Role of oxygen in the zonation of carbohydrate metabolism and gene expression in liver

scientific article published on 01 February 1997

Role of oxygen in the zonation of carbohydrate metabolism and gene expression in liver is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1011544280
P356DOI10.1038/KI.1997.53
P698PubMed publication ID9027713

P2093author name stringK Jungermann
T Kietzmann
P2860cites workPredominant periportal expression of the fructose 1,6-bisphosphatase gene in rat liver: dynamics during the daily feeding rhythm and starvation-refeeding cycleQ48753556
Long-term effects of physiological oxygen concentrations on glycolysis and gluconeogenesis in hepatocyte culturesQ49318615
Predominant localization of phosphoenolpyruvate carboxykinase mRNA in the periportal zone of rat liver parenchyma demonstrated by in situ hybridization.Q51620976
The pattern of glycogen distribution in the liver.Q51688970
Dynamics of liver glycogen: the topochemistry of glycogen synthesis, glycogen content and glycogenolysis under the experimental conditions of glycogen accumulation and depletionQ67516976
Glycogen synthesis via the indirect gluconeogenic pathway in the periportal and via the direct glucose utilizing pathway in the perivenous zone of perfused rat liverQ68468142
Periportal and perivenous hepatocytes retain their zonal characteristics in primary cultureQ70150169
Gluconeogenic-glycolytic capacities and metabolic zonation in liver of rats with streptozotocin, non-ketotic as compared to alloxan, ketotic diabetesQ70153988
Regulation of the expression of the phosphoenolpyruvate carboxykinase gene in cultured rat hepatocytes by glucagon and insulinQ70236096
Modulation by oxygen of the actions of noradrenaline, sympathetic nerve stimulation and prostaglandin F2 alpha on carbohydrate metabolism and hemodynamics in perfused rat liverQ70243551
Detection of mRNAs present at low concentrations in rat liver by in situ hybridization: application to the study of metabolic regulation and azo dye hepatocarcinogenesisQ70332550
Short-term modulation of glycogen metabolism, glycolysis and gluconeogenesis by physiological oxygen concentrations in hepatocyte culturesQ70448142
Zonal expression of the glucokinase gene in rat liver. Dynamics during the daily feeding rhythm and starvation-refeeding cycle demonstrated by in situ hybridizationQ70670898
Regulation of the gluconeogenic phosphoenolpyruvate carboxykinase and glycolytic aldolase A gene expression by O2 in rat hepatocyte cultures. Involvement of hydrogen peroxide as mediator in the response to O2Q71215381
Effects of cobalt on haem proteins of erythropoietin-producing HepG2 cells in multicellular spheroid cultureQ72067251
Modulation of the Glucagon-Dependent Induction of Phosphoenolpyruvate Carboxykinase and Tyrosine Aminotransferase by Arterial and Venous Oxygen Concentrations in Hepatocyte CulturesQ72509019
A ferro-heme protein senses oxygen levels, which modulate the glucagon-dependent activation of the phosphoenolpyruvate carboxykinase gene in rat hepatocyte culturesQ72926803
The distribution of glucose-6-phosphatase in the liver and kidney of the mouseQ73362294
Histochemical distribution pattern of respiratory enzymes in the liver lobuleQ74430396
Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tensionQ24307473
Role of hydrogen peroxide in hypoxia-induced erythropoietin productionQ28369115
Autoregulatory shift from fructolysis to lactate gluconeogenisis in rat hepatocyte suspensions. The problem of metabolic zonation of liver parenchymaQ34066328
Metabolic zonation of the liver: regulation and implications for liver functionQ35417325
Molecular physiology of the regulation of hepatic gluconeogenesis and glycolysisQ35995063
Nervous control of liver metabolism and hemodynamicsQ36336114
Hypoxia-inducible nuclear factors bind to an enhancer element located 3' to the human erythropoietin geneQ37541263
Hepatocyte heterogeneity: the coming of age from the description of a biological curiosity to a partial understanding of its physiological meaning and regulationQ38595904
Functional specialization of different hepatocyte populationsQ38663205
Oxygen Gradients During Hypoxie Steady States in Liver. Urate Oxidase and Cytochrome Oxidase as Intracellular O2IndicatorsQ40112097
Zonation of metabolism and gene expression in liver.Q40459673
Modulation of the glucagon-dependent activation of the phosphoenolpyruvate carboxykinase gene by oxygen in rat hepatocyte cultures. Evidence for a heme protein as oxygen sensorQ41096160
Zonation of parenchymal and nonparenchymal metabolism in liverQ41138372
Regulation of the erythropoietin gene: evidence that the oxygen sensor is a heme proteinQ41337564
Glycogen synthesis from pyruvate in the periportal and from glucose in the perivenous zone in perfused livers from fasted ratsQ41461218
Hypoxic induction of the human erythropoietin gene: cooperation between the promoter and enhancer, each of which contains steroid receptor response elementsQ41591510
Digitonin perfusion of rat liver. A new approach in the study of intra-acinar and intracellular compartmentation in the liverQ41810586
Modulation by oxygen of the glucagon-dependent activation of the phosphoenolpyruvate carboxykinase gene in rat hepatocyte culturesQ42476734
P433issue2
P407language of work or nameEnglishQ1860
P304page(s)402-412
P577publication date1997-02-01
P1433published inKidney InternationalQ6404823
P1476titleRole of oxygen in the zonation of carbohydrate metabolism and gene expression in liver
P478volume51

Reverse relations

cites work (P2860)
Q36134426A Computational Model of Hepatic Energy Metabolism: Understanding Zonated Damage and Steatosis in NAFLD
Q33576042A central role for hypoxic signaling in cartilage, bone, and hematopoiesis
Q49980852A multiscale modelling approach to assess the impact of metabolic zonation and microperfusion on the hepatic carbohydrate metabolism
Q88976368Assessment of the hepatocytic differentiation ability of human skin-derived ABCB5+ stem cells
Q60958429Dynamic Metabolic Zonation of the Hepatic Glucose Metabolism Is Accomplished by Sinusoidal Plasma Gradients of Nutrients and Hormones
Q30531799Effect of oxygen concentration on viability and metabolism in a fluidized-bed bioartificial liver using ³¹P and ¹³C NMR spectroscopy
Q33302056Fasting induces a biphasic adaptive metabolic response in murine small intestine
Q47331988Glycogen content in hepatocytes is related with their size in normal rat liver but not in cirrhotic one.
Q34361034Hepatic glucose uptake, gluconeogenesis and the regulation of glycogen synthesis
Q42496595Human liver cell spheroids in extended perfusion bioreactor culture for repeated-dose drug testing
Q64057372Human three-dimensional in vitro model of hepatic zonation to predict zonal hepatotoxicity
Q41898495Hypoxia-induced down-regulation of CYP1A1/1A2 and up-regulation of CYP3A6 involves serum mediators
Q54996009Hypoxic culture conditions as a solution for mesenchymal stem cell based regenerative therapy.
Q39105478Metabolic zonation of the liver: The oxygen gradient revisited.
Q44829443Oxygen-dependent regulation of hepatic glucose metabolism
Q33828310Oxygen: modulator of metabolic zonation and disease of the liver
Q48040334Periportal localization of glucagon receptor mRNA in rat liver and regulation of its expression by glucose and oxygen in hepatocyte cultures
Q37121662Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME.
Q64115395Relevance of Oxygen Concentration in Stem Cell Culture for Regenerative Medicine
Q28679172Repression of gene expression by oxidative stress
Q92767348Spatial heterogeneity in the mammalian liver
Q34401785Targeting hypoxia in the leukemia microenvironment
Q89579537The hypoxic microenvironment: a driving force for heterotopic ossification progression
Q34746268Tissue-level modeling of xenobiotic metabolism in liver: An emerging tool for enabling clinical translational research
Q27012737Vascular patterning sets the stage for macro and micro hepatic architecture
Q40081986Zonation of hepatic fat accumulation: insights from mathematical modelling of nutrient gradients and fatty acid uptake
Q35023574Zonation of nitrogen and glucose metabolism gene expression upon acute liver damage in mouse
Q42069262β-catenin links hepatic metabolic zonation with lipid metabolism and diet-induced obesity in mice

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