Endomucin inhibits VEGF-induced endothelial cell migration, growth, and morphogenesis by modulating VEGFR2 signaling

scientific article published on 7 December 2017

Endomucin inhibits VEGF-induced endothelial cell migration, growth, and morphogenesis by modulating VEGFR2 signaling is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/S41598-017-16852-X
P932PMC publication ID5719432
P698PubMed publication ID29215001

P50authorMagali Saint-GeniezQ58898025
Yin Shan Eric NgQ59695121
P2093author name stringPatricia A D'Amore
Jinling Yang
Cindy Park-Windhol
Vincent Primo
P2860cites workVascular endothelial growth factor regulates endothelial cell survival through the phosphatidylinositol 3'-kinase/Akt signal transduction pathway. Requirement for Flk-1/KDR activationQ22004269
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MUC1 enhances hypoxia-driven angiogenesis through the regulation of multiple proangiogenic factorsQ39251872
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Type I collagen limits VEGFR-2 signaling by a SHP2 protein-tyrosine phosphatase-dependent mechanism 1.Q46843965
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Norrin stimulates cell proliferation in the superficial retinal vascular plexus and is pivotal for the recruitment of mural cellsQ50431262
Nestin-mediated cytoskeletal remodeling in endothelial cells: novel mechanistic insight into VEGF-induced cell migration in angiogenesis.Q54158031
Human endomucin: distribution pattern, expression on high endothelial venules, and decoration with the MECA-79 epitopeQ24685056
The diversity of endothelial cells: a challenge for therapeutic angiogenesisQ24806970
Endomucin prevents leukocyte-endothelial cell adhesion and has a critical role under resting and inflammatory conditions.Q27335094
Identification of human endomucin-1 and -2 as membrane-bound O-sialoglycoproteins with anti-adhesive activityQ28114989
Human endomucin is an endothelial markerQ28116179
Biochemical characterization and molecular cloning of a novel endothelial-specific sialomucinQ28510561
The 230 kDa mature form of KDR/Flk-1 (VEGF receptor-2) activates the PLC-gamma pathway and partially induces mitotic signals in NIH3T3 fibroblastsQ28565683
Vascular endothelial growth factor-A is a survival factor for retinal neurons and a critical neuroprotectant during the adaptive response to ischemic injury.Q28583917
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VEGF guides angiogenic sprouting utilizing endothelial tip cell filopodiaQ29617501
Permeation of the luminal capillary glycocalyx is determined by hyaluronanQ30304200
Identification of distinct luminal domains for macromolecules, erythrocytes, and leukocytes within mammalian capillariesQ30469009
Endogenous VEGF is required for visual function: evidence for a survival role on müller cells and photoreceptorsQ33382103
Epigenetically coordinated GATA2 binding is necessary for endothelium-specific endomucin expressionQ34027281
RhoA/ROCK signaling is essential for multiple aspects of VEGF-mediated angiogenesis.Q34072195
Molecular mechanisms of blood vessel growthQ34134535
Heparan sulfate regulates VEGF165- and VEGF121-mediated vascular hyperpermeability.Q34452740
Tumor vascular permeability factor stimulates endothelial cell growth and angiogenesisQ34578752
Endothelial cell migration during angiogenesisQ34613912
Mechanotransduction and flow across the endothelial glycocalyxQ35147509
Expression and role of VEGF in the adult retinal pigment epitheliumQ35648344
Synergistic Binding of Vascular Endothelial Growth Factor-A and Its Receptors to Heparin Selectively Modulates Complex AffinityQ35783198
Development and pathology of the hyaloid, choroidal and retinal vasculature.Q35959824
The comings and goings of actin: coupling protrusion and retraction in cell motilityQ36228793
Mechanotransduction and the glycocalyxQ36440487
Defective angiogenesis, endothelial migration, proliferation, and MAPK signaling in Rap1b-deficient mice.Q36478425
VEGF and TGF-beta are required for the maintenance of the choroid plexus and ependymaQ36502881
Vascular endothelial growth factor signaling pathways: therapeutic perspectiveQ36584934
Neuropilin-1 in regulation of VEGF-induced activation of p38MAPK and endothelial cell organizationQ36948568
Arterial versus venous endothelial cells.Q37313072
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P4510describes a project that usesImageJQ1659584
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectmorphogenesisQ815547
P304page(s)17138
P577publication date2017-12-07
P1433published inScientific ReportsQ2261792
P1476titleEndomucin inhibits VEGF-induced endothelial cell migration, growth, and morphogenesis by modulating VEGFR2 signaling
P478volume7

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