The experimental folding landscape of monomeric lactose repressor, a large two-domain protein, involves two kinetic intermediates

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The experimental folding landscape of monomeric lactose repressor, a large two-domain protein, involves two kinetic intermediates is …
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scholarly articleQ13442814

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P819ADS bibcode2005PNAS..10214563W
P356DOI10.1073/PNAS.0505808102
P932PMC publication ID1253568
P698PubMed publication ID16203983
P5875ResearchGate publication ID7561229

P50authorPernilla Wittung-StafshedeQ28792589
Cecilia ClementiQ47328383
P2093author name stringPayel Das
Corey J Wilson
Kathleen S Matthews
P2860cites workCrystal structure of lac repressor core tetramer and its implications for DNA loopingQ27730288
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Prediction of folding mechanism for circular-permuted proteinsQ30167986
Lactose repressor protein: functional properties and structure.Q30428522
Absolute comparison of simulated and experimental protein-folding dynamicsQ30868882
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Linear extrapolation method of analyzing solvent denaturation curvesQ34050401
Characterization of the folding landscape of monomeric lactose repressor: quantitative comparison of theory and experimentQ34078456
Resolution of the fluorescence decay of the two tryptophan residues of lac repressor using single tryptophan mutantsQ34126299
Contact order, transition state placement and the refolding rates of single domain proteins.Q34464266
Deletion of lactose repressor carboxyl-terminal domain affects tetramer formationQ34468180
Protein folding and unfolding at atomic resolutionQ34574339
Meeting halfway on the bridge between protein folding theory and experimentQ34913657
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Protein folding: bringing theory and experiment closer togetherQ35064533
How native-state topology affects the folding of dihydrofolate reductase and interleukin-1betaQ35752174
The lac operator is DNA.Q36453286
Characterization of two mutant lactose repressor proteins containing single tryptophans.Q38337857
Perturbation from a distance: mutations that alter LacI function through long-range effectsQ38347616
Pathways of protein foldingQ40835296
Topological and energetic factors: what determines the structural details of the transition state ensemble and "en-route" intermediates for protein folding? An investigation for small globular proteinsQ41734718
Formation of on- and off-pathway intermediates in the folding kinetics of Azotobacter vinelandii apoflavodoxin.Q45011522
Quantifying the roughness on the free energy landscape: entropic bottlenecks and protein folding ratesQ46797018
Dissociation of the lactose repressor-operator DNA complex: effects of size and sequence context of operator-containing DNA.Q47207391
Unification of the folding mechanisms of non-two-state and two-state proteinsQ47423432
Optimal combination of theory and experiment for the characterization of the protein folding landscape of S6: how far can a minimalist model go?Q50142211
Subunit dissociation affects DNA binding in a dimeric lac repressor produced by C-terminal deletion.Q52513332
Formation of the hinge helix in the lac repressor is induced upon binding to the lac operator.Q54578349
Comparison of solution structure of free and complexed lac operator by molecular modelling with NMR constraints.Q54644693
An early immunoreactive folding intermediate of the tryptophan synthease beta 2 subunit is a 'molten globule'.Q54714787
How do small single-domain proteins fold?Q55067789
The Largest Protein Observed To Fold by Two-State Kinetic Mechanism Does Not Obey Contact-Order CorrelationQ57821948
Characterization and modification of a monomeric mutant of the lactose repressor proteinQ68915361
Genetic analysis of transpositions in the lac region of Escherichia coliQ72887848
Kinetic role of early intermediates in protein foldingQ73070815
Dimerisation mutants of Lac repressor. I. A monomeric mutant, L251A, that binds Lac operator DNA as a dimerQ77967867
P433issue41
P407language of work or nameEnglishQ1860
P921main subjectprotein foldingQ847556
P304page(s)14563-14568
P577publication date2005-10-03
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleThe experimental folding landscape of monomeric lactose repressor, a large two-domain protein, involves two kinetic intermediates
P478volume102

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cites work (P2860)
Q33480934Analysis of the free-energy surface of proteins from reversible folding simulations
Q57035312Biomolecular Assemblies: Moving from Observation to Predictive Design
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Q36288464Consequences of localized frustration for the folding mechanism of the IM7 protein
Q35822949DynaFace: Discrimination between Obligatory and Non-obligatory Protein-Protein Interactions Based on the Complex's Dynamics
Q36044724FRET studies of a landscape of Lac repressor-mediated DNA loops
Q27666589Fructose 1-Phosphate Is the Preferred Effector of the Metabolic Regulator Cra of Pseudomonas putida
Q41056715Leveraging the Mechanism of Oxidative Decay for Adenylate Kinase to Design Structural and Functional Resistances
Q37999300Overview of protein folding mechanisms: experimental and theoretical approaches to probing energy landscapes
Q29299846Simulations of proteins with inhomogeneous degrees of freedom: The effect of thermostats
Q51116602Solution NMR investigation of the response of the lactose repressor core domain dimer to hydrostatic pressure.
Q31135225Structure based design of protein linkers for zinc finger nuclease

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