Development of a novel cellular model of Alzheimer's disease utilizing neurosphere cultures derived from B6C3-Tg(APPswe,PSEN1dE9)85Dbo/J embryonic mouse brain

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Development of a novel cellular model of Alzheimer's disease utilizing neurosphere cultures derived from B6C3-Tg(APPswe,PSEN1dE9)85Dbo/J embryonic mouse brain is …
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scholarly articleQ13442814

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P6179Dimensions Publication ID1021678798
P356DOI10.1186/2193-1801-3-161
P932PMC publication ID4137416
P698PubMed publication ID25140287
P5875ResearchGate publication ID264940822

P2093author name stringGeorge A Carlson
Pankaj S Ghate
Himakshi Sidhar
Ranjit K Giri
P2860cites workBeta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACEQ22010705
Gender differences in the incidence of AD and vascular dementia: The EURODEM StudiesQ22241634
Neurotrophic and neurotoxic effects of amyloid beta protein: reversal by tachykinin neuropeptidesQ22242269
beta-Amyloid(1-42) binds to alpha7 nicotinic acetylcholine receptor with high affinity. Implications for Alzheimer's disease pathologyQ22253223
Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's diseaseQ24316501
The presenilin 2 mutation (N141I) linked to familial Alzheimer disease (Volga German families) increases the secretion of amyloid beta protein ending at the 42nd (or 43rd) residueQ24564792
Soluble amyloid beta peptide concentration as a predictor of synaptic change in Alzheimer's diseaseQ24670696
Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivoQ28131779
Mutant presenilins specifically elevate the levels of the 42 residue beta-amyloid peptide in vivo: evidence for augmentation of a 42-specific gamma secretaseQ28188098
Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's diseaseQ28241772
Early-onset Alzheimer's disease caused by mutations at codon 717 of the beta-amyloid precursor protein geneQ28245149
Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous systemQ28292445
Candidate gene for the chromosome 1 familial Alzheimer's disease locusQ28295424
Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic miceQ28300764
Direct isolation of human central nervous system stem cellsQ28318408
Tau protein kinase I is essential for amyloid beta-protein-induced neurotoxicityQ28378569
Genotype-specific differences between mouse CNS stem cell lines expressing frontotemporal dementia mutant or wild type human tauQ28480475
CNS stem cells express a new class of intermediate filament proteinQ28577391
A specific amyloid-beta protein assembly in the brain impairs memoryQ28854597
Alzheimer's disease is a synaptic failureQ29547670
Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid proteinQ29547803
Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's diseaseQ29614374
Natural oligomers of the amyloid-beta protein specifically disrupt cognitive functionQ29614851
Probing sporadic and familial Alzheimer's disease using induced pluripotent stem cellsQ29615870
Microtubule-associated protein tau (tau) is a major antigenic component of paired helical filaments in Alzheimer diseaseQ29617285
Amyloid deposition as the central event in the aetiology of Alzheimer's diseaseQ29619450
Brain amyloid-β oligomers in ageing and Alzheimer's diseaseQ30539133
Neurogenic effect of beta-amyloid peptide in the development of neural stem cells.Q30981855
CSF amyloid-beta-peptides in Alzheimer's disease, dementia with Lewy bodies and Parkinson's disease dementiaQ33239180
Expression of the amyloid precursor protein gene in mouse oocytes and embryosQ33383984
Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivoQ34063772
Increased hippocampal neurogenesis in Alzheimer's disease.Q34281877
Alzheimer's disease and the amyloid cascade hypothesis: ten years on.Q34489920
Alzheimer's disease and senile dementia: loss of neurons in the basal forebrainQ34714755
Prion infection of mouse neurospheresQ34944193
A dynamic relationship between intracellular and extracellular pools of AbetaQ35070713
SDS-PAGE/immunoblot detection of Abeta multimers in human cortical tissue homogenates using antigen-epitope retrievalQ35187331
Neurofibrillary tangles of Alzheimer disease share antigenic determinants with the axonal microtubule-associated protein tau (tau)Q35609568
Intraneuronal Alzheimer abeta42 accumulates in multivesicular bodies and is associated with synaptic pathologyQ35747757
Intraneuronal Aβ detection in 5xFAD mice by a new Aβ-specific antibody.Q35968298
Beta-amyloid neurotoxicity requires fibril formation and is inhibited by congo red.Q35969894
Neuron loss in the 5XFAD mouse model of Alzheimer's disease correlates with intraneuronal Aβ42 accumulation and Caspase-3 activationQ36556213
Human neurons derived from a teratocarcinoma cell line express solely the 695-amino acid amyloid precursor protein and produce intracellular beta-amyloid or A4 peptidesQ36596465
In vitro-generated neural precursors participate in mammalian brain developmentQ36832239
Neural stem cells isolated from amyloid precursor protein-mutated mice for drug discoveryQ37266566
Astroglia in dementia and Alzheimer's disease.Q37341695
Enrichment of Sca1+ hematopoietic progenitors in polycythemic mice inhibits leukemogenesisQ39827748
Amyloid Peptide-Induced Cytokine and Chemokine Expression in THP-1 Monocytes Is Blocked by Small Inhibitory RNA Duplexes for Early Growth Response-1 Messenger RNAQ40649487
Amyloid beta-peptide is produced by cultured cells during normal metabolismQ41602809
Modeling familial Alzheimer's disease with induced pluripotent stem cellsQ42817521
Early Abeta accumulation and progressive synaptic loss, gliosis, and tangle formation in AD brainQ44810166
Cell cultures from animal models of Alzheimer's disease as a tool for faster screening and testing of drug efficacyQ45020564
Radial glia-like cells persist in the adult rat brain.Q46174836
Accelerating amyloid-beta fibrillization reduces oligomer levels and functional deficits in Alzheimer disease mouse models.Q46380915
Class III beta-tubulin is constitutively coexpressed with glial fibrillary acidic protein and nestin in midgestational human fetal astrocytes: implications for phenotypic identityQ46671841
Different conformations of amyloid beta induce neurotoxicity by distinct mechanisms in human cortical neurons.Q46733868
Differential properties of adult rat and mouse brain-derived neural stem/progenitor cellsQ46904151
Gender differences in the amount and deposition of amyloidbeta in APPswe and PS1 double transgenic miceQ47316442
Oligodendrocytes are a novel source of amyloid peptide generationQ47589539
beta-Amyloid deposition and prion infection in adult primary brain cell long-term culture modelQ48115246
Isolation and culture of adult neurons and neurospheresQ48147846
The levels of soluble versus insoluble brain Abeta distinguish Alzheimer's disease from normal and pathologic agingQ48156883
Preparation of organotypic hippocampal slice cultures: interface methodQ48218802
Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer's disease mutations: potential factors in amyloid plaque formation.Q48404445
Disruption of neurogenesis by amyloid beta-peptide, and perturbed neural progenitor cell homeostasis, in models of Alzheimer's diseaseQ48429549
Nestin-containing cells express glial fibrillary acidic protein in the proliferative regions of central nervous system of postnatal developing and adult mice.Q48455160
Behavioral and neurobiological effects of prenatal stress exposure in male and female APPswe/PS1dE9 mice.Q48459060
Formic acid is essential for immunohistochemical detection of aggregated intraneuronal Abeta peptides in mouse models of Alzheimer's diseaseQ48460015
Improved electrophoretic separation and immunoblotting of beta-amyloid (A beta) peptides 1-40, 1-42, and 1-43.Q48772618
Processing of amyloid precursor protein in human primary neuron and astrocyte culturesQ48793487
Intraneuronal Abeta accumulation precedes plaque formation in beta-amyloid precursor protein and presenilin-1 double-transgenic miceQ48846848
Analysis of heterogeneous A4 peptides in human cerebrospinal fluid and blood by a newly developed sensitive Western blot assayQ48917972
Multipotential stem cells from the adult mouse brain proliferate and self-renew in response to basic fibroblast growth factor.Q49159036
The genetic defect causing familial Alzheimer's disease maps on chromosome 21.Q53189946
Release of excess amyloid beta protein from a mutant amyloid beta protein precursor.Q53209417
A vector for expressing foreign genes in the brains and hearts of transgenic miceQ54965153
Enhancement of immunoblot sensitivity by heating of hydrated filtersQ70145503
Increased production of 4 kDa amyloid beta peptide in serum deprived human primary neuron cultures: possible involvement of apoptosisQ71038666
The oligomerization of amyloid beta-protein begins intracellularly in cells derived from human brainQ74290658
Specific characteristic of radial glia in the human fetal telencephalonQ80486121
Prion infection of differentiated neurospheresQ83142947
P4510describes a project that usesImageJQ1659584
P921main subjectAlzheimer's diseaseQ11081
P304page(s)161
P577publication date2014-03-26
P1433published inSpringerPlusQ24055190
P1476titleDevelopment of a novel cellular model of Alzheimer's disease utilizing neurosphere cultures derived from B6C3-Tg(APPswe,PSEN1dE9)85Dbo/J embryonic mouse brain
P478volume3

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cites work (P2860)
Q33746251Cellular levels of Grb2 and cytoskeleton stability are correlated in a neurodegenerative scenario.
Q38629519Differential Roles of Environmental Enrichment in Alzheimer's Type of Neurodegeneration and Physiological Aging.
Q41871137Ganglioside-Dependent Neural Stem Cell Proliferation in Alzheimer's Disease Model Mice
Q37618138Induction of Bex genes by curcumin is associated with apoptosis and activation of p53 in N2a neuroblastoma cells

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