RhoA/ROCK signaling is essential for multiple aspects of VEGF-mediated angiogenesis.

scientific article

RhoA/ROCK signaling is essential for multiple aspects of VEGF-mediated angiogenesis. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1096/FJ.09-145102
P932PMC publication ID2923346
P698PubMed publication ID20400538
P5875ResearchGate publication ID43183105

P50authorPatricia D'AmoreQ30323567
Magali Saint-GeniezQ58898025
Kensuke NomaQ90710353
James K. LiaoQ110246064
P2093author name stringBrad A Bryan
Dianne C Mitchell
Tony E Walshe
Emily Dennstedt
Jean-Paul Campaigniac
Robyn Loureiro
P2860cites workInhibition of Rho-dependent kinases ROCK I/II activates VEGF-driven retinal neovascularization and sprouting angiogenesisQ24323982
Rho GTPases: biochemistry and biologyQ27860645
The biology of VEGF and its receptorsQ27860704
Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activationQ28131755
Protein Kinase Cα-Induced p115RhoGEF Phosphorylation Signals Endothelial Cytoskeletal RearrangementQ28204845
Caspase-3-mediated cleavage of ROCK I induces MLC phosphorylation and apoptotic membrane blebbingQ28210013
The vascular endothelial growth factor receptor KDR activates multiple signal transduction pathways in porcine aortic endothelial cellsQ28257153
ROCK-I and ROCK-II, two isoforms of Rho-associated coiled-coil forming protein serine/threonine kinase in miceQ28287728
Vascular endothelial growth factor (VEGF) stimulates neurogenesis in vitro and in vivoQ28577046
HMG CoA reductase inhibition modulates VEGF-induced endothelial cell hyperpermeability by preventing RhoA activation and myosin regulatory light chain phosphorylationQ28581798
Role of PLCgamma and Ca(2+) in VEGF- and FGF-induced choroidal endothelial cell proliferationQ28646410
Cell migration: Rho GTPases lead the wayQ29616711
Rho proteins in cell migration and metastasis.Q30437408
Inactivation of the small GTPase Rho disrupts cellular attachment and induces adhesion-dependent and adhesion-independent apoptosisQ30471396
The GTPase Rho has a critical regulatory role in thymus developmentQ33886532
Rac regulates endothelial morphogenesis and capillary assemblyQ33893806
Identification of calponin as a novel substrate of Rho-kinaseQ33907555
Membrane blebbing during apoptosis results from caspase-mediated activation of ROCK I.Q33941102
Vascular endothelial growth factor and the regulation of angiogenesis.Q34063546
Autocrine VEGF signaling is required for vascular homeostasisQ34443661
Targeted disruption of the mouse rho-associated kinase 2 gene results in intrauterine growth retardation and fetal deathQ35107897
VEGF signalling: integration and multi-tasking in endothelial cell biologyQ35594143
PAK and other Rho-associated kinases--effectors with surprisingly diverse mechanisms of regulationQ35952627
Regulation of microtubules in cell migrationQ36032502
The Rho family of small GTPases: crucial regulators of skeletal myogenesisQ36133171
ROCK-I regulates closure of the eyelids and ventral body wall by inducing assembly of actomyosin bundlesQ36321444
Coordinated vascular endothelial growth factor expression and signaling during skeletal myogenic differentiationQ36489148
ROCK1 mediates leukocyte recruitment and neointima formation following vascular injuryQ36540884
Rho activity critically and selectively regulates endothelial cell organization during angiogenesisQ36603820
What tangled webs they weave: Rho-GTPase control of angiogenesis.Q36832262
Tumor-derived endothelial cells exhibit aberrant Rho-mediated mechanosensing and abnormal angiogenesis in vitroQ36837467
Inhibition of Rho kinase (ROCK) leads to increased cerebral blood flow and stroke protectionQ37079168
Decreased perivascular fibrosis but not cardiac hypertrophy in ROCK1+/- haploinsufficient miceQ37092280
Rho kinases play an obligatory role in vertebrate embryonic organogenesisQ38297289
KDR stimulates endothelial cell migration through heterotrimeric G protein Gq/11-mediated activation of a small GTPase RhoA.Q38362761
Transient expression of RhoA, -B, and -C GTPases in HeLa cells potentiates resistance to Clostridium difficile toxins A and B but not to Clostridium sordellii lethal toxinQ39823228
The Rho GTPase effector ROCK regulates cyclin A, cyclin D1, and p27Kip1 levels by distinct mechanismsQ40273270
Anti-RhoA and anti-RhoC siRNAs inhibit the proliferation and invasiveness of MDA-MB-231 breast cancer cells in vitro and in vivo.Q40466398
RhoA induces MMP-9 expression at CD44 lamellipodial focal complexes and promotes HMEC-1 cell invasionQ40611999
Inhibition of endothelial cell migration by cerivastatin, an HMG-CoA reductase inhibitor: contribution to its anti-angiogenic effectQ40808465
VEGF mediates angioblast migration during development of the dorsal aorta in Xenopus.Q40844043
Mechanisms of increased endothelial permeabilityQ41245969
Modulation of cell migration and vessel formation by vascular endothelial growth factor and basic fibroblast growth factor in cultured embryonic heartQ41658989
Vascular permeability factor: a tumor-derived polypeptide that induces endothelial cell and monocyte procoagulant activity, and promotes monocyte migrationQ41711674
Cathepsin B regulates the intrinsic angiogenic threshold of endothelial cellsQ42102273
Involvement of RhoA/Rho kinase signaling in VEGF-induced endothelial cell migration and angiogenesis in vitroQ42437147
Induction of apoptosis in NIH3T3 cells after serum deprivation by overexpression of rho-p21, a GTPase protein of the ras superfamily.Q42829414
Protein kinase C-alpha signals rho-guanine nucleotide dissociation inhibitor phosphorylation and rho activation and regulates the endothelial cell barrier functionQ43579834
3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors interfere with angiogenesis by inhibiting the geranylgeranylation of RhoA.Q44079675
ROCK-I and ROCK-II cooperatively regulate closure of eyelid and ventral body wall in mouse embryoQ46648346
Antiangiogenic properties of fasudil, a potent Rho-Kinase inhibitorQ46679898
GEF-H1 is involved in agonist-induced human pulmonary endothelial barrier dysfunctionQ46781644
Identification of genes involved in VEGF-mediated vascular morphogenesis using embryonic stem cell-derived cystic embryoid bodies.Q47281426
Zoledronate inhibits endothelial cell adhesion, migration and survival through the suppression of multiple, prenylation-dependent signaling pathways.Q53592003
Escherichia coli cytotoxic necrotizing factor 1 (CNF1), a toxin that activates the Rho GTPase.Q54561665
Src Family Kinases Promote Vessel Stability by Antagonizing the Rho/ROCK PathwayQ57372719
ERK-MAPK signaling opposes Rho-kinase to promote endothelial cell survival and sprouting during angiogenesisQ58001185
Contextual role for angiopoietins and TGFbeta1 in blood vessel stabilizationQ62698478
Differential endothelial migration and proliferation to basic fibroblast growth factor and vascular endothelial growth factorQ71880316
Central involvement of Rho family GTPases in TNF-alpha-mediated bovine pulmonary endothelial cell apoptosisQ73483178
Vascular endothelial growth factor upregulates the expression of matrix metalloproteinases in vascular smooth muscle cells: role of flt-1Q77426354
TGF beta is required for the formation of capillary-like structures in three-dimensional cocultures of 10T1/2 and endothelial cellsQ77586992
Fasudil inhibits vascular endothelial growth factor-induced angiogenesis in vitro and in vivoQ80358201
Targeted deletion of ROCK1 protects the heart against pressure overload by inhibiting reactive fibrosisQ83289639
P4510describes a project that usesImageJQ1659584
P433issue9
P407language of work or nameEnglishQ1860
P921main subjectangiogenesisQ539568
P304page(s)3186-3195
P577publication date2010-04-16
P1433published inFASEB JournalQ520194
P1476titleRhoA/ROCK signaling is essential for multiple aspects of VEGF-mediated angiogenesis
P478volume24

Reverse relations

cites work (P2860)
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