Targeted knockdown of Bcl2 in tumor cells using a synthetic TRAIL 3'-UTR microRNA

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Targeted knockdown of Bcl2 in tumor cells using a synthetic TRAIL 3'-UTR microRNA is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1002/IJC.24821
P932PMC publication ID2924819
P698PubMed publication ID19676053
P5875ResearchGate publication ID26737375

P2093author name stringJian Lu
Haibo Wang
Xianqun Fan
Jianjun Zhang
He Zhang
Andrew R Hoffman
Haiyan Guo
Shengfang Ge
Ji-Fan Hu
Shenglin Huang
Guanxiang Qian
P2860cites workThe Hallmarks of CancerQ221226
Identification and characterization of a new member of the TNF family that induces apoptosisQ24318423
Polycistronic RNA polymerase II expression vectors for RNA interference based on BIC/miR-155.Q24542505
Accumulation of miR-155 and BIC RNA in human B cell lymphomasQ24556523
Identification of mammalian microRNA host genes and transcription unitsQ24562298
The microRNAs of Caenorhabditis elegansQ24672515
Identification of tissue-specific microRNAs from mouseQ27860892
MicroRNA-directed cleavage of HOXB8 mRNAQ28131834
The Bcl2 family: regulators of the cellular life-or-death switchQ29614982
The Bcl-2 protein family: arbiters of cell survivalQ29618158
Enhanced therapeutic efficacy by simultaneously targeting two genetic defects in tumorsQ33713001
Safety and antitumor activity of recombinant soluble Apo2 ligandQ33855449
Human Bcl-2 antisense therapy for lymphomasQ33916124
Synthetic small inhibiting RNAs: efficient tools to inactivate oncogenic mutations and restore p53 pathways.Q34156507
The potential of TRAIL for cancer chemotherapyQ34271024
Genasense (Genta Inc).Q34375660
Transcription and processing of human microRNA precursorsQ34378218
Novel approaches to the treatment of non-small cell lung cancer.Q34498105
Apoptosis: a link between cancer genetics and chemotherapyQ34520432
Role of Bcl-2 family of proteins in malignancyQ34733047
Apoptosis-based therapiesQ34742803
Correction of aberrant imprinting of IGF2 in human tumors by nuclear transfer-induced epigenetic reprogrammingQ35130964
The role of Bcl-2 family members in tumorigenesisQ35680535
Promoting apoptosis as a strategy for cancer drug discoveryQ36292878
Directing DNA methylation to inhibit gene expressionQ36482583
Randomized phase II Study of carboplatin and etoposide with or without the bcl-2 antisense oligonucleotide oblimersen for extensive-stage small-cell lung cancer: CALGB 30103.Q37023777
Directing cancer cells to self-destruct with pro-apoptotic receptor agonistsQ37319386
AAV-mediated TRAIL gene expression driven by hTERT promoter suppressed human hepatocellular carcinoma growth in miceQ39981468
Inhibition of Bcl-2 expression by a novel tumor-specific RNA interference system increases chemosensitivity to 5-fluorouracil in Hela cellsQ40330010
Antitumor activity of small interfering RNA/cationic liposome complex in mouse models of cancerQ40486739
Small interfering RNA targeting bcl-2 sensitizes malignant melanomaQ40527363
Intravenous RNA interference gene therapy targeting the human epidermal growth factor receptor prolongs survival in intracranial brain cancerQ40550050
Specific downregulation of bcl-2 and xIAP by RNAi enhances the effects of chemotherapeutic agents in MCF-7 human breast cancer cells.Q40576657
Small interfering RNA (siRNA) inhibits the expression of the Her2/neu gene, upregulates HLA class I and induces apoptosis of Her2/neu positive tumor cell lines.Q40616262
Apoptosis in cancer therapy: crossing the thresholdQ40694262
Bcl-2 inhibits chemotherapy-induced apoptosis in neuroblastoma.Q41461017
Bcl-2 family proteins: regulators of apoptosis and chemoresistance in hematologic malignancies.Q41668626
Overexpression of Bcl2 abrogates chemo- and radiotherapy-induced sensitisation of NCI-H460 non-small-cell lung cancer cells to adenovirus-mediated expression of full-length TRAIL.Q42278494
Expression of the protooncogene bcl-2 in the prostate and its association with emergence of androgen-independent prostate cancerQ42457244
Resistance of prostate cancer cells to soluble TNF-related apoptosis-inducing ligand (TRAIL/Apo2L) can be overcome by doxorubicin or adenoviral delivery of full-length TRAIL.Q43696432
Why G3139 works poorly in cancer trials but might work well against HIV.Q44304093
Stable suppression of tumorigenicity by virus-mediated RNA interferenceQ45730805
Promoter-specific modulation of insulin-like growth factor II genomic imprinting by inhibitors of DNA methylation.Q45985336
Genomic deletion of an imprint maintenance element abolishes imprinting of both insulin-like growth factor II and H19.Q46005770
Downregulation of Bcl-2, FLIP or IAPs (XIAP and survivin) by siRNAs sensitizes resistant melanoma cells to Apo2L/TRAIL-induced apoptosisQ47670151
bcl-2 Protein Expression in Cutaneous Malignant Melanoma and Benign Melanocytic NeviQ50764553
Clinical trials referral resource. Current clinical trials of G3139Q53649278
Synergistic inhibition of tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in human pancreatic β cells by Bcl-2 and X-linked inhibitor of apoptosisQ57462321
Adenovirus-TRAIL can overcome TRAIL resistance and induce a bystander effectQ64377565
High expression of bcl-2 protein in acute myeloid leukemia cells is associated with poor response to chemotherapyQ72081677
A phase I-II study of oblimersen sodium (G3139, Genasense) in combination with doxorubicin in advanced hepatocellular carcinoma (NCI # 5798)Q80149334
P433issue9
P407language of work or nameEnglishQ1860
P921main subjectmicroRNAQ310899
P1104number of pages11
P304page(s)2229-2239
P577publication date2010-05-01
P1433published inInternational Journal of CancerQ332492
P1476titleTargeted knockdown of Bcl2 in tumor cells using a synthetic TRAIL 3'-UTR microRNA
P478volume126

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cites work (P2860)
Q36099255Enhanced therapeutic efficacy of vitamin K2 by silencing BCL-2 expression in SMMC-7721 hepatocellular carcinoma cells
Q35054432Potentiation of tumor radiotherapy by a radiation-inducible oncolytic and oncoapoptotic adenovirus in cervical cancer xenografts
Q39756408SP1 suppresses phorbol 12-myristate 13-acetate induced up-regulation of human regucalcin expression in liver cancer cells
Q39098583The role of Bax and Bcl-2 in gemcitabine-mediated cytotoxicity in uveal melanoma cells

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