| scholarly article | Q13442814 |
| review article | Q7318358 |
| P356 | DOI | 10.1016/0163-7258(92)90055-5 |
| P698 | PubMed publication ID | 1409850 |
| P2093 | author name string | R. Gebhardt | |
| P433 | issue | 3 | |
| P407 | language of work or name | English | Q1860 |
| P304 | page(s) | 275-354 | |
| P577 | publication date | 1992-01-01 | |
| P1433 | published in | Pharmacology & Therapeutics | Q3378596 |
| P1476 | title | Metabolic zonation of the liver: regulation and implications for liver function | |
| P478 | volume | 53 |
| Q55118668 | A central role for hypoxia-inducible factor (HIF)-2α in hepatic glucose homeostasis. |
| Q93123849 | A computational model for hepatotoxicity by coupling drug transport and acetaminophen metabolism equations |
| Q64886066 | A glass-based, continuously zonated and vascularized human liver acinus microphysiological system (vLAMPS) designed for experimental modeling of diseases and ADME/TOX. |
| Q70906629 | A human liver cell atlas reveals heterogeneity and epithelial progenitors |
| Q74645257 | A mechanistic model for the development and maintenance of portocentral gradients in gene expression in the liver |
| Q47151335 | A multi-scale spatial model of hepatitis-B viral dynamics. |
| Q41829992 | A physiologically-based flow network model for hepatic drug elimination II: variable lattice lobule models. |
| Q36651712 | A physiologically-based flow network model for hepatic drug elimination III: 2D/3D DLA lobule models. |
| Q42815692 | A quantitative analysis of the control of glutamine catabolism in rat liver cells. Use of selective inhibitors |
| Q38308053 | A single regulatory module of the carbamoylphosphate synthetase I gene executes its hepatic program of expression. |
| Q36629191 | A theoretical approach to zonation in a bioartificial liver. |
| Q89685239 | A time-resolved multi-omic atlas of the developing mouse liver |
| Q51579926 | Acetaminophen glucuronidation accurately reflects gluconeogenesis in fasted dogs. |
| Q38946453 | An investigation into the stability of commercial versus MG63-derived hepatocyte growth factor under flow cultivation conditions |
| Q40541507 | Analysis of enzyme reactions in situ |
| Q40834664 | Antibacterial efficacy and pharmacokinetic evaluation of sanguinarine in common carp (Cyprinus carpio) following a single intraperitoneal administration |
| Q42812102 | Application of dual-digitonin-pulse perfusion to the study of hepatic mRNA zonation |
| Q34418889 | Biochemistry of peroxisomes in health and disease |
| Q93184920 | Biocompatibility studies of fluorescent diamond particles-(NV)~800nm (part V): in vitro kinetics and in vivo localization in rat liver following long-term exposure |
| Q28554261 | Building a 3D Virtual Liver: Methods for Simulating Blood Flow and Hepatic Clearance on 3D Structures |
| Q34465121 | Bursty gene expression in the intact mammalian liver |
| Q38110522 | Cellular and molecular basis of liver development. |
| Q72690591 | Changes in distribution and activity of glutamine synthetase in carbon tetrachloride-induced cirrhosis in the rat: potential role in hyperammonemia |
| Q38110739 | Chip-based liver equivalents for toxicity testing--organotypicalness versus cost-efficient high throughput |
| Q46211802 | Cholesterol 7alpha-hydroxylase (CYP7A): patterns of messenger RNA expression during rat liver development |
| Q28534639 | Cholesterol-secreting and statin-responsive hepatocytes from human ES and iPS cells to model hepatic involvement in cardiovascular health |
| Q73159476 | Coexpression of periportal and perivenous enzymes in rat hepatocytes after experimental bile duct ligation: comparison with intrasplenically transplanted hepatocytes |
| Q43648980 | Colchicine inhibits taurodeoxycholate transport in pericentral but not in periportal hepatocytes |
| Q71878577 | Cold acclimation induces zonal heterogeneity in gluconeogenic responses to glucagon in rat liver lobule |
| Q30586233 | Computational experiments reveal plausible mechanisms for changing patterns of hepatic zonation of xenobiotic clearance and hepatotoxicity |
| Q39300467 | Computational fluid model incorporating liver metabolic activities in perfusion bioreactor |
| Q64377006 | Conditional disruption of hepatic carbamoyl phosphate synthetase 1 in mice results in hyperammonemia without orotic aciduria and can be corrected by liver-directed gene therapy |
| Q45861441 | Deciphering liver zonation: new insights into the β-catenin, Tcf4, and HNF4α triad |
| Q74575680 | Development of an optimal method for the dual perfusion of the isolated rat liver |
| Q41647938 | Differential expression of apolipoprotein E messenger RNA within the rat liver lobule determined by in situ hybridization |
| Q28486701 | Differential intrahepatic phospholipid zonation in simple steatosis and nonalcoholic steatohepatitis |
| Q52864106 | Dynamic zonation of liver polyploidy. |
| Q41486909 | Dynamics of amino acid metabolism of primary human liver cells in 3D bioreactors |
| Q35010865 | Early growth and coronary heart disease in later life: longitudinal study |
| Q54494404 | Effect of aging on norepinephrine-related proliferative response in primary cultured periportal and perivenous hepatocytes. |
| Q35496210 | Effect of allyl alcohol on hepatic transporter expression: zonal patterns of expression and role of Kupffer cell function |
| Q42726234 | Effect of liver regeneration after partial hepatectomy and ischemia-reperfusion on expression of growth factor receptors |
| Q43744484 | Effect of oxygen concentration on the expression of glutathione S-transferase activity in periportal and perivenous rat hepatocyte cultures |
| Q30531799 | Effect of oxygen concentration on viability and metabolism in a fluidized-bed bioartificial liver using ³¹P and ¹³C NMR spectroscopy |
| Q42559199 | Effects of increased dietary cholesterol with carbohydrate restriction on hepatic lipid metabolism in Guinea pigs |
| Q92463372 | Effects of single parenthood on mothers' behavior, morphology, and endocrine function in the biparental California mouse |
| Q48014053 | Enhanced oxygen delivery to primary hepatocytes within a hollow fiber bioreactor facilitated via hemoglobin-based oxygen carriers |
| Q72567623 | Experimental evidence that the physiological position of the liver within the circulation is not a major determinant of zonation of gene expression |
| Q72569901 | Experimentally induced colon cancer metastases in rat liver increase the proliferation rate and capacity for purine catabolism in liver cells |
| Q94522036 | FBP1 loss disrupts liver metabolism and promotes tumorigenesis through a hepatic stellate cell senescence secretome |
| Q91892410 | Fabrication of Perfusable Vascular Channels and Capillaries in 3D Liver-like Tissue |
| Q33832854 | Fetal hepatic drug elimination |
| Q42822343 | Flexibility of zonation of fatty acid oxidation in rat liver |
| Q35162950 | For debate: Fetal and early postnatal growth restriction lead to diabetes, the metabolic syndrome and renal failure. |
| Q35688096 | Geometry of the Gene Expression Space of Individual Cells |
| Q91559668 | Glutamine/glutamate metabolism rewiring in reprogrammed human hepatocyte-like cells |
| Q72840713 | Growth hormone mediates zone-specific gene expression in liver |
| Q28575524 | Growth hormone-regulated periportal expression of CYP2C7 in rat liver |
| Q42706775 | Ha-ras and β-catenin oncoproteins orchestrate metabolic programs in mouse liver tumors. |
| Q36908863 | Hedgehog signaling is a potent regulator of liver lipid metabolism and reveals a GLI-code associated with steatosis. |
| Q28504728 | Hepatic Hedgehog signaling contributes to the regulation of IGF1 and IGFBP1 serum levels |
| Q36758861 | Hepatic autophagy is differentially regulated in periportal and pericentral zones - a general mechanism relevant for other tissues? |
| Q51585613 | Hepatic glycogen accurately reflected by acetaminophen glucuronide in dogs refed after fasting. |
| Q50706733 | Hepatic precursors derived from murine embryonic stem cells contribute to regeneration of injured liver. |
| Q50530429 | Hepatic stellate cell activation in genetic haemochromatosis. Lobular distribution, effect of increasing hepatic iron and response to phlebotomy. |
| Q73211492 | Hepatic zonation of the formation and hydrolysis of cholesteryl esters in periportal and perivenous parenchymal cells |
| Q34240836 | HepatoNet1: a comprehensive metabolic reconstruction of the human hepatocyte for the analysis of liver physiology |
| Q45134972 | Hepatocyte Ploidy Is a Diversity Factor for Liver Homeostasis. |
| Q73035487 | Hepatocyte ploidy in normal young rat |
| Q40706698 | Hepatocytes of cirrhotic rat liver accumulate glycogen more slowly than normal ones |
| Q39889873 | Hepatoregenerative role of bone morphogenetic protein-9. |
| Q34485399 | Hepatotoxicity in acute iron poisoning |
| Q40459680 | Heterogeneity of kinetic parameters of enzymes in situ in rat liver lobules. |
| Q41010263 | Heterogeneous expression of cholesterol 7 alpha-hydroxylase and sterol 27-hydroxylase genes in the rat liver lobulus |
| Q45996235 | Heterogeneous expression of suppressor of cytokine signalling 2 (SOCS-2) in liver tissue. |
| Q35527605 | High Concentrations of Atmospheric Ammonia Induce Alterations in the Hepatic Proteome of Broilers (Gallus gallus): An iTRAQ-Based Quantitative Proteomic Analysis |
| Q35525188 | High throughput single cell bioinformatics |
| Q42821615 | Hormonal regulation of the zonated expression of cytochrome P-450 3A in rat liver |
| Q50893427 | Human ESC/iPSC-Derived Hepatocyte-like Cells Achieve Zone-Specific Hepatic Properties by Modulation of WNT Signaling. |
| Q64057372 | Human three-dimensional in vitro model of hepatic zonation to predict zonal hepatotoxicity |
| Q36929667 | Hyperammonemia encephalopathy: an important cause of neurological deterioration following chemotherapy. |
| Q48123227 | Identification and functional characterization of regulatory elements of the glutamine synthetase gene from rat liver |
| Q42195805 | Identification of an oxygen-responsive element in the 5'-flanking sequence of the rat cytosolic phosphoenolpyruvate carboxykinase-1 gene, modulating its glucagon-dependent activation |
| Q37695203 | Immunofluorescence identifies distinct subsets of endothelial cells in the human liver |
| Q32061576 | Immunohistochemical demonstration of beta-naphthoflavone-inducible cytochrome P450 1A1/1A2 in rat intrahepatic biliary epithelial cells |
| Q28207820 | Immunohistological analysis of glutathione transferase A4 distribution in several human tissues using a specific polyclonal antibody |
| Q44980345 | In vitro differentiated adult human liver progenitor cells display mature hepatic metabolic functions: a potential tool for in vitro pharmacotoxicological testing. |
| Q90183277 | In vitro metabolic zonation through oxygen gradient on a chip |
| Q77448607 | Induction of UDP-glycosyltransferase family 1 genes in rat liver: different patterns of mRNA expression with two inducers, 3-methylcholanthrene and beta-naphthoflavone |
| Q38285131 | Insulin resistance in the liver: deficiency or excess of insulin? |
| Q41554782 | Interrelationships between astrocyte function, oxidative stress and antioxidant status within the central nervous system. |
| Q35603811 | Intraoperative simulation of remnant liver function during anatomic liver resection with indocyanine green clearance (LiMON) measurements |
| Q35720673 | Inverse zonation of hepatocyte transduction with AAV vectors between mice and non-human primates. |
| Q36523471 | Involvement of cell junctions in hepatocyte culture functionality |
| Q97073785 | Lipid nanoparticle technology for therapeutic gene regulation in the liver |
| Q89976263 | Liver Bioreactor Design Issues of Fluid Flow and Zonation, Fibrosis, and Mechanics: A Computational Perspective |
| Q38960582 | Liver Cell Culture Devices |
| Q64968927 | Liver Zonation in Health and Disease: Hypoxia and Hypoxia-Inducible Transcription Factors as Concert Masters. |
| Q37998978 | Liver progenitor cell interactions with the extracellular matrix. |
| Q24795104 | Liver sinusoidal endothelial cell modulation upon resection and shear stress in vitro |
| Q33950022 | Liver tissue engineering in the evaluation of drug safety |
| Q33886995 | Liver zonation: Novel aspects of its regulation and its impact on homeostasis |
| Q59340375 | Liver-specific Repin1 deficiency impairs transient hepatic steatosis in liver regeneration |
| Q48126212 | Localization and function of the organic anion-transporting polypeptide Oatp2 in rat liver |
| Q51574787 | Localization of glycogen phosphorylase activity in liver of fasted normal and adrenalectomized rats and in fasted adrenalectomized rats after injection of dexamethasone |
| Q90218585 | Mathematical Modeling for Hepatitis B Virus: Would Spatial Effects Play a Role and How to Model It? |
| Q34637602 | Mechanistic considerations in benzene physiological model development |
| Q55384558 | Metabolic Patterning on a Chip: Towards in vitro Liver Zonation of Primary Rat and Human Hepatocytes. |
| Q90288192 | Metabolic aspects in NAFLD, NASH and hepatocellular carcinoma: the role of PGC1 coactivators |
| Q46200127 | Metabolic gradients as key regulators in zonation of tumor energy metabolism: a tissue-scale model-based study |
| Q39105478 | Metabolic zonation of the liver: The oxygen gradient revisited. |
| Q55277291 | Metabolite profiling identifies a signature of tumorigenicity in hepatocellular carcinoma. |
| Q77725647 | Methapyrilene hepatotoxicity is associated with oxidative stress, mitochondrial disfunction and is prevented by the Ca2+ channel blocker verapamil |
| Q54186375 | Molecular and biochemical modifications of liver glutamine synthetase elicited by daytime restricted feeding. |
| Q36991523 | Molecular mechanisms underlying chemical liver injury |
| Q48174531 | Natural Dietary Pigments: Potential Mediators against Hepatic Damage Induced by Over-The-Counter Non-Steroidal Anti-Inflammatory and Analgesic Drugs. |
| Q30986309 | New insights into functional aspects of liver morphology |
| Q43071472 | Norepinephrine modulates the zonally different hepatocyte proliferation through the regulation of transglutaminase activity |
| Q30490781 | Normothermic perfusion in the assessment and preservation of declined livers prior to transplantation: hyperoxia and vasoplegia - important lessons from the first 12 cases. |
| Q35278245 | Notochordal cells in the adult intervertebral disc: new perspective on an old question |
| Q90403546 | Numerical Investigations of Hepatic Spheroids Metabolic Reactions in a Perfusion Bioreactor |
| Q51697079 | Optimality in the zonation of ammonia detoxification in rodent liver. |
| Q52873023 | Orchestrating Wnt signalling for metabolic liver zonation. |
| Q37586372 | Organ patterning in the adult stage: the role of Wnt/beta-catenin signaling in liver zonation and beyond |
| Q52192413 | Organ-specific activity of the 5' regulatory region of the glutamine synthetase gene in developing mice. |
| Q36178225 | Organotypic liver culture models: meeting current challenges in toxicity testing |
| Q33828310 | Oxygen: modulator of metabolic zonation and disease of the liver |
| Q57899616 | Paired-cell sequencing enables spatial gene expression mapping of liver endothelial cells |
| Q42377410 | Paracrine and autocrine regulation of gene expression by Wnt-inhibitor Dickkopf in wild-type and mutant hepatocytes. |
| Q39356585 | Pericentral activity of alpha-fetoprotein enhancer 3 and glutamine synthetase upstream enhancer in the adult liver are regulated by β-catenin in mice. |
| Q24300407 | Peroxisomal localization of inducible nitric oxide synthase in hepatocytes |
| Q42872092 | Phenotype and growth behavior of residual β-catenin-positive hepatocytes in livers of β-catenin-deficient mice. |
| Q41981319 | Physiological oxygen tensions modulate expression of the mdr1b multidrug-resistance gene in primary rat hepatocyte cultures |
| Q41109384 | Physiologically-based modelling in mice suggests an aggravated loss of clearance capacity after toxic liver damage |
| Q34169945 | Plasma microRNA profiles in rat models of hepatocellular injury, cholestasis, and steatosis |
| Q91522961 | Polyploidy in liver development, homeostasis and disease |
| Q93064437 | Polyploidy spectrum: a new marker in HCC classification |
| Q34088873 | Precision-cut liver slices: characteristics and use for in vitro pharmaco-toxicology |
| Q41676765 | Prediction of hepatic clearance from microsomes, hepatocytes, and liver slices |
| Q39805145 | Prediction of human pharmacokinetics--evaluation of methods for prediction of hepatic metabolic clearance |
| Q84589345 | Preservation and inducibility of xenobiotic metabolism in long-term cultures of adult rat liver cell aggregates |
| Q39490117 | Primary metabolism in the new human cell line AGE1.HN at various substrate levels: increased metabolic efficiency and α1-antitrypsin production at reduced pyruvate load |
| Q74203482 | Prognostic significance of glutamine synthetase expression in unifocal advanced hepatocellular carcinoma |
| Q47872916 | Protein phosphatase inhibition in normal and keratin 8/18 assembly-incompetent mouse strains supports a functional role of keratin intermediate filaments in preserving hepatocyte integrity |
| Q98463823 | Real time monitoring of oxygen uptake of hepatocytes in a microreactor using optical microsensors |
| Q37121662 | Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME. |
| Q88639243 | Regulation of Hepatic Lipid Accumulation and Distribution by Agouti-Related Protein in Male Mice |
| Q52184138 | Regulation of the spatiotemporal pattern of expression of the glutamine synthetase gene. |
| Q28546872 | Representative Sinusoids for Hepatic Four-Scale Pharmacokinetics Simulations |
| Q42287151 | Response of mouse liver coumarin 7-hydroxylase activity to hepatotoxins: dependence on strain and agent and comparison to other monooxygenases |
| Q36164717 | Robust regulation of hepatic pericentral amination by glutamate dehydrogenase kinetics |
| Q26864289 | Role and regulation of β-catenin signaling during physiological liver growth |
| Q26749020 | Role of BAF60a/BAF60c in chromatin remodeling and hepatic lipid metabolism |
| Q73059409 | Role of oxygen in the zonation of carbohydrate metabolism and gene expression in liver |
| Q42180664 | Role of the 5' enhancer of the glutamine synthetase gene in its organ-specific expression |
| Q38653817 | Scaffold-Free Liver-On-A-Chip with Multiscale Organotypic Cultures. |
| Q44039549 | Selective poisoning of Ctnnb1-mutated hepatoma cells in mouse liver tumors by a single application of acetaminophen |
| Q30427535 | Selective protein arylation and acetaminophen-induced hepatotoxicity |
| Q36345161 | Selectivity of biopolymer membranes using HepG2 cells |
| Q40094566 | Serum components and activated Ha-ras antagonize expression of perivenous marker genes stimulated by beta-catenin signaling in mouse hepatocytes |
| Q38879910 | Signal integration by the CYP1A1 promoter--a quantitative study |
| Q42320342 | Single-cell spatial reconstruction reveals global division of labour in the mammalian liver |
| Q96127620 | Single-cell technologies in hepatology: new insights into liver biology and disease pathogenesis |
| Q92767348 | Spatial heterogeneity in the mammalian liver |
| Q90172853 | Spatial sorting enables comprehensive characterization of liver zonation |
| Q27322901 | Spatio-temporal simulation of first pass drug perfusion in the liver |
| Q49178798 | Spatiotemporal regulation of liver development by the Wnt/β-catenin pathway. |
| Q40955314 | Stem cell-fed maturational lineages and gradients in signals: relevance to differentiation of epithelia |
| Q28279612 | Subcellular and cellular locations of nitric oxide synthase isoforms as determinants of health and disease |
| Q52311752 | Systems biology in hepatology: approaches and applications. |
| Q90702089 | Targeted Delivery of Stk25 Antisense Oligonucleotides to Hepatocytes Protects Mice Against Nonalcoholic Fatty Liver Disease |
| Q40223393 | Targeted oxygen delivery within hepatic hollow fiber bioreactors via supplementation of hemoglobin-based oxygen carriers |
| Q38037378 | Taurine and liver diseases: a focus on the heterogeneous protective properties of taurine |
| Q35819799 | The Wnt/β-catenin signaling pathway in liver biology and disease |
| Q49109698 | The diverse Michaelis constants and maximum velocities of lactate dehydrogenase in situ in various types of cell |
| Q50993407 | The dynamics of local kinetic parameters of glutamate dehydrogenase in rat liver. |
| Q58275192 | The infant growth of boys who later develop coronary heart disease |
| Q72862910 | The physiological position of the liver in the circulation is not a major determinant of its functional capacity |
| Q35029687 | The role of hepatocytes and oval cells in liver regeneration and repopulation |
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| Q44074293 | Transglutaminase down-regulates the dimerization of epidermal growth factor receptor in rat perivenous and periportal hepatocytes |
| Q31860709 | Triiodothyronine downregulates the periportal expression of alpha class glutathione S-transferase in rat liver |
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