Functional analysis of the influenza virus H5N1 nucleoprotein tail loop reveals amino acids that are crucial for oligomerization and ribonucleoprotein activities

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Functional analysis of the influenza virus H5N1 nucleoprotein tail loop reveals amino acids that are crucial for oligomerization and ribonucleoprotein activities is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1128/JVI.02474-09
P932PMC publication ID2898228
P698PubMed publication ID20463064

P50authorPaul Kay-Sheung ChanQ42915359
Ervin FodorQ60680669
P2093author name stringJia-Huai Wang
Pang-Chui Shaw
Shannon Wing-Ngor Au
Nicole C Robb
Andy Ka-Leung Ng
Mandy Ka-Han Lam
Wai-Hon Chan
P2860cites workThe structure of a biologically active influenza virus ribonucleoprotein complexQ27316702
The mechanism by which influenza A virus nucleoprotein forms oligomers and binds RNAQ27640425
Structure of the influenza virus A H5N1 nucleoprotein: implications for RNA binding, oligomerization, and vaccine designQ27651106
3D structure of the influenza virus polymerase complex: localization of subunit domains.Q27863781
Model suggesting that replication of influenza virus is regulated by stabilization of replicative intermediatesQ27863792
Structure of influenza virus RNP. I. Influenza virus nucleoprotein melts secondary structure in panhandle RNA and exposes the bases to the solventQ28245490
Emerging antiviral targets for influenza A virus.Q30376907
Influenza virus nucleoprotein interacts with influenza virus polymerase proteinsQ33784955
The influenza virus nucleoprotein: a multifunctional RNA-binding protein pivotal to virus replication.Q34119838
Genomic RNAs of influenza viruses are held in a circular conformation in virions and in infected cells by a terminal panhandleQ34367296
Structure of the vesicular stomatitis virus nucleoprotein-RNA complexQ34538707
Crystal structure of the rabies virus nucleoprotein-RNA complexQ34538715
Temperature-sensitive mutants of influenza WSN virus defective in virus-specific RNA synthesisQ36540591
Transcription of the influenza ribonucleic acid genome by a virion polymerase. I. Optimal conditions for in vitro activity of the ribonucleic acid-dependent ribonucleic acid polymeraseQ36581345
Structure of the ribonucleoprotein of influenza virusQ36590126
Analysis of the evolution and variation of the human influenza A virus nucleoprotein gene from 1933 to 1990Q36645539
Influenza virus RNA replication in vitro: synthesis of viral template RNAs and virion RNAs in the absence of an added primerQ36871597
Mutational analysis of conserved amino acids in the influenza A virus nucleoproteinQ37157108
Structure and sequence analysis of influenza A virus nucleoproteinQ37496808
Mutational analysis of influenza A virus nucleoprotein: identification of mutations that affect RNA replicationQ39549297
Temperature-sensitive lesions in two influenza A viruses defective for replicative transcription disrupt RNA binding by the nucleoproteinQ39550900
A single amino acid mutation in the PA subunit of the influenza virus RNA polymerase inhibits endonucleolytic cleavage of capped RNAsQ39684553
Architecture of ribonucleoprotein complexes in influenza A virus particlesQ40325038
Use of specific single stranded DNA probes cloned in M13 to study the RNA synthesis of four temperature-sensitive mutants of HK/68 influenza virusQ40464420
Oligomerization of the influenza virus nucleoprotein: identification of positive and negative sequence elementsQ40942027
Intracellular oligomerization of influenza virus nucleoproteinQ41172139
Studies of fowl plague virus temperature-sensitive mutants with defects in synthesis of virion RNA.Q41528461
Host range mutants of an influenza A virusQ41545637
Roles of the influenza virus polymerase and nucleoprotein in forming a functional RNP structureQ41845291
Three-dimensional reconstruction of a recombinant influenza virus ribonucleoprotein particleQ42724088
Binding of Ribonucleic Acids to the RNP-antigen Protein of Influenza VirusesQ43706484
Structure of influenza virus ribonucleoprotein particles. II. Purified RNA-free influenza virus ribonucleoprotein forms structures that are indistinguishable from the intact influenza virus ribonucleoprotein particlesQ45764537
Isolation and characterization of the ribonucleoprotein of influenza virusQ45825849
Localization of RNA polymerases on influenza viral ribonucleoproteins by immunogold labelingQ68356619
P4510describes a project that usesImageQuantQ112270642
P433issue14
P407language of work or nameEnglishQ1860
P921main subjectribonucleoprotein complexQ417662
P304page(s)7337-7345
P577publication date2010-05-12
P1433published inJournal of VirologyQ1251128
P1476titleFunctional analysis of the influenza virus H5N1 nucleoprotein tail loop reveals amino acids that are crucial for oligomerization and ribonucleoprotein activities
P478volume84

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cites work (P2860)
Q28546866A Novel Antiviral Target Structure Involved in the RNA Binding, Dimerization, and Nuclear Export Functions of the Influenza A Virus Nucleoprotein
Q90598908A Quinolinone Compound Inhibiting the Oligomerization of Nucleoprotein of Influenza A Virus Prevents the Selection of Escape Mutants
Q38111647Adaptive mutations in the H5N1 polymerase complex
Q36138356Binding of RNA by the Nucleoproteins of Influenza Viruses A and B.
Q59352174CDC25B promotes influenza A virus replication by regulating the phosphorylation of nucleoprotein
Q45324749Cellular hnRNP A2/B1 interacts with the NP of influenza A virus and impacts viral replication
Q42630565Cellular splicing factor UAP56 stimulates trimeric NP formation for assembly of functional influenza viral ribonucleoprotein complexes
Q21135288Cyclophilin E functions as a negative regulator to influenza virus replication by impairing the formation of the viral ribonucleoprotein complex
Q35289390E339...R416 salt bridge of nucleoprotein as a feasible target for influenza virus inhibitors
Q44399562Human importin alpha and RNA do not compete for binding to influenza A virus nucleoprotein.
Q36300881Identification of small molecule inhibitors for influenza a virus using in silico and in vitro approaches
Q34741826Identification of two functional domains within the arenavirus nucleoprotein
Q34263308Influenza polymerase activity correlates with the strength of interaction between nucleoprotein and PB2 through the host-specific residue K/E627.
Q30791826Influenza virus RNA polymerase: insights into the mechanisms of viral RNA synthesis
Q38165194Influenza virus nucleoprotein: structure, RNA binding, oligomerization and antiviral drug target.
Q27673286Inhibition of influenza virus replication via small molecules that induce the formation of higher-order nucleoprotein oligomers
Q38764949Intrinsically disordered region of influenza A NP regulates viral genome packaging via interactions with viral RNA and host PI(4,5)P2.
Q30361315Large-scale analysis of influenza A virus nucleoprotein sequence conservation reveals potential drug-target sites.
Q36384462Mapping the phosphoproteome of influenza A and B viruses by mass spectrometry
Q34137464Molecular dynamics studies of the nucleoprotein of influenza A virus: role of the protein flexibility in RNA binding
Q27677207Monomeric Nucleoprotein of Influenza A Virus
Q52330113Mutations Conferring Increased Sensitivity to Tripartite Motif 22 Restriction Accumulated Progressively in the Nucleoprotein of Seasonal Influenza A (H1N1) Viruses between 1918 and 2009.
Q30366669Mutations to PB2 and NP proteins of an avian influenza virus combine to confer efficient growth in primary human respiratory cells.
Q59360823Phosphorylation and dephosphorylation of threonine 188 in nucleoprotein is crucial for the replication of influenza A virus
Q35600285Phosphorylation at the homotypic interface regulates nucleoprotein oligomerization and assembly of the influenza virus replication machinery
Q36194662Pre-mRNA Processing Factor Prp18 Is a Stimulatory Factor of Influenza Virus RNA Synthesis and Possesses Nucleoprotein Chaperone Activity
Q26863710Recent progress in structure-based anti-influenza drug design
Q41684632Regulation of influenza A virus nucleoprotein oligomerization by phosphorylation
Q35077609Replication-coupled and host factor-mediated encapsidation of the influenza virus genome by viral nucleoprotein.
Q39359022Sequence in the influenza A virus nucleoprotein required for viral polymerase binding and RNA synthesis.
Q38959373Stabilization of influenza virus replication intermediates is dependent on the RNA-binding but not the homo-oligomerization activity of the viral nucleoprotein
Q27678470Structural Basis for RNA Binding and Homo-Oligomer Formation by Influenza B Virus Nucleoprotein
Q35993057Structure-based design of novel naproxen derivatives targeting monomeric nucleoprotein of Influenza A virus
Q24632337Structure-based discovery of the novel antiviral properties of naproxen against the nucleoprotein of influenza A virus
Q28071809The Influenza Virus Polymerase Complex: An Update on Its Structure, Functions, and Significance for Antiviral Drug Design
Q28084418The RNA synthesis machinery of negative-stranded RNA viruses
Q41812881The role and assembly mechanism of nucleoprotein in influenza A virus ribonucleoprotein complexes
Q61444455The structure of the nucleoprotein of Influenza D shows that all Orthomyxoviridae nucleoproteins have a similar NP, with or without a NP for nuclear transport
Q27320490Time-Resolved Visualisation of Nearly-Native Influenza A Virus Progeny Ribonucleoproteins and Their Individual Components in Live Infected Cells

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