Functional coupling analysis suggests link between the obesity gene FTO and the BDNF-NTRK2 signaling pathway

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Functional coupling analysis suggests link between the obesity gene FTO and the BDNF-NTRK2 signaling pathway is …
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P6179Dimensions Publication ID1002909238
P356DOI10.1186/1471-2202-12-117
P932PMC publication ID3248879
P698PubMed publication ID22087873
P5875ResearchGate publication ID51802510

P50authorMathias Rask-AndersenQ57305482
Helgi B. SchiöthQ30112644
Markus Sällman AlménQ30112645
Pawel K OlszewskiQ56956867
P2093author name stringRobert Fredriksson
Allen S Levine
Jenny Eriksson
Hans R Olausen
Rohit A Chavan
P2860cites workAssociation ofFTOGene Variants With Adiposity in African-American AdolescentsQ60696735
Effects of common FTO gene variants associated with BMI on dietary intake and physical activity in KoreansQ84585687
The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylaseQ24299948
Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for DNA repairQ24314301
Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genesQ24534395
Profilin II is alternatively spliced, resulting in profilin isoforms that are differentially expressed and have distinct biochemical propertiesQ24551149
A commonly carried allele of the obesity-related FTO gene is associated with reduced brain volume in the healthy elderlyQ24631142
Hypothalamic FTO is associated with the regulation of energy intake not feeding rewardQ24643901
Brain structure and obesityQ24644378
Six new loci associated with body mass index highlight a neuronal influence on body weight regulationQ24646434
A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesityQ24650037
The obesity gene, FTO, is of ancient origin, up-regulated during food deprivation and expressed in neurons of feeding-related nuclei of the brainQ28265784
Variation in FTO contributes to childhood obesity and severe adult obesityQ28301922
Genome-wide association yields new sequence variants at seven loci that associate with measures of obesityQ28303894
A mouse model for the metabolic effects of the human fat mass and obesity associated FTO geneQ28475923
The IntAct molecular interaction database in 2010Q28749230
A Bayesian Networks Approach for Predicting Protein-Protein Interactions from Genomic DataQ29395063
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass indexQ29547208
Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traitsQ29614593
Neurotrophin/Trk receptor signaling mediates C/EBPalpha, -beta and NeuroD recruitment to immediate-early gene promoters in neuronal cells and requires C/EBPs to induce immediate-early gene transcription.Q30478978
Relating whole-genome expression data with protein-protein interactionsQ30669147
Global networks of functional coupling in eukaryotes from comprehensive data integrationQ33412986
Hypothalamic-specific manipulation of Fto, the ortholog of the human obesity gene FTO, affects food intake in rats.Q33526368
Central leptin receptor action and resistance in obesityQ33557577
Regulation of Fto/Ftm gene expression in mice and humansQ33599999
Common SNPs in FTO gene are associated with obesity related anthropometric traits in an island population from the eastern Adriatic coast of Croatia.Q33815915
FTO genetic variation and association with obesity in West Africans and African AmericansQ33869848
Fine mapping of the association with obesity at the FTO locus in African-derived populationsQ33947843
Trophic action of leptin on hypothalamic neurons that regulate feedingQ34311092
Activation and signaling of the p38 MAP kinase pathwayQ34390191
Overexpression of Fto leads to increased food intake and results in obesityQ34479211
Cut-like homeobox 1 (CUX1) regulates expression of the fat mass and obesity-associated and retinitis pigmentosa GTPase regulator-interacting protein-1-like (RPGRIP1L) genes and coordinates leptin receptor signalingQ34503227
Mechanisms of leptin action and leptin resistanceQ34701125
Brain-derived neurotrophic factor (BDNF) in the hypothalamic ventromedial nucleus increases energy expenditureQ35673792
COXPRESdb: a database of coexpressed gene networks in mammalsQ36454116
The C/EBP family of transcription factors: a paradigm for interaction between gene expression and proliferation controlQ36893970
BDNF and memory formation and storage.Q36958200
Loss-of-function mutation in the dioxygenase-encoding FTO gene causes severe growth retardation and multiple malformationsQ37253402
Protein kinases A and C in post-mortem prefrontal cortex from persons with major depression and normal controlsQ37320669
Postsynaptic BDNF-TrkB signaling in synapse maturation, plasticity, and diseaseQ37699047
Transcriptional and translational control of C/EBPs: the case for "deep" genetics to understand physiological functionQ37775595
Rapid rewiring of arcuate nucleus feeding circuits by leptin.Q38342803
The obesity-associated Fto gene is a transcriptional coactivatorQ39653152
The obesity-associated SNPs in intron 1 of the FTO gene affect primary transcript levelsQ41734681
Brain-derived neurotrophic factor in the hypothalamic paraventricular nucleus increases energy expenditure by elevating metabolic rateQ42623653
Purification of RNA using TRIzol (TRI reagent).Q43048322
Combined effects of FTO rs9939609 and MC4R rs17782313 on obesity and BMI in Chinese Han populationsQ43727430
FTO genotype and weight gain in obese and normal weight adults from a Norwegian population based cohort (the HUNT study).Q47437317
Brain-derived neurotrophic factor in the hypothalamic paraventricular nucleus reduces energy intakeQ48130942
Brain-derived neurotrophic factor in the ventromedial nucleus of the hypothalamus reduces energy intakeQ48144460
P921main subjectobesityQ12174
P304page(s)117
P577publication date2011-11-16
P1433published inBMC NeuroscienceQ15766477
P1476titleFunctional coupling analysis suggests link between the obesity gene FTO and the BDNF-NTRK2 signaling pathway
P478volume12