Adaptive mutations in the H5N1 polymerase complex (scientific article published on June 2013)

Single mutation at the amino acid position 627 of PB2 that leads to increased virulence of an H5N1 avian influenza virus during adaptation in mice can be compensated by multiple mutations at other sites of PB2.

Q45385093

Hsp90 inhibitors reduce influenza virus replication in cell culture

Q45394243

A classical bipartite nuclear localization signal on Thogoto and influenza A virus nucleoproteins

Q45753472

Reassortant virus derived from avian and human influenza A viruses is attenuated and immunogenic in monkeys

Q45805045

A single gene determines the host range of influenza virus

Q45890452

A single substitution in amino acid 184 of the NP protein alters the replication and pathogenicity of H5N1 avian influenza viruses in chickens.

Q45993249

The critical cut-off temperature of avian influenza viruses

Q48250102

Difference in growth behavior of human, swine, equine, and avian influenza viruses at a high temperature

Q68462514

A physical and regulatory map of host-influenza interactions reveals pathways in H1N1 infection

Q24294658

Large-scale induced fit recognition of an m(7)GpppG cap analogue by the human nuclear cap-binding complex

Q24310463

Cloning of two novel human importin-alpha subunits and analysis of the expression pattern of the importin-alpha protein family

Q24311981

Rch1, a protein that specifically interacts with the RAG-1 recombination-activating protein

Q24312782

RAG-1 interacts with the repeated amino acid motif of the human homologue of the yeast protein SRP1

Q24316431

Cloning and characterization of hSRP1 gamma, a tissue-specific nuclear transport factor

Q24321853

Human host factors required for influenza virus replication

Q24629972

Full-length cDNAs from chicken bursal lymphocytes to facilitate gene function analysis

Q24805650

The structure of a biologically active influenza virus ribonucleoprotein complex

Q27316702

The mechanism by which influenza A virus nucleoprotein forms oligomers and binds RNA

Q27640425

Structure and nuclear import function of the C-terminal domain of influenza virus polymerase PB2 subunit

Q27643860

The structural basis for cap binding by influenza virus polymerase subunit PB2

Q27650520

Structure of the influenza virus A H5N1 nucleoprotein: implications for RNA binding, oligomerization, and vaccine design

Q27651106

Crystal structure of the polymerase PA(C)-PB1(N) complex from an avian influenza H5N1 virus

Q27651109

The structural basis for an essential subunit interaction in influenza virus RNA polymerase

Q27651365

Host Determinant Residue Lysine 627 Lies on the Surface of a Discrete, Folded Domain of Influenza Virus Polymerase PB2 Subunit

Q27651972

Crystal structure of an avian influenza polymerase PA(N) reveals an endonuclease active site

Q27653656

The cap-snatching endonuclease of influenza virus polymerase resides in the PA subunit

Q27653657

Structural insight into the essential PB1–PB2 subunit contact of the influenza virus RNA polymerase

Q27655568

Biological and Structural Characterization of a Host-Adapting Amino Acid in Influenza Virus

Q27664029

The structure of native influenza virion ribonucleoproteins

Q27683510

Cocrystal structure of the messenger RNA 5' cap-binding protein (eIF4E) bound to 7-methyl-GDP

Q27739838

A novel influenza A virus mitochondrial protein that induces cell death.

Q27863709

A unique cap(m7GpppXm)-dependent influenza virion endonuclease cleaves capped RNAs to generate the primers that initiate viral RNA transcription

Q27865288

The NPI-1/NPI-3 (karyopherin alpha) binding site on the influenza a virus nucleoprotein NP is a nonconventional nuclear localization signal

Q27867699

Generation and comprehensive analysis of an influenza virus polymerase cellular interaction network

Q28118085

Structure of influenza virus RNP. I. Influenza virus nucleoprotein melts secondary structure in panhandle RNA and exposes the bases to the solvent

Q28245490

Fatal outcome of human influenza A (H5N1) is associated with high viral load and hypercytokinemia

Q28262914

NPI-1, the human homolog of SRP-1, interacts with influenza virus nucleoprotein

Q28306037

Characterization of an avian influenza A (H5N1) virus isolated from a child with a fatal respiratory illness

Q29615389

Identification of four conserved motifs among the RNA-dependent polymerase encoding elements

Q29617964

Molecular basis for high virulence of Hong Kong H5N1 influenza A viruses

Q29619144

Airborne transmission of influenza A/H5N1 virus between ferrets

Q29619970

Emergence of multiple genotypes of H5N1 avian influenza viruses in Hong Kong SAR.

Q30330486

The viral polymerase mediates adaptation of an avian influenza virus to a mammalian host.

Q30352150

The polymerase complex genes contribute to the high virulence of the human H5N1 influenza virus isolate A/Vietnam/1203/04.

Q30353368

Growth of H5N1 influenza A viruses in the upper respiratory tracts of mice.

Q30365053

Drosophila RNAi screen identifies host genes important for influenza virus replication

Q30370530

An inhibitory activity in human cells restricts the function of an avian-like influenza virus polymerase.

Q30371316

Transmission of influenza virus in a mammalian host is increased by PB2 amino acids 627K or 627E/701N.

Q30374182

Nuclear import and assembly of influenza A virus RNA polymerase studied in live cells by fluorescence cross-correlation spectroscopy.

Q30382441

Adaptive strategies of the influenza virus polymerase for replication in humans

Q30383307

Identification of amino acids in HA and PB2 critical for the transmission of H5N1 avian influenza viruses in a mammalian host

Q30383968

Genome-wide RNAi screen identifies human host factors crucial for influenza virus replication.

Q30384547

Introduction of virulence markers in PB2 of pandemic swine-origin influenza virus does not result in enhanced virulence or transmission.

Q30385332

PB2 residue 271 plays a key role in enhanced polymerase activity of influenza A viruses in mammalian host cells.

Q30385995

The PB2-E627K mutation attenuates viruses containing the 2009 H1N1 influenza pandemic polymerase

Q30392368

PB2 residue 158 is a pathogenic determinant of pandemic H1N1 and H5 influenza a viruses in mice

Q30395091

Differential use of importin-α isoforms governs cell tropism and host adaptation of influenza virus

Q30398701

Virulence and genetic compatibility of polymerase reassortant viruses derived from the pandemic (H1N1) 2009 influenza virus and circulating influenza A viruses

Q30402043

Amino acids 473V and 598P of PB1 from an avian-origin influenza A virus contribute to polymerase activity, especially in mammalian cells

Q30409573

Influence of PB2 host-range determinants on the intranuclear mobility of the influenza A virus polymerase

Q38325400

Adaptive mutations in NEP compensate for defective H5N1 RNA replication in cultured human cells

Q39355418

Residue 627 of PB2 is a determinant of cold sensitivity in RNA replication of avian influenza viruses.

Q39606273

Functional analysis of the influenza virus H5N1 nucleoprotein tail loop reveals amino acids that are crucial for oligomerization and ribonucleoprotein activities

Q39704622

Correlation between polymerase activity and pathogenicity in two duck H5N1 influenza viruses suggests that the polymerase contributes to pathogenicity

Q39730929

The PA subunit is required for efficient nuclear accumulation of the PB1 subunit of the influenza A virus RNA polymerase complex

Q39755896

Differential polymerase activity in avian and mammalian cells determines host range of influenza virus

Q40120171

Host-range determinants on the PB2 protein of influenza A viruses control the interaction between the viral polymerase and nucleoprotein in human cells

Q40176000

Identification of cellular interaction partners of the influenza virus ribonucleoprotein complex and polymerase complex using proteomic-based approaches

Q40176125

In vitro assembly of PB2 with a PB1-PA dimer supports a new model of assembly of influenza A virus polymerase subunits into a functional trimeric complex

Q40409573

PB2 amino acid at position 627 affects replicative efficiency, but not cell tropism, of Hong Kong H5N1 influenza A viruses in mice

Q40579478

Identification of Hsp90 as a stimulatory host factor involved in influenza virus RNA synthesis

Q40704635

The potential for respiratory droplet-transmissible A/H5N1 influenza virus to evolve in a mammalian host

Q30418377

Interaction of polymerase subunit PB2 and NP with importin alpha1 is a determinant of host range of influenza A virus

Q33318082

Analysis of the interaction of influenza virus polymerase complex with human cell factors

Q33336123

The host-dependent interaction of alpha-importins with influenza PB2 polymerase subunit is required for virus RNA replication

Q33391385

The N-terminal region of the PA subunit of the RNA polymerase of influenza A/HongKong/156/97 (H5N1) influences promoter binding

Q33440587

Molecular basis of replication of duck H5N1 influenza viruses in a mammalian mouse model

Q33987340

Association of the influenza virus RNA polymerase subunit PB2 with the host chaperonin CCT.

Q34055461

The PB2 subunit of the influenza virus RNA polymerase affects virulence by interacting with the mitochondrial antiviral signaling protein and inhibiting expression of beta interferon

Q34055501

The splicing factor proline-glutamine rich (SFPQ/PSF) is involved in influenza virus transcription

Q34082693

Influenza A virus polymerase: structural insights into replication and host adaptation mechanisms

Q34121115

Human-like PB2 627K influenza virus polymerase activity is regulated by importin-α1 and -α7.

Q34139960

Role of position 627 of PB2 and the multibasic cleavage site of the hemagglutinin in the virulence of H5N1 avian influenza virus in chickens and ducks

Q34170376

Influenza polymerase activity correlates with the strength of interaction between nucleoprotein and PB2 through the host-specific residue K/E627.

Q34263308

NP body domain and PB2 contribute to increased virulence of H5N1 highly pathogenic avian influenza viruses in chickens

Q34529786

Interaction of the influenza A virus polymerase PB2 C-terminal region with importin alpha isoforms provides insights into host adaptation and polymerase assembly.

Q34695795

The human H5N1 influenza A virus polymerase complex is active in vitro over a broad range of temperatures, in contrast to the WSN complex, and this property can be attributed to the PB2 subunit

Q34740501

Host- and strain-specific regulation of influenza virus polymerase activity by interacting cellular proteins

Q35169989

Comprehensive proteomic analysis of influenza virus polymerase complex reveals a novel association with mitochondrial proteins and RNA polymerase accessory factors

Q35192767

Reversion of PB2-627E to -627K during replication of an H5N1 Clade 2.2 virus in mammalian hosts depends on the origin of the nucleoprotein

Q35275017

Emergence of avian influenza viruses with enhanced transcription activity by a single amino acid substitution in the nucleoprotein during replication in chicken brains

Q35382854

Involvement of Hsp90 in assembly and nuclear import of influenza virus RNA polymerase subunits

Q35635186

Molecular changes in the polymerase genes (PA and PB1) associated with high pathogenicity of H5N1 influenza virus in mallard ducks

Q35947765

Pattern of mutation in the genome of influenza A virus on adaptation to increased virulence in the mouse lung: identification of functional themes

Q36240827

Virulence of avian influenza A viruses for squirrel monkeys.

Q36333583

An overlapping protein-coding region in influenza A virus segment 3 modulates the host response

Q36554219

Identification of novel influenza A virus proteins translated from PA mRNA

Q36607099

Mutational analysis of the conserved motifs of influenza A virus polymerase basic protein 1

Q36630055

A single amino acid in the PB2 gene of influenza A virus is a determinant of host range.

Q36685680

Selection of H5N1 influenza virus PB2 during replication in humans

Q37192151

A complicated message: Identification of a novel PB1-related protein translated from influenza A virus segment 2 mRNA.

Q37275127

A single-amino-acid substitution in a polymerase protein of an H5N1 influenza virus is associated with systemic infection and impaired T-cell activation in mice

Q37410786

Ostrich involvement in the selection of H5N1 influenza virus possessing mammalian-type amino acids in the PB2 protein

Q37452540

Nuclear import of the influenza A virus transcriptional machinery.

Q38015044

P433

issue

P304

page(s)

53-62

P577

publication date

2013-06-01

P1433

published in

Virus Research

Q15749215

P1476

title

Adaptive mutations in the H5N1 polymerase complex

P478

volume

178

Reverse relations

cites work (P2860)

Q52324500	A Single Amino Acid at the Polymerase Acidic Protein Determines the Pathogenicity of Influenza B Viruses.
Q30387197	A point mutation in the polymerase protein PB2 allows a reassortant H9N2 influenza isolate of wild-bird origin to replicate in human cells
Q40128432	A single mutation in Taiwanese H6N1 influenza hemagglutinin switches binding to human-type receptors.
Q40044615	Adaptation of influenza A (H7N9) virus in primary human airway epithelial cells
Q40719692	Adaptive amino acid substitutions enhance the virulence of a novel human H7N9 influenza virus in mice.
Q30370371	Adaptive amino acid substitutions enhance the virulence of a reassortant H7N1 avian influenza virus isolated from wild waterfowl in mice.
Q30372681	Adaptive amino acid substitutions enhance the virulence of an H7N7 avian influenza virus isolated from wild waterfowl in mice.
Q28387714	Airborne transmission of highly pathogenic H7N1 influenza virus in ferrets
Q41665288	Amino Acid Substitutions Associated with Avian H5N6 Influenza A Virus Adaptation to Mice
Q40747864	Amino acid substitutions occurring during adaptation of an emergent H5N6 avian influenza virus to mammals
Q30369742	D701N mutation in the PB2 protein contributes to the pathogenicity of H5N1 avian influenza viruses but not transmissibility in guinea pigs.
Q55555164	Diversity of Influenza A(H5N1) Viruses in Infected Humans, Northern Vietnam, 2004-2010.
Q61864330	Ebola et autres, ces virus venus d’ailleurs
Q57460390	Genetic characterization of the first detected human case of avian influenza A (H5N6) in Anhui Province, East China
Q47160030	Human Clade 2.3.4.4 A/H5N6 Influenza Virus Lacks Mammalian Adaptation Markers and Does Not Transmit via the Airborne Route between Ferrets.
Q40734659	Human infection with a highly pathogenic avian influenza A (H5N6) virus in Yunnan province, China.
Q30375042	Identification of Influenza A Virus PB2 Residues Involved in Enhanced Polymerase Activity and Virus Growth in Mammalian Cells at Low Temperatures
Q37733749	Identification of Rare PB2-D701N Mutation from a Patient with Severe Influenza: Contribution of the PB2-D701N Mutation to the Pathogenicity of Human Influenza
Q92712391	Immune-Related Gene Expression in Ducks Infected With Waterfowl-Origin H5N6 Highly Pathogenic Avian Influenza Viruses
Q28388026	Influenza A virus transmission via respiratory aerosols or droplets as it relates to pandemic potential
Q92717896	Inventory of molecular markers affecting biological characteristics of avian influenza A viruses
Q97643132	Molecular basis of host-adaptation interactions between influenza virus polymerase PB2 subunit and ANP32A
Q30364868	Molecular determinants of influenza virus pathogenesis in mice.
Q38642261	Mutations Driving Airborne Transmission of A/H5N1 Virus in Mammals Cause Substantial Attenuation in Chickens only when combined
Q59359461	PB2 E627K or D701N substitution does not change the virulence of canine influenza virus H3N2 in mice and dogs
Q30363302	PB2 mutations D701N and S714R promote adaptation of an influenza H5N1 virus to a mammalian host
Q30374833	Phylogenetic Analysis and Functional Characterization of the Influenza A H5N1 PB2 Gene.
Q38415133	Proteomic identification of nuclear processes manipulated by cytomegalovirus early during infection
Q89790236	Suppression of Cytotoxic T Cell Functions and Decreased Levels of Tissue Resident Memory T cell During H5N1 infection
Q30382370	The 1918 Influenza Virus PB2 Protein Enhances Virulence through the Disruption of Inflammatory and Wnt-Mediated Signaling in Mice
Q35492368	Tracking the Evolution in Phylogeny, Structure and Function of H5N1 Influenza Virus PA Gene
Q34167450	Use of fractional factorial design to study the compatibility of viral ribonucleoprotein gene segments of human H7N9 virus and circulating human influenza subtypes
Q40231964	Zoonotic Potential of Emerging Paramyxoviruses: Knowns and Unknowns

P356	DOI	10.1016/J.VIRUSRES.2013.05.010
P698	PubMed publication ID	23732876