Adult-specific functions of animal microRNAs

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Adult-specific functions of animal microRNAs is …
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scholarly articleQ13442814

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P6179Dimensions Publication ID1005490083
P356DOI10.1038/NRG3471
P932PMC publication ID4136762
P698PubMed publication ID23817310

P50authorEric C LaiQ52431492
P2093author name stringKailiang Sun
P2860cites workThe bantam microRNA is associated with drosophila fragile X mental retardation protein and regulates the fate of germline stem cellsQ21145004
Targeted inhibition of miRNA maturation with morpholinos reveals a role for miR-375 in pancreatic islet developmentQ21145874
Most Caenorhabditis elegans microRNAs are individually not essential for development or viabilityQ21563452
miR-145 and miR-143 regulate smooth muscle cell fate and plasticityQ24311186
Frequent deletions and down-regulation of micro- RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemiaQ24539231
A microRNA expression signature of human solid tumors defines cancer gene targetsQ24541455
Nanoparticle-based therapy in an in vivo microRNA-155 (miR-155)-dependent mouse model of lymphomaQ24595213
Genome-wide RNA-mediated interference screen identifies miR-19 targets in Notch-induced T-cell acute lymphoblastic leukaemiaQ24596097
miR-451 protects against erythroid oxidant stress by repressing 14-3-3zetaQ24600133
Defective erythroid differentiation in miR-451 mutant mice mediated by 14-3-3zetaQ24600228
microRNA-1 and microRNA-206 regulate skeletal muscle satellite cell proliferation and differentiation by repressing Pax7Q24615529
The miR-144/451 locus is required for erythroid homeostasisQ24615624
The microRNA miR-34a inhibits prostate cancer stem cells and metastasis by directly repressing CD44Q24617130
Control of glucose homeostasis and insulin sensitivity by the Let-7 family of microRNAsQ24617134
The Lin28/let-7 axis regulates glucose metabolismQ24620363
Epigenetic regulation of miR-184 by MBD1 governs neural stem cell proliferation and differentiationQ24621879
Stress-dependent cardiac remodeling occurs in the absence of microRNA-21 in miceQ24623247
A novel pathway regulates memory and plasticity via SIRT1 and miR-134Q24624906
miR-33a/b contribute to the regulation of fatty acid metabolism and insulin signalingQ24627398
Adult neurogenesis in the mammalian brain: significant answers and significant questionsQ24628935
Antagonism of miR-33 in mice promotes reverse cholesterol transport and regression of atherosclerosisQ24634165
Activation of miR-31 function in already-established metastases elicits metastatic regressionQ24634255
Targeted deletion reveals essential and overlapping functions of the miR-17 through 92 family of miRNA clustersQ24645192
Posttranscriptional regulation of BK channel splice variant stability by miR-9 underlies neuroadaptation to alcoholQ24646484
The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2Q24646996
A role for microRNAs in the Drosophila circadian clockQ24647341
MicroRNAs miR-143 and miR-145 modulate cytoskeletal dynamics and responsiveness of smooth muscle cells to injuryQ24647407
A pleiotropically acting microRNA, miR-31, inhibits breast cancer metastasisQ24649156
Suppression of non-small cell lung tumor development by the let-7 microRNA familyQ24651985
Genetic dissection of the miR-17~92 cluster of microRNAs in Myc-induced B-cell lymphomasQ24652219
miR-19 is a key oncogenic component of mir-17-92Q24652326
microRNA modulation of circadian-clock period and entrainmentQ24652558
MicroRNA-mediated control of cell fate in megakaryocyte-erythrocyte progenitorsQ24653639
miRNAs are essential for survival and differentiation of newborn neurons but not for expansion of neural progenitors during early neurogenesis in the mouse embryonic neocortexQ24653722
Therapeutic microRNA delivery suppresses tumorigenesis in a murine liver cancer modelQ24655262
Requirement of bic/microRNA-155 for normal immune functionQ24656120
miR-375 maintains normal pancreatic alpha- and beta-cell massQ24657284
The PTEN-regulating microRNA miR-26a is amplified in high-grade glioma and facilitates gliomagenesis in vivoQ24657924
Hmga2 promotes neural stem cell self-renewal in young but not old mice by reducing p16Ink4a and p19Arf ExpressionQ24658265
Disrupting the pairing between let-7 and Hmga2 enhances oncogenic transformationQ24658400
Cerebellar neurodegeneration in the absence of microRNAsQ24676165
Smooth muscle miRNAs are critical for post-natal regulation of blood pressure and vascular functionQ33883484
miR-33 links SREBP-2 induction to repression of sterol transportersQ33981907
A resource of vectors and ES cells for targeted deletion of microRNAs in mice.Q33984727
A view from Drosophila: multiple biological functions for individual microRNAsQ34057929
MicroRNA miR-125a controls hematopoietic stem cell numberQ34069509
Comprehensive microRNA expression profiling of the hematopoietic hierarchyQ34100287
OncomiR addiction in an in vivo model of microRNA-21-induced pre-B-cell lymphoma.Q34130311
MicroRNA sponges: progress and possibilitiesQ34139023
Loss of individual microRNAs causes mutant phenotypes in sensitized genetic backgrounds in C. elegansQ34158509
MicroRNA-33 encoded by an intron of sterol regulatory element-binding protein 2 (Srebp2) regulates HDL in vivoQ34182469
MicroRNA-mediated conversion of human fibroblasts to neurons.Q34200249
Regulation of circadian behavioral output via a MicroRNA-JAK/STAT circuitQ34251948
The C. elegans microRNA mir-71 acts in neurons to promote germline-mediated longevity through regulation of DAF-16/FOXOQ34266474
Modulation of K-Ras-dependent lung tumorigenesis by MicroRNA-21.Q34271727
The mechanics of miRNA-mediated gene silencing: a look under the hood of miRISC.Q34278940
High-throughput assessment of microRNA activity and function using microRNA sensor and decoy librariesQ34323384
Unmet expectations: miR-34 plays no role in p53-mediated tumor suppression in vivoQ34368649
Deregulated sex chromosome gene expression with male germ cell-specific loss of Dicer1Q34441340
MicroRNAs both promote and antagonize longevity in C. elegans.Q34502279
MicroRNA therapeutics for cardiovascular disease: opportunities and obstacles.Q34644199
Target protectors reveal dampening and balancing of Nodal agonist and antagonist by miR-430.Q34673364
A skin microRNA promotes differentiation by repressing 'stemness'.Q34756894
Pervasive roles of microRNAs in cardiovascular biologyQ34775686
Epigenetics and genetics. MicroRNAs en route to the clinic: progress in validating and targeting microRNAs for cancer therapyQ35039281
miRNA-132 orchestrates chromatin remodeling and translational control of the circadian clockQ35047068
Loss of the miR-21 allele elevates the expression of its target genes and reduces tumorigenesis.Q35064340
Alternative miRNA biogenesis pathways and the interpretation of core miRNA pathway mutantsQ35222458
microRNA-34c is a novel target to treat dementiasQ35422390
Targeting of the Arpc3 actin nucleation factor by miR-29a/b regulates dendritic spine morphology.Q35514280
Inhibition of miR-33a/b in non-human primates raises plasma HDL and lowers VLDL triglycerides.Q35606800
MicroRNA-124 is a subventricular zone neuronal fate determinant.Q35614391
MicroRNAs and their roles in aging.Q35714517
MicroRNA transgene overexpression complements deficiency-based modifier screens in DrosophilaQ35748253
A family business: stem cell progeny join the niche to regulate homeostasisQ35759478
Sequence-specific inhibition of small RNA functionQ24797869
Normal microRNA maturation and germ-line stem cell maintenance requires Loquacious, a double-stranded RNA-binding domain proteinQ24810079
MicroRNAs in stress signaling and human diseaseQ27027517
MicroRNA predictors of longevity in Caenorhabditis elegansQ27336009
Differential expression of microRNAs in different disease statesQ27693279
Prediction of mammalian microRNA targetsQ27860498
Combinatorial microRNA target predictionsQ27860510
RAS is regulated by the let-7 microRNA familyQ27860522
An extensive class of small RNAs in Caenorhabditis elegansQ27860626
MicroRNAs modulate hematopoietic lineage differentiationQ27860661
A microRNA polycistron as a potential human oncogeneQ27860720
The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14Q27860849
Silencing of microRNAs in vivo with 'antagomirs'Q27860891
An abundant class of tiny RNAs with probable regulatory roles in Caenorhabditis elegansQ27860895
Identification of novel genes coding for small expressed RNAsQ27860917
The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1Q27861068
The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegansQ27861103
Modulation of hepatitis C virus RNA abundance by a liver-specific MicroRNAQ27861124
MicroRNAs 103 and 107 regulate insulin sensitivityQ28240056
Antisense-mediated depletion reveals essential and specific functions of microRNAs in Drosophila developmentQ28259235
Identification and characterization of a novel gene, C13orf25, as a target for 13q31-q32 amplification in malignant lymphomaQ28260227
The DLEU2/miR-15a/16-1 cluster controls B cell proliferation and its deletion leads to chronic lymphocytic leukemiaQ28269786
The let-7 microRNA reduces tumor growth in mouse models of lung cancerQ28272817
A steroid receptor-microRNA switch regulates life span in response to signals from the gonadQ28281375
MicroRNA-34a functions as a potential tumor suppressor by inducing apoptosis in neuroblastoma cellsQ28287986
A developmental timing microRNA and its target regulate life span in C. elegansQ28288431
A pancreatic islet-specific microRNA regulates insulin secretionQ28292726
A microRNA component of the p53 tumour suppressor networkQ28305330
Striatal microRNA controls cocaine intake through CREB signallingQ28397558
A cardiac microRNA governs systemic energy homeostasis by regulation of MED13Q28505950
Obesity-induced overexpression of miRNA-143 inhibits insulin-stimulated AKT activation and impairs glucose metabolismQ28507084
MicroRNA-33 and the SREBP host genes cooperate to control cholesterol homeostasisQ28509140
Maintenance of muscle stem-cell quiescence by microRNA-489Q28509431
Regulation of progenitor cell proliferation and granulocyte function by microRNA-223Q28510667
MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblastsQ28511032
Control of stress-dependent cardiac growth and gene expression by a microRNAQ28587851
SOX9 induces and maintains neural stem cellsQ28591508
miR-122 regulation of lipid metabolism revealed by in vivo antisense targetingQ29547487
Transactivation of miR-34a by p53 broadly influences gene expression and promotes apoptosisQ29547575
Regulation of the germinal center response by microRNA-155Q29547777
LNA-mediated microRNA silencing in non-human primatesQ29615962
MicroRNA sponges: competitive inhibitors of small RNAs in mammalian cellsQ29616080
Endogenous human microRNAs that suppress breast cancer metastasisQ29617352
Analysis of genetic mosaics in developing and adult Drosophila tissuesQ29617838
Micro RNAs are complementary to 3' UTR sequence motifs that mediate negative post-transcriptional regulationQ29618303
Pre-B cell proliferation and lymphoblastic leukemia/high-grade lymphoma in E(mu)-miR155 transgenic miceQ29619279
MiR-150 controls B cell differentiation by targeting the transcription factor c-MybQ29619411
A family of microRNAs encoded by myosin genes governs myosin expression and muscle performanceQ29619547
Transcriptional activation of miR-34a contributes to p53-mediated apoptosisQ29619556
miR-26a is required for skeletal muscle differentiation and regeneration in miceQ30421569
Many families of C. elegans microRNAs are not essential for development or viabilityQ30493862
Silencing microRNA-134 produces neuroprotective and prolonged seizure-suppressive effectsQ30524857
A cooperative microRNA-tumor suppressor gene network in acute T-cell lymphoblastic leukemia (T-ALL).Q31016573
MicroRNAs in metabolism and metabolic disordersQ33612997
Therapeutic silencing of miR-10b inhibits metastasis in a mouse mammary tumor modelQ33780722
Cross talk between microRNA and epigenetic regulation in adult neurogenesisQ33788417
EPAC null mutation impairs learning and social interactions via aberrant regulation of miR-124 and Zif268 translationQ35839517
Inducible deletion of epidermal Dicer and Drosha reveals multiple functions for miRNAs in postnatal skinQ35841006
MicroRNA-214 protects the mouse heart from ischemic injury by controlling Ca²⁺ overload and cell death.Q35858066
Exploiting Drosophila genetics to understand microRNA function and regulationQ35861396
The microRNA miR-34 modulates ageing and neurodegeneration in DrosophilaQ35889746
A resource for the conditional ablation of microRNAs in the mouse.Q35936428
microRNA-206 promotes skeletal muscle regeneration and delays progression of Duchenne muscular dystrophy in miceQ36005429
miR-212/132 expression and functions: within and beyond the neuronal compartmentQ36008128
A genome-wide transgenic resource for conditional expression of Drosophila microRNAsQ36084674
MicroRNA-122 plays a critical role in liver homeostasis and hepatocarcinogenesisQ36129123
Essential metabolic, anti-inflammatory, and anti-tumorigenic functions of miR-122 in liver.Q36129129
Long-term, efficient inhibition of microRNA function in mice using rAAV vectorsQ36169589
Decline in miR-181a expression with age impairs T cell receptor sensitivity by increasing DUSP6 activityQ36303563
Discovering the first microRNA-targeted drugQ36353486
Therapeutic inhibition of the miR-34 family attenuates pathological cardiac remodeling and improves heart functionQ36378477
Deletion of astroglial Dicer causes non-cell-autonomous neuronal dysfunction and degenerationQ36405113
The microcosmos of cancerQ36432986
miR-34 miRNAs provide a barrier for somatic cell reprogrammingQ36522839
Silencing of microRNA families by seed-targeting tiny LNAsQ36522844
MiR-34 modulates Caenorhabditis elegans lifespan via repressing the autophagy gene atg9.Q36528255
Regulation of lipid metabolism by Dicer revealed through SILAC miceQ36729362
The let-7-Imp axis regulates ageing of the Drosophila testis stem-cell nicheQ36791167
The miRNA-212/132 family regulates both cardiac hypertrophy and cardiomyocyte autophagy.Q36855897
Drosophila Argonaute 1 and its miRNA biogenesis partners are required for oocyte formation and germline cell divisionQ37148443
Lessons from microRNA mutants in worms, flies and miceQ37196784
miR-23a functions downstream of NFATc3 to regulate cardiac hypertrophyQ37274522
Biological principles of microRNA-mediated regulation: shared themes amid diversityQ37293110
Muscle stem cell behavior is modified by microRNA-27 regulation of Pax3 expression.Q37304065
Acquisition of the contractile phenotype by murine arterial smooth muscle cells depends on the Mir143/145 gene clusterQ37328540
Conditional loss of Dicer disrupts cellular and tissue morphogenesis in the cortex and hippocampusQ37352375
Muscle stem cells and reversible quiescence: the role of sproutyQ37767988
MicroRNAs and hematopoietic cell developmentQ37988197
MicroRNA control of epithelial-mesenchymal transition and metastasis.Q38017596
Stem cells in the hood: the skeletal muscle niche.Q38033343
MicroRNAs shape the neuronal landscapeQ38033846
MicroRNAs in learning, memory, and neurological diseasesQ38035830
Restitution of tumor suppressor microRNAs using a systemic nanovector inhibits pancreatic cancer growth in mice.Q39534111
MicroRNA profiling of Parkinson's disease brains identifies early downregulation of miR-34b/c which modulate mitochondrial functionQ39545068
A MicroRNA targeting dicer for metastasis controlQ39684280
MiR-33 contributes to the regulation of cholesterol homeostasis.Q39704194
Vectors expressing efficient RNA decoys achieve the long-term suppression of specific microRNA activity in mammalian cellsQ39882902
GW182 controls Drosophila circadian behavior and PDF-receptor signalingQ39926033
Developmental decline in neuronal regeneration by the progressive change of two intrinsic timersQ41409118
Post-developmental microRNA expression is required for normal physiology, and regulates aging in parallel to insulin/IGF-1 signaling in C. elegansQ41751562
miR-124 regulates adult neurogenesis in the subventricular zone stem cell nicheQ42243673
Intact p53-dependent responses in miR-34-deficient mice.Q42251432
Aging and chronic DNA damage response activate a regulatory pathway involving miR-29 and p53.Q42762768
Characterizing light-regulated retinal microRNAs reveals rapid turnover as a common property of neuronal microRNAsQ43061388
Conditional dicer gene deletion in the postnatal myocardium provokes spontaneous cardiac remodelingQ43557501
The K box, a conserved 3' UTR sequence motif, negatively regulates accumulation of enhancer of split complex transcripts.Q46049705
The Bearded box, a novel 3' UTR sequence motif, mediates negative post-transcriptional regulation of Bearded and Enhancer of split Complex gene expression.Q46551228
Stem cell division is regulated by the microRNA pathwayQ47070620
Argonaute 1 regulates the fate of germline stem cells in DrosophilaQ47071390
The miRNA pathway intrinsically controls self-renewal of Drosophila germline stem cellsQ47072117
Differential regulation of microRNAs by p53 revealed by massively parallel sequencing: miR-34a is a p53 target that induces apoptosis and G1-arrestQ48078984
MicroRNA loss enhances learning and memory in miceQ48174132
miR-7a regulation of Pax6 controls spatial origin of forebrain dopaminergic neuronsQ48461810
MicroRNA-34a regulates cardiac ageing and function.Q50320387
Muscle satellite cells are primed for myogenesis but maintain quiescence with sequestration of Myf5 mRNA targeted by microRNA-31 in mRNP granules.Q50797491
Dcr-1 maintains Drosophila ovarian stem cells.Q51994134
MicroRNA-199b targets the nuclear kinase Dyrk1a in an auto-amplification loop promoting calcineurin/NFAT signalling.Q54631073
Obesity-induced overexpression of miR-802 impairs glucose metabolism through silencing of Hnf1bQ59088750
P433issue8
P921main subjectmicroRNAQ310899
P304page(s)535-548
P577publication date2013-07-02
P1433published inNature Reviews GeneticsQ1071824
P1476titleAdult-specific functions of animal microRNAs
P478volume14

Reverse relations

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Q49523681The association between differentially expressed micro RNAs in breast cancer cell lines and the micro RNA-205 gene polymorphism in breast cancer tissue
Q55432827The long and short of lifespan regulation by Argonautes.
Q52655490The mir-279/996 cluster represses receptor tyrosine kinase signaling to determine cell fates in the Drosophila eye.
Q42068637Tumor-suppressive microRNA-195-5p regulates cell growth and inhibits cell cycle by targeting cyclin dependent kinase 8 in colon cancer
Q34086513Understanding functional miRNA-target interactions in vivo by site-specific genome engineering.
Q38743270Upregulation of miR-192 inhibits cell growth and invasion and induces cell apoptosis by targeting TCF7 in human osteosarcoma
Q57165704Upregulation of miR-375 inhibits human liver cancer cell growth by modulating cell proliferation and apoptosis via targeting ErbB2
Q35742454miR-1236 down-regulates alpha-fetoprotein, thus causing PTEN accumulation, which inhibits the PI3K/Akt pathway and malignant phenotype in hepatoma cells
Q90170080miR-143 promotes angiogenesis and osteoblast differentiation by targeting HDAC7
Q90608320miR-144-3p inhibits cell proliferation of colorectal cancer cells by targeting BCL6 via inhibition of Wnt/β-catenin signaling
Q92806469miR-145 improves metabolic inflammatory disease through multiple pathways
Q92841127miR-181 regulation of BAX controls cisplatin sensitivity of prostate cancer cells
Q47725935miR-181d-5p promotes neurite outgrowth in PC12 Cells via PI3K/Akt pathway
Q53539464miR-200b-3p in plasma is a potential diagnostic biomarker in oral squamous cell carcinoma.
Q39127271miR-21 predicts poor prognosis in patients with osteosarcoma
Q99627542miR-212 as potential biomarker suppresses the proliferation of gastric cancer via targeting SOX4
Q38916701miR-23a suppresses proliferation of osteosarcoma cells by targeting SATB1.
Q38476564miR-29s: a family of epi-miRNAs with therapeutic implications in hematologic malignancies.
Q38809687miR-494 suppresses tumor growth of epithelial ovarian carcinoma by targeting IGF1R.
Q52728514miR-519d-3p Inhibits Cell Proliferation and Invasion of Gastric Cancer by Downregulating B-Cell Lymphoma 6.
Q37232827miR-762 promotes porcine immature Sertoli cell growth via the ring finger protein 4 (RNF4) gene
Q38779883miRNA array screening reveals cooperative MGMT-regulation between miR-181d-5p and miR-409-3p in glioblastoma
Q38828807miRNA-miRNA crosstalk: from genomics to phenomics
Q42384091microRNA-132/212 deficiency enhances Aβ production and senile plaque deposition in Alzheimer's disease triple transgenic mice
Q41875279microRNA-181 promotes prostate cancer cell proliferation by regulating DAX-1 expression
Q92276302microRNA-605 directly targets SOX9 to alleviate the aggressive phenotypes of glioblastoma multiforme cell lines by deactivating the PI3K/Akt pathway
Q61808039microRNA-758 inhibits the malignant phenotype of osteosarcoma cells by directly targeting and deactivating the Wnt/β-catenin pathway

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