza Polymerase Can Adopt an Alternative Configuration Involving a Radical Repacking of PB2 Domains
Q34263308Influenza polymerase activity correlates with the strength of interaction between nucleoprotein and PB2 through the host-specific residue K/E627.
Q30791826Influenza virus RNA polymerase: insights into the mechanisms of viral RNA synthesis
Q33997127Influenza virus infection induces the nuclear relocalization of the Hsp90 co-chaperone p23 and inhibits the glucocorticoid receptor response
Q42084631Influenza virus polymerase confers independence of the cellular cap-binding factor eIF4E for viral mRNA translation
Q38444279Influenza virus polymerase: Functions on host range, inhibition of cellular response to infection and pathogenicity.
Q41593760Influenza: An RNA-synthesizing machine
Q37631859Inhibition of translation by IFIT family members is determined by their ability to interact selectively with the 5'-terminal regions of cap0-, cap1- and 5'ppp- mRNAs
Q33646273Innate immune evasion strategies of influenza viruses
Q34574076Integrating computational modeling and functional assays to decipher the structure-function relationship of influenza virus PB1 protein
Q34695795Interaction of the influenza A virus polymerase PB2 C-terminal region with importin alpha isoforms provides insights into host adaptation and polymerase assembly.
Q34262049Interactions between the influenza A virus RNA polymerase components and retinoic acid-inducible gene I.
Q30366402Interactome analysis of the influenza A virus transcription/replication machinery identifies protein phosphatase 6 as a cellular factor required for efficient virus replication.
Q64077290Interplay between Influenza Virus and the Host RNA Polymerase II Transcriptional Machinery
Q30375026Interplay between influenza A virus and host factors: targets for antiviral intervention.
Q36785197Interplay between viruses and host mRNA degradation
Q92717896Inventory of molecular markers affecting biological characteristics of avian influenza A viruses
Q90736243Key Role of the Influenza A Virus PA Gene Segment in the Emergence of Pandemic Viruses
Q93193646Kinase inhibitor roscovitine as a PB2 cap-binding inhibitor against influenza a virus replication
Q38384758Learning from structure-based drug design and new antivirals targeting the ribonucleoprotein complex for the treatment of influenza
Q27008422Library methods for structural biology of challenging proteins and their complexes
Q33949042Library-based methods for identification of soluble expression constructs
Q39719150Limited compatibility of polymerase subunit interactions in influenza A and B viruses
Q28246933Mesoionic heterocyclic compounds as candidate messenger RNA cap analogue inhibitors of the influenza virus RNA polymerase cap-binding activity
Q41130389Molecular Basis of mRNA Cap Recognition by Influenza B Polymerase PB2 Subunit.
Q90281098Molecular mechanisms of Evening Complex activity in Arabidopsis
Q56556612Multiple polymerase gene mutations for human adaptation occurring in Asian H5N1 influenza virus clinical isolates
Q28534627Mutational analysis of the binding pockets of the diketo acid inhibitor L-742,001 in the influenza virus PA endonuclease
Q42428242Mutational and metal binding analysis of the endonuclease domain of the influenza virus polymerase PA subunit
Q30414529Mutations in polymerase genes enhanced the virulence of 2009 pandemic H1N1 influenza virus in mice
Q90020522Mutations in the H7 HA and PB1 genes of avian influenza a viruses increase viral pathogenicity and contact transmission in guinea pigs
Q91206841Mutations of the segment-specific nucleotides at the 3' end of influenza virus NS segment control viral replication
Q35011532New prospects for the rational design of antivirals
Q27314657Novel Polymerase Gene Mutations for Human Adaptation in Clinical Isolates of Avian H5N1 Influenza Viruses
Q40743239Novel Ranking System for Identifying Efficacious Anti-Influenza Virus PB2 Inhibitors
Q41713118Novel residues in avian influenza virus PB2 protein affect virulence in mammalian hosts
Q45325232Nuclear TRIM25 Specifically Targets Influenza Virus Ribonucleoproteins to Block the Onset of RNA Chain Elongation.
Q39801069Nuclear dynamics of influenza A virus ribonucleoproteins revealed by live-cell imaging studies
Q42165218Nuclear localization of influenza B polymerase proteins and their binary complexes
Q27646520Nucleoside Monophosphate Complex Structures of the Endonuclease Domain from the Influenza Virus Polymerase PA Subunit Reveal the Substrate Binding Site inside the Catalytic Center
Q52644426Nucleosides for the treatment of respiratory RNA virus infections
Q27675228Organization of the influenza virus replication machinery
Q30395091PB2 residue 158 is a pathogenic determinant of pandemic H1N1 and H5 influenza a viruses in mice
Q30385995PB2 residue 271 plays a key role in enhanced polymerase activity of influenza A viruses in mammalian host cells.
Q40434822PB2 substitutions V598T/I increase the virulence of H7N9 influenza A virus in mammals
Q101165964Parallel evolution in the emergence of highly pathogenic avian influenza A viruses
Q38089861Poly(A)-specific ribonuclease (PARN): An allosterically regulated, processive and mRNA cap-interacting deadenylase
Q38832421Polycistronic Expression of the Influenza A Virus RNA-Dependent RNA Polymerase by Using the Thosea asigna Virus 2A-Like Self-Processing Sequence
Q30410407Polymerase activity of hybrid ribonucleoprotein complexes generated from reassortment between 2009 pandemic H1N1 and seasonal H3N2 influenza A viruses.
Q39091129Polymerase complex with lysine at position 627 of the PB2 of influenza virus A/Hong Kong/483/97 (H5N1) efficiently transcribes and replicates virus genes in mouse cells
Q97587374Pre-initiation and elongation structures of full-length La Crosse virus polymerase reveal functionally important conformational changes
Q35076802Preclinical activity of VX-787, a first-in-class, orally bioavailable inhibitor of the influenza virus polymerase PB2 subunit
Q40062104Prerequisites for the acquisition of mammalian pathogenicity by influenza A virus with a prototypic avian PB2 gene
Q92568973Priming and realignment by the influenza a virus RdRp is dependent on the length of the host primers and the extent of base pairing to viral RNA
Q30234943Progress of small molecular inhibitors in the development of anti-influenza virus agents
Q92730130Quantifying within-host diversity of H5N1 influenza viruses in humans and poultry in Cambodia
Q38100767RNA synthetic mechanisms employed by diverse families of RNA viruses
Q33641550RNA virus replication complexes
Q90633475Rank orders of mammalian pathogenicity-related PB2 mutations of avian influenza A viruses
Q26863710Recent progress in structure-based anti-influenza drug design
Q38335070Recognition of Cap Structure by Influenza B Virus RNA Polymerase Is Less Dependent on the Methyl Residue than Recognition by Influenza A Virus Polymerase
Q42130090Regulation of Influenza RNA Polymerase Activity and the Switch between Replication and Transcription by the Concentrations of the vRNA 5′ End, the Cap Source, and the Polymerase
Q56427023Replication Cycle of Influenza Viruses
Q30431677Replication and Transcription Activities of Ribonucleoprotein Complexes Reconstituted from Avian H5N1, H1N1pdm09 and H3N2 Influenza A Viruses
Q26746999Replication-Competent Influenza A Viruses Expressing Reporter Genes
Q30387215Residues in the PB2 and PA genes contribute to the pathogenicity of avian H7N3 influenza A virus in DBA/2 mice.
Q46281156Rice Stripe Tenuivirus Has a Greater Tendency To Use the Prime-and-Realign Mechanism in Transcription of Genomic than in Transcription of Antigenomic Template RNAs
Q38994875Role of the C terminus of Lassa virus L protein in viral mRNA synthesis
Q38998940Role of the PB2 627 Domain in Influenza A Virus Polymerase Function
Q36044129Secondary Structure Prediction of Protein Constructs Using Random Incremental Truncation and Vacuum-Ultraviolet CD Spectroscopy
Q38883679Sequencing the cap-snatching repertoire of H1N1 influenza provides insight into the mechanism of viral transcription initiation.
Q42326378Signatures of Host mRNA 5′ Terminus for Efficient Hantavirus Cap Snatching
Q30414976Small molecule inhibitors of influenza A and B viruses that act by disrupting subunit interactions of the viral polymerase
Q37825059So similar, yet so different: selective translation of capped and polyadenylated viral mRNAs in the influenza virus infected cell
Q27671365Structural Analysis of Specific Metal Chelating Inhibitor Binding to the Endonuclease Domain of Influenza pH1N1 (2009) Polymerase
Q27667486Structural Basis for Microcin C7 Inactivation by the MccE Acetyltransferase
Q27653426Structural Basis of the Influenza A Virus RNA Polymerase PB2 RNA-binding Domain Containing the Pathogenicity-determinant Lysine 627 Residue
Q27671357Structural and Biochemical Basis for Development of Influenza Virus Inhibitors Targeting the PA Endonuclease
Q27676615Structural and Functional Characterization of K339T Substitution Identified in the PB2 Subunit Cap-binding Pocket of Influenza A Virus
Q34178189Structural and functional characterization of an influenza virus RNA polymerase-genomic RNA complex
Q27655083Structural basis for m7G-cap hypermethylation of small nuclear, small nucleolar and telomerase RNA by the dimethyltransferase TGS1
Q43258764Structural basis for oseltamivir resistance of influenza viruses
Q33359110Structural basis for the oligomerization of the MADS domain transcription factor SEPALLATA3 in Arabidopsis
Q40071053Structural basis for therapeutic inhibition of influenza A polymerase PB2 subunit.
Q40370553Structural characterization of recombinant IAV polymerase reveals a stable complex between viral PA-PB1 heterodimer and host RanBP5.
Q27696194Structural insight into cap-snatching and RNA synthesis by influenza polymerase
Q27655568Structural insight into the essential PB1–PB2 subunit contact of the influenza virus RNA polymerase
Q39099407Structural insights into RNA synthesis by the influenza virus transcription-replication machine
Q36372058Structural insights into reptarenavirus cap-snatching machinery.
Q38090250Structure and assembly of the influenza A virus ribonucleoprotein complex
Q92343247Structure of a functional cap-binding domain in Rift Valley fever virus L protein
Q42181164Structure of influenza A polymerase bound to the viral RNA promoter
Q93270615Structure of severe fever with thrombocytopenia syndrome virus L protein elucidates the mechanisms of viral transcription initiation
Q38924212Structure of the Lassa virus nucleoprotein revealed by X-ray crystallography, small-angle X-ray scattering, and electron microscopy
Q37496812Structure-function studies of the influenza virus RNA polymerase PA subunit
Q30387969Structures of influenza A proteins and insights into antiviral drug targets.
Q30369689Survival analysis of infected mice reveals pathogenic variations in the genome of avian H1N1 viruses
Q42627674Synergistic effect of PB2 283M and 526R contributes to enhanced virulence of H5N8 influenza viruses in mice
Q38333995Synthesis of a new class of ribose functionalized dinucleotide cap analogues for biophysical studies on interaction of cap-binding proteins with the 5′ end of mRNA
Q59830619Targeting Metalloenzymes for Therapeutic Intervention
Q39466061Targeting of the Influenza A Virus Polymerase PB1-PB2 Interface Indicates Strain-Specific Assembly Differences
Q38047645Targeting the host or the virus: current and novel concepts for antiviral approaches against influenza virus infection
Q57466491Temperature Sensitive Mutations in Influenza A Viral Ribonucleoprotein Complex Responsible for the Attenuation of the Live Attenuated Influenza Vaccine
Q26744324The Feat of Packaging Eight Unique Genome Segments
Q28071809The Influenza Virus Polymerase Complex: An Update on Its Structure, Functions, and Significance for Antiviral Drug Design
Q39799773The Myb domain of LUX ARRHYTHMO in complex with DNA: expression, purification and crystallization.
Q30395961The N terminus of PA polymerase of swine-origin influenza virus H1N1 determines its compatibility with PB2 and PB1 subunits through a strain-specific amino acid serine 186
Q27664647The N-Terminal Domain of the Arenavirus L Protein Is an RNA Endonuclease Essential in mRNA Transcription
Q33440587The N-terminal region of the PA subunit of the RNA polymerase of influenza A/HongKong/156/97 (H5N1) influences promoter binding
Q38963385The PA Endonuclease Inhibitor RO-7 Protects Mice from Lethal Challenge with Influenza A or B Viruses
Q34055501The PB2 subunit of the influenza virus RNA polymerase affects virulence by interacting with the mitochondrial antiviral signaling protein and inhibiting expression of beta interferon
Q27673499The Protein Maker: an automated system for high-throughput parallel purification
Q30413814The RNA Polymerase PB2 Subunit of Influenza A/HongKong/156/1997 (H5N1) Restrict the Replication of Reassortant Ribonucleoprotein Complexes
Q28084418The RNA synthesis machinery of negative-stranded RNA viruses
Q39093232The RNA-dependent RNA polymerase of the influenza A virus
Q34082693The Splicing Factor Proline-Glutamine Rich (SFPQ/PSF) Is Involved in Influenza Virus Transcription
Q57094150The Surface-Exposed PA-Loop of the Influenza A Virus Polymerase Is Required for Viral Genome Replication
Q37708361The VIZIER project: overview; expectations; and achievements
Q30384645The cap-binding site of influenza virus protein PB2 as a drug target.
Q27653657The cap-snatching endonuclease of influenza virus polymerase resides in the PA subunit
Q30371858The crystal structure of the PB2 cap-binding domain of influenza B virus reveals a novel cap recognition mechanism.
Q40161983The highly pathogenic H5N1 influenza A virus down-regulated several cellular MicroRNAs which target viral genome.
Q33391385The host-dependent interaction of alpha-importins with influenza PB2 polymerase subunit is required for virus RNA replication
Q34740501The human H5N1 influenza A virus polymerase complex is active in vitro over a broad range of temperatures, in contrast to the WSN complex, and this property can be attributed to the PB2 subunit
Q30403251The influenza pandemic of 2009: lessons and implications
Q37847896The influenza virus RNA synthesis machine: advances in its structure and function
Q59352771The nucleolar protein LYAR facilitates ribonucleoprotein assembly of influenza A virus
Q26824373The polymerase of negative-stranded RNA viruses
Q37823112The role of the influenza virus RNA polymerase in host shut-off
Q27651365The structural basis for an essential subunit interaction in influenza virus RNA polymerase
Q27316702The structure of a biologically active influenza virus ribonucleoprotein complex
Q38064834Tinkering with Translation: Protein Synthesis in Virus-Infected Cells
Q26772953Towards a structural understanding of RNA synthesis by negative strand RNA viral polymerases
Q28354200Tracking the Evolution of Polymerase Genes of Influenza A Viruses during Interspecies Transmission between Avian and Swine Hosts
Q39110012Transcription and replication mechanisms of Bunyaviridae and Arenaviridae L proteins
Q45361252Two mutations in the C-terminal domain of influenza virus RNA polymerase PB2 enhance transcription by enhancing cap-1 RNA binding activity
Q37415425Ubiquitination up-regulates influenza virus polymerase function.
Q42273561Understanding molecular mechanisms of traditional Chinese medicine for the treatment of influenza viruses infection by computational approaches
Q38664267Unexpected complexity in the interference activity of a cloned influenza defective interfering RNA.
Q28308081Upolu virus and Aransas Bay virus, two presumptive bunyaviruses, are novel members of the family Orthomyxoviridae
Q44856323Virology: One protein, many functions
Q30424508Virulence Determinants of Pandemic A(H1N1)2009 Influenza Virus in a Mouse Model
Q38364349hCLE/C14orf166, a cellular protein required for viral replication, is incorporated into influenza virus particles.
Q36479667pp32 and APRIL are host cell-derived regulators of influenza virus RNA synthesis from cRNA.

Search more.