Precision-cut liver slices: characteristics and use for in vitro pharmaco-toxicology

scientific article

Precision-cut liver slices: characteristics and use for in vitro pharmaco-toxicology is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1016/S0300-483X(00)00316-4
P698PubMed publication ID11090959

P2093author name stringLerche-Langrand C
Toutain HJ
P2860cites workRapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assaysQ25939005
Glucuronide conjugates of 4-aminobiphenyl and its N-hydroxy metabolites. pH stability and synthesis by human and dog liverQ28283468
Determination of 7-hydroxycoumarin and its glucuronide and sulphate conjugates in liver slice incubates by capillary zone electrophoresisQ28287708
Interactive toxicity and stress protein expression by vinylidene chloride and monochloroacetate in precision-cut rat liver slicesQ28369388
Cellular localization of hepatic cytochrome 1B1 expression and its regulation by aromatic hydrocarbons and inflammatory cytokinesQ28566231
Stability of Phase II Conjugation Systems in Cultured Precision-cut Rat Hepatic SlicesQ33639160
Assessment of regional cytochrome P450 activities in rat liver slices using resorufin substrates and fluorescence confocal laser cytometryQ34635754
Liver cell models in in vitro toxicologyQ34941510
Metabolic zonation of the liver: regulation and implications for liver functionQ35417325
Liver slices in in vitro pharmacotoxicology with special reference to the use of human liver tissueQ37775115
Precision-cut tissue slices: applications in pharmacology and toxicologyQ40369234
A biologically based pharmacodynamic model for lipid peroxidation stimulated by trichloroethylene in vitroQ40819645
Characterization of olanzapine (LY170053) in human liver slices by liquid chromatography/tandem mass spectrometryQ40829939
Past, present, and future applications of precision-cut liver slices for in vitro xenobiotic metabolismQ40921670
The metabolism and DNA binding of the cooked-food mutagen, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in precision-cut rat liver slicesQ40985380
Detection of CYP1A1 protein in human liver and induction by TCDD in precision-cut liver slices incubated in dynamic organ cultureQ41007634
High-yield preparation of isolated rat liver parenchymal cells: a biochemical and fine structural studyQ41115222
Cryopreservation of pig and human liver slicesQ41154296
Valproic Acid Hepatotoxicity in Human Liver SlicesQ41170387
Characterization of the cellular reduction of 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT): subcellular localization, substrate dependence, and involvement of mitochondrial electron transport in MTT reductionQ41549753
Liver slices as a model in drug metabolism.Q41619438
Prediction of hepatic clearance from microsomes, hepatocytes, and liver slicesQ41676765
Drug metabolizing enzyme activities in rat liver epithelial cell lines, hepatocytes and bile duct cellsQ41681575
In vitro cytotoxicity of allyl alcohol and bromobenzene in a novel organ culture systemQ42217717
Comparison of the toxicity of allyl alcohol, coumarin and menadione in precision-cut rat, guinea-pig, cynomolgus monkey and human liver slicesQ42551405
Comparative metabolism and toxicity of dichlorobenzenes in Sprague-Dawley, Fischer-344 and human liver slicesQ71880916
Metabolism of coumarin by precision-cut calf liver slices and calf liver microsomesQ71903902
The interactive toxicity of CHCl3 and BrCCl3 in precision-cut rat liver slicesQ71999338
The application of electrospray and neutral-loss mass spectrometry to the identification of the metabolites of S12813 in rat liver slicesQ72046461
Hepatic uptake and metabolism of 2,3,7,8-tetrachlorodibenzo-p-dioxin and 2,3,7,8-tetrachlorodibenzofuranQ72119722
Quinone methide formation from para isomers of methylphenol (cresol), ethylphenol, and isopropylphenol: relationship to toxicityQ72125827
In vitro metabolism of theophylline by rat and human liver tissueQ72171689
Uptake and metabolism of 3H-adrenaline and 3H-noradrenaline by isolated hepatocytes and liver slices of the ratQ72259249
Cresol isomers: comparison of toxic potency in rat liver slicesQ72293724
Metabolism of coumarin and 7-ethoxycoumarin by rat, mouse, guinea pig, cynomolgus monkey and human precision-cut liver slicesQ72381628
Comparison of the metabolism of 7-ethoxycoumarin and coumarin in precision-cut rat liver and lung slicesQ72644399
Use of precision-cut liver slices for studies of unscheduled DNA synthesisQ72719448
Lack of effect of piperonyl butoxide on unscheduled DNA synthesis in precision-cut human liver slicesQ73013258
Precision-cut dog renal cortical slices in dynamic organ culture for the study of cisplatin nephrotoxicityQ73076258
Lipid profiling in renal and hepatic tissue slices following exposure to atractylosideQ73124436
Cytochrome P450 isoenzyme activities in cultured rat and mouse liver slicesQ73335834
In vitro glucuronidation of D-23129, a new anticonvulsant, by human liver microsomes and liver slicesQ73407255
In vitro metabolism of N-(5-chloro-2-methylphenyl)-N'-(2-methylpropyl)thiourea: species comparison and identification of a novel thiocarbamide-glutathione adductQ73571177
Comparison and in vivo relevance of two different in vitro head space metabolic systems: liver S9 and liver slicesQ73591265
Stereoselective metabolism of fenoldopam and its metabolites in human liver microsomes, cytosol, and slicesQ73617641
Comparison of five incubation systems for rat liver slices using functional and viability parametersQ73951905
Induction of CYP3A isoforms in cultured precision-cut human liver slicesQ73980901
In vitro metabolism of GV150013X by using liver microsomes and liver tissue slices from different speciesQ74346139
Thermic transition and glycolytic capacity as critical events in the survival of rat liver slices after overnight cold hypoxic preservationQ74506426
Time- and concentration-dependent induction of CYP1A1 and CYP1A2 in precision-cut rat liver slices incubated in dynamic organ culture in the presence of 2,3,7,8-tetrachlorodibenzo-p-dioxinQ74533898
Structural and functional integrity of precision-cut liver slices in xenobiotic metabolism: a comparison of the dynamic organ and multiwell plate culture proceduresQ74608261
Inhibition of xenobiotic-induced genotoxicity in cultured precision-cut human and rat liver slicesQ74645648
The characterisation of the major metabolite of salmeterol in the dogQ74651828
Effects of taurine in precision-cut liver slices exposed to the pyrrolizidine alkaloid retrorsineQ74678606
Effect of some cooked food mutagens on unscheduled DNA synthesis in cultured precision-cut rat, mouse and human liver slicesQ74801274
Gender aspects of liver slice incubations with N,N,N-triethylene-thiophosphamide (Thio-TEPA) in rats and miceQ77291786
Lack of effect of coumarin on unscheduled DNA synthesis in precision-cut human liver slicesQ77291842
3,3'-Diindolylmethane induces CYP1A2 in cultured precision-cut human liver slicesQ77314605
The toxic mechanism and metabolic effects of atractyloside in precision-cut pig kidney and liver slicesQ77387068
Induction of cytochrome P450 1A1 in rat liver slices by 7-ethoxycoumarin and 4-methyl-7-ethoxycoumarinQ77449569
Monooxygenation, cytochrome P450-mRNA expression and other functions in precision-cut rat liver slicesQ77449579
Immunohistochemical localization of cytochrome P450 1A1 in precision-cut rat liver slices after in vitro exposure to beta-naphthoflavoneQ77449583
Benzo(a)pyrene-induced alterations in growth-related gene expression and signaling in precision-cut adult rat liver and kidney slicesQ77681428
Dose-response relationships for hepatic aflatoxin B1-DNA adduct formation in the rat in vivo and in vitro: the use of immunoslot blotting for adduct quantitationQ77762234
Impairment of TNF-alpha expression and secretion in primary rat liver cell cultures by acetaminophen treatmentQ77909852
The role of oxygen free radicals in isoniazid-induced hepatotoxicityQ77920119
Treatment with aged garlic extract protects against bromobenzene toxicity to precision cut rat liver slicesQ78087007
Effect of some indole derivatives on xenobiotic metabolism and xenobiotic-induced toxicity in cultured rat liver slicesQ78230208
Cytotoxicity of retinoic acid, menadione and aflatoxin B(1) in rat liver slices using Netwell inserts as a new culture systemQ84585496
Time- and dose-response effects of the mycotoxin, fumonisin B(1) on sphingoid base elevations in precision-cut rat liver and kidney slicesQ84585627
DNA adduct formation of selected sex steroids in human liver slices in vitroQ84589474
Optimizing preincubation conditions for precision-cut rat kidney and liver tissue slices: effect of culture media and antioxidantsQ84589521
Use of Fresh and Cryopreserved Human Liver Slices in Toxicology with Special Reference to In vitro Induction of Cytochrome P450Q84589594
Organ slices as an in vitro test system for drug metabolism in human liver, lung and kidneyQ84589627
Adenine and pyridine nucleotide concentrations and relationships to 2,6-dinitrotoluene metabolism in cultured rat liver slicesQ84695724
Effect of peroxisome proliferators and inducers of xenobiotic metabolism on marker enzyme activities in cultured rat liver slicesQ84695853
Assessment of rat liver slices as a suitable model system for studying the simultaneous sulphation and glucuronidation of phenolic xenobioticsQ93896419
Beta2-agonist abuse in food producing animals: use of in vitro liver preparations to assess biotransformation and potential target residues for surveillanceQ93923451
The relative importance of glutathione and metallothionein on protection of hepatotoxicity of menadione in ratsQ43470686
Formation and identification of protein adducts to cytosolic proteins in guinea pig liver slices exposed to halothaneQ44676836
Comparison of the in vitro toxicity of dichloroaniline structural isomersQ45298960
Evidence that the loss of rat liver cytochrome P450 in vitro is not solely associated with the use of collagenase, the loss of cell-cell contacts and/or the absence of an extracellular matrixQ45396531
Predictive value of liver slices for metabolism and toxicity in vivo: use of acetaminophen as a model hepatotoxicantQ46188948
Sevoflurane is biotransformed by guinea pig liver slices but causes minimal cytotoxicityQ46378186
Minimal biotransformation and toxicity of desflurane in guinea pig liver slicesQ46477862
Toxicity of halothane in guinea pig liver slicesQ46527902
Glutathione-S-transferase is a target for covalent modification by a halothane reactive intermediate in the guinea pig liverQ46700753
Effects of halothane and other volatile anaesthetics on protein synthesis and secretion in guinea pig liver slicesQ46886994
Body size and tissue respirationQ47449343
Comparison of hepatocyte cultures and liver slices in in vitro toxicity testing.Q47687877
Morphological and functional integrity of precision-cut rat liver slices in rotating organ culture and multiwell plate culture: effects of oxygen tensionQ47744104
Toxicity of valproic acid in liver slices from sprague-dawley rats and domestic pigsQ47790445
Comparative toxicity of valproic acid and its metabolites in liver slices from adult rats, weanling rats and humansQ47791628
Mechanism of allyl alcohol-induced hepatic necrosisQ48022192
Use of precision-cut rat liver slices for studies of xenobiotic metabolism and toxicity: comparison of the Krumdieck and Brendel tissue slicersQ48033846
Toxicity of atractyloside in precision-cut rat and porcine renal and hepatic tissue slices.Q50659501
The hepatotoxicities of endotoxin and ethanol comparisons in vitro using the precision-cut rat liver slice model.Q50776804
The involvement of Kupffer cells in carbon tetrachloride toxicity.Q50783765
Further examination of the selective toxicity of CCl4 in rat liver slicesQ50796476
Toxicity of ortho-substituted bromobenzenes to isolated hepatocytes: comparison to in vivo results.Q50928505
Effect of cold and warm ischaemia on drug metabolism in isolated hepatocytes and slices from human and monkey liver.Q51519532
Inactivation of cytochromes P450 2B protects against cocaine-mediated toxicity in rat liver slices.Q51634391
Hepatic elimination of diazepam: interactions with albumin, desflurane and sevoflurane.Q51666893
Cocaine hepatotoxicity in cultured liver slices: a species comparison.Q51736280
Mathematical model for chemically induced lipid peroxidation in precision-cut liver slices: computer simulation and experimental calibration.Q52303823
o-Methoxy-4-alkylphenols That Form Quinone Methides of Intermediate Reactivity Are the Most Toxic in Rat Liver SlicesQ52346586
In- Vitro Hepatotoxicity of Three Dichlorobenzene Isomers in Human Liver SlicesQ52444750
Liver slices in dynamic organ culture. I. An alternativein vitrotechnique for the study of rat hepatic drug metabolismQ52446745
Liver slices in dynamic organ culture. II. Anin vitrocellular technique for the study of integrated drug metabolism using human tissueQ52446746
Mycotoxin-induced elevation of free sphingoid bases in precision-cut rat liver slices: specificity of the response and structure-activity relationships.Q52527831
Chemically induced oxidative stress disrupts the E-cadherin/catenin cell adhesion complex.Q52536447
Culture medium composition affects the relative toxicities of chlorobenzenes in rat liver slices and the isolated perfused liver.Q52544516
Dieldrin pretreatment alters [14C]dieldrin and [3H]7,12-dimethylbenz[a]anthracene uptake in rainbow trout liver slices.Q52550182
Determination of aflatoxin B1 biotransformation and binding to hepatic macromolecules in human precision liver slices.Q53458942
O6-Alkylguanine DNA alkyltransferase activity in monkey, human and rat liver.Q53545681
Species differences in hepatic glutathione depletion, covalent binding and hepatic necrosis after acetaminophen.Q53715160
Dynamic organ culture of precision liver slices for in vitro toxicology.Q53917946
Resistance of precision-cut liver slices to the toxic effects of menadione.Q54262193
Cold- and cryopreservation of dog liver and kidney slicesQ57110962
Effect of drug treatment on liver-slice function following 72-hour hypothermic perfusionQ57116182
Biotransformation of a somatostatin analogue in precision-cut liver and kidney slices from rat, dog and manQ59637081
Protective roles of metallothionein and glutathione in hepatotoxicity of cadmiumQ60125367
Preservation of the rate and profile of xenobiotic metabolism in rat hepatocytes stored in liquid nitrogenQ60146194
Metabolism and alkylating activity of thio-TEPA in rat liver slice incubationQ67702722
The hepatotoxicity of chloroform in precision-cut rat liver slicesQ68209515
Rat liver slices: metabolic changes during short time incubation in glucose-free bufferQ68908474
CCl4-induced cytochrome P-450 loss and lipid peroxidation in rat liver slicesQ70226824
Correlation of metabolism, covalent binding and toxicity for a series of bromobenzene derivatives using rat liver slices in vitroQ70488698
Culture of precision-cut liver slices: effect of some peroxisome proliferatorsQ70600103
Bromobenzene Metabolism and Hepatic NecrosisQ70651997
Induction of cytochrome P-450-dependent enzyme activities in cultured rat liver slicesQ70744592
Apparent rates of glutathione turnover in rat tissuesQ70762270
Cell injury and protection in long-term incubation of liver slices after in vivo initiation with paracetamol: cell injury after in vivo initiation with paracetamolQ70855305
Sodium arsenite and heat shock induce stress proteins in precision-cut rat liver slicesQ70897599
Use of tissue slices in chemical mixture toxicology and interspecies investigationsQ70924576
Rat liver epithelial cells express functional cytochrome P450 2E1Q71102706
Use of precision-cut liver slices to evaluate species differences in 2-acetylaminofluorene-induced unscheduled DNA synthesisQ71135008
Induction of cytochrome P450 isoenzymes in cultured precision-cut rat and human liver slicesQ71324150
Metabolism of [ring-U-14C] agaritine by precision-cut rat, mouse and human liver and lung slicesQ71408776
Monooxygenation, cytochrome P4501A1 and P4501A1-mRNA in rat liver slices exposed to beta-naphthoflavone and dexamethasone in vitroQ71422826
A new instrument for the rapid preparation of tissue slicesQ71506932
A comparative study of precision cut liver slices, hepatocytes, and liver microsomes from the Wistar rat using metronidazole as a model substanceQ71563288
Biotransformation of the antiemetic 5-HT3 antagonist tropisetron in liver and kidney slices of human, rat and dog with a comparison to in vivoQ71611362
Ethoxycoumarin O-deethylation (ECOD) activity in rat liver slices exposed to beta-naphthoflavone (BNF) in vitroQ71650657
Use of rat and human liver slices for the detection of steroid hormone-induced DNA-adducts in vitro by means of the (32)P-postlabeling techniqueQ71663277
The role of acetylation in benzidine metabolism and DNA adduct formation in dog and rat liverQ71717402
Validation of precision-cut liver slices in dynamic organ culture as an in vitro model for studying CYP1A1 and CYP1A2 inductionQ71718160
Metabolite kinetics of ondansetron in rat. Comparison of hepatic microsomes, isolated hepatocytes and liver slices, with in vivo dispositionQ71728600
Hormone- and endotoxin-modulated gene expression of a long-term organ culture system of adult rat liverQ71793351
In-vitro metabolic studies of tacrolimus using precision-cut rat and human liver slicesQ71851527
P433issue1-3
P407language of work or nameEnglishQ1860
P304page(s)221-253
P577publication date2000-11-01
P1433published inToxicologyQ1666328
P1476titlePrecision-cut liver slices: characteristics and use for in vitro pharmaco-toxicology
P478volume153

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