Targeting of the Influenza A Virus Polymerase PB1-PB2 Interface Indicates Strain-Specific Assembly Differences

scientific article published on September 28, 2011

Targeting of the Influenza A Virus Polymerase PB1-PB2 Interface Indicates Strain-Specific Assembly Differences is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1128/JVI.00868-11
P953full work available at URLhttps://doi.org/10.1128/jvi.00868-11
https://europepmc.org/articles/PMC3233147
https://europepmc.org/articles/PMC3233147?pdf=render
https://journals.asm.org/doi/pdf/10.1128/JVI.00868-11
https://jvi.asm.org/content/jvi/85/24/13298.full.pdf
P932PMC publication ID3233147
P698PubMed publication ID21957294
P5875ResearchGate publication ID51679699

P50authorPeter ReutherQ45363978
Benjamin MänzQ46149831
Linda BrunotteQ46149844
???Q46149765
P2093author name stringKerstin Wunderlich
P2860cites workRapid and reliable universal cloning of influenza A virus genes by target-primed plasmid amplificationQ36986738
A quantitative strategy to detect changes in accessibility of protein regions to chemical modification on heterodimerizationQ37416358
The influenza virus RNA synthesis machine: advances in its structure and functionQ37847896
A 48-amino-acid region of influenza A virus PB1 protein is sufficient for complex formation with PA.Q38290017
Two aromatic residues in the PB2 subunit of influenza A RNA polymerase are crucial for cap bindingQ38356589
The PA subunit is required for efficient nuclear accumulation of the PB1 subunit of the influenza A virus RNA polymerase complexQ39755896
Mapping the domain structure of the influenza A virus polymerase acidic protein (PA) and its interaction with the basic protein 1 (PB1) subunitQ39956951
Evidence that the C-terminal PB2-binding region of the influenza A virus PB1 protein is a discrete alpha-helical domainQ40060750
Three-dimensional model for the isolated recombinant influenza virus polymerase heterotrimerQ40129576
Role of the influenza virus heterotrimeric RNA polymerase complex in the initiation of replicationQ40221991
In vitro assembly of PB2 with a PB1-PA dimer supports a new model of assembly of influenza A virus polymerase subunits into a functional trimeric complexQ40409573
Rift Valley fever virus L segment: correction of the sequence and possible functional role of newly identified regions conserved in RNA-dependent polymerasesQ40700712
Identification of Hsp90 as a stimulatory host factor involved in influenza virus RNA synthesisQ40704635
Fine mapping of the subunit binding sites of influenza virus RNA polymeraseQ40732397
Detection and characterization of influenza A virus PA-PB2 interaction through a bimolecular fluorescence complementation assayQ42107951
Peptide-mediated interference with influenza A virus polymeraseQ42124512
Genomic events contributing to the high prevalence of amantadine-resistant influenza A/H3N2.Q43174042
Infections with oseltamivir-resistant influenza A(H1N1) virus in the United StatesQ45118572
Hsp90 inhibitors reduce influenza virus replication in cell cultureQ45394243
Functional domains of the influenza A virus PB2 protein: identification of NP- and PB1-binding sitesQ45662724
Cap-recognizing protein of influenza virusQ45794237
Complex formation between influenza virus polymerase proteins expressed in Xenopus oocytesQ45843373
HIV Drug ResistanceQ59448085
The structure of a biologically active influenza virus ribonucleoprotein complexQ27316702
The structural basis for cap binding by influenza virus polymerase subunit PB2Q27650520
Crystal structure of the polymerase PA(C)-PB1(N) complex from an avian influenza H5N1 virusQ27651109
The structural basis for an essential subunit interaction in influenza virus RNA polymeraseQ27651365
Crystal structure of an avian influenza polymerase PA(N) reveals an endonuclease active siteQ27653656
The cap-snatching endonuclease of influenza virus polymerase resides in the PA subunitQ27653657
Structural insight into the essential PB1–PB2 subunit contact of the influenza virus RNA polymeraseQ27655568
Functional analysis of PA binding by influenza a virus PB1: effects on polymerase activity and viral infectivityQ27863706
Identification of two separate domains in the influenza virus PB1 protein involved in the interaction with the PB2 and PA subunits: a model for the viral RNA polymerase structure.Q27867695
Identification of a PA-binding peptide with inhibitory activity against influenza A and B virus replicationQ28476315
Identification of high-affinity PB1-derived peptides with enhanced affinity to the PA protein of influenza A virus polymeraseQ28743238
Identification of four conserved motifs among the RNA-dependent polymerase encoding elementsQ29617964
The viral polymerase mediates adaptation of an avian influenza virus to a mammalian host.Q30352150
The polymerase complex genes contribute to the high virulence of the human H5N1 influenza virus isolate A/Vietnam/1203/04.Q30353368
Influenza A virus strains differ in sensitivity to the antiviral action of Mx-GTPaseQ30367187
Nuclear import and assembly of influenza A virus RNA polymerase studied in live cells by fluorescence cross-correlation spectroscopy.Q30382441
Adaptive strategies of the influenza virus polymerase for replication in humansQ30383307
The Viral Nucleoprotein Determines Mx Sensitivity of Influenza A VirusesQ30403933
Influenza virus polymerase basic protein 1 interacts with influenza virus polymerase basic protein 2 at multiple sites.Q34395842
Neuraminidase inhibitors for influenzaQ34455162
Global transmission of oseltamivir-resistant influenzaQ34955928
Involvement of Hsp90 in assembly and nuclear import of influenza virus RNA polymerase subunitsQ35635186
Mutational analysis identifies functional domains in the influenza A virus PB2 polymerase subunitQ35856754
P433issue24
P407language of work or nameEnglishQ1860
P921main subjectinfluenza A virusQ834390
protein multimerizationQ60439578
P1104number of pages12
P304page(s)13298-13309
P577publication date2011-09-28
P1433published inJournal of VirologyQ1251128
P1476titleTargeting of the influenza A virus polymerase PB1-PB2 interface indicates strain-specific assembly differences
Targeting of the Influenza A Virus Polymerase PB1-PB2 Interface Indicates Strain-Specific Assembly Differences
P478volume85

Reverse relations

cites work (P2860)
Q45353251A peptide derived from the C‐terminus of PB1 inhibits influenza virus replication by interfering with viral polymerase assembly
Q39355418Adaptive mutations in NEP compensate for defective H5N1 RNA replication in cultured human cells
Q29568901Comparative influenza protein interactomes identify the role of plakophilin 2 in virus restriction.
Q57793008Eurasian avian-like swine influenza A viruses escape human MxA restriction by distinct mutations in their nucleoprotein
Q40060300Genetic variation and co-evolutionary relationship of RNA polymerase complex segments in influenza A viruses
Q36191196Identification of a novel small-molecule compound targeting the influenza A virus polymerase PB1-PB2 interface.
Q42221157Optimization of small-molecule inhibitors of influenza virus polymerase: from thiophene-3-carboxamide to polyamido scaffolds
Q30429005Pandemic influenza A viruses escape from restriction by human MxA through adaptive mutations in the nucleoprotein
Q30414976Small molecule inhibitors of influenza A and B viruses that act by disrupting subunit interactions of the viral polymerase
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Q35658224TRIM32 Senses and Restricts Influenza A Virus by Ubiquitination of PB1 Polymerase
Q28071809The Influenza Virus Polymerase Complex: An Update on Its Structure, Functions, and Significance for Antiviral Drug Design
Q28542440The N-terminal fragment of a PB2 subunit from the influenza A virus (A/Hong Kong/156/1997 H5N1) effectively inhibits RNP activity and viral replication

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